Professor Edna   Hardeman
Professor

Professor Edna Hardeman

  • 1987 Fellow in Pharmacology, Stanford University Medical Center
  • 1983 PhD Biological Sciences, Stanford University
  • 1977 BA/BSc (Plan II Interdisciplinary Arts/Biochemistry) (summa cum laude), The University of Texas at Austin
Medicine & Health
Biomedical Research Institute

Professor Hardeman received her doctorate from the Department of Biological Sciences, Stanford University in the field of cholesterol biosynthesis and then took up a postdoctoral fellowship in the Department of Pharmacology, Stanford Medical School to study muscle determination factors funded by an NIH Postdoctoral Fellowship. She established her laboratory, the Muscle Development Unit, at the Children's Medical Research Institute in Sydney, and built an international reputation defining mechanisms of muscle gene regulation, generating mouse models for human muscle diseases of actin thin filaments, and trialing therapies as part of an international consortium of the European Neuromuscular Center.

In 2009 she moved to the University of New South Wales to take up a Research Chair in Anatomy and establish the Cellular and Genetic Medicine Unit. In 2018 she became the Head of Cell Biology in the School of Medical Sciences.

Throughout her research career she has studied the physiology of the actin/tropomyosin cytoskeleton and in collaboration with Professor Peter Gunning, identified tropomyosins as the gatekeepers of actin filament function and established the physiological role of the cancer-associated tropomyosin, Tpm3.1. Her laboratory has examined Tpm3.1 as a druggable target for cancer therapy including demonstrating the efficacy of anti-Tpm3.1 drugs to treat the childhood cancer neuroblastoma, in a mouse xenograft model. They have expanded their drug development programs to target additional tropomyosin isoforms in a range of human disease indications.

She was a member of the Scientific Advisory Boards of the Australian Research Council Special Research Centres for the Molecular Genetics of Development (2004-2009) and Functional and Applied Genomics (2006-2009), President of the Australian and New Zealand Society for Cell and Developmental Biology (200-2011), Member (2009-2013) and Chair (2013-ongoing) of the Australian National Health and Medical Research Council Animal Welfare Committee, and Deputy Chair (2010-2013) and Chair (2014-2016) of the National Committee for Biomedical Sciences, the Australian Academy of Science. She was a member of the UNSW Academic Board and Committee on Research (2010-2013).

Current Appointments & Positions Held

  • Professor, Head of Cell Biology, Department of Pathology, School of Medical Sciences
  • Chair, NHMRC Animal Welfare Committee
  • Member, NHMRC Research Quality Steering Committee
  • Committee Member, Australian and New Zealand Society for Cell and Developmental Biology

Membership in Societies

  • Australian and New Zealand Society for Cell and Developmental Biology
  • Australian Society for Biochemistry and Molecular Biology
  • Australian Society for Medical Research
  • American Society for Cell Biology
Phone
+61-2-9385 3760
Location
School of Medical Sciences Wallace Wurth Building C27, Level 2 East Cnr High St & Botany St Sydney, NSW 2052 Australia

Publications

  • Book Chapters | 2012
    Professor Edna Hardeman
    Kee AJ; Hardeman EC, 2012, 'Thin filament diseases of striated muscle', in Cytoskeleton and Human Disease, Humana Press, Springer, Printforce, The Netherlands, pp. 123 - 140, http://dx.doi.org/10.1007/978-1-61779-788-0_6
    Book Chapters | 2008
    Professor Edna Hardeman
    Nguyen MA; Hardeman EC, 2008, 'Mouse models for thin filament disease', in Advances in Experimental Medicine and Biology, Springer New York LLC, pp. 66 - 77, http://dx.doi.org/10.1007/978-0-387-84847-1_6
    Book Chapters | 1992
    Professor Edna Hardeman
    Hardeman E; Arkell R; Brennan K; Dunwoodie S; Esser K; Gordon M; Joya J; Shalhoub C; Sutherland C, 1992, 'Skeletal muscle gene control and transgenic mice', in Kakulas B; Howell J; Roses A (ed.), Duchenne Muscular Dystrophy: Animal Models and Genetic Manipulation, edn. 1, Raven Press Ltd, New York, pp. 237 - 246
  • Journal articles | 2021
    Professor Edna Hardeman
    Xu X; Wang Y; Bryce NS; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Targeting the actin/tropomyosin cytoskeleton in epithelial ovarian cancer reveals multiple mechanisms of synergy with anti-microtubule agents', British Journal of Cancer, http://dx.doi.org/10.1038/s41416-021-01420-y
    Journal articles | 2021
    Professor Edna Hardeman
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Srivastava P; Potas JR; Hung T; Power C; Hardy P; Ma DD; Kilian KA; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 2021, 'Induction of muscle-regenerative multipotent stem cells from human adipocytes by PDGF-AB and 5-azacytidine', Science Advances, vol. 7, pp. eabd1929 - eabd1929, http://dx.doi.org/10.1126/sciadv.abd1929
    Journal articles | 2021
    Professor Edna Hardeman
    Rae J; Ferguson C; Ariotti N; Webb RI; Cheng HH; Mead JL; Riches JD; Hunter DJB; Martel N; Baltos J; Christopoulos A; Bryce NS; Cagigas ML; Fonseka S; Sayre ME; Hardeman EC; Gunning PW; Gambin Y; Hall TE; Parton RG, 2021, 'A robust method for particulate detection of a genetic tag for 3D electron microscopy', eLife, vol. 10, http://dx.doi.org/10.7554/ELIFE.64630
    Journal articles | 2020
    Professor Edna Hardeman
    Manstein DJ; Meiring JCM; Hardeman EC; Gunning PW, 2020, 'Actin–tropomyosin distribution in non-muscle cells', Journal of Muscle Research and Cell Motility, vol. 41, pp. 11 - 22, http://dx.doi.org/10.1007/s10974-019-09514-0
    Journal articles | 2020
    Professor Edna Hardeman
    Hardeman EC; Bryce NS; Gunning PW, 2020, 'Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms', Seminars in Cell and Developmental Biology, vol. 102, pp. 122 - 131, http://dx.doi.org/10.1016/j.semcdb.2019.10.004
    Journal articles | 2020
    Professor Edna Hardeman
    Wang Y; Stear JH; Swain A; Xu X; Bryce NS; Carnell M; Alieva IB; Dugina VB; Cripe TP; Stehn J; Hardeman EC; Gunning PW, 2020, 'Drug targeting the actin cytoskeleton potentiates the cytotoxicity of low dose vincristine by abrogating actin-mediated repair of spindle defects', Molecular Cancer Research, vol. 18, pp. 1074 - 1087, http://dx.doi.org/10.1158/1541-7786.MCR-19-1122
    Journal articles | 2020
    Professor Edna Hardeman
    Amorim NML; Kee A; Coster ACF; Lucas C; Bould S; Daniel S; Weir JM; Mellett NA; Barbour J; Meikle PJ; Cohn RJ; Turner N; Hardeman EC; Simar D, 2020, 'Irradiation impairs mitochondrial function and skeletal muscle oxidative capacity: significance for metabolic complications in cancer survivors', Metabolism: clinical and experimental, vol. 103, pp. 154025, http://dx.doi.org/10.1016/j.metabol.2019.154025
    Journal articles | 2020
    Professor Edna Hardeman
    Janco M; Dedova I; Bryce NS; Hardeman EC; Gunning PW, 2020, 'Visualizing the in vitro assembly of tropomyosin/actin filaments using TIRF microscopy', Biophysical Reviews, vol. 12, pp. 879 - 885, http://dx.doi.org/10.1007/s12551-020-00720-6
    Journal articles | 2020
    Professor Edna Hardeman
    Abouelezz A; Stefen H; Segerstråle M; Micinski D; Minkeviciene R; Lahti L; Hardeman EC; Gunning PW; Hoogenraad CC; Taira T; Fath T; Hotulainen P, 2020, 'Tropomyosin Tpm3.1 Is Required to Maintain the Structure and Function of the Axon Initial Segment', iScience, vol. 23, http://dx.doi.org/10.1016/j.isci.2020.101053
    Journal articles | 2020
    Professor Edna Hardeman
    Slick R; Tinklenberg J; Meng H; Beatka M; Prom M; Ott E; Montanaro F; Zhang L; Granzier H; Hardeman E; Geurts A; Lawlor M, 2020, 'CONGENITAL MYOPATHIES 1 – NEMALINE', Neuromuscular Disorders, vol. 30, pp. S54 - S54, http://dx.doi.org/10.1016/j.nmd.2020.08.030
    Journal articles | 2020
    Professor Edna Hardeman
    Hardeman EC; Gunning PW, 2020, 'Life and death agendas of actin filaments', Nature Materials, vol. 19, pp. 135 - 136, http://dx.doi.org/10.1038/s41563-019-0583-1
    Journal articles | 2019
    Professor Edna Hardeman
    Meiring JCM; Bryce NS; Niño JLG; Gabriel A; Tay SS; Hardeman EC; Biro M; Gunning PW, 2019, 'Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments', Scientific Reports, vol. 9, http://dx.doi.org/10.1038/s41598-019-42977-2
    Journal articles | 2019
    Professor Edna Hardeman
    Bryce NS; Hardeman EC; Gunning PW; Lock JG, 2019, 'Chemical biology approaches targeting the actin cytoskeleton through phenotypic screening', Current Opinion in Chemical Biology, vol. 51, pp. 40 - 47, http://dx.doi.org/10.1016/j.cbpa.2019.02.013
    Journal articles | 2019
    Professor Edna Hardeman
    Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, vol. 9, pp. 11262, http://dx.doi.org/10.1038/s41598-019-47592-9
    Journal articles | 2019
    Professor Edna Hardeman
    Ebrahim S; Chen D; Weiss M; Malec L; Ng Y; Rebustini I; Krystofiak E; Hu L; Liu J; Masedunskas A; Hardeman E; Gunning P; Kachar B; Weigert R, 2019, 'Dynamic polyhedral actomyosin lattices remodel micron-scale curved membranes during exocytosis in live mice', Nature Cell Biology, vol. 21, pp. 933 - 939, http://dx.doi.org/10.1038/s41556-019-0365-7
    Journal articles | 2019
    Professor Edna Hardeman
    Meiring JCM; Bryce NS; Lastra Cagigas M; Benda A; Whan RM; Ariotti N; Parton RG; Stear JH; Hardeman EC; Gunning PW, 2019, 'Colocation of Tpm3.1 and myosin IIa heads defines a discrete subdomain in stress fibres', Journal of cell science, vol. 132, http://dx.doi.org/10.1242/jcs.228916
    Journal articles | 2019
    Professor Edna Hardeman
    Bryce NS; Failes TW; Stehn JR; Baker K; Zahler S; Arzhaeva Y; Bischof L; Lyons C; Dedova I; Arndt GM; Gaus K; Goult BT; Hardeman EC; Gunning PW; Lock JG, 2019, 'High-Content Imaging of Unbiased Chemical Perturbations Reveals that the Phenotypic Plasticity of the Actin Cytoskeleton Is Constrained', Cell Systems, vol. 9, pp. 496 - 507.e5, http://dx.doi.org/10.1016/j.cels.2019.09.002
    Journal articles | 2019
    Professor Edna Hardeman
    Ross JA; Levy Y; Ripolone M; Kolb JS; Turmaine M; Holt M; Lindqvist J; Claeys KG; Weis J; Monforte M; Tasca G; Moggio M; Figeac N; Zammit PS; Jungbluth H; Fiorillo C; Vissing J; Witting N; Granzier H; Zanoteli E; Hardeman EC; Wallgren-Pettersson C; Ochala J, 2019, 'Impairments in contractility and cytoskeletal organisation cause nuclear defects in nemaline myopathy', Acta Neuropathologica, vol. 138, pp. 477 - 495, http://dx.doi.org/10.1007/s00401-019-02034-8
    Journal articles | 2019
    Professor Edna Hardeman
    Slick R; Tinklenberg J; Vanden Avond M; Beatka M; Meng H; Seibers E; Geurts A; Granzier H; Hardeman E; Zhang L; Montanaro F; Nowak K; Lawlor M, 2019, 'P.155Proteomic profiling in nemaline myopathy to identify molecular phenotypes', Neuromuscular Disorders, vol. 29, pp. S93 - S93, http://dx.doi.org/10.1016/j.nmd.2019.06.210
    Journal articles | 2018
    Professor Edna Hardeman
    Meiring JCM; Bryce NS; Wang Y; Taft MH; Manstein DJ; Liu Lau S; Stear J; Hardeman EC; Gunning PW, 2018, 'Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton', Current Biology, vol. 28, pp. 2331 - 2337.e5, http://dx.doi.org/10.1016/j.cub.2018.05.053
    Journal articles | 2018
    Professor Edna Hardeman
    Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, vol. 131, http://dx.doi.org/10.1242/jcs.212654
    Journal articles | 2018
    Professor Edna Hardeman
    Gunning PW; Hardeman EC, 2018, 'Fundamental differences', eLife, vol. 7, http://dx.doi.org/10.7554/eLife.34477
    Journal articles | 2018
    Professor Edna Hardeman
    Kee AJ; Chagan J; Chan JY; Bryce NS; Lucas CA; Zeng J; Hook J; Treutlein H; Laybutt DR; Stehn JR; Gunning PW; Hardeman EC, 2018, 'On-target action of anti-tropomyosin drugs regulates glucose metabolism', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-22946-x
    Journal articles | 2018
    Professor Edna Hardeman
    Siebers E; Tinklenberg J; Meng H; Ayres S; Vanden Avond M; Slick R; Nowake K; Granzier H; Hardeman E; Montanaro F; Lawlor M, 2018, 'CONGENITAL MYOPATHIES: NEMALINE AND TITINOPATHIES', Neuromuscular Disorders, vol. 28, pp. S102 - S103, http://dx.doi.org/10.1016/j.nmd.2018.06.282
    Journal articles | 2018
    Professor Edna Hardeman
    Gunning PW; Hardeman EC, 2018, 'Tropomyosin-directed tuning of myosin motor function: Insights from mutagenesis', Cytoskeleton, vol. 75, pp. 147 - 149, http://dx.doi.org/10.1002/cm.21441
    Journal articles | 2017
    Professor Edna Hardeman
    Gunning PW; Hardeman EC, 2017, 'Tropomyosins', Current Biology, vol. 27, pp. R8 - R13, http://dx.doi.org/10.1016/j.cub.2016.11.033
    Journal articles | 2017
    Professor Edna Hardeman
    Pleines I; Woods J; Chappaz S; Kew V; Foad N; Ballester-Beltrán J; Aurbach K; Lincetto C; Lane RM; Schevzov G; Alexander WS; Hilton DJ; Astle WJ; Downes K; Nurden P; Westbury SK; Mumford AD; Obaji SG; Collins PW; BioResource N; Delerue F; Ittner LM; Bryce NS; Holliday M; Lucas CA; Hardeman EC; Ouwehand WH; Gunning PW; Turro E; Tijssen MR; Kile BT, 2017, 'Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia', Journal of Clinical Investigation, vol. 127, pp. 814 - 829, http://dx.doi.org/10.1172/JCI86154
    Journal articles | 2017
    Professor Edna Hardeman
    Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'ER/Golgi trafficking is facilitated by unbranched actin filaments containing Tpm4.2', Cytoskeleton, vol. 74, pp. 379 - 389, http://dx.doi.org/10.1002/cm.21405
    Journal articles | 2017
    Professor Edna Hardeman
    Suchowerska AK; Fok S; Stefen H; Gunning PW; Hardeman EC; Power J; Fath T, 2017, 'Developmental profiling of tropomyosin expression in mouse brain reveals Tpm4.2 as the major post-synaptic tropomyosin in the mature brain', Frontiers in Cellular Neuroscience, vol. 11, http://dx.doi.org/10.3389/fncel.2017.00421
    Journal articles | 2017
    Professor Edna Hardeman
    Currier MA; Stehn JR; Swain A; Chen D; Hook J; Eiffe E; Heaton A; Brown D; Nartker BA; Eaves DW; Kloss N; Treutlein H; Zeng J; Alieva IB; Dugina VB; Hardeman EC; Gunning PW; Cripe TP, 2017, 'Identification of cancer-targeted tropomyosin inhibitors and their synergy with microtubule drugs', Molecular Cancer Therapeutics, vol. 16, pp. 1555 - 1565, http://dx.doi.org/10.1158/1535-7163.MCT-16-0873
    Journal articles | 2017
    Professor Edna Hardeman
    Nobis M; Herrmann D; Warren SC; Kadir S; Leung W; Killen M; Magenau A; Stevenson D; Lucas MC; Reischmann N; Vennin C; Conway JRW; Boulghourjian A; Zaratzian A; Law AM; Gallego-Ortega D; Ormandy CJ; Walters SN; Grey ST; Bailey J; Chtanova T; Quinn JMW; Baldock PA; Croucher PI; Schwarz JP; Mrowinska A; Zhang L; Herzog H; Masedunskas A; Hardeman EC; Gunning PW; del Monte-Nieto G; Harvey RP; Samuel MS; Pajic M; McGhee EJ; Johnsson AKE; Sansom OJ; Welch HCE; Morton JP; Strathdee D; Anderson KI; Timpson P, 2017, 'A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts', Cell Reports, vol. 21, pp. 274 - 288, http://dx.doi.org/10.1016/j.celrep.2017.09.022
    Journal articles | 2017
    Professor Edna Hardeman
    Kee AJ; Bryce NS; Yang L; Polishchuk E; Schevzov G; Weigert R; Polishchuk R; Gunning PW; Hardeman EC, 2017, 'Cover Image, Volume 74, Issue 10', Cytoskeleton, vol. 74, pp. C4 - C4, http://dx.doi.org/10.1002/cm.21413
    Journal articles | 2016
    Professor Edna Hardeman
    Akladios B; Mendoza-Reinoso V; Samuel MS; Hardeman EC; Khosrotehrani K; Key B; Beverdam A, 2016, 'Epidermal YAP2-5SA-ΔC Drives β-Catenin Activation to Promote Keratinocyte Proliferation in the Mouse Skin in vivo', Journal of Investigative Dermatology, vol. 137, pp. 716 - 726, http://dx.doi.org/10.1016/j.jid.2016.10.029
    Journal articles | 2016
    Professor Edna Hardeman
    Lindqvist J; Levy Y; Pati-Alam A; Hardeman EC; Gregorevic P; Ochala J, 2016, 'Modulating myosin restores muscle function in a mouse model of nemaline myopathy', Annals of Neurology, vol. 79, pp. 717 - 725, http://dx.doi.org/10.1002/ana.24619
    Journal articles | 2016
    Professor Edna Hardeman
    Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2016, 'Corrigendum to An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake [Traic, (2015), 16, 7, 691-711]', Traffic, vol. 17, pp. 80 - 81, http://dx.doi.org/10.1111/tra.12342
    Journal articles | 2016
    Professor Edna Hardeman
    Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028
    Journal articles | 2016
    Professor Edna Hardeman
    Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Warren SC; Timpson P; Stear JH; Gunning PW; Hardeman EC, 2016, 'Recruitment kinetics of tropomyosin tpm3.1 to actin filament bundles in the cytoskeleton is independent of actin filament kinetics', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0168203
    Journal articles | 2016
    Professor Edna Hardeman
    Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep19816
    Journal articles | 2016
    Professor Edna Hardeman
    Erami Z; Herrmann D; Warren SC; Nobis M; McGhee EJ; Lucas MC; Leung W; Reischmann N; Mrowinska A; Schwarz JP; Kadir S; Conway JRW; Vennin C; Karim SA; Campbell AD; Gallego-Ortega D; Magenau A; Murphy KJ; Ridgway RA; Law AM; Walters SN; Grey ST; Croucher DR; Zhang L; Herzog H; Hardeman EC; Gunning PW; Ormandy CJ; Evans TRJ; Strathdee D; Sansom OJ; Morton JP; Anderson KI; Timpson P, 2016, 'Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue', Cell Reports, vol. 14, pp. 152 - 167, http://dx.doi.org/10.1016/j.celrep.2015.12.020
    Journal articles | 2016
    Professor Edna Hardeman
    Corley SM; Canales CP; Carmona-Mora P; Mendoza-Reinosa V; Beverdam A; Hardeman EC; Wilkins MR; Palmer SJ, 2016, 'RNA-Seq analysis of Gtf2ird1 knockout epidermal tissue provides potential insights into molecular mechanisms underpinning Williams-Beuren syndrome', BMC Genomics, vol. 17, http://dx.doi.org/10.1186/s12864-016-2801-4
    Journal articles | 2016
    Professor Edna Hardeman
    Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; DasGupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', American Journal of Pathology, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008
    Journal articles | 2016
    Professor Edna Hardeman
    Tinklenberg J; Meng H; Yang L; Liu F; Hoffmann RG; Dasgupta M; Allen KP; Beggs AH; Hardeman EC; Pearsall RS; Fitts RH; Lawlor MW, 2016, 'Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy', AMERICAN JOURNAL OF PATHOLOGY, vol. 186, pp. 1568 - 1581, http://dx.doi.org/10.1016/j.ajpath.2016.02.008
    Journal articles | 2016
    Professor Edna Hardeman
    Liang H; Akladios B; Canales CP; Francis R; Hardeman EH; Beverdam A, 2016, 'CUBIC protocol visualizes protein expression at single cell resolution in whole mount skin preparations', Journal of Visualized Experiments, vol. 2016, http://dx.doi.org/10.3791/54401
    Journal articles | 2015
    Professor Edna Hardeman
    Gunning PW; Hardeman EC; Lappalainen P; Mulvihill DP, 2015, 'Tropomyosin - master regulator of actin filament function in the cytoskeleton', Journal of Cell Science, vol. 128, pp. 2965 - 2974, http://dx.doi.org/10.1242/jcs.172502
    Journal articles | 2015
    Professor Edna Hardeman
    Kee AJ; Yang L; Lucas CA; Greenberg MJ; Martel N; Leong GM; Hughes WE; Cooney GJ; James DE; Ostap EM; Han W; Gunning PW; Hardeman EC, 2015, 'An Actin Filament Population Defined by the Tropomyosin Tpm3.1 Regulates Glucose Uptake', Traffic, vol. 16, pp. 691 - 711, http://dx.doi.org/10.1111/tra.12282
    Journal articles | 2015
    Professor Edna Hardeman
    Canales CP; Wong ACY; Gunning PW; Housley GD; Hardeman EC; Palmer SJ, 2015, 'The role of GTF2IRD1 in the auditory pathology of Williams-Beuren Syndrome', European Journal of Human Genetics, vol. 23, pp. 774 - 780, http://dx.doi.org/10.1038/ejhg.2014.188
    Journal articles | 2015
    Professor Edna Hardeman
    Carmona-Mora P; Widagdo J; Tomasetig F; Canales CP; Cha Y; Lee W; Alshawaf A; Dottori M; Whan RM; Hardeman EC; Palmer SJ, 2015, 'The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation', Human Genetics, vol. 134, pp. 1099 - 1115, http://dx.doi.org/10.1007/s00439-015-1591-0
    Journal articles | 2015
    Professor Edna Hardeman
    Jalilian I; Heu C; Cheng H; Freittag H; Desouza M; Stehn JR; Bryce NS; Whan RM; Hardeman EC; Fath T; Schevzov G; Gunning PW, 2015, 'Cell elasticity is regulated by the tropomyosin isoform composition of the actin cytoskeleton', PLoS ONE, vol. 10, http://dx.doi.org/10.1371/journal.pone.0126214
    Journal articles | 2015
    Professor Edna Hardeman
    Schevzov G; Kee AJ; Wang B; Sequeira VB; Hook J; Coombes JD; Lucas CA; Stehn JR; Musgrove EA; Cretu A; Assoian R; Fath T; Hanoch T; Seger R; Pleines I; Kile BT; Hardeman EC; Gunning PW, 2015, 'Regulation of cell proliferation by ERK and signal-dependent nuclear translocation of ERK is dependent on Tm5NM1-containing actin filaments', Molecular Biology of the Cell, vol. 26, pp. 2475 - 2490, http://dx.doi.org/10.1091/mbc.E14-10-1453
    Journal articles | 2015
    Professor Edna Hardeman
    Bryce NS; De Laurentiis A; Failes T; Arndt GM; Stehn JR; Hardeman EC; Gunning PW, 2015, 'Identification of the possible states of organisation of the actin cytoskeleton using high content image screening of a high diversity chemical library.', MOLECULAR BIOLOGY OF THE CELL, vol. 26, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928400229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2015
    Professor Edna Hardeman
    Hardeman EC; Appaduray MA; Masedunskas A; Bryce NS; Lucas CA; Gunning PW, 2015, 'Recruitment kinetics of tropomyosin is independent of actin filaments', MOLECULAR BIOLOGY OF THE CELL, vol. 26, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209928500840&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2014
    Professor Edna Hardeman
    Gineste C; Ottenheijm C; Fur YL; Banzet S; Pecchi E; Vilmen C; Cozzone PJ; Koulmann N; Hardeman EC; Bendahan D; Gondin J, 2014, 'Alterations at the cross-bridge level are associated with a paradoxical gain of muscle function in vivo in a mouse model of Nemaline myopathy', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0109066
    Journal articles | 2014
    Professor Edna Hardeman
    Curthoys NM; Freittag H; Connor A; Desouza M; Brettle M; Poljak A; Hall A; Hardeman E; Schevzov G; Gunning PW; Fath T, 2014, 'Tropomyosins induce neuritogenesis and determine neurite branching patterns in B35 neuroblastoma cells', Molecular and Cellular Neuroscience, vol. 58, pp. 11 - 21, http://dx.doi.org/10.1016/j.mcn.2013.10.011
    Journal articles | 2014
    Professor Edna Hardeman
    Caldwell BJ; Lucas C; Kee AJ; Gaus K; Gunning PW; Hardeman EC; Yap AS; Gomez GA, 2014, 'Tropomyosin isoforms support actomyosin biogenesis to generate contractile tension at the epithelial zonula adherens', Cytoskeleton, vol. 71, pp. 663 - 676, http://dx.doi.org/10.1002/cm.21202
    Journal articles | 2014
    Professor Edna Hardeman
    Head SI; Houweling PJ; Chan S; Chen G; Hardeman EC, 2014, 'Properties of regenerated mouse extensor digitorum longus muscle following notexin injury', Experimental Physiology, vol. 99, pp. 664 - 674, http://dx.doi.org/10.1113/expphysiol.2013.077289
    Journal articles | 2014
    Professor Edna Hardeman
    Masedunskas A; Appaduray M; Gunning PW; Hardeman EC, 2014, 'Lighting up microtubule cytoskeleton dynamics in skeletal muscle', IntraVital, vol. 3, pp. e29293-1-e29293-5, http://dx.doi.org/10.4161/intv.29293
    Journal articles | 2014
    Professor Edna Hardeman
    Lindqvist J; Hardeman EC; Ochala J, 2014, 'Sexually dimorphic myofilament function in a mouse model of nemaline myopathy', Archives of Biochemistry and Biophysics, vol. 564, pp. 37 - 42, http://dx.doi.org/10.1016/j.abb.2014.09.011
    Journal articles | 2013
    Professor Edna Hardeman
    Lees JG; Ching YW; Adams DH; Bach CT; Samuel MS; Kee AJ; Hardeman EC; Gunning P; Cowin AJ; O'Neill GM, 2013, 'Tropomyosin regulates cell migration during skin wound healing', Journal of Investigative Dermatology, vol. 133, pp. 1330 - 1339, http://dx.doi.org/10.1038/jid.2012.489
    Journal articles | 2013
    Professor Edna Hardeman
    Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Davies KE; Laing NG; Nowak KJ, 2013, 'Cardiac alpha-actin over-expression therapy in dominant ACTA1 disease', Human Molecular Genetics, vol. 22, pp. 1 - 11, http://dx.doi.org/10.1093/hmg/ddt252
    Journal articles | 2013
    Professor Edna Hardeman
    Lindqvist J; Cheng AJ; Renaud G; Hardeman E; Ochala J, 2013, 'Distinct Underlying Mechanisms of Limb and Respiratory Muscle Fiber Weaknesses in Nemaline Myopathy', Journal of Neuropathology and Experimental Neurology, vol. 72, pp. 472 - 481, http://dx.doi.org/10.1097/NEN.0b013e318293b1cc
    Journal articles | 2013
    Professor Edna Hardeman
    Gineste C; Le FY; Vilmen C; Le TA; Pecchi E; Cozzone PJ; Hardeman EC; Bendahan D; Gondin J, 2013, 'Combined MRI and 31P-MRS investigations of the ACTA1(H40Y) mouse model of nemaline myopathy show impaired muscle function and altered energy metabolism', PLoS ONE, vol. 8, pp. e61517, http://dx.doi.org/10.1371/journal.pone.0061517
    Journal articles | 2013
    Professor Edna Hardeman
    Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Sequeira VB; Butler TL; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning PW, 2013, 'A novel class of anticancer compounds targets the actin cytoskeleton in tumor cells', Cancer research, vol. 73, pp. 5169 - 5182, http://dx.doi.org/10.1158/0008-5472.CAN-12-4501
    Journal articles | 2013
    Professor Edna Hardeman
    Lee AS; Anderson JE; Joya JE; Head SI; Pather N; Kee AJ; Gunning PW; Hardeman EC, 2013, 'Aged skeletal muscle retains the ability to fully regenerate functional architecture', BioArchitecture, vol. 3, pp. 25 - 37, http://dx.doi.org/10.4161/bioa.24966
    Journal articles | 2013
    Professor Edna Hardeman
    Kee AJ; Tran L; Yang L; Genel F; Weigert R; Gunning P; Hardeman E, 2013, 'Identification of a novel Golgi-associated actin filament population that is important for maintaining Golgi morphology', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Professor Edna Hardeman
    Wang B; Schevzov G; Coombes J; Hook J; Kee A; Lucas C; Stehn J; Sequeira V; Seger R; Hardeman E; Gunning P, 2013, 'Regulation of cell proliferation mediated by the actin filament regulator Tropomyosin 5NM1', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Professor Edna Hardeman
    Masedunskas A; Appaduray M; Hardeman EC; Gunning PW, 2013, 'What makes a model system great?: A case for intravital microscopy for studying the actin cytoskeleton', IntraVital, vol. 2, pp. 1 - 9, http://dx.doi.org/10.4161/intv.26287
    Journal articles | 2013
    Professor Edna Hardeman
    Schevzov G; Kee A; Hook J; Pleines I; Kile B; Hardeman E; Gunning P, 2013, 'Distinct actin filament networks modulate different cell signaling cascades', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2013
    Professor Edna Hardeman
    Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', MOLECULAR BIOLOGY OF THE CELL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348702020&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2012
    Professor Edna Hardeman
    Howard ML; Palmer SJ; Taylor KM; Arthurson GJ; Spitzer MW; Du X; Pang TY; Renoir T; Hardeman EC; Hannan AJ, 2012, 'Mutation of Gtf2ird1 from the Williams-Beuren syndrome critical region results in facial dysplasia, motor dysfunction, and altered vocalisations.', Neurobiology of Disease, vol. 45, pp. 913 - 922, http://dx.doi.org/10.1016/j.nbd.2011.12.010
    Journal articles | 2012
    Professor Edna Hardeman
    Palmer SJ; Taylor KM; Santucci N; Widagdo J; Chan Y-KA; Yeo J-L; Gunning PW; Hardeman EC, 2012, 'GTF2IRD2 from the Williams-Beuren critical region encodes a mobile element-derived fusion protein that antagonizes the action of its related family members', Journal of Cell Science, vol. 125, pp. 5040 - 5050, http://dx.doi.org/10.1242/​jcs.102798
    Journal articles | 2012
    Professor Edna Hardeman
    Widagdo J; Taylor KM; Gunning PW; Hardeman EC; Palmer SJ, 2012, 'SUMOylation of GTF2IRD1 regulates protein partner interactions and ubiquitin-mediated degradation', PLoS ONE, vol. 7, pp. e49283 pg 1 - e49283 pg 10, http://dx.doi.org/10.1371/journal.pone.0049283
    Journal articles | 2011
    Professor Edna Hardeman
    Nguyen MA; Joya JE; Kee AJ; Domazetovska A; Yang N; Hook JW; Lemckert FA; Kettle E; Valova VA; Robinson PJ; North KN; Gunning PW; Mitchell CA; Hardeman EC, 2011, 'Hypertrophy and dietary tyrosine ameliorate the phenotypes of a mouse model of severe nemaline myopathy.', Brain, vol. 134, pp. 3513 - 3526, http://dx.doi.org/10.1093/brain/awr274
    Journal articles | 2010
    Professor Edna Hardeman
    Ittner LM; Ke YD; Delerue F; Bi M; Gladbach A; van Eersel J; Wolfing H; Chieng BC; Christie MJ; Napier IA; Eckert A; Staufenbiel M; Hardeman E; Gotz J, 2010, 'Dendritic function of Tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models', Cell, vol. 142, pp. 387 - 397, http://dx.doi.org/10.1016/j.cell.2010.06.036
    Journal articles | 2010
    Professor Edna Hardeman
    Leong GM; Kee AJ; Millard SM; Martel N; Eriksson N; Turner N; Cooney GJ; Hardeman EC; Muscat GE, 2010, 'The Ski proto-oncogene regulates body composition and suppresses lipogenesis.', International journal of obesity, vol. 34, pp. 524 - 536, http://dx.doi.org/10.1038/ijo.2009.265
    Journal articles | 2010
    Professor Edna Hardeman
    Palmer SJ; Santucci N; Widagdo J; Bontempo SJ; Tay ES; Hook J; Lemckert F; Gunning PW; Hardeman EC, 2010, 'Negative autoregulation of GTF2IRD1 in Williams-Beuren syndrome via a novel DNA binding mechanism', The Journal of Biological Chemistry, vol. 285, pp. 4715 - 4724, http://dx.doi.org/10.1074/jbc.M109.086660
    Journal articles | 2009
    Professor Edna Hardeman
    Lee AS; Kahatapitiya P; Kramer B; Joya JE; Hook J; Liu R; Schevzov G; Alexander IE; McCowage G; Montarras D; Gunning PW; Hardeman EC, 2009, 'Methylguanine DNA methyltransferase-mediated drug resistance-based selective enrichment and engraftment of transplanted stem cells in skeletal muscle', Stem Cells, vol. 27, pp. 1098 - 1108, http://dx.doi.org/10.1002/stem.28
    Journal articles | 2009
    Professor Edna Hardeman
    Kee AJ; Gunning PW; Hardeman EC, 2009, 'Diverse roles of the actin cytoskeleton in striated muscle', Journal of Muscle Research and Cell Motility, vol. 30, pp. 187 - 197, http://dx.doi.org/10.1007/s10974-009-9193-x
    Journal articles | 2009
    Professor Edna Hardeman
    Vlahovich N; Kee AJ; Van der Poel C; Kettle E; Hernandez-Deviez D; Lucas C; Lynch GS; Parton RG; Gunning PW; Hardeman EC, 2009, 'Cytoskeletal tropomyosin Tm5NM1 is required for normal Excitation- contraction coupling in skeletal muscle', Molecular Biology of the Cell, vol. 20, pp. 400 - 409, http://dx.doi.org/10.1091/mbc.E08-06-0616
    Journal articles | 2009
    Professor Edna Hardeman
    Kee AJ; Gunning PW; Hardeman EC, 2009, 'A cytoskeletal tropomyosin can compromise the structural integrity of skeletal muscle', Cell Motility and the Cytoskeleton, vol. 66, pp. 710 - 720, http://dx.doi.org/10.1002/cm.20400
    Journal articles | 2008
    Professor Edna Hardeman
    Kee AJ; Hardeman EC, 2008, 'Tropomyosins in skeletal muscle diseases', Advances in Experimental Medicine and Biology, vol. 644, pp. 143 - 154, http://dx.doi.org/10.1007/978-0-387-85766-4_12
    Journal articles | 2008
    Professor Edna Hardeman
    Cowling BS; McGrath MJ; Nguyen MA; Cottle DL; Kee AJ; Brown S; Schessl J; Zou Y; Joya J; Bonnemann CG; Hardeman EC; Mitchell CA, 2008, 'Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy', Journal of Cell Biology, vol. 183, pp. 1033 - 1048, http://dx.doi.org/10.1083/jcb.200804077
    Journal articles | 2008
    Professor Edna Hardeman
    Gunning PW; O'Neill G; Hardeman EC, 2008, 'Tropomyosin-based regulation of the actin cytoskeleton in time and space', Physiological Reviews, vol. 88, pp. 1 - 35, http://dx.doi.org/10.1152/physrev.00001.2007
    Journal articles | 2008
    Professor Edna Hardeman
    Chang AC; Hook J; Lemckert FA; McDonald M; Nguyen MA; Hardeman EC; Little DG; Gunning PW; Reddel RR, 2008, 'The murine stanniocalcin 2 gene is a negative regulator of postnatal growth', Endocrinology, vol. 149, pp. 2403 - 2410, http://dx.doi.org/10.1210/en.2007-1219
    Journal articles | 2008
    Professor Edna Hardeman
    MacArthur DG; Seto JT; Chan S; Quinlan KG; Raftery JM; Turner N; Nicholson MD; Kee AJ; Hardeman EC; Gunning PW; Cooney GJ; Head SI; Yang N; North KN, 2008, 'An Actn3 knockout mouse provides mechanistic insights into the association between alpha-actinin-3 deficiency and human athletic performance', Human Molecular Genetics, vol. 17, pp. 1076 - 1086, http://dx.doi.org/10.1093/hmg/ddm380
    Journal articles | 2008
    Professor Edna Hardeman
    Vlahovich N; Schevzov G; Nair-Shaliker V; Ilkovski B; Artap ST; Kee AJ; North KN; Gunning PW; Hardeman EC, 2008, 'Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle', Cell Motility and the Cytoskeleton, vol. 65, pp. 73 - 85, http://dx.doi.org/10.1002/cm.20245
    Journal articles | 2008
    Professor Edna Hardeman
    Schevzov G; Fath T; Vrhovski B; Vlahovich N; Rajan S; Hook J; Joya JE; Lemckert F; Puttur F; Lin JJ; Hardeman EC; Wieczorek DF; O'Neill GM; Gunning PW, 2008, 'Divergent regulation of the sarcomere and the cytoskeleton', The Journal of Biological Chemistry, vol. 283, pp. 275 - 283, http://dx.doi.org/10.1074/jbc.M704392200
    Journal articles | 2007
    Professor Edna Hardeman
    Chen W; Ruell PA; Ghoddusi M; Kee A; Hardeman EC; Hoffman KM; Thompson MW, 2007, 'Ultrastructural changes and SR Ca2+ regulation in red vastus muscle following eccentric exercise in the rat', Experimental Physiology, vol. 92, pp. 437 - 447, http://dx.doi.org/10.1113/expphysiol.2006.036442
    Journal articles | 2007
    Professor Edna Hardeman
    Palmer SJ; Tay ES; Santucci N; Cuc Bach TT; Hook J; Lemckert FA; Jamieson RV; Gunning PW; Hardeman EC, 2007, 'Expression of Gtf2ird1, the Williams syndrome-associated gene during mouse development', Gene Expression Patterns, vol. 7, pp. 396 - 404, http://dx.doi.org/10.1016/j.modgep.2006.11.008
    Journal articles | 2007
    Professor Edna Hardeman
    MacArthur DG; Seto JT; Raftery JM; Quinlan KG; Huttley GA; Hook JW; Lemckert FA; Kee AJ; Edwards MR; Berman Y; Hardeman EC; Gunning PW; Easteal S; Yang N; North KN, 2007, 'Loss of ACTN3 gene function alters mouse muscle metabolism and shows evidence of positive selection in humans', Nature Genetics, vol. 39, pp. 1261 - 1265, http://dx.doi.org/10.1038/ng2122
    Journal articles | 2007
    Professor Edna Hardeman
    Domazetovska A; Ilkovski B; Cooper ST; Ghoddusi M; Hardeman EC; Minamide LS; Gunning PW; Bamburg JR; North K, 2007, 'Mechanisms underlying intranuclear rod formation', Brain, vol. 130, pp. 3275 - 3284, http://dx.doi.org/10.1093/brain/awm247
    Journal articles | 2006
    Professor Edna Hardeman
    McGrath MJ; Cottle DL; Nguyen MA; Coghill ID; Robinson PA; Holdsworth M; Cowling BS; Hardeman EC; Mitchell CA; Brown S, 2006, 'Four and a half LIM protein 1 binds myosin binding protein C and regulates myosin filament formation and sarcomere assembly', The Journal of Biological Chemistry, vol. 281, pp. 7666 - 7683, http://dx.doi.org/10.1074/jbc.M512552200
    Journal articles | 2006
    Professor Edna Hardeman
    Butler TL; Au CG; Yang B; Egan JR; Tan YM; Hardeman EC; North KN; Verkman AS; Winlaw DS, 2006, 'Cardiac aquaporin expression in humans, rats, and mice', American Journal of Physiology - Heart and Circulatory Physiology, vol. 291, pp. H705 - H713, http://dx.doi.org/10.1152/ajpheart.00090.2006
    Journal articles | 2006
    Professor Edna Hardeman
    Sanoudou D; Corbett MA; Han M; Ghoddusi M; Nguyen MA; Vlahovich N; Hardeman EC; Beggs AH, 2006, 'Skeletal muscle repair in a mouse model of nemaline myopathy', Human Molecular Genetics, vol. 15, pp. 2603 - 2612, http://dx.doi.org/10.1093/hmg/ddl186
    Journal articles | 2006
    Professor Edna Hardeman
    Issa LL; Palmer SJ; Guven KL; Santucci N; Hodgson VRM; Popovic K; Joya JE; Hardeman EC, 2006, 'MusTRD can regulate postnatal fiber-specific expression', Developmental Biology, vol. 293, pp. 104 - 115, http://dx.doi.org/10.1016/j.ydbio.2006.01.019
    Journal articles | 2005
    Professor Edna Hardeman
    Gunning PW; Schevzov G; Kee AJ; Hardeman EC, 2005, 'Tropomyosin isoforms: divining rods for actin cytoskeleton function', Trends in Cell Biology, vol. 15, pp. 333 - 341, http://dx.doi.org/10.1016/j.tcb.2005.04.007
    Journal articles | 2005
    Professor Edna Hardeman
    Corbett MA; Akkari AP; Domazetovska A; Cooper ST; North K; Laing NG; Gunning PW; Hardeman EC, 2005, 'An alphatropomyosin mutation alters dimer preference in nemaline myopathy', Annals of Neurology, vol. 57, pp. 42 - 49, http://dx.doi.org/10.1002/ana.20305
    Journal articles | 2005
    Professor Edna Hardeman
    Schevzov G; Bryce NS; Almonte-Baldonado R; Joya J; Lin JJ; Hardeman E; Weinberger R; Gunning P, 2005, 'Specific features of neuronal size and shape are regulated by tropomyosin isoforms.', Molecular Biology of the Cell, vol. 16, pp. 3425 - 3437, http://dx.doi.org/10.1091/mbc.E04-10-0951
    Journal articles | 2005
    Professor Edna Hardeman
    Molero JC; Jensen T; Withers P; Couzens M; Herzog H; Thien C; Langdon WY; Walder K; Murphy M; Bowtell D; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'Erratum: c-Cbl-deficient mice have reduced adiposity, higher energy expenditure,and improved peripheral insulin action (vol 114, pg 1326, 2004)', Journal of Clinical Investigation, vol. 115, pp. 476 - 476, http://dx.doi.org/10.1172/JCI21480C1
    Journal articles | 2005
    Professor Edna Hardeman
    Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CBF; Langdon WY; Walder K; Murphy MA; Bowtell DDL; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'Erratum: c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action (Journal of Clinical Investigation (2004) 114 (1326-1333) (doi:10.1172/JCI200421480))', Journal of Clinical Investigation, vol. 115, pp. 476, http://dx.doi.org/10.1172/JCI200521480C1
    Journal articles | 2005
    Professor Edna Hardeman
    Vlahovich N; Elmir S; Schevzov G; Kee A; Gunning P; Hardeman E, 2005, 'Non-muscle tropomyosins define functionally distinct microfilament populations in developing skeletal muscle', MECHANISMS OF DEVELOPMENT, vol. 122, pp. S49 - S49, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000207524100178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2005
    Professor Edna Hardeman
    Molero JC; Jensen TE; Withers PC; Couzens M; Herzog H; Thien CB; Langdon WY; Walder K; Murphy MA; Bowtell DL; Hardeman E; Ghoddusi M; James DE; Cooney GJ, 2005, 'c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action', The Journal of Clinical Investigation, vol. 114, pp. 1326 - 1333, http://dx.doi.org/10.1172/JCI200421480
    Journal articles | 2004
    Professor Edna Hardeman
    Cooper ST; Maxwell AL; Kizana E; Ghoddusi M; Hardeman EC; Alexander IE; Allen DG; North KN, 2004, 'C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression', Cell Motility and the Cytoskeleton, vol. 58, pp. 200 - 211, http://dx.doi.org/10.1002/cm.20010
    Journal articles | 2004
    Professor Edna Hardeman
    Nair-Shalliker V; Kee A; Lucas C; Joya JE; Hoh JF; Hardeman EC, 2004, 'Myofiber adaptational response to exercise in a mouse model of nemaline myopathy', Muscle and Nerve, vol. 30, pp. 470 - 480, http://dx.doi.org/10.1002/mus.20138
    Journal articles | 2004
    Professor Edna Hardeman
    Joya JE; Kee A; Nair-Shalliker V; Ghoddusi M; Nguyen MAT; Luther P; Hardeman EC, 2004, 'Muscle weakness in a mouse model of nemaline myopathy can be reversed with exercise and reveals a novel myofiber repair mechanism', Human Molecular Genetics, vol. 13, pp. 2633 - 2645, http://dx.doi.org/10.1093/hmg/ddh285
    Journal articles | 2004
    Professor Edna Hardeman
    Kee AJ; Schevzov G; Nair-shaliker V; Robinson C; Vrhovski B; Ghoddusi M; Qiu M; Lin JJ; Weinberger R; Gunning P; Hardeman E, 2004, 'Sorting of a nonmuscle tropomyosin to a novel cytoskeletal compartment in skeletal muscle results in muscular dystrophy.', Journal of Cell Biology, vol. 166, pp. 685 - 696, http://dx.doi.org/10.1083/jcb.200406181
    Journal articles | 2003
    Professor Edna Hardeman
    Bryce N; Schevzov G; Ferguson V; Percival J; Lin JJ; Matsumura F; Bamburg J; Jeffrey P; Hardeman E; Gunning P; Weinberger R, 2003, 'Specification of actin filament function and molecular composition by tropomyosin isoforms.', Molecular Biology of the Cell, vol. 14, pp. 1002 - 1016, http://dx.doi.org/10.1091/mbc.E02-04-0244
    Journal articles | 2003
    Professor Edna Hardeman
    Polly P; Haddadi L; Issa LL; Subramaniam N; Palmer S; Tay ES; Hardeman EC, 2003, 'hMusTRD1α1 Represses MEF2 Activation of the Troponin I Slow Enhancer', The Journal of Biological Chemistry, vol. 278, pp. 36603 - 36610, http://dx.doi.org/10.1074/jbc.M212814200
    Journal articles | 2003
    Professor Edna Hardeman
    Tay ES; Guven KL; Subramaniam N; Polly P; Issa LL; Gunning PW; Hardeman EC, 2003, 'Regulation of alternative splicing of Gtf2ird1 and its impact on slow muscle promoter activity', Biochemical Journal, vol. 374, pp. 359 - 367, http://dx.doi.org/10.1042/BJ20030189
    Journal articles | 2002
    Professor Edna Hardeman
    de Haan A; van der Vliet MR; Gommans IM; Hardeman EC; van Engelen BG, 2002, 'Skeletal muscle of mice with a mutation in slow α-tropomyosin is weaker at lower lengths', Neuromuscular Disorders, vol. 12, pp. 952 - 957, http://dx.doi.org/10.1016/S0960-8966(02)00138-4
    Journal articles | 2001
    Professor Edna Hardeman
    Ilkovski B; Cooper ST; Nowak K; Ryan MM; Yang N; Schnell C; Durling HJ; Roddick LG; Wilkinson I; Kornberg AJ; Collins KJ; Wallace G; Gunning PW; Hardeman E; North K, 2001, 'Nemaline myopathy caused by mutations in the muscle alpha-skeletal-actin gene', American Journal of Human Genetics, vol. 68, pp. 1333 - 1343, http://dx.doi.org/10.1086/320605
    Journal articles | 2001
    Professor Edna Hardeman
    Corbett MA; Robinson CS; Yang N; Joya JE; Stewart AW; Schnell C; Gunning PW; North KN; Hardeman E, 2001, 'A mutation in alpha-tropomyosin(slow) affects muscle strength, maturation and hypertrophy in a mouse model for nemaline myopathy', Human Molecular Genetics, vol. 10, pp. 317 - 328
    Journal articles | 2001
    Professor Edna Hardeman
    Gunning P; Ferguson V; Brennan KJ; Hardeman EC, 2001, 'Alpha-skeletal actin induces a subset of muscle genes independently of muscle differentiation and withdrawal from the cell cycle', Journal of Cell Science, vol. 114, pp. 513 - 524
    Journal articles | 2001
    Professor Edna Hardeman
    De Iongh RU; Lovicu FJ; Overbeek PA; Schneider MD; Joya JE; Hardeman E; McAvoy JW, 2001, 'Requirement for TGFβ receptor signaling during terminal lens fiber differentiation', Development, vol. 128, pp. 3995 - 4010
    Journal articles | 2000
    Professor Edna Hardeman
    O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 2000, 'Erratum: Identification of a novel slow-muscle-fiber enhancer binding protein, musTRD1 (Molecular and Cellular Biology (1998) 18:11 (6641-6652))', Molecular and Cellular Biology, vol. 20, pp. 5361, http://dx.doi.org/10.1128/MCB.20.14.5361-5361.2000
    Journal articles | 1999
    Professor Edna Hardeman
    Wadhwa R; Sugihara T; Yoshida A; Duncan EL; Hardeman E; Nomura H; Reddel RR; Kaul SC, 1999, 'Cloning and characterization of a novel gene, striamin, that interacts with the tumor suppressor protein p53', The Journal of Biological Chemistry, vol. 274, pp. 14948 - 14955, http://dx.doi.org/10.1074/jbc.274.21.14948
    Journal articles | 1998
    Professor Edna Hardeman
    O'Mahoney JV; Guven KL; Lin J; Joya JE; Robinson CS; Wade RP; Hardeman EC, 1998, 'Identification of a novel slow-muscle-fiber enhancer binding protein, MusTRD1', Molecular and Cellular Biology, vol. 18, pp. 6641 - 6652, http://dx.doi.org/10.1128/MCB.18.11.6641
    Journal articles | 1998
    Professor Edna Hardeman
    Newlands S; Levitt LK; Robinson CS; Karpf AB; Hodgson VR; Wade RP; Hardeman EC, 1998, 'Transcription occurs in pulses in muscle fibers', Genes and Development, vol. 12, pp. 2748 - 2758, http://dx.doi.org/10.1101/gad.12.17.2748
    Journal articles | 1998
    Professor Edna Hardeman
    Gunning P; Hardeman E; Jeffrey P; Weinberger R, 1998, 'Creating intracellular structural domains: spatial segregation of actin and tropomyosin isoforms in neurons', BioEssays, vol. 20, pp. 892 - 900, http://dx.doi.org/10.1002/(SICI)1521-1878(199811)20:11<892::AID-BIES4>3.0.CO;2-D
    Journal articles | 1998
    Professor Edna Hardeman
    Criswell DS; Hodgson VRM; Hardeman EC; Booth FW, 1998, 'THE NERVE-RESPONSIVE TROPONIN-I SLOW PROMOTER DOES NOT RESPOND TO UNLOADING', Medicine & Science in Sports & Exercise, vol. 30, pp. 143 - 143, http://dx.doi.org/10.1097/00005768-199805001-00810
    Journal articles | 1998
    Professor Edna Hardeman
    Gunning P; Weinberger R; Jeffrey P; Hardeman E, 1998, 'Isoform sorting and the creation of intracellular compartments', Annual Review of Cell and Developmental Biology, vol. 14, pp. 339 - 372, http://dx.doi.org/10.1146/annurev.cellbio.14.1.339
    Journal articles | 1998
    Professor Edna Hardeman
    Criswell DS; Hodgson VR; Hardeman EC; Booth FW, 1998, 'Nerve-responsive troponin I slow promoter does not respond to unloading', Journal of Applied Physiology, vol. 84, pp. 1083 - 1087
    Journal articles | 1997
    Professor Edna Hardeman
    Coumans JV; Yeoh T; Seeto RK; Keogh A; Brennan K; Gunning P; Hardeman E; Dos Remedios CG, 1997, 'Variations in relative mRNA levels of actin and myosin heavy chains do not produce corresponding differences in their proteins in the adult human heart', Journal of Molecular and Cellular Cardiology, vol. 29, pp. 895 - 905, http://dx.doi.org/10.1006/jmcc.1996.0317
    Journal articles | 1997
    Professor Edna Hardeman
    Gunning P; Ferguson V; Brennan K; Hardeman E, 1997, 'Impact of α-Skeletal Actin but not α-Cardiac Actin on Myoblast Morphology', Cell Structure and Function, vol. 22, pp. 173 - 179, http://dx.doi.org/10.1247/csf.22.173
    Journal articles | 1997
    Professor Edna Hardeman
    Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor alpha-sarcomeric actins in postnatal muscle.', Am J Physiol, vol. 273, pp. C1801 - C1810, http://dx.doi.org/10.1152/ajpcell.1997.273.6.C1801
    Journal articles | 1997
    Professor Edna Hardeman
    Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273, http://dx.doi.org/10.1152/ajpcell.1997.273.6.c1801
    Journal articles | 1997
    Professor Edna Hardeman
    Collins T; Joya JE; Arkell RM; Ferguson V; Hardeman EC, 1997, 'Reappearance of the minor α-sarcomeric actins in postnatal muscle', American Journal of Physiology - Cell Physiology, vol. 273, pp. C1801 - C1810
    Journal articles | 1996
    Professor Edna Hardeman
    Dos Remedios CG; Berry DA; Carter LK; Coumans JV; Heinke MY; Kiessling PC; Seeto RK; Thorvaldson T; Trahair T; Yeoh T; Gunning PW; Hardeman E; Humphery-Smith I; Naidoo D; Keogh A, 1996, 'Different electrophoretic techniques produce conflicting data in the analysis of myocardial samples from dilated cardiomyopathy patients: protein levels do not necessarily reflect mRNA levels', Electrophoresis, vol. 17, pp. 235 - 238, http://dx.doi.org/10.1002/elps.1150170140
    Journal articles | 1995
    Professor Edna Hardeman
    Levitt LK; O'mahoney JV; Brennan KJ; Joya JE; Zhu L; Wade RP; Hardeman EC, 1995, 'The Human Troponin I Slow Promoter Directs Slow Fiber-Specific Expression in Transgenic Mice', DNA and Cell Biology, vol. 14, pp. 599 - 607, http://dx.doi.org/10.1089/dna.1995.14.599
    Journal articles | 1995
    Professor Edna Hardeman
    Zhu L; Lyons GE; Juhasz O; Joya JE; Hardeman EC; Wade R, 1995, 'Developmental Regulation of Troponin I Isoform Genes in Striated Muscles of Transgenic Mice', Developmental Biology, vol. 169, pp. 487 - 503, http://dx.doi.org/10.1006/dbio.1995.1163
    Journal articles | 1995
    Professor Edna Hardeman
    Esser KA; Hardeman EC, 1995, 'Changes in contractile protein mRNA accumulation in response to spaceflight', American Journal of Physiology - Cell Physiology, vol. 268, http://dx.doi.org/10.1152/ajpcell.1995.268.2.c466
    Journal articles | 1995
    Professor Edna Hardeman
    Corin SJ; Levitt LK; O'Mahoney JV; Joya JE; Hardeman EC; Wade R, 1995, 'Delineation of a slow-twitch-myofiber-specific transcriptional element by using in vivo somatic gene transfer', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, pp. 6185 - 6189, http://dx.doi.org/10.1073/pnas.92.13.6185
    Journal articles | 1995
    Professor Edna Hardeman
    ESSER K; BRENNAN K; HARDEMAN E, 1995, 'WEIGHT-BEARING ACTIVITY, IN ADDITION TO INNERVATION, IS NECESSARY FOR THE ACQUISITION OF A SLOW CONTRACTILE PROTEIN MESSENGER-RNA PROFILE DURING REGENERATION', FASEB JOURNAL, vol. 9, pp. A655 - A655, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QM40600178&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1995
    Professor Edna Hardeman
    Esser KA; Hardeman EC, 1995, 'Changes in contractile protein mRNA accumulation in response to spaceflight.', Am J Physiol, vol. 268, pp. C466 - C471, http://dx.doi.org/10.1152/ajpcell.1995.268.2.C466
    Journal articles | 1994
    Professor Edna Hardeman
    Dunwoodie SL; Joya JE; Arkell RM; Hardeman EC, 1994, 'Multiple regions of the human cardiac actin gene are necessary for maturation-based expression in striated muscle', Journal of Biological Chemistry, vol. 269, pp. 12212 - 12219
    Journal articles | 1994
    Professor Edna Hardeman
    Esser K; Fauteck S; Kandarlan S; Hardeman E, 1994, '529 MYOSIN HEAVY CHAIN PROTEIN AND mRNA EXPRESSION IN RESPONSE TO SPACEFLIGHT', Medicine & Science in Sports & Exercise, vol. 26, pp. S94 - S94, http://dx.doi.org/10.1249/00005768-199405001-00530
    Journal articles | 1993
    Professor Edna Hardeman
    Brennan KJ; Hardeman EC, 1993, 'Quantitative analysis of the human α-skeletal actin gene in transgenic mice', Journal of Biological Chemistry, vol. 268, pp. 719 - 725
    Journal articles | 1993
    Professor Edna Hardeman
    Sutherland CJ; Esser KA; Elsom VL; Gordon ML; Hardeman EC, 1993, 'Identification of a program of contractile protein gene expression initiated upon skeletal muscle differentiation', Developmental Dynamics, vol. 196, pp. 25 - 36, http://dx.doi.org/10.1002/aja.1001960104
    Journal articles | 1993
    Professor Edna Hardeman
    Esser K; Gunning P; Hardeman E, 1993, 'Nerve-dependent and -independent patterns of mRNA expression in regenerating skeletal muscle', Developmental Biology, vol. 159, pp. 173 - 183, http://dx.doi.org/10.1006/dbio.1993.1231
    Journal articles | 1992
    Professor Edna Hardeman
    Hailstones D; Barton P; Chan-Thomas P; Sasse S; Sutherland C; Hardeman E; Gunning P, 1992, 'Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development', Journal of Biological Chemistry, vol. 267, pp. 23295 - 23300
    Journal articles | 1992
    Professor Edna Hardeman
    CORIN S, 1992, 'In vitro and in vivo expression analysis of the human slow skeletal troponin I gene', Journal of Molecular and Cellular Cardiology, vol. 24, pp. S39 - S39, http://dx.doi.org/10.1016/0022-2828(92)92973-g
    Journal articles | 1991
    Professor Edna Hardeman
    Gunning P; Hardeman E, 1991, 'Multiple mechanisms regulate muscle fiber diversity', The FASEB Journal, vol. 5, pp. 3064 - 3071
    Journal articles | 1991
    Professor Edna Hardeman
    Sutherland CJ; Elsom VL; Gordon ML; Dunwoodie SL; Hardeman EC, 1991, 'Coordination of skeletal muscle gene expression occurs late in mammalian development', Developmental Biology, vol. 146, pp. 167 - 178, http://dx.doi.org/10.1016/0012-1606(91)90457-E
    Journal articles | 1990
    Professor Edna Hardeman
    Wade R; Sutherland C; Gahlmann R; Kedes L; Hardeman E; Gunning P, 1990, 'Regulation of contractile protein gene family mRNA pool sizes during myogenesis', Developmental Biology, vol. 142, pp. 270 - 282, http://dx.doi.org/10.1016/0012-1606(90)90348-M
    Journal articles | 1990
    Professor Edna Hardeman
    Gunning P; Gordon M; Wade R; Gahlmann R; Lin CS; Hardeman E, 1990, 'Differential control of tropomyosin mRNA levels during myogenesis suggests the existence of an isoform competition-autoregulatory compensation control mechanism', Developmental Biology, vol. 138, pp. 443 - 453, http://dx.doi.org/10.1016/0012-1606(90)90210-A
    Journal articles | 1990
    Professor Edna Hardeman
    Webster KA; Gunning P; Hardeman E; Wallace DC; Kedes L, 1990, 'Coordinate reciprocal trends in glycolytic and mitochondrial transcript accumulations during the in vitro differentiation of human myoblasts', Journal of Cellular Physiology, vol. 142, pp. 566 - 573, http://dx.doi.org/10.1002/jcp.1041420316
    Journal articles | 1988
    Professor Edna Hardeman
    Hardeman EC; Minty A; Benton-Vosman P; Kedes L; Blau HM, 1988, 'In vivo system for characterizing clonal variation and tissue-specific gene regulatory factors based on function', Journal of Cell Biology, vol. 106, pp. 1027 - 1034, http://dx.doi.org/10.1083/jcb.106.4.1027
    Journal articles | 1987
    Professor Edna Hardeman
    Gunning P; Hardeman E; Wade R; Ponte P; Bains W; Blau HM; Kedes L, 1987, 'Differential patterns of transcript accumulation during human myogenesis.', Molecular and cellular biology, vol. 7, pp. 4100 - 4114, http://dx.doi.org/10.1128/MCB.7.11.4100
    Journal articles | 1987
    Professor Edna Hardeman
    WADE R; GUNNING P; HARDEMAN E; GAHLMANN R; BLAU H; KEDES L, 1987, 'DISTINCTIVE PATTERNS OF MUSCLE-SPECIFIC MESSENGER-RNA ACCUMULATION DURING HUMAN MYOGENESIS', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 96 - 96, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1987G822600243&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1986
    Professor Edna Hardeman
    KEDES L; MINTY A; WADE R; GUNNING P; HARDEMAN E; BLAU H; BENTONVOSMAN P; BOXER L; ERBA H; FELDMAN D; GAHLMANN R; MIWA T; MUSCAT G; TAYLOR A, 1986, 'MULTILEVEL REGULATION OF GENE-EXPRESSION IN HUMAN MYOGENESIS - DISSOCIATION OF FACTORS RESPONSIBLE FOR MODULATION AND ACTIVATION AND EVIDENCE FOR NON-COORDINATE EXPRESSION', JOURNAL OF CELLULAR BIOCHEMISTRY, pp. 16 - 16, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1986A664400029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1986
    Professor Edna Hardeman
    Hardeman EC; Chiu CP; Minty A; Blau HM, 1986, 'The pattern of actin expression in human fibroblast × mouse muscle heterokaryons suggests that human muscle regulatory factors are produced', Cell, vol. 47, pp. 123 - 130, http://dx.doi.org/10.1016/0092-8674(86)90373-9
    Journal articles | 1985
    Professor Edna Hardeman
    Blau HM; Pavlath GK; Hardeman EC; Chiu CP; Silberstein L; Webster SG; Miller SC; Webster C, 1985, 'Plasticity of the differentiated state', Science, vol. 230, pp. 758 - 766, http://dx.doi.org/10.1126/science.2414846
    Journal articles | 1985
    Professor Edna Hardeman
    Skalnik DG; Brown DA; Brown PC; Friedman RL; Hardeman EC; Schimke RT; Simoni RD, 1985, 'Mechanisms of 3-hydroxy-3-methylglutaryl coenzyme A reductase overaccumulation in three compactin-resistant cell lines', Journal of Biological Chemistry, vol. 260, pp. 1991 - 1994
    Journal articles | 1985
    Professor Edna Hardeman
    Garrison JC; Hardeman E; Wade R; Kedes L; Gunning P, 1985, 'Isolation of full-length cDNAs encoding abundant adult human skeletal muscle mRNAs', Gene, vol. 38, pp. 177 - 188, http://dx.doi.org/10.1016/0378-1119(85)90216-1
    Journal articles | 1984
    Professor Edna Hardeman
    Hardeman EC; Endo A; Simoni RD, 1984, 'Effects of compactin on the levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase in compactin-resistant C100 and wild-type cells', Archives of Biochemistry and Biophysics, vol. 232, pp. 549 - 561, http://dx.doi.org/10.1016/0003-9861(84)90572-1
    Journal articles | 1984
    Professor Edna Hardeman
    CHIU CP; HARDEMAN EC; GUNNING P; BLAU HM, 1984, 'TRANSCRIPTIONAL ACTIVATION OF SARCOMERIC ACTINS IN MUSCLE X NONMUSCLE HETEROKARYONS', JOURNAL OF CELL BIOLOGY, vol. 99, pp. A346 - A346, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1984TM94901278&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1983
    Professor Edna Hardeman
    Rine J; Hansen W; Hardeman E; Davis RW, 1983, 'Targeted selection of recombinant clones through gene dosage effects', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 6750 - 6754, http://dx.doi.org/10.1073/pnas.80.22.6750
    Journal articles | 1983
    Professor Edna Hardeman
    Hardeman EC; Jenke HS; Simoni RD, 1983, 'Overproduction of a M(r) 92,000 protomer of 3 hydroxy 3 methylglutaryl coenzyme A reductase in compactin-resistant C100 cells', Proceedings of the National Academy of Sciences of the United States of America, vol. 80, pp. 1516 - 1520, http://dx.doi.org/10.1073/pnas.80.6.1516
    Journal articles | 1981
    Professor Edna Hardeman
    Ryan J; Hardeman EC; Endo A; Simoni RD, 1981, 'Isolation and characterization of cells resistant to ML236B (Compactin) with increased levels of 3-hydroxy-3-methylglutaryl coenzyme A reductase', Journal of Biological Chemistry, vol. 256, pp. 6762 - 6768
    Journal articles | 1981
    Professor Edna Hardeman
    Brusilow WSA; Gunsalus RP; Hardeman EC, 1981, 'In vitro synthesis of the F0 and F1 components of the proton translocating ATPase of Escherichia coli', Journal of Biological Chemistry, vol. 256, pp. 3141 - 3144
    Journal articles |
    Professor Edna Hardeman
    Yeola A; Subramanian S; Oliver RA; Lucas CA; Thoms JAI; Yan F; Olivier J; Chacon D; Tursky ML; Hung T; Power C; Hardy P; Ma DD; McCarroll J; Kavallaris M; Hesson LB; Beck D; Curtis DJ; Wong JWH; Hardeman EC; Walsh WR; Mobbs R; Chandrakanthan V; Pimanda JE, 'Induction of Muscle Regenerative Multipotent Stem Cells from Human Adipocytes by PDGF-AB and 5-Azacytidine', , http://dx.doi.org/10.1101/2020.06.04.130872
  • Conference Papers | 2021
    Professor Edna Hardeman
    Xu X; Wang Y; Bryce N; Tang K; Meagher NS; Kang EY; Kelemen LE; Köbel M; Ramus SJ; Friedlander M; Ford CE; Hardeman EC; Gunning PW, 2021, 'Abstract 1045: Combined targeting of actin/tropomyosin and microtubules underlies a potential treatment strategy of epithelial ovarian cancer with cell-cycle dependent synergy', in Experimental and Molecular Therapeutics, American Association for Cancer Research, presented at Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA, http://dx.doi.org/10.1158/1538-7445.am2021-1045
    Conference Papers | 2020
    Professor Edna Hardeman
    Gunning P; Wang Y; Stear JH; Swain A; Xu X; Bryce N; Alieva IB; Dugina VB; Cripe T; Stehn J; Hardeman EC, 2020, 'Anti-tropomyosin drugs prevent the rescue of vincristine-induced mitotic spindle defects', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-5817
    Conference Posters | 2016
    Professor Edna Hardeman
    Hardeman EC; Kee AJ; Lucas CA; Chagan J; Gunning PW, 2016, 'Metabolic impact of targeting the tropomyosin/actin cytoskeleton to treat cancer', San Francisco, CA, Vol. 27, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), San Francisco, CA, 03 December 2016 - 07 December 2016, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396046900905&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2015
    Professor Edna Hardeman
    Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Hardeman E; Cohn RJ; Barres R; Simar D, 2015, 'Radiation-induced metabolic complications: potential role for the microbiota', in Radiation-induced metabolic complications: potential role for the microbiota, Nutrient & Metabolite Sensing, Copenhagen, Denmark, presented at Nutrient & Metabolite Sensing, Copenhagen, Denmark, 01 November 2015 - 05 November 2015
    Conference Abstracts | 2015
    Professor Edna Hardeman
    Eslami S; Boysen L; Amorim N; Bould S; Kee A; Lucas C; Johnston K; Cohn R; Hardeman E; Barres R; Simar D, (eds.), 2015, 'Metabolic complications in cancer survivors: role of adipose tissue dysfunction', in Metabolic complications in cancer survivors: role of adipose tissue dysfunction, Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, presented at Keystone Symposia: Systems Biology of Lipid Metabolism, Breckenridge, Colorado, USA, 09 February 2015 - 13 February 2015
    Conference Presentations | 2014
    Professor Edna Hardeman
    Hardeman EC; Yang L; Kee AJ; Polishchuk E; Polishchuk R; Pleines I; Kile B; Weigert R; Gunning PW, 2014, 'A novel actin filament population defined by the tropomyosin Tm4 regulates ER-to-Golgi trafficking.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094104105&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Professor Edna Hardeman
    Tinklenberg J; Meng H; Yang L; Hardeman E; Pearsall S; Fitts R; Lawlor M, 2014, 'Treatment with ActRIIB-mFc Improves Lifespan, Behavior and Pathology in the Acta1 H40Y Murine Model of Nemaline Myopathy', in JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, LIPPINCOTT WILLIAMS & WILKINS, Portland, OR, pp. 614 - 614, presented at 90th Annual Meeting of the American-Association-of-Neuropathologists-Inc, Portland, OR, 12 June 2014 - 15 June 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000336732100120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Edna Hardeman
    Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100056&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Edna Hardeman
    Jalilian I; Schevzov G; Fath T; Heu C; Bischof L; Vindin H; Stehn JR; Tate MK; Hardeman EC; Gunning PW, 2014, 'Determining the impact of the actin cytoskeleton on the mechanical properties of cells', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094106265&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Edna Hardeman
    Schevzov G; Wang B; Hook JW; Tonthat C; Pleines I; Kile B; Hardeman EC; Gunning PW, 2014, 'Distinct Actin Filament Networks Modulate Different Cell Signalling Pathways Involved in Cell Proliferation and Senescence.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094106093&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Edna Hardeman
    Jalilian I; Schevzov G; Fath T; Heu C; Bischof L; Vindin H; Stehn JR; Tate MK; Hardeman EC; Gunning PW, 2014, 'Determining the impact of the actin cytoskeleton on the mechanical properties of cells.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100060&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Presentations | 2014
    Professor Edna Hardeman
    Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Posters | 2013
    Professor Edna Hardeman
    Suchowerska A; Chen B; Mueller J; Ittner A; Hardeman E; Ittner L; Janitz M; Gunning P; Fath T, 2013, 'Increased levels of actin filaments containing the tropomyosin Tm5NM1 regulate excitotoxicity in the mouse', Vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348705376&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Edna Hardeman
    Kee AJ; Lucas CA; Yang L; Szokolai RC; Martel N; Leong GM; Muscat GE; Hughes W; Cooney G; James DE; Gunning PW; Hardeman EC, 2012, 'The actin regulatory protein Tropomyosin 5NM1 regulates glucose uptake and GLUT4 trafficking in the mouse.', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000209348601218&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2012
    Professor Edna Hardeman
    Ravenscroft G; McNamara E; Griffiths LM; Papadimitriou JM; Hardeman EC; Bakker AJ; Laing NG; Nowak KJ, 2012, 'Efficacy of cardiac actin over-expression therapy for ACTA1 disease seems mutation specific', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Perth, AUSTRALIA, pp. 839 - 839, presented at 17th International Congress of the World-Muscle-Society (WMS), Perth, AUSTRALIA, 09 October 2012 - 13 October 2012, http://dx.doi.org/10.1016/j.nmd.2012.06.125
    Conference Papers | 2012
    Professor Edna Hardeman
    Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Butler T; Allanson M; Fath T; Hill TA; McCluskey A; Schevzov G; Palmer S; Hardeman EC; Winlaw D; Reeve VE; Dixon I; Weninger W; Cripe TP; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in EXPERIMENTAL DERMATOLOGY, WILEY-BLACKWELL, Marburg, GERMANY, pp. e43 - e43, presented at 39th Annual Meeting of the Arbeitsgemeinschaft-Dermatologische-Forschung (ADF), Marburg, GERMANY, 01 March 2012 - 03 March 2012, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000300931700252&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2012
    Professor Edna Hardeman
    Stehn JR; Haass NK; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PR; Han MH; Hill TA; McCluskey A; Palmer S; Hardeman EC; Weninger W; Cripe TR; Gunning P, 2012, 'Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-1827
    Conference Abstracts | 2012
    Professor Edna Hardeman
    Segueira VB; Stehn JR; Haass N; Bonello T; Guven K; Desouza M; Schevzov G; Kottyan G; McCluskey A; Bischof L; Palmer S; Hardeman EC; Allanson M; Reeve V; Weninger W; Cripe TP; Gunning P, 2012, 'Improving the specificity of drugs which target the actin cytoskeleton for cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Vol. 72, http://dx.doi.org/10.1158/1538-7445.AM2012-5230
    Conference Papers | 2012
    Professor Edna Hardeman
    Hardeman EC; Darhed HA; Lee ASJ; Chen G; Shah J; Joya JE; Gunning PW, 2012, 'BLOOD BORNE AGENTS RESCUE REGENERATION IMPAIRED MUSCLE', in WOUND REPAIR AND REGENERATION, WILEY-BLACKWELL, pp. A59 - A59, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000308945000025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Professor Edna Hardeman
    Kee A; Lucas C; Szokolai R; Yang L; Martel N; Leong G; Muscat G; Hughes W; James D; Gunning P; Hardeman E, 2011, 'A novel actin filament class that regulates glucose uptake and GLUT4 trafficking', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 December 2011 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505500204&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Professor Edna Hardeman
    Stehn JR; Haass NK; Bonello T; Desouza M; Kottyan G; Treutlein H; Zeng J; Nascimento PRBB; Butler T; Hill TA; McCluskey A; Palmer S; Hardeman EC; Winlaw D; Weninger W; Cripe TP; Gunning P, 2011, 'Abstract A178: Developing chemotherapeutics which selectively disable the actin cytoskeleton of tumor cells.', in New Molecular Targets, American Association for Cancer Research, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA, http://dx.doi.org/10.1158/1535-7163.targ-11-a178
    Conference Papers | 2011
    Professor Edna Hardeman
    Curthoys N; Freittag H; Connor A; Desouza M; Hardeman E; Gunning P; Schevzov G; Fath T, 2011, 'Tropomyosins induce neurite formation in B35 neuroblastoma cells and control neurite branching', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Denver, CO, presented at Annual Meeting of the American-Society-for-Cell-Biology (ASCB), Denver, CO, 03 December 2011 - 07 December 2011, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000305505503094&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Professor Edna Hardeman
    Stehn J; Schevzov G; Bonello T; McCluskey A; Haass N; Palmer S; Hardeman E; Allanson M; Reeve V; Gunning P, 2010, 'Tropomyosin Tm5NM1: A novel target for cancer therapy', in EJC SUPPLEMENTS, PERGAMON-ELSEVIER SCIENCE LTD, Berlin, GERMANY, pp. 107 - 107, presented at 22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Berlin, GERMANY, 16 November 2010 - 19 November 2010, http://dx.doi.org/10.1016/S1359-6349(10)72041-3
    Conference Papers | 2006
    Professor Edna Hardeman
    Macarthur D; Yang N; Seto J; Raftery J; Kee A; Hardeman E; Gunning P; North K, 2006, 'A gene for speed: the ACTN3 R577X polymorphism influences muscle performance', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Istanbul, TURKEY, pp. S59 - S59, presented at 11th International Congress on Neuromuscular Diseases, Istanbul, TURKEY, 02 July 2006 - 07 July 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2006
    Professor Edna Hardeman
    Yang N; MacArthur DG; Kee AJ; Kettle E; Hardeman EC; Lemckert F; Hook J; Gunning PW; North KN, 2006, 'An alpha -actinin-3 Knockout Mouse Suffers Increased Sarcomeric Damage from Eccentric Exercise', in MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, LIPPINCOTT WILLIAMS & WILKINS, pp. S123 - S124, http://dx.doi.org/10.1249/00005768-200605001-01445
    Conference Papers | 2006
    Professor Edna Hardeman
    Domazetovska A; Ilkovski B; Cooper S; Valova V; Lemckert F; Hook J; Hardeman E; Robinson P; Yang N; Gunning P; North K, 2006, 'Unravelling the thin filament: mechanisms of weakness in inherited muscle disease', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, Istanbul, TURKEY, pp. S60 - S61, presented at 11th International Congress on Neuromuscular Diseases, Istanbul, TURKEY, 02 July 2006 - 07 July 2006, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000239229400046&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2004
    Professor Edna Hardeman
    Schevzov G; Vrhovski B; Bryce NS; Elmir S; Qiu M; Yang N; Verrills NM; Kavallaris M; Puttur F; Hardeman E; Gunning P, 2004, 'Tropomyosin antibodies identify functionally distinct populations of actin filaments', in MOLECULAR BIOLOGY OF THE CELL, AMER SOC CELL BIOLOGY, Washington, DC, pp. 143A - 143A, presented at Annual Meeting of the American-Society-for-Cell-Biology, Washington, DC, 04 December 2004 - 08 December 2004, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224648801136&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Professor Edna Hardeman
    Hardeman EC; Nguyen MA; Corbett MA; Ghoddusi M; Joya JE; Gunning PW; North KN, 2003, 'A mouse model for severe actin nemaline myopathy', in NEUROMUSCULAR DISORDERS, PERGAMON-ELSEVIER SCIENCE LTD, SZEGED, HUNGARY, pp. 620 - 620, presented at 8th International Congress of the World-Muscle-Society, SZEGED, HUNGARY, 03 September 2003 - 06 September 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000185007600028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Awards

Grants

  • 2021 TroBio Therapeutics - Drug targeting tropomyosins in human diseases
  • 2021 ARC LIEF - Integrated multimodal system for multiplexed imaging of signal transduction
  • 2018-2020 Dept of Industry, Innovation and Science CRC-P Grant - Targeting tropomyosin as a novel anti-cancer therapy
  • 2018 UNSW RIS - IncuCyte S3 – Long term, dual colour, high throughput live cell analysis system
  • 2016-2020 NHMRC Project Grant - Regulation of ERK driven cell proliferation by the actin cytoskeleton
  • 2016-2018 ARC Discovery Project - Single molecule intracellular intravital imaging of actin dynamics
  • 2016 Diabetes Australia Research Trust - Targeting the actin cytoskeleton in the development of insulin resistance
  • 2016 UNSW RIS - Live cell TIRF microscope for HILO application
  • 2015-2020 NHMRC Project Grant - Molecular dissection of the actin cytoskeleton in exocytosis using intravital microscopy
  • 2015-2017 The Kids’ Cancer Project – C4 Cytoskeleton ConsortiumDevelopment of a novel intracellular intravital assay for ATM activity

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