Dr Emily Frost

Dr Emily Frost

Research Associate

PhD (Medical Biochemistry, University of Newcastle, 2021)

BBiomedSc (Honours I, University of Newcastle, 2017)

Medicine & Health
School of Clinical Medicine

As a reproductive biologist, I work on understanding the molecular mechanisms underpinning female fertility. The focus of my current research is to identify factors that support oocyte development within the ovary and use these factors to improve oocyte culture. This also involves understanding granulosa cell biology, the somatic cells that are in direct contact with the oocyte throughout development. I use a combination of high-throughput techniques, including proteomics and single-cell sequencing, and molecular biology techniques to better understand oocyte development.

Prior to this position at UNSW, I completed my joint PhD at the University of Newcastle and the Francis Crick Institute UK, studying the role of cell cycle regulation in the activation of ovarian follicles. Following my PhD, I worked as a postdoctoral scientist at the Hudson Institute for Medical Research in Melbourne, working with Prof Vincent Harley on Differences of Sex Development and the role of transcription factors in driving testicular and ovarian fate. 

Wallace Wurth Building
  • Journal articles | 2024
    Frost ER; Gilchrist RB, 2024, 'Making human eggs in a dish: are we close?', Trends in Biotechnology, 42, pp. 168 - 178, http://dx.doi.org/10.1016/j.tibtech.2023.07.007
    Journal articles | 2024
    Green ES; Chan HY; Frost E; Griffiths M; Hutchison J; Martin JH; Mihalas BP; Newman T; Dunleavy JEM, 2024, 'Recent advances in reproductive research in Australia and New Zealand: highlights from the Annual Meeting of the Society for Reproductive Biology, 2022', Reproduction, Fertility and Development, 36, http://dx.doi.org/10.1071/RD23213
    Journal articles | 2023
    Bird AD; Frost ER; Bagheri-Fam S; Croft BM; Ryan JM; Zhao L; Koopman P; Harley VR, 2023, 'Somatic FGFR2 is Required for Germ Cell Maintenance in the Mouse Ovary', Endocrinology (United States), 164, http://dx.doi.org/10.1210/endocr/bqad031
    Journal articles | 2023
    Frost ER; Ford EA; Peters AE; Lovell-Badge R; Taylor G; McLaughlin EA; Sutherland JM, 2023, 'A New Understanding, Guided by Single-Cell Sequencing, of the Establishment and Maintenance of the Ovarian Reserve in Mammals', Sexual Development, 17, pp. 145 - 155, http://dx.doi.org/10.1159/000526426
    Journal articles | 2023
    Mihalas BP; Frost ER; Kadam KM; Sucquart IE; Sirigeri P; Ledger WL; Gilchrist RB, 2023, 'A strong foundation for the next generation', Molecular Reproduction and Development, 90, pp. 773, http://dx.doi.org/10.1002/mrd.23709
    Journal articles | 2023
    Reyes AP; León NY; Frost ER; Harley VR, 2023, 'Genetic control of typical and atypical sex development', Nature Reviews Urology, 20, pp. 434 - 451, http://dx.doi.org/10.1038/s41585-023-00754-x
    Journal articles | 2022
    Bagheri-Fam S; Alankarage D; Frost ER; Harley VR, 2022, 'Dataset of differentially expressed genes in mouse P12 testes in response to the loss of ATRX in Sertoli cells', DATA IN BRIEF, 42, http://dx.doi.org/10.1016/j.dib.2022.108230
    Journal articles | 2022
    Ford EA; Frost ER; Beckett EL; Roman SD; McLaughlin EA; Sutherland JM, 2022, 'Transcriptomic profiling of neonatal mouse granulosa cells reveals new insights into primordial follicle activation', Biology of Reproduction, 106, pp. 503 - 514, http://dx.doi.org/10.1093/biolre/ioab193
    Journal articles | 2021
    Frost ER; Ford EA; Taylor G; Boeing S; Beckett EL; Roman SD; Lovell-Badge R; McLaughlin EA; Sutherland JM, 2021, 'Two alternative methods for the retrieval of somatic cell populations from the mouse ovary', Molecular Human Reproduction, 27, http://dx.doi.org/10.1093/molehr/gaab033
    Journal articles | 2021
    Frost ER; Taylor G; Baker MA; Lovell-Badge R; Sutherland JM, 2021, 'Establishing and maintaining fertility: the importance of cell cycle arrest', GENES & DEVELOPMENT, 35, pp. 619 - 634, http://dx.doi.org/10.1101/gad.348151.120
    Journal articles | 2020
    Frost ER; Ford EA; Peters AE; Reed NL; McLaughlin EA; Baker MA; Lovell-Badge R; Sutherland JM, 2020, 'Signal transducer and activator of transcription (STAT) 1 and STAT3 are expressed in the human ovary and have Janus kinase 1-independent functions in the COV434 human granulosa cell line', Reproduction, Fertility and Development, 32, pp. 1027 - 1039, http://dx.doi.org/10.1071/RD20098
    Journal articles | 2019
    Martin JH; John Aitken R; Bromfield EG; Cafe SL; Sutherland JM; Frost ER; Nixon B; Lord T, 2019, 'Investigation into the presence and functional significance of proinsulin C-peptide in the female germline', Biology of Reproduction, 100, pp. 1275 - 1289, http://dx.doi.org/10.1093/biolre/ioz008
    Journal articles | 2018
    Sutherland JM; Frost ER; Ford EA; Peters AE; Reed NL; Seldon AN; Mihalas BP; Russel DL; Dunning KR; McLaughlin EA, 2018, 'Janus kinase JAK1 maintains the ovarian reserve of primordial follicles in the mouse ovary', Molecular Human Reproduction, 24, pp. 533 - 542, http://dx.doi.org/10.1093/molehr/gay041
  • Preprints | 2024
    Ming Z; Bagheri-Fam S; Frost E; Ryan J; Binder M; Harley V, 2024, Roles of TYRO3 Family Receptors in Germ Cell Development During Mouse Testis Formation, , http://dx.doi.org/10.1101/2024.03.05.583252
    Preprints | 2022
    Frost E; Taylor G; Boeing S; Galichet C; Baker M; Sutherland J; Lovell-Badge R, 2022, p27kip1-dependent gene activity within granulosa cells reveals pathways relevant for control of primordial follicle activation in mice, , http://dx.doi.org/10.1101/2022.10.24.513438