Professor Guangzhao Mao
Head of School

Professor Guangzhao Mao

Nanjing University, China                                            Chemistry                                          B.Sc. 1988

University of Minnesota, USA                                     Chemical Engineering                     Ph.D. 1994

University of Minnesota, USA                                     Materials Science                              Postdoc 09/94‒07/95

  

Engineering
School of Chemical Engineering

Professor Guangzhao Mao received her BSc degree in chemistry from Nanjing University, China and her PhD degree in chemical engineering from University of Minnesota, USA.  She holds the position of Professor and Head of School, School of Chemical Engineering, UNSW Sydney, Australia. Professor Mao was a professor at Wayne State University, USA and served as the Chair of the Department of Chemical Engineering and Materials Science at Wayne State University from 2015 to 2020. Professor Mao's research is in nanotechnology including applying electrochemistry to make chemical sensors and engineering nanoparticles for targeted drug delivery. Professor Mao has received a Faculty CAREER award from the U.S. National Science Foundation, a Fulbright Senior Fellowship from the U.S. Department of State, and an ELATE Fellowship from the International Center for Executive Leadership in Academics. Professor Mao was a visiting professorship at the Max Planck Institute of Colloids and Interfaces in Germany. Professor Mao is a member of the Australian Centre for NanoMedicine.   

Phone
+61-2-9385 4813
  • Journal articles | 2022
    Zare I; Yaraki MT; Speranza G; Najafabadi AH; Shourangiz-Haghighi A; Nik AB; Manshian BB; Saraiva C; Soenen SJ; Kogan MJ; Lee JW; Apollo NV; Bernardino L; Araya E; Mayer D; Mao G; Hamblin MR, 2022, 'Gold nanostructures: synthesis, properties, and neurological applications', Chemical Society Reviews, vol. 51, pp. 2601 - 2680, http://dx.doi.org/10.1039/d1cs01111a
    Journal articles | 2018
    An M; Yu C; Xi J; Reyes J; Mao G; Wei WZ; Liu H, 2018, 'Induction of necrotic cell death and activation of STING in the tumor microenvironment via cationic silica nanoparticles leading to enhanced antitumor immunity', Nanoscale, vol. 10, pp. 9311 - 9319, http://dx.doi.org/10.1039/c8nr01376d
    Journal articles | 2018
    Saadat N; Liu F; Haynes B; Nangia-Makker P; Bao X; Li J; Polin LA; Gupta S; Mao G; Shekhar MP, 2018, 'Nano-delivery of RAD6/translesion synthesis inhibitor SMI#9 for triple-negative breast cancer therapy', Molecular Cancer Therapeutics, vol. 17, pp. 2586 - 2597, http://dx.doi.org/10.1158/1535-7163.MCT-18-0364
    Journal articles | 2017
    Jena BP; Stemmer PM; Wang S; Mao G; Lewis KT; Walz DA, 2017, 'Human Platelet Vesicles Exhibit Distinct Size and Proteome', Journal of Proteome Research, vol. 16, pp. 2333 - 2338, http://dx.doi.org/10.1021/acs.jproteome.7b00309
    Journal articles | 2016
    Haynes B; Zhang Y; Liu F; Li J; Petit S; Kothayer H; Bao X; Westwell AD; Mao G; Shekhar MPV, 2016, 'Gold nanoparticle conjugated Rad6 inhibitor induces cell death in triple negative breast cancer cells by inducing mitochondrial dysfunction and PARP-1 hyperactivation: Synthesis and characterization', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, pp. 745 - 757, http://dx.doi.org/10.1016/j.nano.2015.10.010
    Journal articles | 2016
    Minic Z; Zhang Y; Mao G; Goshgarian HG, 2016, 'Transporter protein-coupled DPCPX nanoconjugates induce diaphragmatic recovery after SCI by blocking adenosine A1 receptors', Journal of Neuroscience, vol. 36, pp. 3441 - 3452, http://dx.doi.org/10.1523/JNEUROSCI.2577-15.2016
    Journal articles | 2016
    Senut MC; Zhang Y; Liu F; Sen A; Ruden DM; Mao G, 2016, 'Size-Dependent Toxicity of Gold Nanoparticles on Human Embryonic Stem Cells and Their Neural Derivatives', Small, vol. 12, pp. 631 - 646, http://dx.doi.org/10.1002/smll.201502346
    Journal articles | 2015
    Zou Y; Jayasuriya S; Manke CW; Mao G, 2015, 'Influence of Nanoscale Surface Roughness on Colloidal Force Measurements', Langmuir, vol. 31, pp. 10341 - 10350, http://dx.doi.org/10.1021/acs.langmuir.5b02672
    Journal articles | 2014
    Hou X; Lewis KT; Wu Q; Wang S; Chen X; Flack A; Mao G; Taatjes DJ; Sun F; Jena BP, 2014, 'Proteome of the porosome complex in human airway epithelia: Interaction with the cystic fibrosis transmembrane conductance regulator (CFTR)', Journal of Proteomics, vol. 96, pp. 82 - 91, http://dx.doi.org/10.1016/j.jprot.2013.10.041
    Journal articles | 2014
    Wickramasinghe LD; Mazumder S; Gonawala S; Perera MM; Baydoun H; Thapa B; Li L; Xie L; Mao G; Zhou Z; Schlegel HB; Verani CN, 2014, 'The mechanisms of rectification in Au', Angewandte Chemie - International Edition, vol. 53, pp. 14462 - 14467, http://dx.doi.org/10.1002/anie.201408649
    Journal articles | 2014
    Zou Y; Xie L; Carroll S; Muniz M; Gibson H; Wei WZ; Liu H; Mao G, 2014, 'Layer-by-layer films with bioreducible and nonbioreducible polycations for sequential DNA release', Biomacromolecules, vol. 15, pp. 3965 - 3975, http://dx.doi.org/10.1021/bm5010433
    Journal articles | 2013
    Gérard HC; Mishra MK; Mao G; Wang S; Hali M; Whittum-Hudson JA; Kannan RM; Hudson AP, 2013, 'Dendrimer-enabled DNA delivery and transformation of Chlamydia pneumoniae', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 9, pp. 996 - 1008, http://dx.doi.org/10.1016/j.nano.2013.04.004
    Journal articles | 2013
    Kannan RM; Gérard HC; Mishra MK; Mao G; Wang S; Hali M; Whittum-Hudson JA; Hudson AP, 2013, 'Dendrimer-enabled transformation of Chlamydia trachomatis', Microbial Pathogenesis, vol. 65, pp. 29 - 35, http://dx.doi.org/10.1016/j.micpath.2013.08.003
    Journal articles | 2013
    Lee JS; Hou X; Bishop N; Wang S; Flack A; Cho WJ; Chen X; Mao G; Taatjes DJ; Sun F; Zhang K; Jena BP, 2013, 'Aquaporin-assisted and ER-mediated mitochondrial fission: A hypothesis', Micron, vol. 47, pp. 50 - 58, http://dx.doi.org/10.1016/j.micron.2013.01.005
    Journal articles | 2011
    Gary DJ; Lee H; Sharma R; Lee JS; Kim Y; Cui ZY; Jia D; Bowman VD; Chipman PR; Wan L; Zou Y; Mao G; Park K; Herbert BS; Konieczny SF; Won YY, 2011, 'Influence of nano-carrier architecture on in vitro siRNA delivery performance and in vivo biodistribution: Polyplexes vs micelleplexes', ACS Nano, vol. 5, pp. 3493 - 3505, http://dx.doi.org/10.1021/nn102540y
    Journal articles | 2011
    Wan L; Li L; Mao G, 2011, 'Nanospiral Formation by Droplet Drying: One Molecule at a Time', Nanoscale Research Letters, vol. 6, pp. 1 - 8, http://dx.doi.org/10.1007/s11671-010-9793-9
    Journal articles | 2010
    Blacklock J; Mao G; Oupický D; Möhwald H, 2010, 'DNA release dynamics from bioreducible layer-by-layer films', Langmuir, vol. 26, pp. 8597 - 8605, http://dx.doi.org/10.1021/la904673r
    Journal articles | 2010
    Blacklock J; Sievers TK; Handa H; You YZ; Oupický D; Mao G; Möhwald H, 2010, 'Cross-linked bioreducible layer-by-layer films for increased cell adhesion and transgene expression', Journal of Physical Chemistry B, vol. 114, pp. 5283 - 5291, http://dx.doi.org/10.1021/jp100486h
    Journal articles | 2010
    Han HJ; Kannan RM; Wang S; Mao G; Kusanovic JP; Romero R, 2010, 'Multifunctional dendrimer-templated antibody presentation on biosensor surfaces for improved biomarker detection', Advanced Functional Materials, vol. 20, pp. 409 - 421, http://dx.doi.org/10.1002/adfm.200901293
    Journal articles | 2009
    Blacklock J; You YZ; Zhou QH; Mao G; Oupický D, 2009, 'Gene delivery in vitro and in vivo from bioreducible multilayered polyelectrolyte films of plasmid DNA', Biomaterials, vol. 30, pp. 939 - 950, http://dx.doi.org/10.1016/j.biomaterials.2008.10.012
    Journal articles | 2009
    Kakade S; Manickam DS; Handa H; Mao G; Oupický D, 2009, 'Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles', International Journal of Pharmaceutics, vol. 365, pp. 44 - 52, http://dx.doi.org/10.1016/j.ijpharm.2008.08.019
    Journal articles | 2009
    Wan L; You Y; Zou Y; Oupický D; Mao G, 2009, 'DNA release dynamics from bioreducible poly(amido amine) polyplexes', Journal of Physical Chemistry B, vol. 113, pp. 13735 - 13741, http://dx.doi.org/10.1021/jp901835u
    Journal articles | 2008
    Handa H; Gurczynski S; Jackson MP; Auner G; Walker J; Mao G, 2008, 'Recognition of Salmonella typhimurium by immobilized phage P22 monolayers', Surface Science, vol. 602, pp. 1392 - 1400, http://dx.doi.org/10.1016/j.susc.2008.01.036
    Journal articles | 2008
    Khdair A; Gerard B; Handa H; Mao G; Shekhar MPV; Panyam J, 2008, 'Surfactant - Polymer nanoparticles enhance the effectiveness of anticancer photodynamic therapy', Molecular Pharmaceutics, vol. 5, pp. 795 - 807, http://dx.doi.org/10.1021/mp800026t
    Journal articles | 2008
    Wan L; Manickam DS; Oupický D; Mao G, 2008, 'DNA release dynamics from reducible polyplexes by atomic force microscopy', Langmuir, vol. 24, pp. 12474 - 12482, http://dx.doi.org/10.1021/la802088y
    Journal articles | 2007
    You YZ; Zhou QH; Manickam DS; Wan L; Mao GZ; Oupický D, 2007, 'Dually responsive multiblock copolymers via reversible addition- fragmentation chain transfer polymerization: Synthesis of temperature- and redox-responsive copolymers of poly(N-isopropylacrylamide) and poly(2-(dimethylamino)ethyl methacrylate)', Macromolecules, vol. 40, pp. 8617 - 8624, http://dx.doi.org/10.1021/ma071176p

National Institutes of Health 

US Air Force

ARC Hub in Connected Health

ELATE Fellow, Drexel University

Fulbright Senior Scholar, Fulbright Program

Visiting Professor, Max Planck Institute of Colloids and Interfaces

Faculty CAREER Award, National Science Foundation

Research Area 1: Targeted Drug Delivery for Spinal Cord Injury Using Retrograde Transport of Nanoconjugates

This project develops a novel approach that combines nanotechnology with proven neurobiological principles to selectively target neurons responsible for respiratory recovery post spinal cord injury (SCI). Our nanotherapeutic design consists of a targeting transporter protein chemically conjugated to a gold nanoparticle, which in turn is chemically conjugated to an SCI drug. Our targeted drug administration induces recovery of the hemidiaphragm in a validated SCI model using a small fraction of the systemic dose necessary to induce the same recovery. In addition, the nanoconjugate induces persistent recovery after only one-time injection. The aim is to translate basic nanoscience discoveries into nanotherapeutic products for the treatment of breathing problems associated with SCI. 

Research Area 2: Substrate-directed Crystallization and Its Application for Making Nanowire Sensors

We apply substrate-mediated crystallization principles towards scalable manufacturing of nanowire sensors. We explore a simple, low-cost electrocrystallization method to deposit charge-transfer salt nanowires from a solution droplet at room temperature directly on electronic substrates. The nanowires are grown by substrate-mediated electrocrystallization using lithographic metal patterns as nucleation points. The nanowire assembly is capable of detecting gases of interest to civilian and defence industries by electrochemical impedance. We aim to provide fundamental understanding of seed-mediated crystallization, a widely used industrial separation and purification process, and contribute a solution-based method to incorporate nanowires into MEMS devices.

My Research Supervision

Dr Mostak Ahmed (postdoctoral fellow)

Dr Md Musfizur Hassan (postdoctoral fellow)

Dr Wenqian Wang (postdoctoral fellow)

Mohamed Kilani (PhD student)