Dr Howard   Yim
Postdoctoral Fellow

Dr Howard Yim

Degrees
  • Bachelor of Science, The University of Hong Kong
  • Master of Philosophy, The University of Hong Kong
  • Doctor of Philosophy, The University of Hong Kong

Accreditations

  •  Monash Supervisor Accreditation Level 1 Membership in 2016
  •  “Foundation of Teaching Associate” Course, Monash University Continuing Education Excellence Development program in 2016
Medicine & Health
St. George Clin Sch- Operating

My Current Research Interests:

Dr. Yim's current research focuses on the investigation of the role of gut microbiota in the development of colorectal cancer. He is interested in understanding the pathogenesis of colorectal cancer and identifying the host or microbial factors leading to this disease. He is also interested in translating these research outcome into therapeutic and preventive strategies to tackle or protect against the disease. 

 My Background:

Dr Howard Yim completed his PhD in the Department of Paediatrics and Adolescent Medicine at The University of Hong Kong, Hong Kong. In his PhD study, he identified several viral and host proteins that contribute to the pathogenesis of infectious diseases, including AIDS and tuberculosis. He then continued his research in the pathogenesis of inflammatory disorders including inflammatory bowel diseases (IBD) when he worked as a postdoctoral research fellow at the Hudson Institute of Medical Research, Monash University, Australia. 

 

Society Memberships & Professional Activities:

  • Member of Australia Chinese Association for Biomedical Science, Melbourne, Australia
  • Member of International Cytokine and Interferon Society, Bethesda MD, USA
  • Member of the Hong Kong Society for Immunology, Hong Kong
  • Member of the Victorian Infection and Immunity Network, Australia
  • Adjunct Research Fellow, Monash University
Phone
+61 02 9113 1350
Location
Department of Medicine St George & Sutherland Clinical School | Faculty of Medicine | UNSW Australia Level 2 Clinical Sciences (WR Pitney) Building St George Hospital | Short St KOGARAH NSW 2217

Publications

  • Book Chapters | 2020
    Dr Howard Yim
    Wu N; Yim HCH; Grimm M; El-Omar E, 2020, 'Epithelial Barrier Function', in Encyclopedia of Gastroenterology, Elsevier, pp. 300 - 313, http://dx.doi.org/10.1016/b978-0-12-801238-3.65657-x
    Book Chapters | 2019
    Dr Howard Yim
    El-Assaad F; Gong L; Gia A; Yim HCH; El-Omar EM, 2019, 'Chapter 2 Helicobacter pylori, Peptic Ulcer Disease and Gastric Cancer', in Gastrointestinal Diseases and their Associated Infections, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2019
    Dr Howard Yim
    El-Assaad F; Gong L; Gia A; Yim H; El-Omar E, 2019, 'Helicobacter pylori, peptic ulcer disease and gastric cancer', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, St Louis, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2017
    Dr Howard Yim
    Ong HS; Yim HC, 2017, 'Microbial Factors in Inflammatory Diseases and Cancers', in Xu D (ed.), Regulation of Inflammatory Signaling in Health and Disease, pp. 153 - 174, http://dx.doi.org/10.1007/978-981-10-5987-2_7
  • Journal articles | 2020
    Dr Howard Yim
    Yim HCH; Leon TYY; Li JCB, 2020, 'MXD1 regulates the H9N2 and H1N1 influenza A virus–induced chemokine expression and their replications in human macrophage', Journal of Leukocyte Biology, vol. 108, pp. 1631 - 1640, http://dx.doi.org/10.1002/JLB.4MA0620-703RR
    Journal articles | 2020
    Dr Howard Yim
    Yim HCH; El-Omar EM, 2020, 'Risk of physical activity and hepatobiliary diseases: east meets west.', Br J Sports Med, http://dx.doi.org/10.1136/bjsports-2020-103348
    Journal articles | 2019
    Dr Howard Yim
    Fang HF; Lee TY; Hui KC; Ho Yim HC; Chi MJ; Chung MH, 2019, 'Association between sedative-hypnotics and subsequent cancer in patients with and without insomnia: A 14-year follow-up study in Taiwan', Journal of Cancer, vol. 10, pp. 2288 - 2298, http://dx.doi.org/10.7150/jca.30680
    Journal articles | 2017
    Dr Howard Yim
    Dou Y; Yim HCH; Kirkwood CD; Williams BRG; Sadler AJ, 2017, 'The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation', EMBO Journal, vol. 36, pp. 2742 - 2757, http://dx.doi.org/10.15252/embj.201696273
    Journal articles | 2017
    Dr Howard Yim
    Ahmed AU; Yim HH; Alorro M; Ernst M; Williams BRG, 2017, 'Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis', Journal of Immunology, vol. 199, pp. 2128 - 2139, http://dx.doi.org/10.4049/jimmunol.1700125
    Journal articles | 2016
    Dr Howard Yim
    Yim HCH; Wang D; Yu L; White CL; Faber PW; Williams BRG; Sadler AJ, 2016, 'The kinase activity of PKR represses inflammasome activity', Cell Research, vol. 26, pp. 367 - 379, http://dx.doi.org/10.1038/cr.2016.11
    Journal articles | 2015
    Dr Howard Yim
    Sadler AJ; Rossello FJ; Yu L; Deane JA; Yuan X; Wang D; Irving AT; Kaparakis-Liaskos M; Gantier MP; Ying H; Yim HCH; Hartland EL; Notini AJ; De Boer S; White SJ; Mansell A; Liu JP; Watkins DN; Gerondakis S; Williams BRG; Xu D, 2015, 'BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, pp. 1535 - 1540, http://dx.doi.org/10.1073/pnas.1409728112
    Journal articles | 2014
    Dr Howard Yim
    Yim HCH; Williams BRG, 2014, 'Protein kinase R and the inflammasome', Journal of Interferon and Cytokine Research, vol. 34, pp. 447 - 454, http://dx.doi.org/10.1089/jir.2014.0008
    Journal articles | 2014
    Dr Howard Yim
    Liu MS; Wang D; Morimoto H; Yim HCH; Irving AT; Williams BRG; Sadler AJ, 2014, 'Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation', Journal of Molecular Cell Biology, vol. 6, pp. 473 - 485, http://dx.doi.org/10.1093/jmcb/mju044
    Journal articles | 2013
    Dr Howard Yim
    Li JCB; Chan LLY; Yim HCH; Cheung BKW; Lee DCW; Lau ASY, 2013, 'Suppression of cellular antibacterial effects by HIV', Hong Kong Medical Journal, vol. 19, pp. S19 - S23
    Journal articles | 2012
    Dr Howard Yim
    Yim HCH; Chakrabarti A; Silverman R; Williams B; Sadler A, 2012, 'P045 A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway', Cytokine, vol. 59, pp. 533 - 533, http://dx.doi.org/10.1016/j.cyto.2012.06.129
    Journal articles | 2011
    Dr Howard Yim
    Li JCB; Au KY; Fang JW; Yim HC; Chow KH; Ho PL; Lau ASY, 2011, 'HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction', AIDS, vol. 25, pp. 15 - 25, http://dx.doi.org/10.1097/QAD.0b013e328340fd61
    Journal articles | 2011
    Dr Howard Yim
    Yim HCH; Li JCB; Pong JCH; Lau ASY, 2011, 'A role for c-Myc in regulating anti-mycobacterial responses', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, pp. 17749 - 17754, http://dx.doi.org/10.1073/pnas.1104892108
    Journal articles | 2011
    Dr Howard Yim
    Fang JW; Li JCB; Au KY; Yim HCH; Lau ASY, 2011, 'Interleukin-17A differentially modulates BCG induction of cytokine production in human blood macrophages', Journal of Leukocyte Biology, vol. 90, pp. 333 - 341, http://dx.doi.org/10.1189/jlb.0510311
    Journal articles | 2011
    Dr Howard Yim
    Ling WWL; Wang L; Yim HCH; Lau ASY; LI JCB, 2011, 'PS1-038. A role for interleukin 17 in mycobacterial infection', Cytokine, vol. 56, pp. 26 - 27, http://dx.doi.org/10.1016/j.cyto.2011.07.058
    Journal articles | 2010
    Dr Howard Yim
    Li JCB; Yim HCH; Lau AS, 2010, 'Role of HIV-1 Tat in AIDS pathogenesis: Its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection', AIDS, vol. 24, pp. 1609 - 1623, http://dx.doi.org/10.1097/QAD.0b013e32833ac6a0
    Journal articles | 2009
    Dr Howard Yim
    Mak WWS; Cheung F; Woo J; Lee D; Li P; Chan KS; Tam CM, 2009, 'A comparative study of the stigma associated with infectious diseases (SARS, AIDS, TB)', HONG KONG MEDICAL JOURNAL, vol. 15, pp. 34 - 37, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000216394800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Dr Howard Yim
    Cheung BKW; Chan MMP; Yim HCH; Chan LL; Li JCB; Lee DCW; Lau ASY, 2009, 'Immunotherapy of mycobacterial infections: A cell and molecular model', Hong Kong Medical Journal, vol. 15, pp. 32 - 36
    Journal articles | 2009
    Dr Howard Yim
    Cheung BKW; Yim HCH; Lee NCM; Lau ASY, 2009, 'A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1', BMC Immunology, vol. 10, http://dx.doi.org/10.1186/1471-2172-10-64
    Journal articles | 2009
    Dr Howard Yim
    Yim HCH; Li JCB; Lau JSH; Lau ASY, 2009, 'HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: Microbial interactions in HIV infection', AIDS, vol. 23, pp. 1473 - 1484, http://dx.doi.org/10.1097/QAD.0b013e32832d7abe
    Journal articles | 2009
    Dr Howard Yim
    Au KY; Li JCB; Yim HCH; Fang JW; Lau ASY, 2009, 'HIV Tat modulation of IFN-γ-induced expression of autophagy-associated genes in primary human blood macrophages', Cytokine, vol. 48, pp. 67 - 67, http://dx.doi.org/10.1016/j.cyto.2009.07.218
    Journal articles | 2009
    Dr Howard Yim
    Li JCB; Cheng SM; Yim HCH; Lee DCW; Lau ASY, 2009, 'Mechanisms underlying HIV-1 suppression of IFNγ signaling pathways: A role for transactivator Tat in the induction of SOCS-2 in primary human blood monocytes', Cytokine, vol. 48, pp. 63 - 63, http://dx.doi.org/10.1016/j.cyto.2009.07.201
    Journal articles | 2009
    Dr Howard Yim
    Cheung BKW; Yim HCH; Lau ASY, 2009, 'Positive role of mitogen-activated protein kinase phosphatase-1 in regulating the anti-mycobacterial immune responses', Cytokine, vol. 48, pp. 61 - 62, http://dx.doi.org/10.1016/j.cyto.2009.07.194
    Journal articles | 2008
    Dr Howard Yim
    Yim HCH; Li JCB; Lee DCW; Lau AS, 2008, '323 Microbial interactions in AIDS pathogenesis: HIV-TAT suppression of endotoxin-TLR4 induced interferon induction and cytokine dysregulation', Cytokine, vol. 43, pp. 320 - 320, http://dx.doi.org/10.1016/j.cyto.2008.07.407
    Journal articles | 2007
    Dr Howard Yim
    Law AHY; Lee DCW; Cheung BKW; Yim HCH; Lau ASY, 2007, 'Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation', Journal of Virology, vol. 81, pp. 416 - 422, http://dx.doi.org/10.1128/JVI.02336-05
  • Conference Abstracts | 2014
    Dr Howard Yim
    Yim HH; Yu L; Wang D; Chakrabarti A; Silverman R; Williams BRW; Sadler AJ, 2014, 'A role for protein kinase R in regulating NLRP3 inflammasome assembly', in SI: 2014 ICIS Abstract Issue, ICIS Conference, Melbourne, Australia, presented at ICIS Conference, Melbourne, Australia, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.212
    Conference Abstracts | 2013
    Dr Howard Yim
    Yim HH; Pindel A, 2013, 'The protein kinase R as a repressor of inflammasome activity', in 2013 ICS Abstract Issue, ICIS Conference, presented at ICIS Conference, http://dx.doi.org/10.1016/j.cyto.2013.06.293
    Conference Abstracts | 2012
    Dr Howard Yim
    Pong JC; Li JC; Yim HH; Lau AS, 2012, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection', in 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, Vol. 59, pp. 522 - 522, presented at 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, 11 September 2012 - 14 September 2012, http://dx.doi.org/10.1016/j.cyto.2012.06.096
    Conference Abstracts | 2008
    Dr Howard Yim
    Li JC; Yim HC; Rieder MJ; Lee DC; Lau AS, 2008, 'Immunomodulatory effects of drug metaboites: An unexpected role of sulfamethoxazole in the regulation of inflammation', in CYTOKINES IN CANCER, INFLAMMATION AND INFECTIOUS DISEASES: TRANSLATING SCIENCE INTO HEALTH, Cytokine, Elsevier, Montreal, Quebec, Canada, Vol. 43, pp. 250 - 250, presented at 7thJoint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Montreal, Quebec, Canada, 12 October 2008 - 16 August 2017, http://dx.doi.org/10.1016/j.cyto.2008.07.101

Awards

The Milstein Travel Award, International Society for Interferon and Cytokine Research, Bethesda MD, USA - 2012

Best Oral Presentation Award, the Hong Kong Society for Paediatric Immunology and Infectious Diseases, Hong Kong. 2008

Seymour and Vivian Milstein Student Research Travel Award, International Society for Interferon and Cytokine Research, Bethesda MD, USA. 2006

Grants

Fellowships

  • NHMRC Early Career (Australia-China) Fellowship, National Health and Medical Research Council, Australia.  2013-2015
  • Ron Evans Cancer Research Fellowship, Evans & Partners. 2012.

Grants

 

  • 2017, UNSW 2018 Research Infrastructure Scheme: Supporting Collaborative Research, The University of New South Wales, Australia “Advanced Endoscopic In Vivo Imaging System”Principal Investigator: Prof. Emad El-OmarCo-Investigators: Prof. Michael Grimm, A/Prof. Winston Liauw, A/Prof. Zekry Amany, Dr. Lan Gong, Dr. Howard CH Yim, Prof. Steven Krilis, Prof. Beng Chong.

  • 2017, Microbiome Establishment Grant, St George and Sutherland Medical Research Foundation, Australia. “Understanding the longitudinal impact of systemic anti-cancer therapy on the gut microbiome and correlates with efficacy and safety in patients with metastatic colorectal cancer.” Principal Investigator: A/Prof. Winston Liauw Co-Investigators: Prof. Emad El-Omar, Dr. Howard CH Yim, Linda Zhang

  • 2011, Research Fund for the Control of Infectious Diseases, HKSAR Government. “A role for oncogene in bacteria-induced immune responses: a potential building block for the new treatment development.” Principal Investigator: Dr. James C.B. Li ; Co-Investigators: Prof. Allan SY Lau and Dr. Howard CH Yim

  • 2011, Research Fund for the Control of Infectious Diseases, HKSAR Government. “Cellular Oncogene Dysregulation of Chemokine and Cytokine Expression in Virus Infection.” Principal Investigator: Prof. Allan SY Lau; Co-Investigators: Dr. YY Leon, Dr. James C.B. Li and Dr. Howard CH Yim

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