Dr Howard Yim

Dr Howard Yim

  • Bachelor of Science, The University of Hong Kong
  • Master of Philosophy, The University of Hong Kong
  • Doctor of Philosophy, The University of Hong Kong


  •  Monash Supervisor Accreditation Level 1 Membership in 2016
  •  “Foundation of Teaching Associate” Course, Monash University Continuing Education Excellence Development program in 2016
Medicine & Health
School of Clinical Medicine

My Background:

Dr Howard Yim completed his PhD in the Department of Paediatrics and Adolescent Medicine at The University of Hong Kong, Hong Kong. In his PhD study, he identified several viral and host proteins that contribute to the pathogenesis of infectious diseases, including AIDS and tuberculosis. He then continued his research in the pathogenesis of inflammatory disorders including inflammatory bowel diseases (IBD) when he worked as a postdoctoral research fellow at the Hudson Institute of Medical Research, Monash University, Australia. 


Society Memberships & Professional Activities:

  • Member of Australia Chinese Association for Biomedical Science, Melbourne, Australia
  • Member of International Cytokine and Interferon Society, Bethesda MD, USA
  • Member of the Hong Kong Society for Immunology, Hong Kong
  • Member of the Victorian Infection and Immunity Network, Australia
  • Adjunct Research Fellow, Monash University
+61 2 9065 2623
Microbiome Research Centre Level 2, REC Building, 4-10 South Street, KOGARAH NSW 2217
  • Book Chapters | 2022
    2022, 'Tumors of the stomach', in , Wiley, pp. 1023 - 1046, http://dx.doi.org/10.1002/9781119600206.ch52
    Book Chapters | 2019
    2019, 'Chapter 2 Helicobacter pylori, Peptic Ulcer Disease and Gastric Cancer', in Gastrointestinal Diseases and their Associated Infections, Elsevier, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2019
    2019, 'Epithelial Barrier Function', in Encyclopedia of Gastroenterology, Second Edition, Elsevier, pp. 300 - 313, http://dx.doi.org/10.1016/B978-0-12-801238-3.65657-X
    Book Chapters | 2019
    2019, 'Helicobacter pylori, peptic ulcer disease and gastric cancer', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, St Louis, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2017
    2017, 'Microbial Factors in Inflammatory Diseases and Cancers', in Xu D (ed.), Regulation of Inflammatory Signaling in Health and Disease, pp. 153 - 174, http://dx.doi.org/10.1007/978-981-10-5987-2_7
  • Journal articles | 2023
    2023, 'SARS-CoV-2 and male infertility: from short- to long-term impacts', Journal of Endocrinological Investigation, http://dx.doi.org/10.1007/s40618-023-02055-x
    Journal articles | 2023
    2023, 'The protein kinase R modifies gut physiology to limit colitis', Frontiers in Immunology, 14, http://dx.doi.org/10.3389/fimmu.2023.1106737
    Journal articles | 2022
    2022, 'Dysbiosis in Head and Neck Cancer: Determining Optimal Sampling Site for Oral Microbiome Collection', Pathogens, 11, pp. 27 - 28, http://dx.doi.org/10.3390/pathogens11121550
    Journal articles | 2022
    2022, 'Editorial: Manipulation of gut microbiota as a key target to intervene on the onset and progression of digestive system diseases', Frontiers in Medicine, 9, pp. 999005, http://dx.doi.org/10.3389/fmed.2022.999005
    Journal articles | 2022
    2022, 'Fecal DNA Virome Is Associated with the Development of Colorectal Neoplasia in a Murine Model of Colorectal Cancer', Pathogens, 11, http://dx.doi.org/10.3390/pathogens11040457
    Journal articles | 2022
    2022, 'The microbiome and male infertility: looking into the past to move forward', Human Fertility, http://dx.doi.org/10.1080/14647273.2022.2098540
    Journal articles | 2022
    2022, 'The repertoire of testicular extracellular vesicle cargoes and their involvement in inter-compartmental communication associated with spermatogenesis', BMC Biology, 20, pp. 78, http://dx.doi.org/10.1186/s12915-022-01268-5
    Journal articles | 2021
    2021, 'A perspective on the role of microbiome for colorectal cancer treatment', Cancers, 13, http://dx.doi.org/10.3390/cancers13184623
    Journal articles | 2021
    2021, 'Risk of physical activity and hepatobiliary diseases: East meets west', British Journal of Sports Medicine, 55, pp. 1003 - 1004, http://dx.doi.org/10.1136/bjsports-2020-103348
    Journal articles | 2020
    2020, 'MXD1 regulates the H9N2 and H1N1 influenza A virus–induced chemokine expression and their replications in human macrophage', Journal of Leukocyte Biology, 108, pp. 1631 - 1640, http://dx.doi.org/10.1002/JLB.4MA0620-703RR
    Journal articles | 2019
    2019, 'Association between sedative-hypnotics and subsequent cancer in patients with and without insomnia: A 14-year follow-up study in Taiwan', Journal of Cancer, 10, pp. 2288 - 2298, http://dx.doi.org/10.7150/jca.30680
    Journal articles | 2017
    Dou Y; Yim HC H; Kirkwood CD; Williams BR G; Sadler AJ, 2017, 'The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation', EMBO Journal, 36, pp. 2742 - 2757, http://dx.doi.org/10.15252/embj.201696273
    Journal articles | 2017
    2017, 'Integrin-Linked Kinase Expression in Myeloid Cells Promotes Inflammatory Signaling during Experimental Colitis', Journal of Immunology, 199, pp. 2128 - 2139, http://dx.doi.org/10.4049/jimmunol.1700125
    Journal articles | 2016
    Yim HC H; Wang D; Yu L; White CL; Faber PW; Williams BR G; Sadler AJ, 2016, 'The kinase activity of PKR represses inflammasome activity', Cell Research, 26, pp. 367 - 379, http://dx.doi.org/10.1038/cr.2016.11
    Journal articles | 2015
    Sadler AJ; Rossello FJ; Yu L; Deane JA; Yuan X; Wang D; Irving AT; Kaparakis-Liaskos M; Gantier MP; Ying H; Yim HC H; Hartland EL; Notini AJ; De Boer S; White SJ; Mansell A; Liu JP; Watkins DN; Gerondakis S; Williams BR G; Xu D, 2015, 'BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs', Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 1535 - 1540, http://dx.doi.org/10.1073/pnas.1409728112
    Journal articles | 2014
    Liu MS; Wang D; Morimoto H; Yim HC H; Irving AT; Williams BR G; Sadler AJ, 2014, 'Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation', Journal of Molecular Cell Biology, 6, pp. 473 - 485, http://dx.doi.org/10.1093/jmcb/mju044
    Journal articles | 2014
    Yim HC H; Williams BR G, 2014, 'Protein kinase R and the inflammasome', Journal of Interferon and Cytokine Research, 34, pp. 447 - 454, http://dx.doi.org/10.1089/jir.2014.0008
    Journal articles | 2013
    Li JC B; Chan LL Y; Yim HC H; Cheung BK W; Lee DC W; Lau AS Y, 2013, 'Suppression of cellular antibacterial effects by HIV', Hong Kong Medical Journal, 19, pp. S19 - S23
    Journal articles | 2013
    2013, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection (P4235)', The Journal of Immunology, 190, pp. 130.17 - 130.17, http://dx.doi.org/10.4049/jimmunol.190.supp.130.17
    Journal articles | 2012
    2012, 'A role for Protein Kinase R in regulating NLRP3 inflammasome signaling pathway', CYTOKINE, 59, pp. 533 - 533, http://dx.doi.org/10.1016/j.cyto.2012.06.129
    Journal articles | 2011
    Fang JW; Li JC B; Au KY; Yim HC H; Lau AS Y, 2011, 'Interleukin-17A differentially modulates BCG induction of cytokine production in human blood macrophages', Journal of Leukocyte Biology, 90, pp. 333 - 341, http://dx.doi.org/10.1189/jlb.0510311
    Journal articles | 2011
    Li JC B; Au KY; Fang JW; Yim HC; Chow KH; Ho PL; Lau AS Y, 2011, 'HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction', AIDS, 25, pp. 15 - 25, http://dx.doi.org/10.1097/QAD.0b013e328340fd61
    Journal articles | 2011
    Yim HC H; Li JC B; Pong JC H; Lau AS Y, 2011, 'A role for c-Myc in regulating anti-mycobacterial responses', Proceedings of the National Academy of Sciences of the United States of America, 108, pp. 17749 - 17754, http://dx.doi.org/10.1073/pnas.1104892108
    Journal articles | 2011
    2011, 'A role for interleukin 17 in mycobacterial infection', CYTOKINE, 56, pp. 26 - 27, http://dx.doi.org/10.1016/j.cyto.2011.07.058
    Journal articles | 2010
    Li JC B; Yim HC H; Lau AS, 2010, 'Role of HIV-1 Tat in AIDS pathogenesis: Its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection', AIDS, 24, pp. 1609 - 1623, http://dx.doi.org/10.1097/QAD.0b013e32833ac6a0
    Journal articles | 2009
    Cheung BK W; Chan MM P; Yim HC H; Chan LL; Li JC B; Lee DC W; Lau AS Y, 2009, 'Immunotherapy of mycobacterial infections: A cell and molecular model', Hong Kong Medical Journal, 15, pp. 32 - 36
    Journal articles | 2009
    Cheung BK W; Yim HC H; Lee NC M; Lau AS Y, 2009, 'A novel anti-mycobacterial function of mitogen-activated protein kinase phosphatase-1', BMC Immunology, 10, http://dx.doi.org/10.1186/1471-2172-10-64
    Journal articles | 2009
    Mak WW S; Cheung F; Woo J; Lee D; Li P; Chan KS; Tam CM, 2009, 'A comparative study of the stigma associated with infectious diseases (SARS, AIDS, TB)', HONG KONG MEDICAL JOURNAL, 15, pp. 34 - 37, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000216394800010&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Yim HC H; Li JC B; Lau JS H; Lau AS Y, 2009, 'HIV-1 Tat dysregulation of lipopolysaccharide-induced cytokine responses: Microbial interactions in HIV infection', AIDS, 23, pp. 1473 - 1484, http://dx.doi.org/10.1097/QAD.0b013e32832d7abe
    Journal articles | 2009
    2009, 'HIV Tat modulation of IFN-gamma-induced expression of autophagy-associated genes in primary human blood macrophages', CYTOKINE, 48, pp. 67 - 67, http://dx.doi.org/10.1016/j.cyto.2009.07.218
    Journal articles | 2009
    2009, 'Mechanisms underlying HIV-1 suppression of IFN gamma signaling pathways: A role for transactivator Tat in the induction of SOCS-2 in primary human blood monocytes', CYTOKINE, 48, pp. 63 - 63, http://dx.doi.org/10.1016/j.cyto.2009.07.201
    Journal articles | 2009
    2009, 'Positive role of mitogen-activated protein kinase phosphatase-1 in regulating the anti-mycobacterial immune responses', CYTOKINE, 48, pp. 61 - 62, http://dx.doi.org/10.1016/j.cyto.2009.07.194
    Journal articles | 2008
    2008, 'Microbial interactions in AIDS pathogenesis: HIV-TAT suppression of endotoxin-TLR4 induced interferon induction and cytokine dysregulation', CYTOKINE, 43, pp. 320 - 320, http://dx.doi.org/10.1016/j.cyto.2008.07.407
    Journal articles | 2007
    Law AH Y; Lee DC W; Cheung BK W; Yim HC H; Lau AS Y, 2007, 'Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation', Journal of Virology, 81, pp. 416 - 422, http://dx.doi.org/10.1128/JVI.02336-05
  • Conference Papers | 2022
    Pandey D; Szczesniak M; Maclean J; Yim HCH; Zhang F; Graham P; El-Omar EM; Wu P, 2022, 'Dysbiosis in Head and Neck Cancer: Determining Optimal Sampling Site for Oral Microbiome Collection', in Pathogens, WILEY, pp. 27 - 28, http://dx.doi.org/10.3390/pathogens11121550
    Preprints | 2021
    2021, The repertoire of testicular extracellular vesicles cargoes and their involvement in inter-compartmental communication required for spermatogenesis, , http://dx.doi.org/10.1101/2021.01.08.426002
    Conference Abstracts | 2014
    Yim HH; Yu L; Wang D; Chakrabarti A; Silverman R; Williams BR W; Sadler AJ, 2014, 'A role for protein kinase R in regulating NLRP3 inflammasome assembly', in SI: 2014 ICIS Abstract Issue, ICIS Conference, Melbourne, Australia, presented at ICIS Conference, Melbourne, Australia, 26 October 2014 - 29 October 2014, http://dx.doi.org/10.1016/j.cyto.2014.07.212
    Conference Abstracts | 2013
    Yim HH; Pindel A, 2013, 'The protein kinase R as a repressor of inflammasome activity', in 2013 ICS Abstract Issue, ICIS Conference, presented at ICIS Conference, http://dx.doi.org/10.1016/j.cyto.2013.06.293
    Conference Abstracts | 2012
    Pong JC; Li JC; Yim HH; Lau AS, 2012, 'The role of c-Myc in regulating HIV-1 Tat protein induced cytokine expression and consequent effects on opportunistic infection', in 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, Vol. 59, pp. 522 - 522, presented at 10th Joint Meeting of International Cytokine Society and International Society for Interferon and Cytokine Research, Geneva, Switzerland, 11 September 2012 - 14 September 2012, http://dx.doi.org/10.1016/j.cyto.2012.06.096
    Conference Abstracts | 2008
    Li JC; Yim HC; Rieder MJ; Lee DC; Lau AS, 2008, 'Immunomodulatory effects of drug metaboites: An unexpected role of sulfamethoxazole in the regulation of inflammation', in CYTOKINES IN CANCER, INFLAMMATION AND INFECTIOUS DISEASES: TRANSLATING SCIENCE INTO HEALTH, Cytokine, Elsevier, Montreal, Quebec, Canada, Vol. 43, pp. 250 - 250, presented at 7thJoint Conference of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Montreal, Quebec, Canada, 12 October 2008 - 16 August 2017, http://dx.doi.org/10.1016/j.cyto.2008.07.101
    Conference Papers | 2008
    2008, 'Immunomodulatory Effects of Drug Metabolites: An Unexpected Role of Sulfamethoxazole in the Regulation of Inflammation', in Hiscott J (ed.), PROCEEDINGS OF THE 7TH JOINT MEETING OF THE INTERNATIONAL MEETING OF THE INTERNATIONAL CYTOKINE SOCIETY AND THE INTERNATIONAL SOCIETY FOR INTERFERON AND CYTOKINE RESEARCH, MEDIMOND S R L, CANADA, Montreal, pp. 55 - 58, presented at 7th Joint Conference of the International-Cytokines-Society/International-Society-for-Interferon-and-Cytoklin-Research, CANADA, Montreal, 12 October 2008 - 16 October 2008, http://dx.doi.org/10.1145/1370788.1370803
    Conference Papers | 2006
    2006, 'Effects of HIV-1 tat on lipopolysaccharide induced cytokine response', in Schwarzmeier JD (ed.), Proceedings of the 6th International Cytokine Conference, MEDIMOND S R L, AUSTRIA, Vienna, pp. 163 - 166, presented at 6th International Cytokine Conference, AUSTRIA, Vienna, 27 August 2006 - 31 August 2006, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000243535100030&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1


  • NHMRC Early Career (Australia-China) Fellowship, National Health and Medical Research Council, Australia.  2013-2015
  • Ron Evans Cancer Research Fellowship, Evans & Partners. 2012.


  • 2023, Cancer Australia - "A Novel Probiotic as a preventive strategy for Colorectal Neoplasia" - CIA: Dr. Howard Yim

  • 2019, Health and Medical Research Fund - Infectious Disease. “A pilot study on semen metagenomics, and spent culture media of patients undergoing conventional IVF treatment” Principal Investigator: Dr. LEUNG Bo Wah Marran Co-investigator: Prof. CHAN David Yiu Leung, Prof. FOK Ellis Kin Lam, Dr. Howard CH Yim and Dr. JIANG Xiaotao, and Prof. LI Tin Chiu 

  • 2017, UNSW 2018 Research Infrastructure Scheme: Supporting Collaborative Research, The University of New South Wales, Australia “Advanced Endoscopic In Vivo Imaging System”Principal Investigator: Prof. Emad El-OmarCo-Investigators: Prof. Michael Grimm, A/Prof. Winston Liauw, A/Prof. Zekry Amany, Dr. Lan Gong, Dr. Howard CH Yim, Prof. Steven Krilis, Prof. Beng Chong.

  • 2011, Research Fund for the Control of Infectious Diseases, HKSAR Government. “A role for oncogene in bacteria-induced immune responses: a potential building block for the new treatment development.” Principal Investigator: Dr. James C.B. Li ; Co-Investigators: Prof. Allan SY Lau and Dr. Howard CH Yim

  • 2011, Research Fund for the Control of Infectious Diseases, HKSAR Government. “Cellular Oncogene Dysregulation of Chemokine and Cytokine Expression in Virus Infection.” Principal Investigator: Prof. Allan SY Lau; Co-Investigators: Dr. YY Leon, Dr. James C.B. Li and Dr. Howard CH Yim

The Milstein Travel Award, International Society for Interferon and Cytokine Research, Bethesda MD, USA - 2012

Best Oral Presentation Award, the Hong Kong Society for Paediatric Immunology and Infectious Diseases, Hong Kong. 2008

Seymour and Vivian Milstein Student Research Travel Award, International Society for Interferon and Cytokine Research, Bethesda MD, USA. 2006

Dr. Yim is leading the Cancer Theme at the UNSW Microbiome Research Centre. 

My Current Research Themes:

  • Development of next generation probiotics against colon cancer
  • Understanding the role of Virome in the pathogenesis of colon cancer
  • Role of Microbiome in Male Infertilty
  • Role of Microbiome in pancreatic cancer and its treatment.