Dr Xin (Jessie) Chen

Dr Xin (Jessie) Chen

Research Associate

PhD, MPH

Medicine & Health
The Kirby Institute

Dr Jessie C. holds PhD in Public Health and Infectious Diseases, and Master of Public Health (Specialisation: Infectious Diseases Epidemiology and Control) from UNSW. Her PhD research is focused on the advanced analytical methods of outbreak investigation. She developed the highly sensitive risk assessment system (modified Grunow-Finke tool) for the detection of unnatural epidemics including bioterrorism events. She investigated the Middle East Respiratory Syndrome Coronavirus (MERS-CoV) outbreak based on epidemiology, phylogeography and risk assessment to inform the epidemic response. 

She is working as the Research Fellow (Risk Analysis) and a member of EPIWATCH Global Observatory which provides daily outbreak scanning to inform rapid epidemic response globally. Her research fields include disease outbreaks investigation, and risk analysis of unnatural outbreaks using methods of statistical analysis (SPSS, SAS), phylogeographic analysis (Geneious, BEAST, SpreaD3), and risk analysis of bioterrorism (Modified Grunow-Finke scoring system). These research skills have been successfully applied to the investigation of the past and ongoing disease outbreaks. An output of her research includes 25 published research papers in high impact peer-reviewed journals within the past 5 years.

  • Journal articles | 2024
    Chen X; Kalyar F; Chughtai AA; MacIntyre CR, 2024, 'Use of a risk assessment tool to determine the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)', Risk Analysis, 44, pp. 1896 - 1906, http://dx.doi.org/10.1111/risa.14291
    Journal articles | 2024
    Kalyar F; Chen X; Chughtai AA; MacIntyre CR, 2024, 'Origin of the H1N1 (Russian influenza) pandemic of 1977—A risk assessment using the modified Grunow–Finke tool (mGFT)', Risk Analysis, http://dx.doi.org/10.1111/risa.14343
    Journal articles | 2023
    Chen X; Kunasekaran MP; Hutchinson D; Stone H; Zhang T; Aagerup J; Moa A; MacIntyre CR, 2023, 'Enhanced EPIRISK tool for rapid epidemic risk analysis', Public Health, 224, pp. 159 - 168, http://dx.doi.org/10.1016/j.puhe.2023.08.032
    Journal articles | 2023
    Costantino V; Bahl P; Doolan C; De Silva C; Heslop D; Chen X; Lim S; MacIntyre CR, 2023, 'Modeling on the Effects of Deliberate Release of Aerosolized Inhalational Bacillus anthracis (Anthrax) on an Australian Population', Health Security, 21, pp. 61 - 69, http://dx.doi.org/10.1089/hs.2022.0100
    Journal articles | 2023
    Hutchinson D; Kunasekaran M; Stone H; Chen X; Quigley A; Moa A; Macintyre CR, 2023, 'Healthcare Workers' SARS-CoV-2 Infections in Four Hospital Outbreaks during Delta Variant Prevalence in Sydney, Australia', Nursing Research and Practice, 2023, pp. 1806909, http://dx.doi.org/10.1155/2023/1806909
    Journal articles | 2023
    MacIntyre CR; Chen X; Kunasekaran M; Quigley A; Lim S; Stone H; Paik HY; Yao L; Heslop D; Wei W; Sarmiento I; Gurdasani D, 2023, 'Artificial intelligence in public health: the potential of epidemic early warning systems', Journal of International Medical Research, 51, http://dx.doi.org/10.1177/03000605231159335
    Journal articles | 2022
    Honeyman DA; Moa A; Chen X; Macintyre R, 2022, 'Re-emergence of poliomyelitis in the Ukraine, caused by circulating vaccine-derived poliovirus type 2 (cVDPV2)', Global Biosecurity, 4, http://dx.doi.org/10.31646/gbio.157
    Journal articles | 2022
    Hutchinson D; Kunasekaran M; Chen X; Moa A, 2022, 'Japanese Encephalitis Outbreak in South-Eastern Australia, 2022', Global Biosecurity, 4, http://dx.doi.org/10.31646/gbio.159
    Journal articles | 2022
    Kunasekaran M; Hutchinson D; Stone H; Chen X, 2022, 'Unknown skin disease among Senegalese fishermen', Global Biosecurity, 4, http://dx.doi.org/10.31646/gbio.153
    Journal articles | 2022
    Lai YA; Chen X; Kunasekaran M; Rahman B; MacIntyre CR, 2022, 'Global epidemiology of vaccine-derived poliovirus 2016–2021: A descriptive analysis and retrospective case-control study', eClinicalMedicine, 50, http://dx.doi.org/10.1016/j.eclinm.2022.101508
    Journal articles | 2022
    Zhang T; Rabhi F; Behnaz A; Chen X; Paik HY; Yao L; MacIntyre CR, 2022, 'Use of automated machine learning for an outbreak risk prediction tool', Informatics in Medicine Unlocked, 34, http://dx.doi.org/10.1016/j.imu.2022.101121
    Journal articles | 2021
    Adam DC; Chen X; Scotch M; MacIntyre CR; Dwyer D; Kok J, 2021, 'The Molecular Epidemiology and Clinical Phylogenetics of Rhinoviruses Among Paediatric Cases in Sydney, Australia', International Journal of Infectious Diseases, 110, pp. 69 - 74, http://dx.doi.org/10.1016/j.ijid.2021.06.046
    Journal articles | 2021
    Kunasekaran M; Hutchinson D; Stone H; Chen X; Moa A, 2021, 'Is the Delta Plus Variant (B.1.617.2/AY1) more serious than the Delta Variant?', Global Biosecurity, 3, http://dx.doi.org/10.31646/gbio.139
    Journal articles | 2020
    Chen X; Adam DC; Chughtai AA; Stelzer-Braid S; Scotch M; MacIntyre CR, 2020, 'The phylogeography of MERS-CoV in hospital outbreak-associated cases compared to sporadic cases in Saudi Arabia', Viruses, 12, http://dx.doi.org/10.3390/v12050540
    Journal articles | 2020
    Chen X; Bahl P; De Silva C; Heslop D; Doolan C; Lim S; MacIntyre CR, 2020, 'Systematic Review and Evaluation of Mathematical Attack Models of Human Inhalational Anthrax for Supporting Public Health Decision Making and Response', Prehospital and Disaster Medicine, 35, pp. 412 - 419, http://dx.doi.org/10.1017/S1049023X20000734
    Journal articles | 2020
    Chen X; Chughtai AA; MacIntyre CR, 2020, 'Application of a Risk Analysis Tool to Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Outbreak in Saudi Arabia', Risk Analysis, 40, pp. 915 - 925, http://dx.doi.org/10.1111/risa.13472
    Journal articles | 2020
    Kpozehouen EB; Chen X; Zhu M; Macintyre CR, 2020, 'Using Open-Source Intelligence to Detect Early Signals of COVID-19 in China: Descriptive Study (Preprint)', , http://dx.doi.org/10.2196/preprints.18939
    Journal articles | 2020
    Kpozehouen EB; Chen X; Zhu M; Macintyre CR, 2020, 'Using open-source intelligence to detect early signals of COVID-19 in China: Descriptive study', JMIR Public Health and Surveillance, 6, http://dx.doi.org/10.2196/18939
    Journal articles | 2020
    MacIntyre CR; Chen X; Adam DC; Chughtai AA, 2020, 'Epidemiology of paediatric Middle East respiratory syndrome coronavirus and implications for the control of coronavirus virus disease 2019', Journal of Paediatrics and Child Health, 56, pp. 1561 - 1564, http://dx.doi.org/10.1111/jpc.15014
    Journal articles | 2020
    MacIntyre CR; Chen X; Kunasekaran M; Kannan A; Nayak V; Bayaraa K; Sitnikova E; Nguyen PY; German T, 2020, 'Tailored intelligence to detect unusual epidemic activity following the explosion at Vector, Russia', Global Biosecurity, 1, http://dx.doi.org/10.31646/gbio.85
    Journal articles | 2020
    Nguyen PY; Chen XJ; Kunasekaran M, 2020, 'Rise in pneumonia cases of unknown aetiology in Kazakhstan in June 2020: A rapid analysis', Global Biosecurity, 2, http://dx.doi.org/10.31646/gbio.81
    Journal articles | 2019
    Chen X; Chughtai AA; Macintyre CR, 2019, 'Recalibration of the grunow–finke assessment tool to improve performance in detecting unnatural epidemics', Risk Analysis, 39, pp. 1465 - 1475, http://dx.doi.org/10.1111/risa.13255
    Journal articles | 2019
    Kunasekaran M; Chen X; Costantino V; Chughtai A; MacIntyre R, 2019, 'Evidence for Residual Immunity to Smallpox After Vaccination', Prehospital and Disaster Medicine, 34, pp. s129 - s129, http://dx.doi.org/10.1017/s1049023x19002802
    Journal articles | 2019
    Kunasekaran MP; Chen X; Costantino V; Chughtai AA; MacIntyre CR, 2019, 'Evidence for residual immunity to smallpox after vaccination and implications for re-emergence', Military Medicine, 184, pp. e668 - e679, http://dx.doi.org/10.1093/milmed/usz181
    Journal articles | 2019
    MacIntyre CR; Das A; Chen X; de Silva C; Doolan C, 2019, 'Evidence of long-distance aerial convection of variola virus and implications for disease control', Viruses, 12, http://dx.doi.org/10.3390/v12010033
    Journal articles | 2019
    Moa A; Muscatello D; Chughtai A; Chen X; Raina MacIntyre C, 2019, 'Flucast: A real-time tool to predict severity of an influenza season', Journal of Medical Internet Research, 21, http://dx.doi.org/10.2196/11780
    Journal articles | 2018
    Chen X; Chughtai A; MacIntyre RAINA, 2018, 'Recalibration of the Grunow-Finke Assessment Tool to Improve Performance in Detecting Unnatural Epidemics', Risk Analysis, http://dx.doi.org/10.1111/risa.13255
    Journal articles | 2018
    Chughtai AA; Chen X; Macintyre CR, 2018, 'Risk of self-contamination during doffing of personal protective equipment', American Journal of Infection Control, 46, pp. 1329 - 1334, http://dx.doi.org/10.1016/j.ajic.2018.06.003
    Journal articles | 2018
    MacIntyre CR; Costantino V; Chen X; Segelov E; Chughtai AA; Kelleher A; Kunasekaran M; Lane JM, 2018, 'Influence of population immunosuppression and past vaccination on smallpox reemergence', Emerging Infectious Diseases, 24, pp. 646 - 653, http://dx.doi.org/10.3201/eid2404.171233
    Journal articles | 2018
    Raina MacIntyre C; Engells TE; Scotch M; Heslop DJ; Gumel AB; Poste G; Chen X; Herche W; Steinhöfel K; Lim S; Broom A; MacIntyre R, 2018, 'Converging and emerging threats to health security', Environment Systems and Decisions, 38, pp. 198 - 207, http://dx.doi.org/10.1007/s10669-017-9667-0
    Journal articles | 2017
    Chen X; Chughtai AA; Dyda A; Macintyre CR, 2017, 'Comparative epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) in Saudi Arabia and South Korea', Emerging Microbes and Infections, 6, pp. 1 - 6, http://dx.doi.org/10.1038/emi.2017.40
    Journal articles | 2017
    Chen X; Chughtai AA; MacIntyre CR, 2017, 'Herd protection effect of N95 respirators in healthcare workers', Journal of International Medical Research, 45, pp. 1760 - 1767, http://dx.doi.org/10.1177/0300060516665491
    Journal articles | 2017
    Chen X; Chughtai AA; Raina Macintyre C, 2017, 'A systematic review of risk analysis tools for differentiating unnatural from natural epidemics', Military Medicine, 182, pp. e1827 - e1835, http://dx.doi.org/10.7205/MILMED-D-17-00090