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Dr Jingjing Li
Postdoctoral Fellow

Dr Jingjing Li

Doctor of Philosophy (Biomedical Engineering) (2015 – 2019), University of New South Wales, Sydney, Australia

Master of Biomedical Engineering (by research) (2009-2011), University of New South Wales, Sydney, Australia

Bachelor of Biomedical Engineering (2003 – 2007), Capital Medical University, Beijing, China

 

 

Engineering
Grad Sch: Biomedical Eng

Dr Jingjing Li is a  Postdoctoral Fellow at the Graduate School of Biomedical Engineering. She is working with A/Prof Robert Nordon on ARC Linkage and CRC-P project developing an automated microscale bioreactor for cell and gene therapy. Her research is at the interface of biology and engineering, focusing on the development of microfluidic organ on chip systems and their application in stem cell science, cardiovascular and blood development. 

Being trained as a biomedical engineer, she developed multidiscipline skills spans from microfluidics, stem cell biology, and bioinformatics. Her PhD and Post-Doctoral research focus on studying the influence of pulsatile fluid shear stress on human embryonic blood formation using microfluidic model mimicking foetal circulation, live cell imaging of hPSC differentiation and single-cell RNA sequencing of developing blood niches. She is now working on upscaling the microfluidic organ-on-a-chip models and applying them in the expansion, maturation and engraftment of blood stem and progenitor cells.
E-mail
jingjing.li@unsw.edu.au
Location
Samuels 514, F25 UNSW Sydney Kensington 2052
  • Journal articles | 2023
    Li J; Malouf C; Miles LA; Willis MB; Pietras EM; King KY, 2023, 'Chronic inflammation can transform the fate of normal and mutant hematopoietic stem cells.', Exp Hematol, http://dx.doi.org/10.1016/j.exphem.2023.08.008
    Journal articles | 2022
    Li J; Lao O; Bruveris FF; Wang L; Chaudry K; Yang Z; Farbehi N; Ng ES; Stanley EG; Harvey RP; Elefanty AG; Nordon RE, 2022, 'Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development', Cell Reports, 40, pp. 111339, http://dx.doi.org/10.1016/j.celrep.2022.111339
    Journal articles | 2021
    Li J; Lao O; Nordon RE, 2021, 'The method to generate pulsatile circulatory fluid flow using microfluidics', MethodsX, 8, pp. 101269 - 101269, http://dx.doi.org/10.1016/j.mex.2021.101269
    Journal articles | 2020
    Cornwell JA; Li J; Mahadevan S; Draper JS; Joun GL; Zoellner H; Asli NS; Harvey RP; Nordon RE, 2020, 'TrackPad: Software for semi-automated single-cell tracking and lineage annotation', SoftwareX, 11, http://dx.doi.org/10.1016/j.softx.2020.100440
    Journal articles | 2020
    Wang L; Li J; Coad BR; McFarland CD; Nordon RE, 2020, 'Interaction of endothelial cells with plasma-polymer modified surfaces', Materialia, 9, http://dx.doi.org/10.1016/j.mtla.2020.100613
    Journal articles | 2019
    Chen H; Yu Z; Bai S; Lu H; Xu D; Chen C; Liu D; Zhu Y, 2019, 'Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development', TrAC - Trends in Analytical Chemistry, 117, pp. 186 - 199, http://dx.doi.org/10.1016/j.trac.2019.06.023
    Journal articles | 2013
    Cornwell J; Zhang H; Lim T; Resurreccion R; Port T; Rosengarten G; Nordon R; chen H, 2013, 'Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale', Lab on a chip : miniaturisation for chemistry, biology and bioengineering, 13, pp. 2999 - 3007, http://dx.doi.org/10.1039/c3lc50123j
    Journal articles | 2011
    Chen H; Li J; Zhang H; Li M; Rosengarten G; Nordon RE, 2011, 'Microwell perfusion array for high-throughput, long-term imaging of clonal growth', Biomicrofluidics, 5, pp. Article number: 044117, http://dx.doi.org/10.1063/1.3669371
    Journal articles | 2010
    Li JY; Yu ABOYAOYA-B; Bridgwater J; Rought S, 2010, 'Spontaneous inter-particle percolation: a kinematic simulation study', Powder Technology, 203, pp. 397 - 403, http://dx.doi.org/10.1016/j.powtec.2010.05.037
  • Conference Abstracts | 2022
    Ziaee F; Du E; Li J; Rnjak-Kovacina J; Thordarson P; Nordon R, 2022, 'DEVELOPING FULLY DEFINED SELF-ASSEMBLY PEPTIDE HYDROGELS FOR HUMAN PLURIPOTENT STEM CELL CULTURE', in TISSUE ENGINEERING PART A, MARY ANN LIEBERT, INC, Vol. 28, pp. S537 - S537, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000821187303022&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Li J; Bruveris F; Ed S; Elefanty A; Lao O; Ng E; Nordon R; Ralph P, 2019, 'THE ROLE OF SHEAR STRESS IN THE GENERATION OF DEFINITIVE HAEMATOPOIETIC LINEAGES AND ARTERIAL VASCULATURE FROM HUMAN PLURIPOTENT STEM CELLS AT THE SINGLE-CELL LEVEL', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vol. 76, pp. S73 - S74, http://dx.doi.org/10.1016/j.exphem.2019.06.390
    Conference Abstracts | 2013
    Nordon RE; Cornwell J; Li J; Harvey RP; Schroeder T, 2013, 'Mapping and modelling ex vivo cell culture processes directly from cell tracking data', in Cytotherapy, INFORMA HEALTHCARE, Vol. 15, pp. S7 - S7, http://dx.doi.org/10.1016/j.jcyt.2013.01.025
    Conference Papers | 2013
    Radford J; Wang L; Li J; McFarland C; Nordon RE, 2013, 'A Novel Flash Detection Algorithm for Single Molecule Counting with TIRF Microscopy', in From Nano to Macro, San Francisco, CA, USA, pp. 1066 - 1069, presented at International Symposium on Biomedical Imaging: From Nano to Macro, San Francisco, CA, USA, 07 April 2013 - 11 April 2013, http://dx.doi.org/10.1109/ISBI.2013.6556662
    Conference Papers | 2010
    Ostrovski O; Zhang G; Kononov R; Dewan MA; Li J, 2010, 'Carbothermal Solid State Reduction of Stable Metal Oxides', in Steel Research International, Stockholm, Sweden, pp. 841 - 846, presented at Prof. S Seetharaman Symposium, Stockholm, Sweden, 14 June 2010 - 15 June 2010, http://dx.doi.org/10.1002/srin.201000177

CIA, Early Career Researcher Seed Grant ,UNSW Engineering Faculty (2021)

CIA, International Seed Grant, UNSW Engineering Faculty (2022)

Contributor for  

Scaling microfluidics for cell manufacture. Australian Research Council Linkage Grant LP160100570 (2016-2019)

Manufacturing 3D microstructures for the medical device industry. Australian Research Council Linkage Grant LP160100573 (2016-2019)

CRC-P "Making cell and gene therapy affordable with a microbioreactor" UNSW, Genesys, CSL (2021-2023)

Travel Grants

2022      The Australasian Society for Stem Cell Research (ASSCR) and the Australasian Gene and Cell Therapy Society (AGCTS) Joint Scientific Meeting / National Stem Cell Foundation of Australia (NSCFA) Travel Award 

2019      The Australasian Society for Stem Cell Research (ASSCR) and the Australasian Gene and Cell Therapy Society (AGCTS) Joint Scientific Meeting / National Stem Cell Foundation of Australia (NSCFA) Travel Award            

2019     International Society of Experimental Hematology Conference Award                         

2018     International Society of Stem Cell Research ECR and student Conference Award                                     

2017     Australian Society for Stem Cell Research ECR and student Conference Award   

2015-2017   Stem Cell Australia (SCA) Meeting Travel Grant

2010   Australian Society for Stem Cell Research (ASSCR) Conference Travel Award                               

Scholarship, Awards and Fellowship:

2019                  Best Poster Presentation Award, UNSW Cross Faculty Research Symposium           

2018-2019         Postdoctoral Writing Fellow Award, UNSW

2015-2019        Women in Engineering Award, UNSW 

2015-2019         Faculty Top-up Scholarship, UNSW, Engineering

2015-2019         Australia Postgraduate Award             

      

           

 

1. Modelling human heart, vascular and blood development from pluripotent stem cells on a microfluidic chip

We have used lab-on-chip to mimic foetal circulation and to model human blood formation from cells that line blood vessels. We are currently studying the influence of pulsatile blood flow and circulation on the generation of precursor blood stem cells. We are also investigating the use of hydrogels to pattern embryonic development of the cardiovascular system.

2. Enhancing the development of aortic vasculature and blood stem cell from pluripotent stem cells using dynamic culture system

We use upscaled Microfluidic circulation system and orbital shearing culture system to enhance the development of precursor blood stem cells. This work has been featured in UNSW newsroom and The conversation.

3. Stem cell engineering: the modification of human CD34+ blood stem and progenitor cells.

CD34+ blood stem and progenitor cells derived from sources such as cord blood, bone marrow, mobilised peripheral blood, and human pluripotent stem cells can be manipulated through various techniques of separation, stimulation and genetic modification. These modifications target the genetic or physical traits of the cells with the goal of improving their functionality, therapeutic potential, and compatibility for diverse applications in the field of medicine, particularly in the realm of cell and gene therapy.

 

Research Society and Committee

International Society of Stem Cell Research (ISSCR)

International Society of Experimental Hematology (ISEH) - New Investigator Committee (NIC) Member

International Society of Cell Therapy (ISCT) - Stem Cell Engineering Committee Member 

UNSW Cardiac, Vascular & Metabolic Medicine Theme (CVMM) - Early Career Researcher Committee Member

IEEE Medical Imaging and Image processing

IEEE Engineering in Medicine & Biology Society (EMBS)

Australia Society of Stem Cell Research (ASSCR)

Engineers Australia

NSW Stem Cell Network

 

Professional Society

Academic Representative, Level 3 WHS committee, Graduate School of Biomedical Engineering, UNSW

 

My Research Supervision

Co-supervising PhD Candidate:

Ada Lee, Lab-on-a-chip scale-out of autologous cell and gene therapies.

 

 

My Teaching

BIOM9640 Biomedical Instrumentation

BIOM1010 Engineering in Medicine and Biology