I am a PhD candidate interested in the how cognitive processes are impaired as a result of obesity. Using rodent models, my research investigates the role of the insulin receptor, and insulin resistance, in appetitive learning, hippocampal-dependent memory, and decision-making. It aims to outline how dietary induced obesity and subsequent central insulin resistance 1) impacts transport of insulin across the blood-brain barrier and 2) disrupts goal-directed appetitive behaviours. I use Pavlovian-instrumental transfer paradigms, viral techniques, and transgenics to carry out these investigations. More broadly, I am interested in the translation between neuroscientific advances and public health prevention for obesity related/induced dementias and cognitive decline.
Ganesan K; Ghorbanpour S; Kendall W; Broome ST; Gladding JM; Dhungana A; Abiero AR; Mahmoudi M; Castorina A; Kendig MD; Becchi S; Valova V; Cole L; Bradfield LA, 2025, 'Hippocampal neuroinflammation induced by lipopolysaccharide causes sex-specific disruptions in action selection, food approach memories, and neuronal activation', Brain Behavior and Immunity, 124, pp. 9 - 27, http://dx.doi.org/10.1016/j.bbi.2024.11.011
Journal articles | 2024
Burton TJ; Kumar AR; Lingawi NW; Gladding JM; Balleine BW; Laurent V, 2024, 'Response-independent outcome presentations dissociate stimulus and value based choice', Neurobiology of Learning and Memory, 215, http://dx.doi.org/10.1016/j.nlm.2024.107989
Journal articles | 2024
Gladding JM; Rafiei N; Mitchell CS; Begg DP, 2024, 'Excision of the endothelial blood–brain barrier insulin receptor does not alter spatial cognition in mice fed either a chow or high-fat diet', Neurobiology of Learning and Memory, 212, http://dx.doi.org/10.1016/j.nlm.2024.107938
Journal articles | 2024
Park J; Lingawi NW; Crimmins BE; Gladding JM; Nolan CR; Burton TJ; Laurent V, 2024, 'Stimulus–Outcome Associations Are Required for the Expression of Specific Pavlovian-Instrumental Transfer', Journal of Experimental Psychology Animal Learning and Cognition, 50, pp. 25 - 38, http://dx.doi.org/10.1037/xan0000371
Journal articles | 2024
Rehn S; Gladding J; Bradfield L; Kendig M, 2024, 'Binge eating in adolescent rats', Obesity Research & Clinical Practice, 18, pp. S14 - S14, http://dx.doi.org/10.1016/j.orcp.2024.09.033
Journal articles | 2023
Gladding JM; Bradfield LA; Kendig MD, 2023, 'Diet and obesity effects on cue-driven food-seeking: insights from studies of Pavlovian-instrumental transfer in rodents and humans', Frontiers in Behavioral Neuroscience, 17, http://dx.doi.org/10.3389/fnbeh.2023.1199887
Journal articles | 2023
Gladding JM; Lingawi NW; Leung BK; Kendig MD; Chieng BC; Laurent V, 2023, 'High fat diet allows food-predictive stimuli to energize action performance in the absence of hunger, without distorting insulin signaling on accumbal cholinergic interneurons', Appetite, 188, http://dx.doi.org/10.1016/j.appet.2023.106769
Journal articles | 2022
Chew AW; Oo CZ; Wong ALH; Gladding J, 2022, 'An initial evaluation of research data management online training at the University of New South Wales', Ifla Journal, 48, pp. 510 - 522, http://dx.doi.org/10.1177/03400352211054120
Journal articles | 2022
Goodman EK; Mitchell CS; Teo JD; Gladding JM; Abbott KN; Rafiei N; Zhang L; Herzog H; Begg DP, 2022, 'The effect of insulin receptor deletion in neuropeptide Y neurons on hippocampal dependent cognitive function in aging mice', Journal of Integrative Neuroscience, 21, http://dx.doi.org/10.31083/j.jin2101006
Journal articles | 2022
Oo CZ; Chew AW; Wong ALH; Gladding J; Stenstrom C, 2022, 'Delineating the successful features of research data management training: a systematic review', International Journal for Academic Development, 27, pp. 249 - 264, http://dx.doi.org/10.1080/1360144X.2021.1898399
Journal articles | 2018
Gladding JM; Abbott KN; Antoniadis CP; Stuart A; Begg DP, 2018, 'The Effect of Intrahippocampal Insulin Infusion on Spatial Cognitive Function and Markers of Neuroinflammation in Diet-induced Obesity', Frontiers in Endocrinology, 9, pp. 752, http://dx.doi.org/10.3389/fendo.2018.00752
Gladding J; Lingawi N; Leung B; Kendig M; Chieng B; Laurent V, 2023, High fat diet allows food-predictive stimuli to energize action performance in the absence of hunger, without distorting insulin signaling on accumbal cholinergic interneurons, http://dx.doi.org/10.1101/2023.03.29.534845
1 Minute Thesis Psychology Runner Up | 2019, 2020
Obesity has been associated with brain insulin resistance and my research is interested in examining whether this resistance distorts activity in the neural circuitry supporting pavlovian-instrumental transfer (PIT). PIT looks at whether a pavlovian stimulus that predicts food energises instrumental performance on an action also delivering food. My current research focuses on the role played by insulin receptors expressed on cholinergic interneurons in the nucleus accumbens, which is known to regulate the expression of PIT.
