Professor Johannes   le Coutre
Professor

Professor Johannes le Coutre

Dipl. Biol. (M.Sc.)
Dr. rer nat.
Engineering
Sch: Chemical Engineering

 

Johannes le Coutre joined UNSW in 2019 as Professor – Food & Health. With the goal to strengthen food security and to alleviate the agricultural burden on the environment he is developing a broad research agenda on cellular agriculture. Current food systems around the globe will not be able to provide sustainable food security, and rigorous scientific investigation is required to deliver innovation for agriculture and food industry. He is teaching within the UNSW food program.
Le Coutre holds a Ph.D. in Biophysics for studying the reaction mechanism of the light-driven proton pump bacteriorhodopsin using time resolved Fourier Transform Infrared (FTIR) spectroscopy at the Max-Planck-Institute for Nutritional Physiology. He discovered the critical role for protein-based proton conduction of highly ordered and dynamic hydrogen-bonded networks. This came after a Diploma (MSc) in Biology for a thesis on bacterial photosynthesis from the University of Regensburg, Germany. 
Fascinated by fundamental biological questions of “outside vs. inside” and the underlying biophysics describing substrate fluxes and energy transfer, Johannes went to the Howard Hughes Medical Institute (HHMI) at UCLA in Los Angeles, USA. In the laboratory of H. Ronald Kaback he studied sugar transport in Escherichia coli and the Lactose Permease using a variety of biochemical and biophysical approaches. Arguably this bacterial system can be seen as the simplest form of cellular nutrition.
With the human genome becoming available in 2000, le Coutre was recruited for a position at the Nestlé Research Center in Lausanne, Switzerland, to operationalize the emerging insights on molecular taste physiology for research on food and flavours. As the head of Perception Physiology, he has been driving various large corporate research projects. Le Coutre’s lab has been among the initial research groups who identified taste receptors to be expressed in the gastrointestinal tract.
His research led to important technology developments that were commercialized in key markets and product categories. He is the co-inventor of numerous patents and author of peer reviewed scientific publications.
From 2009 to 2017 le Coutre held a visiting Professorship at the University of Tokyo, where he has been involved with teaching and with a project on taste perception in the Elderly (Mikaku). Also in 2009, le Coutre initiated a well perceived course on innovation at École polytechnique fédérale de Lausanne (EPFL).
In 2016 le Coutre has been promoted to Head of the Greater London Research Program. He established and led a portfolio of scientific collaborations between Nestlé and lmperial College London, where he holds a visiting Professorship. This program features clinical work on microbiota, on spices and on food-related human perception.
Prior to joining UNSW, in addition to his research activities, he served as the Secretary General for Nestlé’s Scientific Advisory board and as coordinator of the International Nutrition Symposium, an annual event featuring world-leading scientists debating critical topics in food and nutrition.
Professor le Coutre is the founding Field Chief Editor for FRONTIERS in Nutrition, an open access journal by the Frontiers Media company.

 

Phone
+61-2-9385 7195
Location
Science and Engineering Building – E8, Room 437

Publications

  • Edited Books | 2010
    Professor Johannes le Coutre
    Montmayeur J-P; le Coutre J, (ed.), 2010, Fat Detection: Taste, Texture, and Post Ingestive Effects, CRC Press/Taylor & Francis, Boca Raton
    Book Chapters | 2010
    Professor Johannes le Coutre
    Toepel U; Knebel J-F; Hudry J; le Coutre J; Murray MM, 2010, 'Advantageous Object Recognition for High-Fat Food Images', in Montmayeur J-P; le Coutre J (ed.), Fat Detection : Taste, Texture, and Post Ingestive Effects, CRC Press/Taylor & Francis, Boca Raton, Florida, https://www.ncbi.nlm.nih.gov/books/NBK53534/
    Book Chapters | 2009
    Professor Johannes le Coutre
    le Coutre J; Scharer-Zublin E, 2009, 'La saveur, le veritable goût', in Recherche et alimentation en dialogue, Wiley-Blackwell, Vevey, pp. 59 - 62
    Book Chapters | 2002
    Professor Johannes le Coutre
    Whitelegge JP; Kaback HR; le Coutre J, 2002, 'Mass spectrometry of membrane transport proteins', in Transmembrane Transporters, Wiley-Liss, pp. 179 - 189, http://dx.doi.org/10.1002/0471434043
    Book Chapters |
    Professor Johannes le Coutre
    Whitelegge JP; Kaback HR; le Coutre J, 'Mass Spectrometry of Membrane Transport Proteins', in Receptor Biochemistry and Methodology, John Wiley & Sons, Inc., pp. 179 - 189, http://dx.doi.org/10.1002/0471434043.ch11
  • Journal articles | 2021
    Professor Johannes le Coutre
    Bassaganya-Riera J; Berry EM; Blaak EE; Burlingame B; le Coutre J; van Eden W; El-Sohemy A; German JB; Knorr D; Lacroix C; Muscaritoli M; Nieman DC; Rychlik M; Scholey A; Serafini M, 2021, 'Goals in Nutrition Science 2020-2025', Frontiers in Nutrition, vol. 7, http://dx.doi.org/10.3389/fnut.2020.606378
    Journal articles | 2021
    Professor Johannes le Coutre
    le Coutre J, 2021, 'Editorial: Cultured Meat—Are We Getting it Right?', Frontiers in Nutrition, vol. 8, http://dx.doi.org/10.3389/fnut.2021.675797
    Journal articles | 2019
    Professor Johannes le Coutre
    Samaras K; Tevaearai H; Goldman M; Le Coutre J; Holly JMP, 2019, 'Editorial: With obesity becoming the new normal, what should we do?', Frontiers in Endocrinology, vol. 10, http://dx.doi.org/10.3389/fendo.2019.00250
    Journal articles | 2016
    Professor Johannes le Coutre
    Michlig S; Merlini JM; Beaumont M; Ledda M; Tavenard A; Mukherjee R; Camacho S; Le Coutre J, 2016, 'Effects of TRP channel agonist ingestion on metabolism and autonomic nervous system in a randomized clinical trial of healthy subjects', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep20795
    Journal articles | 2015
    Professor Johannes le Coutre
    Camacho S; Michlig S; De Senarclens-Bezençon C; Meylan J; Meystre J; Pezzoli M; Markram H; Le Coutre J, 2015, 'Anti-obesity and anti-hyperglycemic effects of cinnamaldehyde via altered ghrelin secretion and functional impact on food intake and gastric emptying', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep07919
    Journal articles | 2015
    Professor Johannes le Coutre
    Allison DB; Bassaganya-Riera J; Burlingame B; Brown AW; le Coutre J; Dickson SL; van Eden W; Garssen J; Hontecillas R; Khoo CSH; Knorr D; Kussmann M; Magistretti PJ; Mehta T; Meule A; Rychlik M; Vögele C, 2015, 'Goals in Nutrition Science 2015–2020', Frontiers in Nutrition, vol. 2, http://dx.doi.org/10.3389/fnut.2015.00026
    Journal articles | 2015
    Professor Johannes le Coutre
    Toepel U; Bielser ML; Forde C; Martin N; Voirin A; le Coutre J; Murray MM; Hudry J, 2015, 'Brain dynamics of meal size selection in humans', NeuroImage, vol. 113, pp. 133 - 142, http://dx.doi.org/10.1016/j.neuroimage.2015.03.041
    Journal articles | 2015
    Professor Johannes le Coutre
    Rezzonico E; Mercenier A; Baetge E; Parkinson S; Beck T; Le Coutre J; Brüssow H, 2015, 'Nestlé's research on nutrition and the human gut microbiome', Scientific American, vol. 312, pp. W1 - W6, http://dx.doi.org/10.1038/scientificamerican0315-79
    Journal articles | 2015
    Professor Johannes le Coutre
    Rezzonico E; Mercenier A; Baetge E; Parkinson S; Beck T; le Coutre J; Bruessow H, 2015, 'Nestle's research on nutrition and the human gut microbiome', NATURE, vol. 518, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000350097300031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2014
    Professor Johannes le Coutre
    Rueedi R; Ledda M; Nicholls AW; Salek RM; Marques-Vidal P; Morya E; Sameshima K; Montoliu I; Da Silva L; Collino S; Martin FP; Rezzi S; Steinbeck C; Waterworth DM; Waeber G; Vollenweider P; Beckmann JS; Le Coutre J; Mooser V; Bergmann S; Genick UK; Kutalik Z, 2014, 'Genome-Wide Association Study of Metabolic Traits Reveals Novel Gene-Metabolite-Disease Links', PLoS Genetics, vol. 10, http://dx.doi.org/10.1371/journal.pgen.1004132
    Journal articles | 2014
    Professor Johannes le Coutre
    le Coutre J, 2014, 'Grand Challenges in Nutrition', Frontiers in Nutrition, vol. 1, http://dx.doi.org/10.3389/fnut.2014.00001
    Journal articles | 2014
    Professor Johannes le Coutre
    Pezzoli M; Elhamdani A; Camacho S; Meystre J; González SM; Le Coutre J; Markram H, 2014, 'Dampened neural activity and abolition of epileptic-like activity in cortical slices by active ingredients of spices', Scientific Reports, vol. 4, http://dx.doi.org/10.1038/srep06825
    Journal articles | 2014
    Professor Johannes le Coutre
    Ledda M; Kutalik Z; Destito MCS; Souza MM; Cirillo CA; Zamboni A; Martin N; Morya E; Sameshima K; Beckmann JS; Coutre JL; Bergmann S; Genick UK, 2014, 'GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics', Human Molecular Genetics, vol. 23, pp. 259 - 267, http://dx.doi.org/10.1093/hmg/ddt404
    Journal articles | 2014
    Professor Johannes le Coutre
    Toepel U; Ohla K; Hudry J; le Coutre J; Murray MM, 2014, 'Verbal labels selectively bias brain responses to high-energy foods', NeuroImage, vol. 87, pp. 154 - 163, http://dx.doi.org/10.1016/j.neuroimage.2013.10.038
    Journal articles | 2013
    Professor Johannes le Coutre
    Godinot N; Yasumatsu K; Barcos ME; Pineau N; Ledda M; Viton F; Ninomiya Y; le Coutre J; Damak S, 2013, 'Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice', Neuroscience, vol. 250, pp. 20 - 30, http://dx.doi.org/10.1016/j.neuroscience.2013.06.043
    Journal articles | 2013
    Professor Johannes le Coutre
    Montoliu I; Genick U; Ledda M; Collino S; Martin FP; Le Coutre J; Rezzi S, 2013, 'Current status on genome-metabolome-wide associations: An opportunity in nutrition research', Genes and Nutrition, vol. 8, pp. 19 - 27, http://dx.doi.org/10.1007/s12263-012-0313-7
    Journal articles | 2013
    Professor Johannes le Coutre
    Cettour-Rose P; Bezençon C; Darimont C; Le Coutre J; Damak S, 2013, 'Quinine controls body weight gain without affecting food intake in male C57BL6 mice', BMC Physiology, vol. 13, http://dx.doi.org/10.1186/1472-6793-13-5
    Journal articles | 2013
    Professor Johannes le Coutre
    Tzieropoulos H; Rytz A; Hudry J; de Coutre J, 2013, 'Dietary fat induces sustained reward response in the human brain without primary taste cortex discrimination', Frontiers in Human Neuroscience, http://dx.doi.org/10.3389/fnhum.2013.00036
    Journal articles | 2013
    Professor Johannes le Coutre
    Maeda N; Kawakami S; Ohmoto M; Le Coutre J; Vinyes-Pares G; Arigoni F; Okada S; Abe K; Aizawa H; Misaka T, 2013, 'Differential expression analysis throughout the weaning period in the mouse cerebral cortex', Biochemical and Biophysical Research Communications, vol. 431, pp. 437 - 443, http://dx.doi.org/10.1016/j.bbrc.2012.12.150
    Journal articles | 2013
    Professor Johannes le Coutre
    Le Coutre J; Mattson MP; Dillin A; Friedman J; Bistrian B, 2013, 'Nutrition and the biology of human ageing: Cognitive decline/food intake & caloric restriction', Journal of Nutrition, Health and Aging, vol. 17, pp. 717 - 720, http://dx.doi.org/10.1007/s12603-013-0375-2
    Journal articles | 2013
    Professor Johannes le Coutre
    Stellingwerff T; Godin JP; Beaumont M; Tavenard A; Grathwohl D; Van Bladeren PJ; Kapp AF; Le Coutre J; Damak S, 2013, 'Effects of pre-exercise sucralose ingestion on carbohydrate oxidation during exercise', International Journal of Sport Nutrition and Exercise Metabolism, vol. 23, pp. 584 - 592, http://dx.doi.org/10.1123/ijsnem.23.6.584
    Journal articles | 2013
    Professor Johannes le Coutre
    Gasser SM; Le Coutre J, 2013, 'Nutrition and the biology of human ageing: Molecular mechanisms underlying ageing', Journal of Nutrition, Health and Aging, vol. 17, pp. 710 - 711, http://dx.doi.org/10.1007/s12603-013-0373-4
    Journal articles | 2012
    Professor Johannes le Coutre
    Ohla K; Toepel U; le Coutre J; Hudry J, 2012, 'Visual-gustatory interaction: Orbitofrontal and insular cortices mediate the effect of high-calorie visual food cues on taste pleasantness', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0032434
    Journal articles | 2012
    Professor Johannes le Coutre
    Toepel U; Knebel JF; Hudry J; Coutre J; Murray MM, 2012, 'Gender and weight shape brain dynamics during food viewing', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0036778
    Journal articles | 2012
    Professor Johannes le Coutre
    Sherman H; Gutman R; Chapnik N; Meylan J; le Coutre J; Froy O, 2012, 'All-trans retinoic acid modifies the expression of clock and disease marker genes', Journal of Nutritional Biochemistry, vol. 23, pp. 209 - 217, http://dx.doi.org/10.1016/j.jnutbio.2010.11.017
    Journal articles | 2012
    Professor Johannes le Coutre
    Lietti CV; Murray MM; Hudry J; le Coutre J; Toepel U, 2012, 'The role of energetic value in dynamic brain response adaptation during repeated food image viewing', Appetite, vol. 58, pp. 11 - 18, http://dx.doi.org/10.1016/j.appet.2011.09.016
    Journal articles | 2012
    Professor Johannes le Coutre
    Offord E; Major G; Vidal K; Gentile-Rapinett G; Baetge E; Beck T; le Coutre J, 2012, 'Nutrition throughout life: innovation for healthy ageing', Nature, vol. 492, https://www.nature.com/nature/outlook/ageing/pdf/nestle.pdf
    Journal articles | 2011
    Professor Johannes le Coutre
    Labbe D; Martin N; Le Coutre J; Hudry J, 2011, 'Impact of refreshing perception on mood, cognitive performance and brain oscillations: An exploratory study', Food Quality and Preference, vol. 22, pp. 92 - 100, http://dx.doi.org/10.1016/j.foodqual.2010.08.002
    Journal articles | 2011
    Professor Johannes le Coutre
    Sherman H; Frumin I; Gutman R; Chapnik N; Lorentz A; Meylan J; le Coutre J; Froy O, 2011, 'Long-term restricted feeding alters circadian expression and reduces the level of inflammatory and disease markers', Journal of Cellular and Molecular Medicine, vol. 15, pp. 2745 - 2759, http://dx.doi.org/10.1111/j.1582-4934.2010.01160.x
    Journal articles | 2011
    Professor Johannes le Coutre
    Sherman H; Gutman R; Chapnik N; Meylan J; Le Coutre J; Froy O, 2011, 'Caffeine alters circadian rhythms and expression of disease and metabolic markers', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 829 - 838, http://dx.doi.org/10.1016/j.biocel.2011.02.008
    Journal articles | 2011
    Professor Johannes le Coutre
    Genick UK; Kutalik Z; Ledda M; Souza Destito MC; Souza MM; Cirillo CA; Godinot N; Martin N; Morya E; Sameshima K; Bergmann S; le Coutre J, 2011, 'Sensitivity of genome-wide-association signals to phenotyping strategy: The PROP-TAS2R38 taste association as a benchmark', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0027745
    Journal articles | 2011
    Professor Johannes le Coutre
    le Coutre J; Blum S; Damak S; Nutten S; Benyacoub J; Dean J; Mercenier A; van Bladeren P, 2011, 'Nutrition and the immune system', Nature, vol. 479, https://www.nature.com/nature/outlook/allergies/pdf/nestle.pdf
    Journal articles | 2010
    Professor Johannes le Coutre
    Cartoni C; Yasumatsu K; Ohkuri T; Shigemura N; Yoshida R; Godinot N; Le Coutre J; Ninomiya Y; Damak S, 2010, 'Taste preference for fatty acids is mediated by GPR40 and GPR120', Journal of Neuroscience, vol. 30, pp. 8376 - 8382, http://dx.doi.org/10.1523/JNEUROSCI.0496-10.2010
    Journal articles | 2010
    Professor Johannes le Coutre
    Ohla K; Toepel U; Le Coutre J; Hudry J, 2010, 'Electrical neuroimaging reveals intensity-dependent activation of human cortical gustatory and somatosensory areas by electric taste', Biological Psychology, vol. 85, pp. 446 - 455, http://dx.doi.org/10.1016/j.biopsycho.2010.09.007
    Journal articles | 2010
    Professor Johannes le Coutre
    Montoliu I; Martin FP; Guy PA; Tavazzi I; Bruce S; Collino S; Galindo-Cuspinera V; Genick U; Martin N; Le Coutre J; Kochhar S; Rezzi S, 2010, 'Validation on high variance metabolic profiles: Taste stratification in a free living population', Chemometrics and Intelligent Laboratory Systems, vol. 104, pp. 8 - 19, http://dx.doi.org/10.1016/j.chemolab.2010.02.002
    Journal articles | 2010
    Professor Johannes le Coutre
    Frenk J; le Coutre J; van Bladeren P; Blum S, 2010, 'Health, nutrition, and public policy', FOOD AND NUTRITION BULLETIN, vol. 31, pp. 524 - 529, http://dx.doi.org/10.1177/156482651003100406
    Journal articles | 2010
    Professor Johannes le Coutre
    Kussmann M; Dean J; Middleton RP; Van Bladeren PJ; le Coutre J, 2010, 'Harnessing the power of epigenetics for targeted nutrition', Nature, vol. 468, https://www.nature.com/nature/outlook/nutrigenomics/pdf/nutrition.pdf
    Journal articles | 2009
    Professor Johannes le Coutre
    Menozzi C; Riera CE; Munari C; Coutre JL; Robert F, 2009, 'Synthesis and evaluation of new alkylamides derived from α-hydroxysanshool, the pungent molecule in szechuan pepper', Journal of Agricultural and Food Chemistry, vol. 57, pp. 1982 - 1989, http://dx.doi.org/10.1021/jf803067r
    Journal articles | 2009
    Professor Johannes le Coutre
    Riera CE; Menozzi-Smarrito C; Affolter M; Michlig S; Munari C; Robert F; Vogel H; Simon SA; Le Coutre J, 2009, 'Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels', British Journal of Pharmacology, vol. 157, pp. 1398 - 1409, http://dx.doi.org/10.1111/j.1476-5381.2009.00307.x
    Journal articles | 2009
    Professor Johannes le Coutre
    Ohla K; Hudry J; Le Coutre J, 2009, 'The cortical chronometry of electrogustatory event-related potentials', Brain Topography, vol. 22, pp. 73 - 82, http://dx.doi.org/10.1007/s10548-009-0076-7
    Journal articles | 2009
    Professor Johannes le Coutre
    Riera CE; Vogel H; Simon SA; Damak S; Coutre JL, 2009, 'Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels', Journal of Neuroscience, vol. 29, pp. 2654 - 2662, http://dx.doi.org/10.1523/JNEUROSCI.4694-08.2009
    Journal articles | 2009
    Professor Johannes le Coutre
    Toepel U; Knebel JF; Hudry J; le Coutre J; Murray MM, 2009, 'The brain tracks the energetic value in food images', NeuroImage, vol. 44, pp. 967 - 974, http://dx.doi.org/10.1016/j.neuroimage.2008.10.005
    Journal articles | 2008
    Professor Johannes le Coutre
    Bezençon C; Fürholz A; Raymond F; Mansourian R; Métairon S; Le Coutre J; Damak S, 2008, 'Murine intestinal cells expressing Trpm5 are mostly brush cells and express markers of neuronal and inflammatory cells', Journal of Comparative Neurology, vol. 509, pp. 514 - 525, http://dx.doi.org/10.1002/cne.21768
    Journal articles | 2008
    Professor Johannes le Coutre
    Knebel JF; Toepel U; Hudry J; Le Coutre J; Murray MM, 2008, 'Generating controlled image sets in cognitive neuroscience research', Brain Topography, vol. 20, pp. 284 - 289, http://dx.doi.org/10.1007/s10548-008-0046-5
    Journal articles | 2008
    Professor Johannes le Coutre
    Coutre JL; Schmitt JAJ, 2008, 'Food ingredients and cognitive performance', Current Opinion in Clinical Nutrition and Metabolic Care, vol. 11, pp. 706 - 710, http://dx.doi.org/10.1097/MCO.0b013e32831394a5
    Journal articles | 2008
    Professor Johannes le Coutre
    Riera CE; Vogel H; Simon SA; Damak S; le Coutre J, 2008, 'The capsaicin receptor participates in artificial sweetener aversion', Biochemical and Biophysical Research Communications, vol. 376, pp. 653 - 657, http://dx.doi.org/10.1016/j.bbrc.2008.09.029
    Journal articles | 2008
    Professor Johannes le Coutre
    Blum S; German B; van Bladeren P; le Coutre J, 2008, 'Translating research into action: nutritional strategies for the cancer patient', Nature, vol. 452, https://www.nature.com/nature/supplements/insights/cancerdiagnostics/pdf/nestle-white-paper-Mar-08.pdf?origin=ppub
    Journal articles | 2008
    Professor Johannes le Coutre
    Damak S; Le Coutre J, 2008, 'Molecular taste physiology of tongue and gut', Agro Food Industry Hi-Tech, vol. 19, pp. 58 - 60
    Journal articles | 2007
    Professor Johannes le Coutre
    Bezençon C; le Coutre J; Damak S, 2007, 'Taste-signaling proteins are coexpressed in solitary intestinal epithelial cells', Chemical Senses, vol. 32, pp. 41 - 49, http://dx.doi.org/10.1093/chemse/bjl034
    Journal articles | 2007
    Professor Johannes le Coutre
    Riera CE; Vogel H; Simon SA; Le Coutre J, 2007, 'Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 293, http://dx.doi.org/10.1152/ajpregu.00286.2007
    Journal articles | 2007
    Professor Johannes le Coutre
    Michlig S; Damak S; Le Coutre J, 2007, 'Claudin-based permeability barriers in taste buds', Journal of Comparative Neurology, vol. 502, pp. 1003 - 1011, http://dx.doi.org/10.1002/cne.21354
    Journal articles | 2004
    Professor Johannes le Coutre
    Parry CM; Erkner A; Le Coutre J, 2004, 'Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees', Proceedings of the National Academy of Sciences of the United States of America, vol. 101, pp. 14830 - 14834, http://dx.doi.org/10.1073/pnas.0404894101
    Journal articles | 2004
    Professor Johannes le Coutre
    Rossier O; Cao J; Huque T; Spielman AI; Feldman RS; Medrano JF; Brand JG; le Coutre J, 2004, 'Analysis of a human fungiform papillae cDNA library and identification of taste-related genes', Chemical Senses, vol. 29, pp. 13 - 23, http://dx.doi.org/10.1093/chemse/bjh002
    Journal articles | 2003
    Professor Johannes le Coutre
    Journal articles | 2003
    Professor Johannes le Coutre
    Le Coutre J, 2003, 'Taste: The metabolic sense', Food Technology, vol. 57, pp. 34 - 39
    Journal articles | 2002
    Professor Johannes le Coutre
    Le Coutre J; Turk E; Kaback HR; Wright EM, 2002, 'Ligand-induced differences in secondary structure of the Vibrio parahaemolyticus Na+/galactose cotransporter', Biochemistry, vol. 41, pp. 8082 - 8086, http://dx.doi.org/10.1021/bi025692d
    Journal articles | 2000
    Professor Johannes le Coutre
    Coutre JL; Ronald Kaback H, 2000, 'Structure-function relationships of integral membrane proteins: Membrane transporters vs channels', Biopolymers - Peptide Science Section, vol. 55, pp. 297 - 307, http://dx.doi.org/10.1002/1097-0282(2000)55:4<297::AID-BIP1003>3.0.CO;2-H
    Journal articles | 2000
    Professor Johannes le Coutre
    Le Coutre J; Whitelegge JP; Gross A; Turk E; Wright EM; Kaback HR; Faull KF, 2000, 'Proteomics on full-length membrane proteins using mass spectrometry', Biochemistry, vol. 39, pp. 4237 - 4242, http://dx.doi.org/10.1021/bi000150m
    Journal articles | 2000
    Professor Johannes le Coutre
    Turk E; Kim O; Le Coutre J; Whitelegge JP; Eskandari S; Lam JT; Kreman M; Zampighi G; Faull KF; Wright EM, 2000, 'Molecular characterization of Vibrio parahaemolyticus vSGLT. A model for sodium-coupled sugar cotransporters', Journal of Biological Chemistry, vol. 275, pp. 25711 - 25716, http://dx.doi.org/10.1074/jbc.M003127200
    Journal articles | 1999
    Professor Johannes le Coutre
    Sahin-Tóth M; Le Coutre J; Kharabi D; Le Maire G; Lee JC; Kaback HR, 1999, 'Characterization of Glu126 and Arg144, two residues that are indispensable for substrate binding in the lactose permease of Escherichia coli', Biochemistry, vol. 38, pp. 813 - 819, http://dx.doi.org/10.1021/bi982200h
    Journal articles | 1999
    Professor Johannes le Coutre
    Whitelegge JP; Le Coutre J; Lee JC; Engel CK; Privé GG; Faull KF; Kaback HR, 1999, 'Toward the bilayer proteome, electrospray ionization-mass spectrometry of large, intact transmembrane proteins', Proceedings of the National Academy of Sciences of the United States of America, vol. 96, pp. 10695 - 10698, http://dx.doi.org/10.1073/pnas.96.19.10695
    Journal articles | 1998
    Professor Johannes le Coutre
    Le Coutre J; Kaback HR; Patel CKN; Heginbotham L; Miller C, 1998, 'Fourier transform infrared spectroscopy reveals a rigid α-helical assembly for the tetrameric Streptomyces lividans K+ channel', Proceedings of the National Academy of Sciences of the United States of America, vol. 95, pp. 6114 - 6117, http://dx.doi.org/10.1073/pnas.95.11.6114
    Journal articles | 1997
    Professor Johannes le Coutre
    Le Coutre J; Narasimhan LR; Patel CKN; Kaback HR, 1997, 'The lipid bilayer determines helical tilt angle and function in lactose permease of Escherichia coli', Proceedings of the National Academy of Sciences of the United States of America, vol. 94, pp. 10167 - 10171, http://dx.doi.org/10.1073/pnas.94.19.10167
    Journal articles | 1997
    Professor Johannes le Coutre
    le Coutre J; Narasimhan LR; Patel CKN; Kaback HR, 1997, 'ATR-FTIR spectroscopy on the Lactose Permease of E. coli', Biophysical Journal, vol. 72, pp. TH343 - TH343
    Journal articles | 1996
    Professor Johannes le Coutre
    Le Coutre J; Gerwert K, 1996, 'Kinetic isotope effects reveal an ice-like and a liquid-phase-type intramolecular proton transfer in bacteriorhodopsin', FEBS Letters, vol. 398, pp. 333 - 336, http://dx.doi.org/10.1016/S0014-5793(96)01254-9
    Journal articles | 1996
    Professor Johannes le Coutre
    le Coutre J, 1996, 'The molecular reaction mechanism of a membrane protein', Futura
    Journal articles | 1995
    Professor Johannes le Coutre
    le Coutre J; Rüdiger M; Oesterhelt D; Gerwert K, 1995, 'FTIR investigation of the blue to acid-purple transition of Bacteriorhodopsin by use of induced halide binding', Journal of Molecular Structure, vol. 349, pp. 165 - 168, http://dx.doi.org/10.1016/0022-2860(95)08735-E
    Journal articles | 1995
    Professor Johannes le Coutre
    Le Coutre J; Tittor J; Oesterhelt D; Gerwert K, 1995, 'Experimental evidence for hydrogen-bonded network proton transfer in bacteriorhodopsin shown by Fourier-transform infrared spectroscopy using azide as catalyst', Proceedings of the National Academy of Sciences of the United States of America, vol. 92, pp. 4962 - 4966, http://dx.doi.org/10.1073/pnas.92.11.4962
    Journal articles | 1994
    Professor Johannes le Coutre
    Schütz M; Zirngibl S; le Coutre J; Büttner M; Xie DL; Nelson N; Deutzmann R; Hauska G, 1994, 'A transcription unit for the Rieske FeS-protein and cytochrome b in Chlorobium limicola', Photosynthesis Research, vol. 39, pp. 163 - 174, http://dx.doi.org/10.1007/BF00029383
    Journal articles | 1992
    Professor Johannes le Coutre
    Zirngibl S; Xie D; Riedel A; Nitschke W; Nelson H; Nelson N; Liebl U; le Coutre J; Hauska G; Kellner E; Groditzki D; Buettner M, 1992, 'Low Potential Rieske FeS-Centers of Menaquinol oxidizing Cytochrome bc-complexes', Research in Photosynthesis, vol. 2, pp. 471 - 478
  • Patents | 2019
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Camacho S; le Coutre J, 2019, Compositions and methods using P-anisaldehyde, Patent No. US-9931308-B2
    Patents | 2017
    Professor Johannes le Coutre
    Actis G; Patin A; Gonzalez S; Camacho S; Legrand C; le Coutre J; Castaneda E; Zolezzi I, 2017, Compositions comprising 3'-oglucuronide epicatechin and methods of making and using such compositions, Patent No. WO2017102965-A1
    Patents | 2016
    Professor Johannes le Coutre
    Actis G; Amaury P; Gonzalez S; LeGrand C; le Coutre J; Camacho S, 2016, Compositions comprising 3'-omethyl-5-o-sulfate epicatechin and therapeutic uses of such compositions, Patent No. WO2017129422-A1
    Patents | 2016
    Professor Johannes le Coutre
    Actis G; Amaury P; Gonzalez S; Legrand C; Camacho S; le Coutre J, 2016, Compositions comprising 3'-omethyl-4'-o-sulfate epicatechin and therapeutic uses of such compositions, Patent No. WO2017129421-A1
    Patents | 2015
    Professor Johannes le Coutre
    le Coutre J; Actis G; Patin A; Gonzalez S; Gutierrez E; Zolezzi I, 2015, Compositions comprising 4'-oglucuronide epicatechin and methods of making and using such compositions, Patent No. WO2017102968-A1
    Patents | 2015
    Professor Johannes le Coutre
    Camacho S; Gonzalez S; Actis G; Merlini J; le Coutre J, 2015, Compositions comprising cinnamaldehyde and zinc and methods of using such compositions, Patent No. CA-2985564-A1
    Patents | 2014
    Professor Johannes le Coutre
    Gonzalez S; Beaumont M; le Coutre J, 2014, Methods using facial temperature to evaluate postingestive impact of food ingredients on fat oxidation, Patent No. US-2017367588A1
    Patents | 2014
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Camacho S; le Coutre J, 2014, Compositions comprising cinnamaldehyde and zinc and methods of using such compositions, Patent No. US-2017164648A1
    Patents | 2014
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Burbidge A; le Coutre J, 2014, Composition comprising cinnamaldehyde and zinc to improve swallowing, Patent No. US-2017224729A1
    Patents | 2014
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Burbridge A; le Coutre J, 2014, Methods and compositions for using cinnamaldehyde and zinc for weight management, Patent No. US-2016339058A1
    Patents | 2013
    Professor Johannes le Coutre
    Gonzalez S; le Coutre J, 2013, Methods and compositions for increasing energy expenditure using cinnamaldehyde, Patent No. US-2016303055A1
    Patents | 2013
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Camacho S; le Coutre J, 2013, Compositions and methods using p-anisaldehyde, Patent No. US-2016175264A1
    Patents | 2013
    Professor Johannes le Coutre
    Gonzalez S; Merlini J; Camacho S; le Coutre J, 2013, Compositions and methods using cuminaldehyde, Patent No. US-9867790-B2
    Patents | 2013
    Professor Johannes le Coutre
    Gonsalez S; Merlini J; Camacho S; le Coutre J, 2013, Compositions and methods using tiglic aldehyde, Patent No. US-9801833-B2
    Patents | 2013
    Professor Johannes le Coutre
    Camacho S; Gonzales S; le Coutre J; Markram H; Pezzoli M, 2013, Treatment or prevention of non-inflammatory neuronal damage from brain trauma and strokes using menthol, linalool and/or icilin, Patent No. US-2017189403A1
    Patents | 2013
    Professor Johannes le Coutre
    Camacho S; Gonzalez S; le Coutre J; Markram H; Pezzoli M, 2013, Treatment or prevention of autism disorders using menthol, linalool and/or icilin, Patent No. US-2016089370A1
    Patents | 2013
    Professor Johannes le Coutre
    Camacho S; Gonzalez S; le Coutre J; Markram H; Pezzoli M, 2013, Treatment or prevention of depression using menthol and/or icilin, Patent No. US-2016108005A1
    Patents | 2013
    Professor Johannes le Coutre
    Camacho S; Gonzalez S; le Coutre J; Markram H; Pezzoli M, 2013, Treatment or prevention of neurodegenerative disorders using menthol, linalool and/or icilin, Patent No. US-2016108004A1
    Patents | 2012
    Professor Johannes le Coutre
    Genick U; Ledda M; Montoliu R; le Coutre J; Rezzi S; Collino S; Martin F-P; Da S, 2012, Fucose as a biomarker for gut immunity, Patent No. EP-2687845-A1
    Patents | 2011
    Professor Johannes le Coutre
    Damak S; Cellour-Rose P; le Coutre J, 2011, Trpm5 inhibitors support body weight reduction without reducing food intake, Patent No. US-2014024674A1
    Patents | 2010
    Professor Johannes le Coutre
    le Coutre J; van Bladeren P; Damak S; Stellingwerff T, 2010, Artificial sweeteners and performance, Patent No. WO2011113799-A1
    Patents | 2009
    Professor Johannes le Coutre
    Damak S; Godinot N; le Coutre J; Martin N; Barcos ME, 2009, Low caloric fat replacers, Patent No. WO2011069958-A2
    Patents | 2008
    Professor Johannes le Coutre
    Hudry J; le Coutre J; Erin A, 2008, Isoamyl acetate for weight management, Patent No. US-8647687-B2
    Patents | 2008
    Professor Johannes le Coutre
    Riera C; Menozzi C; Robert F; le Coutre J, 2008, Acylamino acid compounds and food preparations containing same, Patent No. EP-2140770-A1
    Patents | 2008
    Professor Johannes le Coutre
    Riera C; Menozzi C; Robert F; le Coutre J, 2008, Acylamino acid compounds and food preparations containing same, Patent No. EP-2123176-A1
    Patents | 2008
    Professor Johannes le Coutre
    Riera C; Menozzi C; Robert F; le Coutre J, 2008, Acylamino acid compounds and food preparations containing same, Patent No. WO2009141294-A1
    Patents | 2007
    Professor Johannes le Coutre
    Labbe DP; Riera C; Schlup-Ollivier G; le Coutre J, 2007, Tingling trigeminal composition, Patent No. WO2009063009-A1
    Patents | 2006
    Professor Johannes le Coutre
    le Coutre J; Parry CM, 2006, Salt taste receptor and its use in an assay for salt taste, Patent No. WO2006082110A3
    Patents | 2005
    Professor Johannes le Coutre
    Damak S; le Coutre J; Bezencon C; Cartoni C, 2005, Fat taste receptors and their methods of use, Patent No. WO2007014824-A1

Awards

 
  • 2016    PURINA Patent Incentive Award
  • 2013    Nestlé R&D award for Innovation Partnership
  • 2010    Nestlé R&D award for Innovation Partnership
  • 1997    Human Frontier Science Program (HFSP) Long-Term-Fellowship
  • 1996    Stipend, Deutsche Forschungsgemeinschaft (DFG)
  • 1992    Fellow, Boehringer Ingelheim Fonds
  • 1991    Fellowship, Max-Planck-Society 

Grants

Media