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Dr Kristina Warton

Dr Kristina Warton

Senior Research Fellow
Medicine & Health
School of Clinical Medicine

Dr Kristina Warton completed her PhD at the University of New South Wales, before working for a number of years in biotech and then returning to academia. She is currently leading a project within the Gynaecological Cancer Research Group to develop a blood test for the early diagnosis of ovarian cancer. 
  • Book Chapters | 2022
    Mahon K; Samimi G; Warton K, 2022, 'Considerations in Biobanking Blood Samples and Plasma Volume for Circulating DNA Studies', in Cell-Free Circulating DNA, WORLD SCIENTIFIC, pp. 47 - 62, http://dx.doi.org/10.1142/9789811244681_0003
    Book Chapters | 2022
    Warton K; Stirzaker C; Samimi G; Clark S, 2022, 'DNA Methylation Analysis of Circulating DNA Biomarkers', in Cell-Free Circulating DNA: Purification and Analysis Techniques, WORLD SCIENTIFIC, pp. 247 - 277, http://dx.doi.org/10.1142/9789811244681_0009
  • Journal articles | 2023
    Werner B; Sjoquist KM; Espinoza D; Yip S; Chang G; Cummins MM; Mileshkin LR; Ananda S; Shannon CM; Friedlander M; Warton K; Ford C, 2023, 'Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response: A translational sub-study of the REZOLVE (ANZGOG-1101) clinical trial.', Journal of Clinical Oncology, 41, pp. 5561 - 5561, http://dx.doi.org/10.1200/jco.2023.41.16_suppl.5561
    Journal articles | 2022
    Alonso A; Yuwono NL; Houshdaran S; Abbott J; Rodgers R; Ford CE; Warton K, 2022, 'Comparison of total and endometrial circulating cell-free DNA in women with and without endometriosis', Reproductive BioMedicine Online, 44, pp. 495 - 503, http://dx.doi.org/10.1016/j.rbmo.2021.11.006
    Journal articles | 2022
    Fisher T; Ford CE; Warton K, 2022, 'Recovery Efficiency of Cell-Free DNA After Bisulfite Conversion', Clinical chemistry, 68, pp. 1219 - 1220, http://dx.doi.org/10.1093/clinchem/hvac107
    Journal articles | 2022
    Hossain KR; Escobar Bermeo JD; Warton K; Valenzuela SM, 2022, 'New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer.', Front Bioeng Biotechnol, 10, pp. 819183, http://dx.doi.org/10.3389/fbioe.2022.819183
    Journal articles | 2022
    Werner B; Warton K; Ford CE, 2022, 'Endogenous cell-free DNA in fetal bovine serum introduces artifacts to in vitro cell-free DNA models', BioTechniques, 73, pp. 219 - 226, http://dx.doi.org/10.2144/btn-2022-0040
    Journal articles | 2022
    Werner B; Warton K; Ford CE, 2022, 'Transcending Blood—Opportunities for Alternate Liquid Biopsies in Oncology', Cancers, 14, pp. 1309 - 1309, http://dx.doi.org/10.3390/cancers14051309
    Journal articles | 2022
    Yuwono NL; Alonso A; Abbott J; Houshdaran S; Henry CE; Rodgers R; Ford CE; Warton K, 2022, 'Circulating cell-free endometrial DNA level is unaltered during menstruation and in endometriosis', Human Reproduction, 37, pp. 2560 - 2569, http://dx.doi.org/10.1093/humrep/deac198
    Journal articles | 2022
    Yuwono NL; Boyd MAA; Henry CE; Werner B; Ford CE; Warton K, 2022, 'Circulating cell-free DNA undergoes significant decline in yield after prolonged storage time in both plasma and purified form', Clinical Chemistry and Laboratory Medicine, 60, pp. 1287 - 1298, http://dx.doi.org/10.1515/cclm-2021-1152
    Journal articles | 2021
    Hagstrom AD; Yuwono N; Warton K; Ford CE, 2021, 'Sex Bias in Cohorts Included in Sports Medicine Research', Sports Medicine, 51, pp. 1799 - 1804, http://dx.doi.org/10.1007/s40279-020-01405-6
    Journal articles | 2021
    Werner B; Yuwono N; Duggan J; Liu D; David C; Srirangan S; Provan P; DeFazio A; Arora V; Farrell R; Lee YC; Warton K; Ford C, 2021, 'Cell-free DNA is abundant in ascites and represents a liquid biopsy of ovarian cancer', Gynecologic Oncology, 162, pp. 720 - 727, http://dx.doi.org/10.1016/j.ygyno.2021.06.028
    Journal articles | 2021
    Yuwono NL; Henry CE; Ford CE; Warton K, 2021, 'Total and endothelial cell-derived cell-free DNA in blood plasma does not change during menstruation', PLoS ONE, 16, http://dx.doi.org/10.1371/journal.pone.0250561
    Journal articles | 2021
    Yuwono NL; Warton K; Ford CE, 2021, 'The influence of biological and lifestyle factors on circulating cell-free dna in blood plasma', eLife, 10, http://dx.doi.org/10.7554/eLife.69679
    Journal articles | 2020
    Ford CE; Werner B; Hacker NF; Warton K, 2020, 'The untapped potential of ascites in ovarian cancer research and treatment', British Journal of Cancer, 123, pp. 9 - 16, http://dx.doi.org/10.1038/s41416-020-0875-x
    Journal articles | 2020
    Warton K; Xu Y; Ford CE, 2020, 'Target sequence heterogeneity causes the 'hook effect' in fluorescent dye-based quantitative PCR', BioTechniques, 69, pp. 81 - 84, http://dx.doi.org/10.2144/BTN-2020-0016
    Journal articles | 2019
    Werner B; Yuwono NL; Henry C; Gunther K; Rapkins RW; Ford CE; Warton K, 2019, 'Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight', PLoS ONE, 14, pp. e0224338, http://dx.doi.org/10.1371/journal.pone.0224338
    Journal articles | 2018
    Warton K; Graham LJ; Yuwono N; Samimi G, 2018, 'Comparison of 4 commercial kits for the extraction of circulating DNA from plasma', Cancer Genetics, 228-229, pp. 143 - 150, http://dx.doi.org/10.1016/j.cancergen.2018.02.004
    Journal articles | 2017
    Warton K; Yuwono NL; Cowley MJ; McCabe MJ; So A; Ford CE, 2017, 'Evaluation of Streck BCT and PAXgene Stabilised Blood Collection Tubes for Cell-Free Circulating DNA Studies in Plasma', Molecular Diagnosis and Therapy, 21, pp. 563 - 570, http://dx.doi.org/10.1007/s40291-017-0284-x
    Journal articles | 2016
    Warton K; Mahon KL; Samimi G, 2016, 'Methylated circulating tumor DNA in blood: Power in cancer prognosis and response', Endocrine-Related Cancer, 23, pp. R157 - R171, http://dx.doi.org/10.1530/ERC-15-0369
    Journal articles | 2015
    Warton K; Samimi G, 2015, 'Methylation of cell-free circulating DNA in the diagnosis of cancer', Frontiers in Molecular Biosciences, 2, http://dx.doi.org/10.3389/fmolb.2015.00013
    Journal articles | 2014
    Warton K; Lin V; Navin T; Armstrong NJ; Kaplan W; Ying K; Gloss B; Mangs H; Nair SS; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2014, 'Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma', BMC Genomics, 15, http://dx.doi.org/10.1186/1471-2164-15-476
    Journal articles | 2013
    Warton K; Vita L; Armstrong NJ; Kaplan W; Ying K; Mangs H; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2013, 'Whole genome sequencing of free circulating DNA from plasma of HGSOC patients', CLINICAL CANCER RESEARCH, 19, http://dx.doi.org/10.1158/1078-0432.OVCA13-A4
    Journal articles | 2012
    Montavon C; Gloss B; Warton K; Barton CA; Statham AL; Scurry J; Tabor B; Nguyen TV; Qu WJ; Samimi G; Hacker NF; Sutherland RL; Clark SJ; O'Brien P, 2012, 'Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer', Gynecologic Oncology, 124, pp. 582 - 588, http://dx.doi.org/10.1016/j.ygyno.2011.11.026
    Journal articles | 2010
    Thompson EW; Warton K; Blick T; Wafai R; Hill P; Stanley K, 2010, 'Multiplexed tandem polymerase chain reaction identifies strong expression of oestrogen receptor and Her-2 from single, formalin-fixed, paraffin-embedded breast cancer sections', Pathology, 42, pp. 165 - 172, http://dx.doi.org/10.3109/00313020903494102
    Journal articles | 2007
    van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138, http://dx.doi.org/10.1016/j.jim.2007.07.016
    Journal articles | 2006
    Gurisik E; Warton K; Martin DK; Valenzuela SM, 2006, 'An in vitro study of the effects of exposure to a GSM signal in two human cell lines: Monocytic U937 and neuroblastoma SK-N-SH', Cell Biology International, 30, pp. 793 - 799, http://dx.doi.org/10.1016/j.cellbi.2006.06.001
    Journal articles | 2004
    Warton K; Foster NC; Gold WA; Stanley K, 2004, 'A novel gene family induced by acute inflammation in endothelial cells', Gene, 342, pp. 85 - 95, http://dx.doi.org/10.1016/j.gene.2004.07.027
    Journal articles | 2002
    Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PM; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese Hamster Ovary cells expressing CLIC1', The Journal of Biological Chemistry, 277, pp. 26003 - 26011, http://dx.doi.org/10.1074/jbc.M203666200
    Journal articles | 2001
    Harrop SJ; Demaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A resolution', The Journal of Biological Chemistry, 276, pp. 44993 - 45000, http://dx.doi.org/10.1074/jbc.M107804200
    Journal articles | 2000
    Tonini R; Ferroni A; Valenzuela SM; Warton K; Campbell TJ; Breit SN; Mazzanti M, 2000, 'Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells', Federation of American Societies for Experimantal Biology Journal, 14, pp. 1171 - 1178
    Journal articles | 2000
    Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Warton K; Musgrove EA; Campbell TJ; Breit SN, 2000, 'The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle', Journal of Physiology, 529, pp. 541 - 552, http://dx.doi.org/10.1111/j.1469-7793.2000.00541.x
    Journal articles | 2000
    Warton K; Valenzuela S; Tonini R; Mazzanti M; Breit S, 2000, 'Intracellular Ion Channel NCC27 Moves between a Soluble and a Transmembrane State', Biochemical Society Transactions, 28, pp. A471 - A471, http://dx.doi.org/10.1042/bst028a471c
    Journal articles | 1998
    Ludowyke RI; Warton K; Scurr LL, 1998, 'Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors', Cell Biology International, 22, pp. 855 - 865, http://dx.doi.org/10.1006/cbir.1998.0332
    Journal articles | 1997
    Valenzuela SM; Martin DJ; Warton K; Por SB; Robbins JM; Bootcov MR; Schofield PR; Campbell TJ; Breit SN, 1997, 'Molecular cloning and expression of a chloride ion channel of cell nuclei.', The Journal of Biological Chemistry, 272, pp. 12575 - 12582, http://dx.doi.org/10.1074/jbc.272.19.12575
  • Conference Papers | 2020
    Warton K; Yuwono N; Henry C; Hacker N; Ford C, 2020, 'Abstract B28: Optimizing DNA processing and ovarian cancer methylation-specific PCR assays for the detection of early-stage ovarian cancer', in Clinical Cancer Research, American Association for Cancer Research (AACR), pp. B28 - B28, presented at Abstracts: AACR Special Conference on Advances in Ovarian Cancer Research; September 13-16, 2019; Atlanta, GA, http://dx.doi.org/10.1158/1557-3265.ovca19-b28
    Conference Abstracts | 2020
    Yuwono NL; Warton K; Henry C; Ford C, 2020, 'Deciphering the origin of circulating cell-free DNA and its alterations during menstruation', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 80, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-731
    Conference Papers | 2002
    Mazzanti M; Warton K; Tonini R; Lorenzi G; Fairlie D; Matthews JM; Valenzuela S; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Campbell TJ; Curmi PMG; Breit SN, 2002, 'NCC27 (CLIC1) interacts with artifical bylayer in a pH dependent manner to form chloride ion channels', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 244A - 244A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000173252701198&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Circulating DNA is DNA that is found in blood plasma and is not associated with any cell population. In patients with cancer, a proportion of this DNA is derived from tumour cells that have died and released their DNA into the bloodstream, so it contains the same mutations and methylation changes as the tumour. We are investigating targeting circulating DNA as a diagnostic test for early ovarian cancer.

• Circulating DNA in early diagnosis of ovarian cancer

• Biobanking

• Mechanisms of circulating DNA generation