Dr Lan Gong
Adjunct Fellow Levels A-C

Dr Lan Gong

PhD in Microbiology and Immunology, UNSW

Medicine & Health
School of Clinical Medicine

Dr. Gong is a Senior Research Fellow at the Microbiome Research Centre, St George Hospital and St George & Sutherland Clinical School, UNSW, investigating the role of gut microbiome in gastrointestinal diseases, especially the immuno-pathogenesis of obesity-related liver diseases such as non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, and liver cancer. The extensive projects utilise multi-omics techniques including metagenomics, proteomics and metabolomics to analyse samples from clinical cohorts and animal models.

Before joining Microbiome Research Centre, Dr. Gong completed his PhD in Microbiology and Immunology at UNSW, and worked as a Research Fellow at ARC Centre of Excellence in Structural and Functional Microbial Genomics, Department of Biochemistry and Molecular Biology, Monash University, where he investigated the role of autophagy in stem cell differentiation and host-pathogen interaction, especially host autophagic and innate immune responses against infection of human pathogens such as Helicobacter pylori, Burkholderia pseudomallei, Mycobacterium tuberculosis and malaria parasite.

Google Scholar: h-index 19, citations 1157

Location
Microbiome Research Centre Department of Medicine St George & Sutherland Clinical School
  • Books | 2022
    Shi D; Turroni S; Gong L; Wu W; Yim HCH, 2022, Manipulation of Gut Microbiota as a Key Target to Intervene on the Onset and Progression of Digestive System Diseases, Frontiers Media SA
  • Book Chapters | 2019
    Chen F; Freyer C; Gong L; Zekry A, 2019, 'Chapter 4 Hepatitis B Virus, Hepatitis C Virus, the Microbiome, and Hepatocellular Carcinoma', in Gastrointestinal Diseases and their Associated Infections, Elsevier, pp. 41 - 54, http://dx.doi.org/10.1016/b978-0-323-54843-4.00004-0
    Book Chapters | 2019
    Chen F; Fryer C; Gong L; Zekry A, 2019, 'Hepatitis B virus, hepatitis C virus, the microbiome and hepatocellular carcinoma', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, pp. 41 - 54
    Book Chapters | 2019
    El-Assaad F; Gong L; Gia A; Yim H; El-Omar E, 2019, 'Helicobacter pylori, peptic ulcer disease and gastric cancer', in Eslick G (ed.), Gastrointestinal Diseases and Their Associated Infections, Elsevier, St Louis, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2019
    El-Assaad F; Gong L; Gia A; Yim HCH; El-Omar EM, 2019, 'Chapter 2 Helicobacter pylori, Peptic Ulcer Disease and Gastric Cancer', in Gastrointestinal Diseases and their Associated Infections, Elsevier, pp. 17 - 29, http://dx.doi.org/10.1016/b978-0-323-54843-4.00002-7
    Book Chapters | 2019
    Gong L; Zekry A, 2019, 'Transplantation Immunology', in Reference Module in Biomedical Research, Elsevier, http://dx.doi.org/10.1016/B978-0-12-801238-3.65668-4
  • Journal articles | 2022
    Chen J; Zeng P; Gong L; Zhang X; Ling Z; Bi K; Shi F; Wang K; Zhang Q; Jiang J; Zhang Y; Uede T; El-Omar EM; Diao H, 2022, 'Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner', MBIO, http://dx.doi.org/10.1128/mbio.02531-22
    Journal articles | 2022
    Dong Y; Wu X; Han L; Bian J; He C; El-Omar E; Gong L; Wang M, 2022, 'The Potential Roles of Dietary Anthocyanins in Inhibiting Vascular Endothelial Cell Senescence and Preventing Cardiovascular Diseases', Nutrients, vol. 14, http://dx.doi.org/10.3390/nu14142836
    Journal articles | 2022
    Jiang J; Li Y; Sun Z; Gong L; Li X; Shi F; Yao J; Meng Y; Meng X; Zhang Q; Wang Y; Su X; Diao H, 2022, 'LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination', iScience, vol. 25, pp. 104607, http://dx.doi.org/10.1016/j.isci.2022.104607
    Journal articles | 2022
    Li K; Xiao Y; Bian J; Han L; He C; El-Omar E; Gong L; Wang M, 2022, 'Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases', Nutrients, vol. 14, http://dx.doi.org/10.3390/nu14122549
    Journal articles | 2022
    Luo Z; Li M; Yang J; Li J; Zhang Y; Liu F; El-Omar E; Han L; Bian J; Gong L; Wang M, 2022, 'Ferulic acid attenuates high-fat diet-induced hypercholesterolemia by activating classic bile acid synthesis pathway', Frontiers in Nutrition, vol. 9, pp. 976638, http://dx.doi.org/10.3389/fnut.2022.976638
    Journal articles | 2022
    Luo Z; Li M; Yang Q; Zhang Y; Liu F; Gong L; Han L; Wang M, 2022, 'Ferulic Acid Prevents Nonalcoholic Fatty Liver Disease by Promoting Fatty Acid Oxidation and Energy Expenditure in C57BL/6 Mice Fed a High-Fat Diet', Nutrients, vol. 14, pp. 2530 - 2530, http://dx.doi.org/10.3390/nu14122530
    Journal articles | 2022
    Shi D; Turroni S; Gong L; Wu W; Yim HCH, 2022, 'Editorial: Manipulation of gut microbiota as a key target to intervene on the onset and progression of digestive system diseases', Frontiers in Medicine, vol. 9, pp. 999005, http://dx.doi.org/10.3389/fmed.2022.999005
    Journal articles | 2022
    Xiao Y; Li K; Bian J; Liu H; Zhai X; El-Omar E; Han L; Gong L; Wang M, 2022, 'Urolithin A Attenuates Diabetes-Associated Cognitive Impairment by Ameliorating Intestinal Barrier Dysfunction via N-glycan Biosynthesis Pathway', Molecular Nutrition and Food Research, vol. 66, pp. e2100863, http://dx.doi.org/10.1002/mnfr.202100863
    Journal articles | 2022
    Zhang N; Wang Z; Lv J; Zhang S; Liu Y; Liu T; Li W; Gong L; Zhang X; El-Omar EM; Lu W, 2022, 'Characterization of Gut Microbiota and Exploration of Potential Predictive Model for Hepatocellular Carcinoma Microvascular Invasion', Frontiers in Medicine, vol. 9, pp. 836369, http://dx.doi.org/10.3389/fmed.2022.836369
    Journal articles | 2021
    Behary J; Amorim N; Jiang XT; Raposo A; Gong L; McGovern E; Ibrahim R; Chu F; Stephens C; Jebeili H; Fragomeli V; Koay YC; Jackson M; O’Sullivan J; Weltman M; McCaughan G; El-Omar E; Zekry A, 2021, 'Gut microbiota impact on the peripheral immune response in non-alcoholic fatty liver disease related hepatocellular carcinoma', Nature Communications, vol. 12, pp. 187, http://dx.doi.org/10.1038/s41467-020-20422-7
    Journal articles | 2021
    Behary J; Raposo AE; Amorim NML; Zheng H; Gong L; McGovern E; Chen J; Liu K; Beretov J; Theocharous C; Jackson MT; Seet-Lee J; McCaughan GW; El-Omar EM; Zekry A, 2021, 'Defining the temporal evolution of gut dysbiosis and inflammatory responses leading to hepatocellular carcinoma in Mdr2 −/− mouse model', BMC Microbiology, vol. 21, pp. 113, http://dx.doi.org/10.1186/s12866-021-02171-9
    Journal articles | 2021
    Chen W; Jiang J; Gong L; Shu Z; Xiang D; Zhang X; Bi K; Diao H, 2021, 'Hepatitis B virus P protein initiates glycolytic bypass in HBV-related hepatocellular carcinoma via a FOXO3/miRNA-30b-5p/MINPP1 axis', Journal of Experimental and Clinical Cancer Research, vol. 40, http://dx.doi.org/10.1186/s13046-020-01803-8
    Journal articles | 2021
    Gong L; El-Omar EM, 2021, 'Application of molecular techniques in Helicobacter pylori detection: limitations and improvements', Helicobacter, vol. 26, pp. e12841, http://dx.doi.org/10.1111/hel.12841
    Journal articles | 2021
    Hathi Z; Mettu S; Priya A; Athukoralalage S; Lam TN; Choudhury NR; Dutta NK; El-Omar EM; Gong L; Mohan G; Lin CSK, 2021, 'Methodological advances and challenges in probiotic bacteria production: Ongoing strategies and future perspectives', Biochemical Engineering Journal, vol. 176, pp. 108199 - 108199, http://dx.doi.org/10.1016/j.bej.2021.108199
    Journal articles | 2020
    Alwis PA; Treerat P; Gong L; Deveson Lucas D; Allwood EM; Prescott M; Devenish RJ; Adler B; Boyce JD, 2020, 'Disruption of the Burkholderia pseudomallei two-component signal transduction system BbeR-BbeS leads to increased extracellular DNA secretion and altered biofilm formation', Veterinary Microbiology, vol. 242, pp. 108603 - 108603, http://dx.doi.org/10.1016/j.vetmic.2020.108603
    Journal articles | 2019
    Chen W; Jiang J; Wang PP; Gong L; Chen J; Du W; Bi K; Diao H, 2019, 'Identifying Hepatocellular Carcinoma Driver Genes by Integrative Pathway Crosstalk and Protein Interaction Network', DNA and Cell Biology, vol. 38, pp. 1112 - 1124, http://dx.doi.org/10.1089/dna.2019.4869
    Journal articles | 2019
    Chen W; Lin C; Gong L; Chen J; Liang Y; Zeng P; Diao H, 2019, 'Comprehensive analysis of the mRNA-lncRNA co-expression profile and ceRNA networks patterns in chronic hepatitis B', Current Genomics, vol. 20, pp. 231 - 245, http://dx.doi.org/10.2174/1389202920666190820122126
    Journal articles | 2019
    Chen W; Zhuang J; Gong L; Dai Y; Diao H, 2019, 'Investigating the dysfunctional pathogenesis of Wilms’ tumor through a multidimensional integration strategy', Annals of translational medicine, vol. 7, http://dx.doi.org/10.21037/atm.2019.03.37
    Journal articles | 2019
    Gemmell M; Berry S; Mukhopadhya I; Gong L; Hansen R; Hold G, 2019, 'Draft genome sequences of a Campylobacter curvus and three Campylobacter ureolyticus strains isolated from human colonic mucosal tissue', Microbiota in Health and Disease, vol. 1, pp. e148 - e148, http://dx.doi.org/10.26355/mhd_201911_148
    Journal articles | 2019
    Lin T; Zhang X; Lu Y; Gong L, 2019, 'Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis', DNA AND CELL BIOLOGY, vol. 38, pp. 887 - 894, http://dx.doi.org/10.1089/dna.2018.4590
    Journal articles | 2017
    Dimasuay KG; Gong L; Rosario F; McBryde E; Spelman T; Glazier J; Rogerson SJ; Beeson JG; Jansson T; Devenish RJ; Boeuf P, 2017, 'Impaired placental autophagy in placental malaria', PLoS ONE, vol. 12, http://dx.doi.org/10.1371/journal.pone.0187291
    Journal articles | 2015
    Deen NS; Gong L; Naderer T; Devenish RJ; Kwok T, 2015, 'Analysis of the Relative Contribution of Phagocytosis, LC3-Associated Phagocytosis, and Canonical Autophagy During Helicobacter pylori Infection of Macrophages', Helicobacter, vol. 20, pp. 449 - 459, http://dx.doi.org/10.1111/hel.12223
    Journal articles | 2015
    Gong L; Lai SC; Treerat P; Prescott M; Adler B; Boyce JD; Devenish RJ, 2015, 'Burkholderia pseudomallei Type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors', Infection and Immunity, vol. 83, pp. 1276 - 1285, http://dx.doi.org/10.1128/IAI.03070-14
    Journal articles | 2014
    He L; Zhang W; Zhang J; Cao L; Gong L; Ma J; Huang H; Zeng J; Zhu C; Gong J; Xu Y; Zhang Z; Zhao J; Zhang H, 2014, 'Diaphragmatic motion studied by M-mode ultrasonography in combined pulmonary fibrosis and emphysema.', Lung, vol. 192, pp. 553 - 561, http://dx.doi.org/10.1007/s00408-014-9594-5
    Journal articles | 2013
    Deen NS; Huang SJ; Gong L; Kwok T; Devenish RJ, 2013, 'The impact of autophagic processes on the intracellular fate of Helicobacter pylori More tricks from an enigmatic pathogen?', Autophagy, vol. 9, pp. 639 - 652, http://dx.doi.org/10.4161/auto.23782
    Journal articles | 2013
    Don Paul C; Kiss C; Traore DAK; Gong L; Wilce MCJ; Devenish RJ; Bradbury A; Prescott M, 2013, 'Correction: Phanta: A Non-Fluorescent Photochromic Acceptor for pcFRET', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/annotation/b83e925b-2f2a-47b9-b939-0a1eeab18324
    Journal articles | 2013
    Don Paul C; Kiss C; Traore DAK; Gong L; Wilce MCJ; Devenish RJ; Bradbury A; Prescott M, 2013, 'Phanta: A Non-Fluorescent Photochromic Acceptor for pcFRET', PLoS ONE, vol. 8, http://dx.doi.org/10.1371/journal.pone.0075835
    Journal articles | 2012
    Gong L; Devenish RJ; Prescott M, 2012, 'Autophagy as a macrophage response to bacterial infection', IUBMB Life, vol. 64, pp. 740 - 747, http://dx.doi.org/10.1002/iub.1070
    Journal articles | 2012
    Gong L; Ramm G; Devenish RJ; Prescott M, 2012, 'HcRed, a genetically encoded fluorescent binary cross-linking agent for cross-linking of mitochondrial ATP synthase in saccharomyces cerevisiae', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0035095
    Journal articles | 2012
    Hatfaludi T; Al-Hasani K; Gong L; Boyce JD; Ford M; Wilkie IW; Quinsey N; Dunstone MA; Hoke DE; Adler B, 2012, 'Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0039973
    Journal articles | 2012
    Pettikiriarachchi A; Gong L; Perugini MA; Devenish RJ; Prescott M, 2012, 'Ultramarine, a chromoprotein acceptor for förster resonance energy transfer', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0041028
    Journal articles | 2011
    D'Cruze T; Gong L; Treerat P; Ramm G; Boyce JD; Prescott M; Adler B; Devenish RJ, 2011, 'Role for the Burkholderia pseudomallei type three secretion system cluster 1 bpscn gene in virulence', Infection and Immunity, vol. 79, pp. 3659 - 3664, http://dx.doi.org/10.1128/IAI.01351-10
    Journal articles | 2011
    Gong L; Cullinane M; Treerat P; Ramm G; Prescott M; Adler B; Boyce JD; Devenish RJ, 2011, 'The Burkholderia pseudomallei type III secretion system and BopA are required for evasion of LC3-associated phagocytosis', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0017852
    Journal articles | 2011
    Tra T; Gong L; Kao LP; Li XL; Grandela C; Devenish RJ; Wolvetang E; Prescott M, 2011, 'Autophagy in human embryonic stem cells', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0027485
    Journal articles | 2008
    Cullinane M; Gong L; Li X; Lazar-Adler N; Tra T; Wolvetang E; Prescott M; Boyce JD; Devenish RJ; Adler B, 2008, 'Stimulation of autophagy suppresses the intracellular survival of Burkholderia pseudomallei in mammalian cell lines', Autophagy, vol. 4, pp. 744 - 753, http://dx.doi.org/10.4161/auto.6246
    Journal articles | 2002
    Gong L; Takayama KM; Kjelleberg S, 2002, 'Role of spoT-dependent ppGpp accumulation in the survival of light-exposed starved bacteria', Microbiology, vol. 148, pp. 559 - 570, http://dx.doi.org/10.1099/00221287-148-2-559
    Journal articles | 2002
    McDougald D; Gong L; Srinivasan S; Hild E; Thompson L; Takayama KM; Rice SA; Kjelleberg S, 2002, 'Defences against oxidative stress during starvation in bacteria', Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology, vol. 81, pp. 3 - 13, http://dx.doi.org/10.1023/A:1020540503200
    Journal articles | 2000
    Gong L; Gu X-F; Chen Y-D; Ren Z-R; Huang S-Z; Zeng Y-T, 2000, 'Reversal of aberrant splicing of β-thalassaemia allele (IVS-2-654 C→T) by antisense RNA expression vector in cultured human erythroid cells', British Journal of Haematology, vol. 111, pp. 351 - 358, http://dx.doi.org/10.1111/j.1365-2141.2000.02311.x
    Journal articles | 2000
    Gong L; Gu XF; Chen YD; Ren ZR; Huang SZ; Zeng YT, 2000, 'Reversal of aberrant splicing of β-thalassaemia allele (IVS-2-654 C→T) by antisense RNA expression vector in cultured human erythroid cells', British Journal of Haematology, vol. 111, pp. 351 - 358, http://dx.doi.org/10.1046/j.1365-2141.2000.02311.x
    Journal articles | 1999
    Zeng Y; Gu X; Chen Y; Gong L; Ren Z; Huang S, 1999, 'Reversal of aberrant splicing of β-thalassemia allele by antisense RNA in vitro and in vivo', Chinese Medical Journal, vol. 112, pp. 107 - 111
    Journal articles | 1998
    Gong L; Gu X; Wang M; Huang S; Zeng Y, 1998, 'Construction of antisense RNA expression vectors and correction of splicing defect in human β-globin gene (IVS-2-654 C→T mutant) in HeLa cells', Science in China, Series C: Life Sciences, vol. 41, pp. 99 - 106, http://dx.doi.org/10.1007/BF02882712
    Journal articles | 1997
    Gu X; Gong L; Zhang W, 1997, 'Repair of the splicing defect of thalassemic allele beta IVS-2-654 C-->T in cultured human erythroid cells by antisense RNA', Zhonghua yi xue za zhi, vol. 77, pp. 815 - 818
    Journal articles | 1997
    Shen S; Gong L; Jin R, 1997, 'Nucleotide sequence of the Rhizobium huakuii common nodution genes nodA and nodBC', Wei sheng wu xue bao = Acta microbiologica Sinica, vol. 37, pp. 355 - 361
    Journal articles | 1996
    Chen Y; Gong L; Yu J; Gu D, 1996, 'Structural alterations of resistance vessels of spontaneously hypertensive rats and protective effects of captopril', Chinese Medical Journal, vol. 109, pp. 873 - 876
  • Conference Posters | 2022
    Zhang N; Wang Z; Lv J; Liu Y; Liu T; Zhang S; Li W; Gong L; Zhang X; El-Omar E; Lu W, 2022, 'Characterization of gut microbiota and exploration of potential predictive model for hepatocellular carcinoma microvascular invasion', ENGLAND, London, Vol. 77, pp. S920 - S921, presented at International Liver Congress, ENGLAND, London, 22 June 2022 - 26 June 2022, http://dx.doi.org/10.1016/s0168-8278(22)02125-0
    Conference Abstracts | 2022
    Zhu W; Zhang N; Wang Z; Zhang S; Yue X; Sun L; Sun J; Gong L; El-Omar EM; Lu W, 2022, 'Characterization analysis of gut and bile microbiota for cholangiocarcinomas.', in Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 40, pp. e16150 - e16150, http://dx.doi.org/10.1200/jco.2022.40.16_suppl.e16150
    Conference Abstracts | 2020
    Behary J; Amorim N; Jiang X; Raposo A; Gong L; Mcgovern E; Chu F; Stephens C; Jebeili H; Fragomeli V; Koay YC; Jackson M; O'Sullivan J; Weltman M; Mccaughan G; El-Omar E; Zekry A, 2020, 'Impact of the gut microbiome and metabolome on the peripheral immune response in non-alcoholic fatty liver disease-related hepatocellular carcinoma', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 35, pp. 19 - 20, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589476200024&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Behary J; Raposo A; Zheng H; Amorim N; Gong L; Mcgovern E; Chen J; Liu K; Beretov J; Theocharous C; Jackson M; Mccaughan G; El-Omar E; Zekry A, 2020, 'Defining the temporal evolution of the gut microbiome and associated intrahepatic immune response in the Mdr2-/- model of hepatocellular carcinoma', in JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, WILEY, Vol. 35, pp. 19 - 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000589476200023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Zhong Y; Li W; Guo W; Gong L; Lodewijks G, 2015, 'A method of modeling and service encapsulation on cloud logistics resources', in Proceedings of the 2015 IEEE 19th International Conference on Computer Supported Cooperative Work in Design, CSCWD 2015, pp. 383 - 388, http://dx.doi.org/10.1109/CSCWD.2015.7230990
    Conference Proceedings (Editor of) | 2001
    McDougald D; Gong L; Srinivasan S; Hild E; Thompson L; Takayama KM; Rice SA; Kjelleberg S, (eds.), 2001, 'Antonie van Leeuwenhoek International Journal of General and Molecular Microbiology', Kluwer Academic Publ, Dordrecht, Netherlands, presented at 9th International Symposium on Microbial Ecology, -

  • UNSW Research Infrastructure Scheme: Supporting Collaborative Research
  • St George and Sutherland Medical Research Foundation

Dr Gong is a Senior Research Fellow at the Microbiome Research Centre, St George Hospital and St George & Sutherland Clinical School, UNSW, investigating the role of gut microbiome in gastrointestinal and liver diseases by using multi-omics including metagenomics and metabolomics.