Dr Lucy Coupland
Adjunct Senior Lecturer

Dr Lucy Coupland

Medicine & Health
School of Clinical Medicine

Dr Coupland is a Senior Clinical Research Scientist in the Intensive Care Unit at Liverpool Hospital where she is the scientific lead of a research program that focuses on the use of new point-of-care technologies to assess and guide treatment of fibrinolysis resistance in the critically ill. Prof Anders Aneman, Senior Intensivist, is the clinical lead of this program.

Lucy has a background of 15 years conducting clinical trials in public hospitals and 15 years conducting pre-clinical laboratory-based research with the main focus of her research including platelet biology and pathology, mechanisms of carcinoma and sarcoma metastasis, novel uses of viscoelastic testing, and the development of novel histone inhibitors and homeostatic agents.  

Location
Intensive Care Unit Liverpool Hospital, NSW, Australia and Ingham Institute for Applied Medical Research
  • Journal articles | 2023
    Coupland LA; Rabbolini DJ; Schoenecker JG; Crispin PJ; Miller JJ; Ghent T; Medcalf RL; Aneman AE, 2023, 'Point-of-care diagnosis and monitoring of fibrinolysis resistance in the critically ill: results from a feasibility study', Critical Care, 27, http://dx.doi.org/10.1186/s13054-023-04329-5
    Journal articles | 2023
    Crispin PJ; Coupland LA; Gardiner EE, 2023, 'Achieving haemostasis in thrombocytopenia in remote settings: an in vitro comparison of frozen and lyophilized products', Blood Transfusion, 21, pp. 289 - 295, http://dx.doi.org/10.2450/2022.0128-22
    Journal articles | 2023
    Kang CW; Blackburn AC; Loh AHP; Hong KC; Goh JY; Hein N; Drygin D; Parish CR; Hannan RD; Hannan KM; Coupland LA, 2023, 'Targeting RNA Polymerase I Transcription Activity in Osteosarcoma: Pre-Clinical Molecular and Animal Treatment Studies', Biomedicines, 11, http://dx.doi.org/10.3390/biomedicines11041133
    Journal articles | 2022
    Crispin P; Hicks S; Coupland LA; Ali S; Gardiner EE, 2022, 'Cryoprecipitate as an alternative to platelet transfusion in thrombocytopenia.', EJHaem, 3, pp. 80 - 85, http://dx.doi.org/10.1002/jha2.358
    Journal articles | 2022
    Kang CW; Hannan KM; Blackburn AC; Loh AHP; Hong KC; Yuan GJ; Hein N; Drygin D; Hannan RD; Coupland LA, 2022, 'The therapeutic potential of RNA Polymerase I transcription inhibitor, CX-5461, in uterine leiomyosarcoma', Investigational New Drugs, 40, pp. 529 - 536, http://dx.doi.org/10.1007/s10637-022-01222-w
    Journal articles | 2022
    Mohamed E; Coupland L; Gibson S; Crispin P; Nisbet D; Tsuzuki T, 2022, 'Strong influence of morphology on the hemostatic performance of nanofibers irrespective of surface charge', Materials Letters, 327, http://dx.doi.org/10.1016/j.matlet.2022.133023
    Journal articles | 2022
    Mohamed E; Wang Y; Crispin PJ; Fitzgerald A; Dahlstrom JE; Fowler S; Nisbet DR; Tsuzuki T; Coupland LA, 2022, 'Superior Hemostatic and Wound-Healing Properties of Gel and Sponge Forms of Nonoxidized Cellulose Nanofibers: In Vitro and In Vivo Studies', Macromolecular Bioscience, 22, http://dx.doi.org/10.1002/mabi.202200222
    Journal articles | 2022
    O'Connor JH; McNamara HA; Cai Y; Coupland LA; Gardiner EE; Parish CR; McMorran BJ; Ganusov VV; Cockburn IA, 2022, 'Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8+ T Cell Localization in the Murine Liver', Journal of Immunology, 208, pp. 2738 - 2748, http://dx.doi.org/10.4049/jimmunol.2101037
    Journal articles | 2022
    Popp SK; Vecchio F; Brown DJ; Fukuda R; Suzuki Y; Takeda Y; Wakamatsu R; Sarma MA; Garrett J; Giovenzana A; Bosi E; Lafferty ARA; Brown KJ; Gardiner EE; Coupland LA; Thomas HE; Chong BH; Parish CR; Battaglia M; Petrelli A; Simeonovic CJ, 2022, 'Circulating platelet-neutrophil aggregates characterize the development of type 1 diabetes in humans and NOD mice', JCI Insight, 7, http://dx.doi.org/10.1172/jci.insight.153993
    Journal articles | 2021
    Mohamed E; Coupland LA; Crispin PJ; Fitzgerald A; Nisbet DR; Tsuzuki T, 2021, 'Non-oxidized cellulose nanofibers as a topical hemostat: In vitro thromboelastometry studies of structure vs function', Carbohydrate Polymers, 265, http://dx.doi.org/10.1016/j.carbpol.2021.118043
    Journal articles | 2020
    Harris MA; Shekhar TM; Coupland LA; Miles MA; Hawkins CJ, 2020, 'Transient NK Cell Depletion Facilitates Pulmonary Osteosarcoma Metastases after Intravenous Inoculation in Athymic Mice', Journal of Adolescent and Young Adult Oncology, 9, pp. 667 - 671, http://dx.doi.org/10.1089/jayao.2019.0172
    Journal articles | 2020
    Hicks SM; Coupland LA; Jahangiri A; Choi PY; Gardiner EE, 2020, 'Novel scientific approaches and future research directions in understanding ITP', Platelets, 31, pp. 315 - 321, http://dx.doi.org/10.1080/09537104.2020.1727871
    Journal articles | 2020
    Meara CHO; Coupland LA; Kordbacheh F; Quah BJC; Chang CW; Simon Davis DA; Bezos A; Browne AM; Freeman C; Hammill DJ; Chopra P; Pipa G; Madge PD; Gallant E; Segovis C; Dulhunty AF; Arnolda LF; Mitchell I; Khachigian LM; Stephens RW; von Itzstein M; Parish CR, 2020, 'Neutralizing the pathological effects of extracellular histones with small polyanions', Nature Communications, 11, http://dx.doi.org/10.1038/s41467-020-20231-y
    Journal articles | 2020
    Montague SJ; Hicks SM; Lee CSM; Coupland LA; Parish CR; Lee WM; Andrews RK; Gardiner EE, 2020, 'Fibrin exposure triggers αIIbβ3-independent platelet aggregate formation, ADAM10 activity and glycoprotein VI shedding in a charge-dependent manner', Journal of Thrombosis and Haemostasis, 18, pp. 1447 - 1458, http://dx.doi.org/10.1111/jth.14797
    Journal articles | 2020
    Vulliamy P; Montague SJ; Gillespie S; Chan MV; Coupland LA; Andrews RK; Warner TD; Gardiner EE; Brohi K; Armstrong PC, 2020, 'Loss of GPVI and GPIbα contributes to trauma-induced platelet dysfunction in severely injured patients', Blood Advances, 4, pp. 2623 - 2630, http://dx.doi.org/10.1182/bloodadvances.2020001776
    Journal articles | 2020
    Yoon J; Parish CR; Blackburn AC; Coupland LA, 2020, 'Potential contrasting effects of platelets on the migration and invasion of sarcomas versus carcinomas', Platelets, pp. 1 - 9, http://dx.doi.org/10.1080/09537104.2020.1792433
    Journal articles | 2020
    Yoon J; Parish CR; Coupland LA, 2020, 'A rapid and accurate bioluminescence-based migration assay permitting analysis of tumor cell/stromal cell interactions', Methods and Protocols, 3, pp. 1 - 12, http://dx.doi.org/10.3390/mps3010010
    Journal articles | 2019
    Jing W; Yabas M; Bröer A; Coupland L; Gardiner EE; Enders A; Bröer S, 2019, 'Calpain cleaves phospholipid flippase ATP8A1 during apoptosis in platelets', Blood Advances, 3, pp. 219 - 229, http://dx.doi.org/10.1182/bloodadvances.2018023473
    Journal articles | 2019
    Tian DD; Bennett SK; Coupland LA; Forwood K; Lwin Y; Pooryousef N; Tea I; Truong TT; Neeman T; Crispin P; D’Rozario J; Blackburn AC, 2019, 'GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial', Pharmacology Research and Perspectives, 7, http://dx.doi.org/10.1002/prp2.526
    Journal articles | 2018
    Simes J; Robledo KP; White HD; Espinoza D; Stewart RA; Sullivan DR; Zeller T; Hague W; Nestel PJ; Glasziou PP; Keech AC; Elliott J; Blankenberg S; Tonkin AM, 2018, 'D-dimer predicts long-term cause-specific mortality, cardiovascular events, and cancer in patients with stable coronary heart disease LIPID study', Circulation, 138, pp. 712 - 723, http://dx.doi.org/10.1161/CIRCULATIONAHA.117.029901
    Journal articles | 2017
    Coupland L; Hindmarsh E; Gardiner E; Parish C, 2017, 'The influence of platelet membranes on tumour cell behaviour', Cancer and Metastasis Reviews, 36, pp. 215 - 224, http://dx.doi.org/10.1007/s10555-017-9671-3
    Journal articles | 2017
    Kordbacheh F; O'Meara CH; Coupland LA; Lelliott PM; Parish CR, 2017, 'Extracellular histones induce erythrocyte fragility and anemia', Blood, 130, pp. 2884 - 2888, http://dx.doi.org/10.1182/blood-2017-06-790519
    Journal articles | 2017
    Stewart RAH; Colquhoun DM; Marschner SL; Kirby AC; Simes J; Nestel PJ; Glozier N; O'Neil A; Oldenburg B; White HD; Tonkin AM, 2017, 'Persistent psychological distress and mortality in patients with stable coronary artery disease', Heart, 103, pp. 1860 - 1866, http://dx.doi.org/10.1136/heartjnl-2016-311097
    Journal articles | 2015
    Fraser ST; Midwinter RG; Coupland LA; Kong S; Berger BS; Yeo JH; Andrade OC; Cromer D; Suarna C; Lam M; Maghzal GJ; Chong BH; Parish CR; Stocker R, 2015, 'Heme oxygenase-1 deficiency alters erythroblastic Island formation, steady-state erythropoiesis and red blood cell lifespan in mice', Haematologica, 100, pp. 601 - 610, http://dx.doi.org/10.3324/haematol.2014.116368
    Journal articles | 2015
    Pang JH; Coupland LA; Freeman C; Chong BH; Parish CR, 2015, 'Activation of tumour cell ECM degradation by thrombin-activated platelet membranes: potentially a P-selectin and GPIIb/IIIa-dependent process', Clinical and Experimental Metastasis, 32, pp. 495 - 505, http://dx.doi.org/10.1007/s10585-015-9722-5
    Journal articles | 2015
    Tonkin AM; Blankenberg S; Kirby A; Zeller T; Colquhoun DM; Funke-Kaiser A; Hague W; Hunt D; Keech AC; Nestel P; Stewart R; Sullivan DR; Thompson PL; West M; White HD; Simes J, 2015, 'Biomarkers in stable coronary heart disease, their modulation and cardiovascular risk: The LIPID biomarker study', International Journal of Cardiology, 201, pp. 499 - 507, http://dx.doi.org/10.1016/j.ijcard.2015.07.080
    Journal articles | 2014
    Coupland LA; Parish CR, 2014, 'Platelets, selectins, and the control of tumor metastasis', Seminars in Oncology, 41, pp. 422 - 434, http://dx.doi.org/10.1053/j.seminoncol.2014.04.003
    Journal articles | 2014
    Funke-Kaiser A; Mann K; Colquhoun D; Zeller T; Hunt D; Simes J; Sullivan D; Sydow K; West M; White H; Blankenberg S; Tonkin AM, 2014, 'Midregional proadrenomedullin and its change predicts recurrent major coronary events and heart failure in stable coronary heart disease patients: The LIPID study', International Journal of Cardiology, 172, pp. 411 - 418, http://dx.doi.org/10.1016/j.ijcard.2014.01.064
    Journal articles | 2014
    White HD; Tonkin A; Simes J; Stewart R; Mann K; Thompson P; Colquhoun D; West M; Nestel P; Sullivan D; Keech AC; Hunt D; Blankenberg S, 2014, 'Association of contemporary sensitive troponin i levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: Results from the LIPID study (Long-Term Intervention with Pravastatin in Ischaemic Disease)', Journal of the American College of Cardiology, 63, pp. 345 - 354, http://dx.doi.org/10.1016/j.jacc.2013.08.1643
    Journal articles | 2014
    Yabas M; Coupland LA; Cromer D; Winterberg M; Teoh NC; D'rozario J; Kirk K; Bröer S; Parish CR; Enders A, 2014, 'Mice deficient in the putative phospholipid flippase Atp11c exhibit altered erythrocyte shape, anemia, and reduced erythrocyte life span', Journal of Biological Chemistry, 289, pp. 19531 - 19537, http://dx.doi.org/10.1074/jbc.C114.570267
    Journal articles | 2013
    Coupland LA; Chong BH; Parish CR, 2013, 'Beware of NK cells in pre-clinical metastasis models', Clinical and Experimental Metastasis, 30, pp. 945 - 947, http://dx.doi.org/10.1007/s10585-013-9582-9
    Journal articles | 2013
    White HD; Simes J; Stewart RAH; Blankenberg S; Barnes EH; Marschner IC; Thompson P; West M; Zeller T; Colquhoun DM; Nestel P; Keech AC; Sullivan DR; Hunt D; Tonkin A, 2013, 'Changes in lipoprotein-associated phospholipase A2 activity predict coronary events and partly account for the treatment effect of pravastatin: Results from the long-term intervention with pravastatin in ischemic disease study', Journal of the American Heart Association, 2, pp. 1 - 13, http://dx.doi.org/10.1161/JAHA.113.000360
    Journal articles | 2012
    Coupland L; Chong BH; Parish CR, 2012, 'Platelets and P-selectin control tumor metastasis in an organ-specific manner and independently of NK cells. Cancer Research', Cancer Research, 72, pp. 4662 - 4671, http://dx.doi.org/10.1158/0008-5472.CAN-11-4010
    Journal articles | 2010
    Coupland LA; Cromer D; Davenport MP; Parish CR, 2010, 'A novel fluorescent-based assay reveals that thrombopoietin signaling and Bcl-X(L) influence, respectively, platelet and erythrocyte lifespans', Experimental Hematology, 38, pp. 453 - 461
    Journal articles | 2009
    Soderberg S; Colquhoun D; Keech A; Yallop J; Barnes EH; Pollicino C; Simes J; Tonkin AM; Nestel P, 2009, 'Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study', INTERNATIONAL JOURNAL OF OBESITY, 33, pp. 123 - 130, http://dx.doi.org/10.1038/ijo.2008.224
    Journal articles | 2008
    West MJ; Nestel PJ; Kirby AC; Schnabel R; Sullivan D; Simes RJ; Pollicino C; Lubos E; Münzel TF; White HD; Tonkin AM; Bickel C; Tiret L; Blankenberg S, 2008, 'The value of N-terminal fragment of brain natriuretic peptide and tissue inhibitor of metalloproteinase-1 levels as predictors of cardiovascular outcome in the LIPID study', European Heart Journal, 29, pp. 923 - 931, http://dx.doi.org/10.1093/eurheartj/ehn007
    Journal articles | 2006
    Coupland LA; Brun M; Jammu V; D'Rozario JM, 2006, 'A variant chronic B-cell lymphoma characterized by villous cells with novel immunophenotypic and cytogenetic profiles', Leukemia and Lymphoma, 47, pp. 129 - 134, http://dx.doi.org/10.1080/10428190500277126
    Journal articles | 2005
    Stewart RAH; White HD; Kirby AC; Heritier SR; Simes RJ; Nestel PJ; West MJ; Colquhoun DM; Tonkin AM, 2005, 'White blood cell count predicts reduction in coronary heart disease mortality with pravastatin', CIRCULATION, 111, pp. 1756 - 1762, http://dx.doi.org/10.1161/01.CIR.0000160924.73417.26
    Journal articles | 2004
    Colquhoun D; Keech A; Hunt D; Marschner I; Simes J; Glaszlou P; White H; Barter P; Tonkin A, 2004, 'Effects of pravastatin on coronary events in 2073 patients with low levels of both low-density lipoprotein cholesterol and high-density lipoprotein cholesterol: Results from the LIPID study', European Heart Journal, 25, pp. 771 - 777, http://dx.doi.org/10.1016/j.ehj.2004.03.013
    Journal articles | 2003
    Hague W; Forder P; Simes J; Hunt D; Tonkin A, 2003, 'Prevention and rehabilitation - Effect of pravastatin on cardiovascular events and mortality in 1516 women with coronary heart disease: Results from the Long-Term Intervention with Pravastatin in Ischemic Disease (LIPID) study', AMERICAN HEART JOURNAL, 145, pp. 643 - 651, http://dx.doi.org/10.1067/mhj.2003.1
    Journal articles | 2003
    Keech A; Colquhoun D; Best J; Kirby A; Simes RJ; Hunt D; Hague W; Beller E; Arulchelvam M; Baker J; Tonkin A, 2003, 'Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes of impaired fasting glucose: Results from the LIPID trial', Diabetes Care, 26, pp. 2713 - 2721, http://dx.doi.org/10.2337/diacare.26.10.2713
    Journal articles | 2002
    Coupland LA; Jammu V; Pidcock ME, 2002, 'Partial deletion of chromosome 1 in a case of acute myelocytic leukemia', Cancer Genetics and Cytogenetics, 139, pp. 60 - 62, http://dx.doi.org/10.1016/S0165-4608(02)00597-6
    Journal articles | 2002
    Simes RJ; Hunt D; Kirby A; Tonkin A; Keech A; Aylward P; Colquhoun D; Glasziou P; Hague W; MacMahon S; Thompson P; West M; White H, 2002, 'Long-term effectiveness and safety of pravastatin in 9014 patients with coronary heart disease and average cholesterol concentrations: The LIPID trial follow-up', Lancet, 359, pp. 1379 - 1387, http://dx.doi.org/10.1016/S0140-6736(02)08351-4
    Journal articles | 2002
    Simes RJ; Marschner IC; Hunt D; Colquhoun D; Sullivan D; Stewart RAH; Hague W; Keech A; Thompson P; White H; Shaw J; Tonkin A, 2002, 'Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) trial: To what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?', Circulation, 105, pp. 1162 - 1169, http://dx.doi.org/10.1161/hc1002.105136
    Journal articles | 2000
    Khurana OK; Coupland LA; Shelden MC; Howitt SM, 2000, 'Homologous mutations in two diverse sulphate transporters have similar effects', FEBS Letters, 477, pp. 118 - 122, http://dx.doi.org/10.1016/S0014-5793(00)01783-X
    Journal articles | 1999
    Coupland LA; Cooke-Yarborough CM; Dalla-Pozza L, 1999, 'The New Children's Hospital Tumour Bank [2]', Medical Journal of Australia, 170, pp. 284 - 285, http://dx.doi.org/10.5694/j.1326-5377.1999.tb127765.x
    Journal articles | 1998
    Tonkin A; Alyward P; Colquhoun D; Glasziou P; Harris P; Hunt D; Keech A; MacMahon S; Magnus P; Newel D; Nestel P; Sharpe N; Shaw J; Simes RJ; Thompson P; Thompson A; West M; White H; Simes S; Hague W; Caleo S; Hall J; Martin A; Mulray S; Barter P; Beilin L; Collins R; McNeil J; Meier P; Willimott H; Smithers D; Wallace P; Baker J; Hobbs M; Sullivan D; Anderson N; Hankey G; Watson J; Arulchelvam M; Chup S; Daly J; Hanna J; Leach A; Lee M; Loughhead J; Lundie-Jenkin H; Morrison J; Netting S; Nguyen A; Pater H; Philip R; Pinna G; Rattos D; Ryerson S; Sazhin V; Walsh R; Claque A; Mackie M; Yallop J; Boss K; Shepard M; Leach J; Gandy M; Joughin J; Seabrook J; Abraham R; Allen J; Bates F; Beinart I; Breed E; Brown D; Bunyan N; Calvert D; Campbell T; Condon-Paoloni D; Conway B; Coupland L; Crowe J; Cunio N; Cuthbert B; Cuthbert N; D'Arcy S; Davidson P; Dwyer B; England J; Friend C; Fulcher G; Grant S; Hellestrand K; Kava M; Kritharides L; McGill D; McKee H; McLean A; Neaverson M; Nelson G; O'Neill M; Onuma C; O'Reilly F, 1998, 'Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels', New England Journal of Medicine, 339, pp. 1349 - 1357, http://dx.doi.org/10.1056/NEJM199811053391902
    Journal articles | 1995
    Tonkin A; Aylward P; Colquhoun D; Glasziou P; Harris P; Hunt D; MacMahon S; Nestel P; Sharpe N; Símes J; Thompson P; Thomson A; West M; White H; Shaw J; Ablett M; MacAskill M; Turner R; Magnus P; Wallace P; Keech A; Newell D; Raupach H; Hague W; Hall J; Mulray S; Wiseman V; Davies P; Smithers D; Baker J; Hobbs M; Sullivan D; Daly J; Lundie-Jenkins H; Morrison J; Pater H; Philip R; Ryerson S; Simes S; Sazhin V; Martin A; Nguyen A; Drew J; Rattos D; Clague A; Hall A; Mackie M; Yallop J; Boss K; Barter P; Beilin L; Collins R; McNeil J; Meier P; Willimott H; Whiting M; Shepard M; Leach J; Gandy M; Joughan J; Seabrook J; Coupland L; McGill D; Tarimer P; Beinart I; McKee H; Abraham R; Parnell G; England J; Viles A; Bunyan N; Grant S; O'Neill M; Wikramanayake R; Brown-Paul P; Crowe J; Waites J; Walker R; Allen J; Marel M; Pawsey C; Wyndham R; Bates F; Brown D; Thomas J; Woods J; Hellestrand K; Paterson S; Calvert D; Condon-Paoloni D; Owensby A; Owensby D; Ryan J; Silberberg J; Taylor M; Onuma S; Wee K; Kava M; McLean A; Quinn K, 1995, 'Design features and baseline characteristics of the LIPID (long-term intervention with pravastatin in ischemic disease) study: A randomized trial in patients with previous acute myocardial infarction and/or unstable angina pectoris', The American Journal of Cardiology, 76, pp. 474 - 479, http://dx.doi.org/10.1016/S0002-9149(99)80133-7
  • Preprints | 2022
    Coupland L; Rabbolini D; Schoenecker J; Crispin P; Miller J; Ghent T; Medcalf R; Aneman A, 2022, Point-of-care Diagnosis and Monitoring of Hypofibrinolysis in the Critically Ill: Results from a Feasibility Study., , http://dx.doi.org/10.21203/rs.3.rs-2223534/v1
    Preprints | 2021
    O’Connor J; McNamara H; Cai Y; Coupland L; Gardiner E; Parish C; McMorran B; Ganusov V; Cockburn I, 2021, Platelets are dispensable for the ability of CD8+ T cells to accumulate, patrol, kill and reside in the liver, , http://dx.doi.org/10.1101/2021.11.09.467964

NHMRC Ideas Grant 2024: Fibrinolysis Resistance in the Critically Ill: Rapid Detection, Characterisation and Treatment Discovery