Dr Maitreyee Roy
Senior Lecturer

Dr Maitreyee Roy

Medicine & Health
School of Optometry and Vision Science

Dr Roy was awarded a PhD in Physical Optics from School of Physics at the University of Sydney. Her PhD research was focused on the fundamental principle of “Geometric Phase” in optics and its application for 3D imaging for biological and non-biological samples. One of her major contributions in this area was to demonstrate achromatic nature of geometric phase, which has opened up new insights into broadband interferometry with applications ranging from biological systems (Optical Coherence Tomography), electronics (Semiconductor industry) to astronomy (Stellar Interferometry).

Prior to joining UNSW in 2015, she worked in multidisciplinary research projects in government and academic institutions including the School of Physics and Australian Key Centre for Microscopy & Microanalysis at the University of Sydney and National Measurement Institute, Australia (NMIA). While at NMIA as a Research Scientist, she conducted and led various Optical Standards and Nano-metrology projects focusing on establishing and maintaining the capabilities underpinning the delivery of measurement services for industry, government and to the research community.

She has also worked in several international research labs: Charles Fabry Laboratory, University d’ Orsay, France; Department of Applied Physics, Osaka University; National Measurement & Standards Laboratory, NRC, Canada; Department of Optics, National Institute of Astrophysics, Optics and Electronica, Mexico and Mechanical Engineering Laboratory, Tsukuba, Japan.  

Dr Roy holds numerous memberships with professional societies nationally and internationally, notably a member of Optical Society of Australia, a Fellow of Optical Society of America, Member of the International Society for Optical Engineering, a member of Optical Society of India, a member of Australian Microscopy and Microanalysis Society and an Australian Standards Committee member for eye and face protection standards.

 

RESEARCH

  • Visualizing tear film using Quantum dots
  • Automated detection of ocular diseases with Artificial Intelligence.
  • 3D reconstruction and visualisation of ocular disease model from OCT images
  • The effect of blue-blocking lenses on visual and non-visual functions.
  • Development of novel instrumentation and imaging technology for rapid, sensitive, non-contact, non-invasive methods for high-resolution three-dimensional imaging for biomedical applications which incorporate the Full-Field optical coherence microscopy based on liquid crystal geometric phase-shifting technology coupled with fluorescence microscopy.

TEACHING & OUTREACH

Courses I teach and coordinate

  • VISN1111 - Geometrical and Physical Optics
  • VISN1221 - Visual Optics
  • OPTM 3201- Ocular Imaging & Applied Vision Science

PROFESSIONAL AFFILIATIONS

  • Fellow of the Optical Society of America
  • Member of the Australian Microscopy and Microanalysis Society Inc
  • Member of the Australian Optical Society
  • Member of the Metrological Society Australia
  • Member of the Optical Society of India
  • Member of the International Society for Optical Engineering (SPIE)
  • Australian Standards Committee, Eye & Face Protection

AWARDS & ACHIEVEMENTS

  • NMI World Metrology Day Outstanding Achievement Awards, 2013- NETs Team: For an outstandingly successful program delivering world-class measurement standards and services and for active and effective engagement with a wide range of stakeholders to focus and apply these capabilities                                          
  • NMI World Metrology Day Outstanding Achievement Awards, 2011- Optical Standards Team: Excellent work in satisfying optical measurement requirements of a major strategic client, Department of Defence
  • ProSciTech Trans-Tasman Award,2006, For significant research using microscopy or microanalysis, especially work for lasting value to people/ or the environment, Australian Microscopy and Microanalysis Society
  • Australian Academy of Science: France-Australia Science Innovation Collaboration Program, 2007 
  • Denison travel fellowship, School of Physics, University of Sydney,2006
  • JSPS invitation fellowship (Japan Society for Promotion of Science), 2004
  • Australian Academy of Science travel fellowship, 2003, “Scientific visits to the United States of America, Canada and Mexico” scheme
  • AIST Fellow (Agency of Industrial Science and Technology), Japan, 1999
  • Daimler-Benz Award, 1999- Best overall papers by the collaborative team (Japanese) presented at 31st International Symposium on Automotive Technology & Automation, Germany

 

Research Groups

Research Topics

  • Automated detection of ocular diseases with Artificial Intelligence
  • Blue light blocking lenses, effects on visual and non-visual systems
  • Functionalised nanoparticles as contrast agents for bio-imaging
  • Optical coherence microscopy for ultrahigh-resolution 3D imaging
Phone
+61 2 9385 7874
Location
School of Optometry and Vision Science Level 3, Room 3.025 North Wing, Rupert Myers Building
  • Book Chapters | 2007
    Sheppard CJR; Roy M, 2007, 'Low-coherence interference microscopy', in Kao F-J; Torok P (ed.), Optical Imaging and Microscopy Techniques and advanced systems, Springer -Verlag
    Book Chapters | 2006
    Sheppard CJR; Gan X; Gu M; Roy M, 2006, 'Signal-to-noise ratio in confocal microscopes', in Handbook of Biological Confocal Microscopy: Third Edition, pp. 442 - 452, http://dx.doi.org/10.1007/978-0-387-45524-2_22
  • Journal articles | 2022
    Akter N; Fletcher J; Perry S; Simunovic MP; Briggs N; Roy M, 2022, 'Glaucoma diagnosis using multi-feature analysis and a deep learning technique.', Sci Rep, vol. 12, pp. 8064, http://dx.doi.org/10.1038/s41598-022-12147-y
    Journal articles | 2022
    Alzahrani HS; Khuu SK; Roy M, 2022, 'Modelling the effect of light through commercially available blue-blocking lenses on the human circadian system', Clinical and Experimental Optometry, vol. 105, pp. 275 - 280, http://dx.doi.org/10.1080/08164622.2021.1898276
    Journal articles | 2021
    Ali A; Roy M; Alzahrani HS; Khuu SK, 2021, 'The effect of blue light filtering lenses on speed perception', Scientific Reports, vol. 11, pp. 17583, http://dx.doi.org/10.1038/s41598-021-96941-0
    Journal articles | 2021
    Alzahran HS; Roy M; Honson V; Khuu SK, 2021, 'Effect of blue-blocking lenses on colour contrast sensitivity', Clinical and Experimental Optometry, vol. 104, pp. 207 - 214, http://dx.doi.org/10.1111/cxo.13135
    Journal articles | 2021
    Baldasso M; Roy M; Boon M; Dain SJ, 2021, 'Effect of blue–blocking lenses on colour discrimination', Clinical and Experimental Optometry, vol. 104, pp. 56 - 61, http://dx.doi.org/10.1111/cxo.13139
    Journal articles | 2021
    Hossain MS; Pathan AQMSU; Islam MN; Tonmoy MIQ; Rakib MI; Munim MA; Saha O; Fariha A; Reza HA; Roy M; Bahadur NM; Rahaman MM, 2021, 'Genome-wide identification and prediction of SARS-CoV-2 mutations show an abundance of variants: Integrated study of bioinformatics and deep neural learning', Informatics in Medicine Unlocked, vol. 27, http://dx.doi.org/10.1016/j.imu.2021.100798
    Journal articles | 2020
    Alzahrani HS; Khuu SK; Ali A; Roy M, 2020, 'The Effect of Blue-blocking Lenses on Photostress Recovery Times', Optometry and vision science : official publication of the American Academy of Optometry, vol. 97, pp. 995 - 1004, http://dx.doi.org/10.1097/OPX.0000000000001601
    Journal articles | 2020
    Alzahrani HS; Khuu SK; Roy M, 2020, 'Modelling the effect of commercially available blue-blocking lenses on visual and non-visual functions', Clinical and Experimental Optometry, vol. 103, pp. 339 - 346, http://dx.doi.org/10.1111/cxo.12959
    Journal articles | 2020
    Matsuda K; Yasumoto M; Akter N; Misawa M; Aguilar JC; Suzuki Y; Takeuchi A; Hibino K; Rehman S; Roy M, 2020, 'Hard x-ray phase-contrast microscopy using a Gabor hologram without a zero-order term', Applied Optics, vol. 59, pp. 5918 - 5923, http://dx.doi.org/10.1364/AO.393008
    Journal articles | 2019
    Alzahrani H; Khuu SK; Roy M, 2019, 'EVALUATION OF THE SAFETY OF USING COMMERCIALLY AVAILABLE BLUE-BLOCKING LENSES UNDER DIFFERENT BLUE LIGHT EXPOSURES', International Journal of Latest Trends in Engineering and Technology
    Journal articles | 2019
    Sarwat S; Stapleton F; Willcox M; Roy M, 2019, 'Quantum Dots in Ophthalmology: A Literature Review', Current Eye Research, vol. 44, pp. 1037 - 1046, http://dx.doi.org/10.1080/02713683.2019.1660793
    Journal articles | 2018
    Matsuda K; Lopez JCA; Rehman S; Misawa M; Suzuki Y; Takeuchi A; Yasumoto M; Hibino K; Roy M; Hanayama R; Ishii K, 2018, 'Differential interference contrast microscopy for cells using hard x-ray holography', Applied Optics, vol. 57, pp. 4795 - 4801, http://dx.doi.org/10.1364/AO.57.004795
    Journal articles | 2015
    Chekli L; Roy M; Tijing LD; Donner E; Lombi E; Shon HK, 2015, 'Agglomeration behaviour of titanium dioxide nanoparticles in river waters: A multi-method approach combining light scattering and field-flow fractionation techniques', Journal of Environmental Management, vol. 159, pp. 135 - 142, http://dx.doi.org/10.1016/j.jenvman.2015.05.011
    Journal articles | 2013
    Chekli L; Phuntsho S; Roy M; Lombi E; Donner E; Shon HK, 2013, 'Assessing the aggregation behaviour of iron oxide nanoparticles under relevant environmental conditions using a multi-method approach', Water Research, vol. 47, pp. 4585 - 4599, http://dx.doi.org/10.1016/j.watres.2013.04.029
    Journal articles | 2013
    Chekli L; Phuntsho S; Roy M; Shon HK, 2013, 'Characterisation of Fe-oxide nanoparticles coated with humic acid and Suwannee River natural organic matter', Science of the Total Environment, vol. 461-462, pp. 19 - 27, http://dx.doi.org/10.1016/j.scitotenv.2013.04.083
    Journal articles | 2009
    Roy M; Schmit J; Hariharan P, 2009, 'White-light interference microscopy: Minimization of spurious diffraction effects by geometric phase-shifting', Optics Express, vol. 17, pp. 4495 - 4499, http://dx.doi.org/10.1364/OE.17.004495
    Journal articles | 2007
    Hariharan P; Roy M, 2007, 'Improved pinhole spatial filter', Optics and Laser Technology, vol. 39, pp. 155 - 156, http://dx.doi.org/10.1016/j.optlastec.2005.04.002
    Journal articles | 2006
    Roy M; Sheppard CJR; Cox G; Hariharan P, 2006, 'White-light interference microscopy: A way to obtain high lateral resolution over an extended range of heights', Optics Express, vol. 14, pp. 6788 - 6793, http://dx.doi.org/10.1364/OE.14.006788
    Journal articles | 2005
    Cooper IJ; Roy M; Sheppard CJR, 2005, 'Focusing of pseudoradial polarized beams', Optics Express, vol. 13, pp. 1066 - 1071, http://dx.doi.org/10.1364/OPEX.13.001066
    Journal articles | 2005
    Cooper IJ; Sheppard CJR; Roy M, 2005, 'The numerical integration of fundamental diffraction integrals for converging polarized spherical waves using a two-dimensional form of Simpson's 1/3 rule', Journal of Modern Optics, vol. 52, pp. 1123 - 1134, http://dx.doi.org/10.1080/09500340512331323439
    Journal articles | 2005
    Hariharan P; Ciddor PE; Roy M, 2005, 'Improved switchable achromatic phase shifters, part 2', Optical Engineering, vol. 44, http://dx.doi.org/10.1117/1.2084587
    Journal articles | 2005
    Roy M; Cooper I; Moore P; Sheppard CJR; Hariharan P, 2005, 'White-light interference microscopy: Effects of multiple reflections within a surface film', Optics Express, vol. 13, pp. 164 - 170, http://dx.doi.org/10.1364/OPEX.13.000164
    Journal articles | 2005
    Roy M; Cox G; Hariharan P, 2005, 'Low-coherence interference microscopy with an improved switchable achromatic phase-shifter', Optics Express, vol. 13, pp. 9125 - 9130, http://dx.doi.org/10.1364/OPEX.13.009125
    Journal articles | 2004
    Roy M, 2004, 'Technique maps complex microsurfaces', Photonics Spectra, vol. 38, pp. 65 - 68
    Journal articles | 2004
    Roy M; Sheppard CJR; Hariharan P, 2004, 'Low-coherence interference microscopy using a ferro-electric liquid crystal phase-modulator', Optics Express, vol. 12, pp. 2512 - 2516, http://dx.doi.org/10.1364/OPEX.12.002512
    Journal articles | 2004
    Sheppard CJR; Roy M; Sharma MD, 2004, 'Image formation in low-coherence and confocal interference microscopes', Applied Optics, vol. 43, pp. 1493 - 1502, http://dx.doi.org/10.1364/AO.43.001493
    Journal articles | 2002
    Matsuda K; Roy M; Eiju T; O’byrne JW; Sheppard CJR; Mazur E, 2002, 'Straightness measurements with a reflection confocal optical system-an experimental study', Applied Optics, vol. 41, pp. 3966 - 3970, http://dx.doi.org/10.1364/AO.41.003966
    Journal articles | 2002
    Roy M; Svahn P; Cherel L; Sheppard CJR, 2002, 'Geometric phase-shifting for low-coherence interference microscopy', Optics and Lasers in Engineering, vol. 37, pp. 631 - 641, http://dx.doi.org/10.1016/S0143-8166(01)00146-4
    Journal articles | 2001
    Roy M; Svahn P; Sheppard CJR, 2001, 'Geometric phase low-coherence interference microscopy at high numerical apertures', Proceedings of SPIE - The International Society for Optical Engineering, vol. 4417, pp. 529 - 532, http://dx.doi.org/10.1117/12.441347
    Journal articles | 1999
    Matsuda K; Eiju T; Roy M; O'Byrne JW; Fekete PW; Sheppard CJR, 1999, 'Straightness measurements using a reflection confocal optical system', Proceedings of SPIE - The International Society for Optical Engineering, vol. 3749, pp. 589 - 590
    Journal articles | 1999
    Matsuda K; Roy M; O’byrne JW; Fekete PW; Eiju T; Sheppard CJR, 1999, 'Straightness measurements by use of a reflection confocal optical system', Applied Optics, vol. 38, pp. 5310 - 5318, http://dx.doi.org/10.1364/AO.38.005310
    Journal articles | 1999
    Roy M; Cherel L; Sheppard CJR, 1999, 'Geometric phase coherence probe microscope for surface profiling', Proceedings of SPIE - The International Society for Optical Engineering, vol. 3749, pp. 462 - 463
    Journal articles | 1996
    Hariharan P; Roy M, 1996, 'Achromatic phase-shifting for two-wavelength phase-stepping interferometry', Optics Communications, vol. 126, pp. 220 - 222, http://dx.doi.org/10.1016/0030-4018(96)00118-6
    Journal articles | 1996
    Hariharan P; Roy M, 1996, 'Interferometric surface profiling with white light: Effects of surface films', Journal of Modern Optics, vol. 43, pp. 1797 - 1800, http://dx.doi.org/10.1080/09500349608232850
    Journal articles | 1996
    Sheppard CJR; Roy M, 1996, 'Total integrated scatter in the Kirchhoff approximation', Optik (Jena), vol. 103, pp. 42 - 44
    Journal articles | 1995
    Hariharan P; Roy M, 1995, 'White-light phase-stepping interferometry: Measurement of the fractional interference order', Journal of Modern Optics, vol. 42, pp. 2357 - 2360, http://dx.doi.org/10.1080/09500349514552051
    Journal articles | 1994
    Hariharan P; Larkin KG; Roy M, 1994, 'The geometric phase: Interferometric observations with white light', Journal of Modern Optics, vol. 41, pp. 663 - 667, http://dx.doi.org/10.1080/09500349414550681
    Journal articles | 1994
    Hariharan P; Roy M, 1994, 'White-light phase-stepping interferometry for surface profiling', Journal of Modern Optics, vol. 41, pp. 2197 - 2201, http://dx.doi.org/10.1080/09500349414552041
    Journal articles | 1993
    Hariharan P; Roy M, 1993, 'The geometric phase in optical rotation', Journal of Modern Optics, vol. 40, pp. 1687 - 1690, http://dx.doi.org/10.1080/09500349314551701
    Journal articles | 1993
    Hariharan P; Roy M; Robinson PA; O'byrne JW, 1993, 'The geometric phase observations at the single-photon level', Journal of Modern Optics, vol. 40, pp. 871 - 877, http://dx.doi.org/10.1080/09500349314550881
    Journal articles | 1993
    Roy M; Sheppard CJR, 1993, 'Effects of image processing on the noise properties of confocal images', Micron, vol. 24, pp. 623 - 635, http://dx.doi.org/10.1016/0968-4328(93)90040-8
    Journal articles | 1992
    Hariharan P; Roy M, 1992, 'A geometric-phase interferometer', Journal of Modern Optics, vol. 39, pp. 1811 - 1815, http://dx.doi.org/10.1080/09500349214551881
    Journal articles | 1992
    Sheppard CJR; Gu M; Roy M, 1992, 'Signal‐to‐noise ratio in confocal microscope systems', Journal of Microscopy, vol. 168, pp. 209 - 218, http://dx.doi.org/10.1111/j.1365-2818.1992.tb03264.x
    Journal articles |
    Alzahrani HS; Khuu SK; Ali A; Roy M, 'The effect of blue-blocking lenses on photostress recovery times for low and high contrast chromatic and achromatic stimuli', , http://dx.doi.org/10.1101/745000
  • Conference Papers | 2066
    Roy M, 2066, 'Slit-scanning Confocal Raman Microscopy for Multispectral Imaging of Living Hela Cells', in Australasian Physical and Engineering Sciences in Medicine, Springer, Noosa, Queenland, pp. 409 - 410, presented at Engineering & Physical Sciences In Medicine (EPSM), Noosa, Queenland, 17 September 2066 - 21 September 2006
    Conference Papers | 2020
    Akter N; Perry S; Fletcher J; Simunovic M; Roy M, 2020, 'Automated Artifacts and Noise Removal from Optical Coherence Tomography Images Using Deep Learning Technique', in 2020 IEEE Symposium Series on Computational Intelligence, SSCI 2020, pp. 2536 - 2542, http://dx.doi.org/10.1109/SSCI47803.2020.9308336
    Conference Papers | 2020
    Akter N; Young J; Lee N; Roy M, 2020, '3D reconstruction of retinal vascular structure from 2D OCT-a images for glaucoma diagnosis', in Optics InfoBase Conference Papers
    Conference Papers | 2019
    Akter N; Phu J; Perry S; Fletcher J; Kalloniatis M; Roy M, 2019, 'Analysis of OCT images to optimize glaucoma diagnosis', in Optics InfoBase Conference Papers, http://dx.doi.org/10.1364/ISA.2019.ITh2B.2
    Conference Papers | 2018
    Roy M; Sarwat S; O'Mara P; Almaimani M; Tilley R; Gooding J; Willcox M; Stapleton F, 2018, 'Imaging of tear film lipids using quantum dots', in Optics InfoBase Conference Papers, http://dx.doi.org/10.1364/3D.2018.JW4A.18
    Conference Papers | 2018
    Roy M; Zheng W; Sheppard CJR, 2018, 'Rapid full-field optical coherence tomography using geometric phase ferroelectric liquid crystal technology', in Optics InfoBase Conference Papers, http://dx.doi.org/10.1364/ISA.2018.IM3B.2
    Conference Presentations | 2017
    Nguyen, N; Roy M, 2017, 'A laser multi-vergence optometer induces the accommodation of myopes', presented at Arvo-Asia, Brisbane, 05 February 2017 - 08 February 2017
    Conference Papers | 2017
    Roy M, 2017, 'Is colour discrimination changed by wearing “blue blocking lenses”?', in Is colour discrimination changed by wearing “blue blocking lenses”?, ASIA ARVO, Brisbane, presented at ASIA ARVO, Brisbane, 01 April 2017 - 07 April 2017
    Conference Papers | 2013
    Jämting AK; Roy M; Catchpoole HJ; Lawn M; Babic B; Coleman VA; Herrmann J, 2013, 'The influence of technique on the measured particle size distribution of complex nanoparticle systems', in Technical Proceedings of the 2013 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2013, pp. 163 - 166
    Conference Papers | 2011
    Coleman VA; Jämting AK; Catchpoole HJ; Roy M; Herrmann J, 2011, 'Nanoparticles and metrology: A comparison of methods for the determination of particle size distributions', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.894297
    Conference Papers | 2011
    Roy M; Manson P; Thorvaldson ED; Atkinson EG; Ballico MJ, 2011, 'Aperture area metrology using confocal laser beam scanning technique', in 2011 Int. Quantum Electron. Conf., IQEC 2011 and Conf. Lasers and Electro-Optics, CLEO Pacific Rim 2011 Incorporating the Australasian Conf. Optics, Lasers and Spectroscopy and the Australian Conf., pp. 1664 - 1666, http://dx.doi.org/10.1109/IQEC-CLEO.2011.6193962
    Conference Papers | 2011
    Roy M; Manson P; Thorvaldson ED; Atkinson EG; Ballico MJ, 2011, 'Aperture area metrology using confocal laser beam scanning technique', in Optics InfoBase Conference Papers, pp. 1664 - 1667
    Conference Abstracts | 2006
    Matsuda K; Roy M; Rehman S; Yamauchi M; Kawata S; Roy M, 2006, 'Phase Difference Amplification Using Digital Holography: A Technique for Imaging Biological Samples at Nanometre Resolution', in Australasian Physical and Engineering Sciences in Medicine, Springer, Noosa, Queensland, pp. 406 - 407, presented at Engineering & Physical Sciences In Medicine (EPSM), Noosa, Queensland, 17 September 2006 - 21 September 2006
    Conference Abstracts | 2006
    Roy M; Braet F; Sheppard CJR; Cox G; Soon L; Baldock C, 2006, 'Full-field Geometric Phase Optical Coherence Tomography', in Australasian College of Physical Scientists and Engineers in Medicine, Springer, Noosa, Queensland, Vol. 29, pp. 409 - 409, presented at Engineering & Physical Sciences In Medicine (EPSM), Noosa, Queensland, 17 September 2006 - 21 September 2006
    Conference Abstracts | 2006
    Roy M; Hamada K; Fujita K; Kobayashi M; Kawata S, 2006, 'Slit-scanning Confocal Raman Microscopy for Multispectral Imaging of Living Hela Cells', in Australasian Physical and Engineering Sciences in Medicine, Springer, Noosa, Queensland, Vol. 29, pp. 353 - 353, presented at Engineering & Physical Sciences In Medicine (EPSM), Noosa, Queensland, 17 September 2006 - 21 September 2006
    Conference Papers | 2000
    Sheppard CJR; Roy M; Svahn P, 2000, 'Low-coherence interference microscopy at high numerical apertures', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 57 - 60, http://dx.doi.org/10.1117/12.390567
    Conference Papers | 1998
    Matsuda K; Roy M; Fekete PW; Eiju T; Sheppard CJR; O'Byrne JW, 1998, 'A novel method for beam collimation using multiple beam shearing interferometry', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 2 - 8, http://dx.doi.org/10.1117/12.304405
    Conference Papers | 1996
    Hariharan P; Roy M, 1996, 'Achromatic phase-shifting for polarization interferometry', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 100 - 106, http://dx.doi.org/10.1117/12.276294
    Conference Papers | 1995
    Roy M; Hariharan P, 1995, 'White-light geometric phase interferometer for surface profiling', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 64 - 72
    Conference Papers | 1995
    Sheppard CJ; Quartel JC; Roy M, 1995, 'Scattering and imaging of random media', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 13 - 19
    Conference Papers | 1993
    Hariharan P; Roy M; Robinson PA; O'Byrne JW, 1993, 'Geometric phase in optics: observations at the classical and quantum limits', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 508 - 512
    Conference Papers | 1992
    Sheppard CJ; Gu M; Roy M, 1992, 'Signal strength and its effects on processing of confocal images', in Proceedings of SPIE - The International Society for Optical Engineering, pp. 243 - 249
    Preprints |
    Sarwat S; Stapleton FJ; Perry Willcox MD; O’Mara PB; Tilley RD; Gooding JJ; Roy M, Evaluation of optically tailored fluorescent silicon quantum dots for bioimaging of the tear film, http://dx.doi.org/10.1101/2020.12.09.411876

Investigation of Blue light blocking lenses effect on visual and non-visual systems

Visible light, in particular, blue light, plays an ambiguous role in health & vision. Blue light may damage retinae, but it is also essential for sleep regulation. “Blue-blocking” lenses are ̶being marketed as protection against blue light without affecting sleep. While the need to provide eye protection against ultraviolet is well established, the need to protect blue light is not proved for anything other than direct viewing of the sun and some artificial sources such as welding arcs.

Control of the blue hazard could interact with the regulation of melatonin and sleep patterns.

This proposed project will help to build an understanding of how light, and the manipulation of lens coatings, may impact on sleep, colour perception and other indicators of visual comfort and health.

Automated detection of ocular diseases with Artificial Intelligence

Currently, artificial intelligence (AI), especially Machine learning (ML), techniques are revolutionising healthcare for its potential in image-based diagnosis, disease-prognostication, and risk-assessment. In ophthalmology, AI is also becoming common for screening, image-interpretation, early diagnosis and guiding treatment of eye conditions. This research aims are to - devise and evaluate new clinically meaningful metrics for analysing ocular images, implement novel machine and deep-learning algorithms for automatic segmentation, disease detection and progression-classification of eye diseases using both fundus photographs and optical coherence tomography (OCT) images from both healthy subjects and patients undergoing treatment for eye disease. 

Visualising Tear Film Lipid Layer Using Quantum Dots

Quantum dots (QDs) are semiconductor nanocrystals that can provide a range of diagnostic and therapeutic applications in ophthalmology for effective treatment of ocular diseases. Tear film evaporation is one of the key factors responsible for dry eyes that can lead to visual disturbances and contact lens in tolerance. Tear film evaporation depends on the structure of the lipid layer. Understanding the fundamental of tear dynamics has importance for developing treatment modalities for ocular surface diseases.

The thrust of this research project is to develop a novel instrumentation and imaging technique to visualise tear film layers in vivo using silicon QDS as they are non-toxic and emit discrete wavelengths of light which are very bright and stable.

3D reconstruction and visualization of ocular disease model from OCT images with virtual reality

3D reconstruction of medical images helps in image interpretation with visualising depth and understanding the underlying pathological process in disease. Additionally, the modern technology of 3D visualisation with virtual or augmented reality makes the treatment and diagnosis process very faster and more comfortable even in a surgical setting for all clinicians. It also helps the patient to understand the state of his/her disease very evidently. In this project, the 2D slices of OCT images of glaucoma patients will be collected and reconstructed with volume rendering process in different 3D software and afterwards, the 3D model will visualize with the virtual reality devices. Moreover, the project will also comprise some 3D animation and roaming in the visualisation environment to make it more realistic for the understanding of disease for diagnosis purpose. One of the goals of this project is to measure its impact on patient health literacy, to determine if this method can be used to enhance patient understanding of ocular disease processes.

Multi-modal optical coherence imaging for early detection of eye diseases

Visual impairment and loss due to eye diseases are common problems in older Australians. Age-Related Macular Degeneration and Glaucoma are the leading eye disease causes of blindness. Early detection of these eye diseases can prevent permanent vision loss. The thrust of the project is to develop a coherence-domain microscopy system based on our previously published geometric phase liquid-crystal technology with multi-modalities features, including polarisation and fluorescence imaging techniques.

The novelty of the system lies in two folds. By using a novel geometric phase-shifting technique based on liquid crystal, technology will improve the image acquisition and simplifies the optical setup by avoiding the necessity for using the instrumentationally complex, lateral point scanning scheme. Secondly, by coupling two different imaging techniques such as polarisation and fluorescence imaging techniques will provide morphology, anatomical and physiological properties, eg. birefringence of ocular tissues. This will facilitate and enhance early diagnosis of ocular pathologies leading to more effective treatments and preventing vision loss.

  • The Computational Imaging Lab/Berkeley Artificial Intelligence Research (CIL/BAIR) Lab, A/Prof Laura Waller, USA, Lead investigator, Department of Electrical Engineering and Computer Sciences, University of California, Berkeley, USA
  • Co-Director, Optics and Radiometry Laboratory (ORLAB), SOVS, UNSW Sydney
  • Prof. Kiyofumi Matsuda, Emeritus Professor at Tokyo Institute of Technology, Optical Information Processing and Systems Engineering Lab, The Graduate School for the Creation of New Photonics Industries, Japan
  • Centre for Eye Health (CFEH), UNSW Sydney