Dr Marthe-Susanna   Wegner
Adjunct Lecturer

Dr Marthe-Susanna Wegner

Science
School of Biotech & Biomolecular Science

I studied Biology at the Johann Wolfgang Goethe University in Frankfurt am Main (Germany) and did my PhD in Pharmacy at the University Clinic Frankfurt am Main. In 2015, I established my research group and currently I am visiting the School of BABS at UNSW.

  • Journal articles | 2022
    Byrne FL; Olzomer EM; Lolies N; Hoehn KL; Wegner M-S, 2022, 'Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma', International Journal of Molecular Sciences, vol. 23, pp. 4477 - 4477, http://dx.doi.org/10.3390/ijms23094477
    Journal articles | 2021
    Wegner MS; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, 'Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells', Cellular and Molecular Life Sciences, vol. 78, pp. 7025 - 7041, http://dx.doi.org/10.1007/s00018-021-03958-9
    Journal articles | 2020
    Hahnefeld L; Gruber L; Schömel N; Fischer C; Mattjus P; Gurke R; Beretta M; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'Ether lipid and sphingolipid expression patterns are estrogen receptor-dependently altered in breast cancer cells', International Journal of Biochemistry and Cell Biology, vol. 127, http://dx.doi.org/10.1016/j.biocel.2020.105834
    Journal articles | 2020
    Schömel N; Geisslinger G; Wegner MS, 2020, 'Influence of glycosphingolipids on cancer cell energy metabolism', Progress in Lipid Research, vol. 79, http://dx.doi.org/10.1016/j.plipres.2020.101050
    Journal articles | 2020
    Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, vol. 10, pp. 8182, http://dx.doi.org/10.1038/s41598-020-65182-y
    Journal articles | 2019
    Kurz J; Barthelmes J; Blum L; Ulshöfer T; Wegner M-S; Ferreirós N; Roser L; Geisslinger G; Grösch S; Schiffmann S, 2019, 'Role of ceramide synthase 2 in G-CSF signaling and G-CSF-R translocation into detergent-resistant membranes.', Sci Rep, vol. 9, pp. 747, http://dx.doi.org/10.1038/s41598-018-37342-8
    Journal articles | 2019
    Wegner M-S; Gruber L; Schömel N; Trautmann S; Brachtendorf S; Fuhrmann D; Schreiber Y; Olesch C; Brüne B; Geisslinger G; Grösch S, 2019, 'GPER1 influences cellular homeostasis and cytostatic drug resistance via influencing long chain ceramide synthesis in breast cancer cells.', Int J Biochem Cell Biol, vol. 112, pp. 95 - 106, http://dx.doi.org/10.1016/j.biocel.2019.05.002
    Journal articles | 2019
    Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, vol. 9, pp. 15665, http://dx.doi.org/10.1038/s41598-019-52169-7
    Journal articles | 2018
    Wegner MS; Schömel N; Gruber L; Örtel SB; Kjellberg MA; Mattjus P; Kurz J; Trautmann S; Peng B; Wegner M; Kaulich M; Ahrends R; Geisslinger G; Grösch S, 2018, 'UDP-glucose ceramide glucosyltransferase activates AKT, promoted proliferation, and doxorubicin resistance in breast cancer cells', Cellular and Molecular Life Sciences, vol. 75, pp. 3393 - 3410, http://dx.doi.org/10.1007/s00018-018-2799-7
    Journal articles | 2018
    Brachtendorf S; Wanger RA; Birod K; Thomas D; Trautmann S; Wegner M-S; Fuhrmann DC; Brüne B; Geisslinger G; Grösch S, 2018, 'Chemosensitivity of human colon cancer cells is influenced by a p53-dependent enhancement of ceramide synthase 5 and induction of autophagy.', Biochim Biophys Acta Mol Cell Biol Lipids, vol. 1863, pp. 1214 - 1227, http://dx.doi.org/10.1016/j.bbalip.2018.07.011
    Journal articles | 2018
    Wegner M-S; Gruber L; Mattjus P; Geisslinger G; Grösch S, 2018, 'The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1).', BMC Cancer, vol. 18, pp. 153, http://dx.doi.org/10.1186/s12885-018-4084-4
    Journal articles | 2017
    Oertel S; Scholich K; Weigert A; Thomas D; Schmetzer J; Trautmann S; Wegner M-S; Radeke HH; Filmann N; Brüne B; Geisslinger G; Tegeder I; Grösch S, 2017, 'Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.', Cell Mol Life Sci, vol. 74, pp. 3039 - 3055, http://dx.doi.org/10.1007/s00018-017-2518-9
    Journal articles | 2016
    Wegner M-S; Schiffmann S; Parnham MJ; Geisslinger G; Grösch S, 2016, 'The enigma of ceramide synthase regulation in mammalian cells.', Prog Lipid Res, vol. 63, pp. 93 - 119, http://dx.doi.org/10.1016/j.plipres.2016.03.006
    Journal articles | 2016
    Wobst I; Ebert L; Birod K; Wegner M-S; Hoffmann M; Thomas D; Angioni C; Parnham MJ; Steinhilber D; Tegeder I; Geisslinger G; Grösch S, 2016, 'R-Flurbiprofen Traps Prostaglandins within Cells by Inhibition of Multidrug Resistance-Associated Protein-4.', Int J Mol Sci, vol. 18, http://dx.doi.org/10.3390/ijms18010068
    Journal articles | 2014
    Wegner M-S; Wanger RA; Oertel S; Brachtendorf S; Hartmann D; Schiffmann S; Marschalek R; Schreiber Y; Ferreirós N; Geisslinger G; Grösch S, 2014, 'Ceramide synthases CerS4 and CerS5 are upregulated by 17β-estradiol and GPER1 via AP-1 in human breast cancer cells.', Biochem Pharmacol, vol. 92, pp. 577 - 589, http://dx.doi.org/10.1016/j.bcp.2014.10.007
    Journal articles | 2014
    Eberle M; Ebel P; Wegner M-S; Männich J; Tafferner N; Ferreiros N; Birod K; Schreiber Y; Krishnamoorthy G; Willecke K; Geisslinger G; Grösch S; Schiffmann S, 2014, 'Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.', Biochem Pharmacol, vol. 92, pp. 326 - 335, http://dx.doi.org/10.1016/j.bcp.2014.08.016
    Journal articles | 2013
    Hartmann D; Wegner M-S; Wanger RA; Ferreirós N; Schreiber Y; Lucks J; Schiffmann S; Geisslinger G; Grösch S, 2013, 'The equilibrium between long and very long chain ceramides is important for the fate of the cell and can be influenced by co-expression of CerS.', Int J Biochem Cell Biol, vol. 45, pp. 1195 - 1203, http://dx.doi.org/10.1016/j.biocel.2013.03.012
    Journal articles | 2013
    Schiffmann S; Birod K; Männich J; Eberle M; Wegner M-S; Wanger R; Hartmann D; Ferreiros N; Geisslinger G; Grösch S, 2013, 'Ceramide metabolism in mouse tissue.', Int J Biochem Cell Biol, vol. 45, pp. 1886 - 1894, http://dx.doi.org/10.1016/j.biocel.2013.06.004
  • Preprints |
    Hahnefeld L; Gruber L; Schömel N; Fischer C; Mattjus P; Gurke R; Beretta M; Ferreirós N; Geisslinger G; Wegner M-S, Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells, http://dx.doi.org/10.1101/2020.07.20.212894
    Preprints |
    Byrne F; Olzomer E; Lolies N; Hoehn KL; Wegner M-S, Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma, http://dx.doi.org/10.20944/preprints202203.0309.v1
    Preprints |
    Wegner M-S; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells, http://dx.doi.org/10.21203/rs.3.rs-454533/v1

hormone-dependent regulation of sphingolipid metabolism enzymes in breast cancer cells, glycosphingolipids and their impact on cell energy metabolism in breast and liver cancer cells, multidrug resistance development in cancer cells