Dr Mykola Pinkevych

Post-Doc Res Fellow (UNSW)

BSc in Applied Mathematics from Kyiv National Taras Shevchenko University, Kyiv Ukraine
MSc in Social Informatics from Kyiv National Taras Shevchenko University, Kyiv Ukraine.
PhD in pathology from the University of New South Wales at School of Medical Sciences.

Medicine & Health

The Kirby Institute

During my undergraduate study, I learned numerous mathematical and computing method. My Master’s degree course taught to apply these skills for analysis of social, ecological and biological processes. During my PhD candidature, I gained the experience of using mathematical and computing methods for the analysis of complex experimental data predominantly of malaria. Currently, I work as a postdoctoral research fellow at Kirby Institute, UNSW in the Infection Analytics Program studying the dynamics of HIV infection.

Phone

+61 (02)9385 0900

E-mail

mpinkevych@kirby.unsw.edu.au

Journal articles | 2024

Keele BF; Okoye AA; Fennessey CM; Varco-Merth B; Immonen TT; Kose E; Conchas A; Pinkevych M; Lipkey L; Newman L; MacAiran A; Bosche M; Bosche WJ; Berkemeier B; Fast R; Hull M; Oswald K; Shoemaker R; Silipino L; Gorelick RJ; Duell D; Marenco A; Brantley W; Smedley J; Axthelm M; Davenport MP; Lifson JD; Picker LJ, 2024, 'Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir', PLoS Pathogens, 20, pp. e1012135, http://dx.doi.org/10.1371/journal.ppat.1012135

Journal articles | 2023

Docken SS; McCormick K; Pampena MB; Samer S; Lindemuth E; Pinkevych M; Viox EG; Wu Y; Schlub TE; Cromer D; Keele BF; Paiardini M; Betts MR; Bar KJ; Davenport MP, 2023, 'Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency', PLoS Pathogens, 19, pp. e1011755, http://dx.doi.org/10.1371/journal.ppat.1011755

Journal articles | 2023

Pinkevych M; Docken SS; Okoye AA; Fennessey CM; Del Prete GQ; Pino M; Harper JL; Betts MR; Paiardini M; Keele BF; Davenport MP, 2023, 'Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication', PLoS Pathogens, 19, pp. e1011660, http://dx.doi.org/10.1371/journal.ppat.1011660

Journal articles | 2023

Statzu M; Jin W; Fray EJ; Wong AKH; Kumar MR; Ferrer E; Docken SS; Pinkevych M; McBrien JB; Fennessey CM; Keele BF; Liang S; Harper JL; Mutascio S; Franchitti L; Wang H; Cicetti D; Bosinger SE; Carnathan DG; Vanderford TH; Margolis DM; Garcia-Martinez JV; Chahroudi A; Paiardini M; Siliciano J; Davenport MP; Kulpa DA; Siliciano RS; Silvestri G, 2023, 'CD8+ lymphocytes do not impact SIV reservoir establishment under ART', Nature Microbiology, 8, pp. 299 - 308, http://dx.doi.org/10.1038/s41564-022-01311-9

Journal articles | 2022

2022, 'PP 2.3 – 00034 CD8+ T-Cell Sieving During SIV Reactivation from Latency', Journal of Virus Eradication, 8, pp. 100159 - 100159, http://dx.doi.org/10.1016/j.jve.2022.100159

Journal articles | 2021

Okoye AA; Duell DD; Fukazawa Y; Varco-Merth B; Marenco A; Behrens H; Chaunzwa M; Selseth AN; Gilbride RM; Shao J; Edlefsen PT; Geleziunas R; Pinkevych M; Davenport MP; Busman-Sahay K; Nekorchuk M; Park H; Smedley J; Axthelm MK; Estes JD; Hansen SG; Keele BF; Lifson JD; Picker LJ, 2021, 'CD8⁺T cells fail to limit SIV reactivation following ART withdrawal until after viral amplification', Journal of Clinical Investigation, 131, http://dx.doi.org/10.1172/JCI141677

Journal articles | 2020

Wu Y; Pinkevych M; Xu Z; Keele BF; Davenport MP; Cromer D, 2020, 'Impact of fluctuation in frequency of human immunodeficiency virus/simian immunodeficiency virus reactivation during antiretroviral therapy interruption', Proceedings of the Royal Society B: Biological Sciences, 287, http://dx.doi.org/10.1098/rspb.2020.0354

Journal articles | 2019

Pinkevych M; Fennessey CM; Cromer D; Reid C; Trubey CM; Lifson JD; Keele BF; Davenport MP, 2019, 'Predictors of SIV recrudescence following antiretroviral treatment interruption', eLife, 8, pp. e49022, http://dx.doi.org/10.7554/eLife.49022

Journal articles | 2018

Pinkevych M; Fennessey CM; Cromer D; Tolstrup M; Søgaard OS; Rasmussen TA; Keele BF; Davenport MP, 2018, 'Estimating initial viral levels during simian immunodeficiency virus/human immunodeficiency virus reactivation from latency', Journal of Virology, 92, pp. 10.1128/jvi.01667 - 10.1128/jvi.01617, http://dx.doi.org/10.1128/JVI.01667-17

Journal articles | 2017

Cromer D; Pinkevych M; Rasmussen TA; Lewin SR; Kent SJ; Davenport MP, 2017, 'Modeling of antilatency treatment in HIV: What is the optimal duration of antiretroviral therapy-free HIV remission?', Journal of Virology, 91, pp. 10.1128/jvi.01395 - 10.1128/jvi.01317, http://dx.doi.org/10.1128/JVI.01395-17

Journal articles | 2017

Fennessey CM; Pinkevych M; Immonen TT; Reynaldi A; Venturi V; Nadella P; Reid C; Newman L; Lipkey L; Oswald K; Bosche WJ; Trivett MT; Ott DE; Estes JD; Del Prete GQ; Lifson JD; Davenport MP; Keele BF, 2017, 'Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy', PLoS Pathogens, 13, pp. e1006359, http://dx.doi.org/10.1371/journal.ppat.1006359

Journal articles | 2016

, 2016, 'Oral abstracts of the 21st International AIDS Conference 18-22 July 2016, Durban, South Africa.', J Int AIDS Soc, 19, pp. 21264, http://dx.doi.org/10.7448/IAS.19.6.21264

Journal articles | 2016

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2016, 'Erratum: HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days-Implications for HIV Remission (PLoS Pathogens (2015) 11:7 (e1005000) DOI: 10.1371/journal.ppat.1005000)', PLoS Pathogens, 12, pp. e1005745, http://dx.doi.org/10.1371/journal.ppat.1005745

Journal articles | 2016

Pinkevych M; Kent SJ; Tolstrup M; Lewin SR; Cooper DA; Søgaard OS; Rasmussen TA; Kelleher AD; Cromer D; Davenport MP, 2016, 'Modeling of Experimental Data Supports HIV Reactivation from Latency after Treatment Interruption on Average Once Every 5–8 Days', PLoS Pathogens, 12, pp. e1005740, http://dx.doi.org/10.1371/journal.ppat.1005740

Journal articles | 2016

Pinkevych M; Reynaldi A; Fennessey C; Reid C; Nadella P; Lipkey L; Newman L; Ayala V; Jain S; Del Prete G; Estes J; Ott D; Lifson J; Ohlen C; Keele B; Davenport M, 2016, 'OA2-1 Frequent and ‘burst-like’ reactivation from latency in SIVmac239M infected macaques', Journal of Virus Eradication, 2, pp. 2 - 2, http://dx.doi.org/10.1016/s2055-6640(20)31008-6

Journal articles | 2015

Adekunle AI; Pinkevych M; McGready R; Luxemburger C; White LJ; Nosten F; Cromer D; Davenport MP, 2015, 'Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo', PLoS Neglected Tropical Diseases, 9, pp. e0003595, http://dx.doi.org/10.1371/journal.pntd.0003595

Journal articles | 2015

Liehl P; Meireles P; Albuquerque IS; Pinkevych M; Baptista F; Mota MM; Davenport MP; Prudêncio M, 2015, 'Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections', Infection and Immunity, 83, pp. 1172 - 1180, http://dx.doi.org/10.1128/IAI.02796-14

Journal articles | 2015

Pinkevych M; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2015, 'Time-to-infection by Plasmodium falciparum is largely determined by random factors', BMC Medicine, 13, pp. 19, http://dx.doi.org/10.1186/s12916-014-0252-9

Journal articles | 2015

Pinkevych M; Cromer D; Tolstrup M; Grimm AJ; Cooper DA; Lewin SR; Søgaard OS; Rasmussen TA; Kent SJ; Kelleher AD; Davenport MP, 2015, 'HIV Reactivation from Latency after Treatment Interruption Occurs on Average Every 5-8 Days—Implications for HIV Remission', PLoS Pathogens, 11, pp. e1005000, http://dx.doi.org/10.1371/journal.ppat.1005000

Journal articles | 2015

Pinkevych M; Petravic J; Bereczky S; Rooth I; Färnert A; Davenport MP, 2015, 'Understanding the relationship between plasmodium falciparum growth rate and multiplicity of infection', Journal of Infectious Diseases, 211, pp. 1121 - 1127, http://dx.doi.org/10.1093/infdis/jiu561

Journal articles | 2014

Pinkevych M; Petravic J; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2014, 'Decreased growth rate of P. falciparum blood stage parasitemia with age in a holoendemic population', Journal of Infectious Diseases, 209, pp. 1136 - 1143, http://dx.doi.org/10.1093/infdis/jit613

Journal articles | 2013

Freeman MW; Burkum CE; Lanzer KG; Roberts AJ; Pinkevych M; Davenport MP; Kummer LW; Szaba FM; Woodland DL; Smiley ST, 2013, 'Gammaherpesvirus latency induces antibody-associated thrombocytopenia in mice', Journal of Autoimmunity, 42, pp. 71 - 79, http://dx.doi.org/10.1016/j.jaut.2012.11.005

Journal articles | 2013

Pinkevych M; Petravic J; Chelimo K; Vulule J; Kazura JW; Moormann AM; Davenport MP, 2013, 'Density-dependent blood stage Plasmodium falciparum suppresses malaria super-infection in a malaria holoendemic population', American Journal of Tropical Medicine and Hygiene, 89, pp. 850 - 856, http://dx.doi.org/10.4269/ajtmh.13-0049

Journal articles | 2012

Pinkevych M; Petravic J; Chelimo K; Kazura J; Moormann A; Davenport MP, 2012, 'The Dynamics of Naturally Acquired Immunity to Plasmodium falciparum Infection', PLoS Computational Biology, 8, pp. Article number e1002729, http://dx.doi.org/10.1371/journal.pcbi.1002729

Journal articles | 2010

Liang SX; Pinkevych M; Khachigian LM; Parish CR; Davenport MP; Chong BH, 2010, 'Drug-induced thrombocytopenia (DITP): development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG', Blood, 116, pp. 1958 - 1960
Conference Posters | 2022

Docken S; McCormick K; Pampena M; Pinkevych M; Viox E; Keele B; Paiardini M; Betts M; Bar K; Davenport M; Samer S; Cromer D; Schlub T, 2022, 'PP 2.3 – 00034 CD8+ T-Cell Sieving During SIV Reactivation from Latency', Vol. 8, pp. 100159 - 100159, http://dx.doi.org/10.1016/j.jve.2022.100159

Conference Abstracts | 2022

Keele B; Okoye A; Immonen T; Pinkevych M; Fennessey C; Varco-Merth B; Davenport M; Lifson J; Picker L, 2022, 'Early antiretroviral therapy in SIV-infected rhesus macaques reveals a highly dynamic accumulation of the rebound competent viral reservoir', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, Vol. 51, pp. 303 - 303, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100032&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2022

Lau JSY; Cromer D; Pinkevych M; Lewin SR; Rasmussen TA; McMahon JH; Davenport MP, 2022, 'Balancing Statistical Power and Risk in HIV Cure Clinical Trial Design', in Journal of Infectious Diseases, pp. 236 - 245, http://dx.doi.org/10.1093/infdis/jiac032

Conference Papers | 2022

Statzu M; Wong A; McBrien J; Choe Y; Enemuo C; Ngo J; Jimenez L; Wang J; Pinkevych M; Docken S; Davenport M; Keele B; Vanderford T; Paiardini M; Silvestri G; Kulpa D, 2022, 'CD8(+) T cell depletion does not affect viral reservoir size, but influences the rebound after ART interruption in SIV-infected rhesus macaques', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, pp. 323 - 324, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100075&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2022

Viox E; Samer S; Nguyen K; Docken S; Lindemuth E; Mampe F; Pinkevych M; Keele B; Betts M; Davenport M; Paiardini M; Bar K, 2022, 'Impact of CD4 binding-site bNAb therapy on viral rebound in barcoded TF-SHIV-D-infected rhesus macaques at ATI', in JOURNAL OF MEDICAL PRIMATOLOGY, WILEY, Vol. 51, pp. 301 - 302, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000852720100028&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Papers | 2018

Okoye A; Duell D; Maxwel A; Brantley W; Marenco A; Lidell M; Behrens H; Selseth A; Varco-Merth B; Smedley J; Hesselgesser J; Geleziunas R; Pinkevych M; Davenport M; Axthelm M; Hansen S; Deeks S; Keele B; Lifson J; Picker L, 2018, 'CD8+T Cells Do Not Control SIV Replication During ART or Viral Relapse After ART Withdrawal', in AIDS RESEARCH AND HUMAN RETROVIRUSES, MARY ANN LIEBERT, INC, SPAIN, Madrid, pp. 33 - 33, presented at HIV Research for Prevention Meeting (HIVR4P) - AIDS Vaccine, Microbicide and ARV-Based Prevention Science, SPAIN, Madrid, 21 October 2018 - 25 October 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000448371600042&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2017

Fennessey C; Pinkevych M; Immonen T; Camus C; Del Prete G; Estes J; Lifson J; Davenport M; Keele B, 2017, 'Assessing individual viral reactivations of the latent reservoir using a novel barcoded virus', in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, JOHN WILEY & SONS LTD, Vol. 20, pp. 1 - 1, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000406429800002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Adekunle AI; Pinkevych M; Cromer D; Davenport MP, 2016, 'UNDERSTANDING THE MECHANISM OF PLASMODIUM VIVAX HYPNOZOITES REACTIVATION', in AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, AMER SOC TROP MED & HYGIENE, GA, Atlanta, Vol. 95, pp. 115 - 115, presented at 65th Annual Meeting of the American-Society-of-Tropical-Medicine-and-Hygiene (ASTMH), GA, Atlanta, 13 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000412851501369&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

Conference Abstracts | 2016

Pinkevych M; Reynaldi A; Fennessey C; Reid C; Nadella P; Lipkey L; Newman L; Ayala V; Jain S; Del Prete G; Estes J; Ott D; Lifson J; Ohlen C; Keele B; Davenport M, 2016, 'Frequent and "burst-like'' reactivation from latency in SIVmac239M infected macaques', in JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, JOHN WILEY & SONS LTD, Vol. 19, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000395394300134&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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Dr Mykola Pinkevych