Dr Omid Faridani
Post-Doc Res Fellow (UNSW)

Dr Omid Faridani

Medicine & Health
School of Medical Sciences

Dr Faridani is interested in developing single-cell transcriptomic technologies to characterise circulating tumour cells (CTCs). CTCs are diverse cells in the form of single cells or cell clusters that are released by solid tumours into the circulation (blood circulation and lymphatic system). CTCs can be used as a liquid biopsy to obtain information from tumours in a minimally invasive way. He aims to investigate whether CTC can potentially serve as a predictive/prognostic biomarker in solid cancers. 

Dr Faridani completed his PhD at the Karolinska Institute in Sweden where he studied the biology of natural antisense RNAs. Then, he moved to the lab of professor Rickard Sandberg at Ludwig Institute for Cancer Research as a postdoc to develop single-cell sequencing technologies. Later, he worked as a senior scientist at the Karolinska/AstraZeneca Integrated Cardiometabolic Center. Here, at UNSW, Dr Faridani a group leader at the Lowy Cancer Research Centre at the Adult Cancer Program. He is also a group leader at the Garvan Institute of Medical Research.
Phone
+61293858796
E-mail
o.faridani@unsw.edu.au
  • Journal articles | 2022
    Von Grothusen C; Frisendahl C; Modhukur V; Lalitkumar PG; Peters M; Faridani OR; Salumets A; Boggavarapu NR; Gemzell-Danielsson K, 2022, 'Uterine fluid microRNAs are dysregulated in women with recurrent implantation failure', Human Reproduction, vol. 37, pp. 734 - 746, http://dx.doi.org/10.1093/humrep/deac019
    Journal articles | 2021
    Godakumara K; Ord J; Lättekivi F; Dissanayake K; Viil J; Boggavarapu NR; Faridani OR; Jääger K; Velthut-Meikas A; Jaakma Ü; Salumets A; Fazeli A, 2021, 'Trophoblast derived extracellular vesicles specifically alter the transcriptome of endometrial cells and may constitute a critical component of embryo-maternal communication', Reproductive Biology and Endocrinology, vol. 19, pp. 115, http://dx.doi.org/10.1186/s12958-021-00801-5
    Journal articles | 2021
    Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Han Y; James T; Khademi M; Al Nimer F; Scicluna P; Huang J; Kockum I; Faridani OR; Olsson T; Piehl F; Jagodic M, 2021, 'Small noncoding RNA profiling across cellular and biofluid compartments and their implications for multiple sclerosis immunopathology', Proceedings of the National Academy of Sciences of the United States of America, vol. 118, http://dx.doi.org/10.1073/pnas.2011574118
    Journal articles | 2020
    Hagemann-Jensen M; Ziegenhain C; Chen P; Ramsköld D; Hendriks GJ; Larsson AJM; Faridani OR; Sandberg R, 2020, 'Single-cell RNA counting at allele and isoform resolution using Smart-seq3', Nature Biotechnology, vol. 38, pp. 708 - 714, http://dx.doi.org/10.1038/s41587-020-0497-0
    Journal articles | 2020
    Ramsköld D; Luo S; Wang YC; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R, 2020, 'Author Correction: Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells (Nature Biotechnology, (2012), 30, 8, (777-782), 10.1038/nbt.2282)', Nature Biotechnology, vol. 38, pp. 374, http://dx.doi.org/10.1038/s41587-020-0427-1
    Journal articles | 2020
    Zheleznyakova GY; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Khademi M; Nimer FA; Scicluna P; Faridani O; Olsson T; Piehl F; Jagodic M, 2020, 'Profiling of small non-coding RNAs across cellular and biofluid compartments: implications for multiple sclerosis immunopathology', , http://dx.doi.org/10.1101/2020.05.15.097519
    Journal articles | 2019
    Larsson AJM; Johnsson P; Hagemann-Jensen M; Hartmanis L; Faridani OR; Reinius B; Segerstolpe Å; Rivera CM; Ren B; Sandberg R, 2019, 'Genomic encoding of transcriptional burst kinetics', Nature, vol. 565, pp. 251 - 254, http://dx.doi.org/10.1038/s41586-018-0836-1
    Journal articles | 2018
    Hagemann-Jensen M; Abdullayev I; Sandberg R; Faridani OR, 2018, 'Small-seq for single-cell small-RNA sequencing', Nature Protocols, vol. 13, pp. 2407 - 2424, http://dx.doi.org/10.1038/s41596-018-0049-y
    Journal articles | 2016
    Faridani OR; Abdullayev I; Hagemann-Jensen M; Schell JP; Lanner F; Sandberg R, 2016, 'Single-cell sequencing of the small-RNA transcriptome', Nature Biotechnology, vol. 34, pp. 1264 - 1266, http://dx.doi.org/10.1038/nbt.3701
    Journal articles | 2016
    Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalen M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson P-O; Hagglund H; Mattsson M; Lehtio J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo K-H; Le Blanc K, 2016, 'In Vivo Effects of Mesenchymal Stromal Cells in Two Patients With Severe Acute Respiratory Distress Syndrome (vol 4, pg 1199, 2015)', STEM CELLS TRANSLATIONAL MEDICINE, vol. 5, pp. 845 - 845, http://dx.doi.org/10.5966/sctm.2015-0021erratum
    Journal articles | 2015
    Faridani OR; Sandberg R, 2015, 'Putting cells in their place', Nature biotechnology, vol. 33, pp. 490 - 491, http://dx.doi.org/10.1038/nbt.3219
    Journal articles | 2015
    Simonson OE; Mougiakakos D; Heldring N; Bassi G; Johansson HJ; Dalén M; Jitschin R; Rodin S; Corbascio M; El Andaloussi S; Wiklander OPB; Nordin JZ; Skog J; Romain C; Koestler T; Hellgren-Johansson L; Schiller P; Joachimsson PO; Hägglund H; Mattiasmattsson M; Lehtiö J; Faridani OR; Sandberg R; Korsgren O; Krampera M; Weiss DJ; Grinnemo KH; Le Blanc K, 2015, 'In vivo effects of mesenchymal stromal cells in two patients with severe acute respiratory distress syndrome', Stem Cells Translational Medicine, vol. 4, pp. 1199 - 1213, http://dx.doi.org/10.5966/sctm.2015-0021
    Journal articles | 2014
    Callegari S; Gastaldello S; Faridani OR; Masucci MG, 2014, 'Epstein-Barr virus encoded microRNAs target SUMO-regulated cellular functions', FEBS Journal, vol. 281, pp. 4935 - 4950, http://dx.doi.org/10.1111/febs.13040
    Journal articles | 2014
    Picelli S; Faridani OR; Björklund AK; Winberg G; Sagasser S; Sandberg R, 2014, 'Full-length RNA-seq from single cells using Smart-seq2', Nature Protocols, vol. 9, pp. 171 - 181, http://dx.doi.org/10.1038/nprot.2014.006
    Journal articles | 2013
    Picelli S; Björklund AK; Faridani OR; Sagasser S; Winberg G; Sandberg R, 2013, 'Smart-seq2 for sensitive full-length transcriptome profiling in single cells', Nature Methods, vol. 10, pp. 1096 - 1100, http://dx.doi.org/10.1038/nmeth.2639
    Journal articles | 2012
    Ramsköld D; Luo S; Wang YC; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R, 2012, 'Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells', Nature Biotechnology, vol. 30, pp. 777 - 782, http://dx.doi.org/10.1038/nbt.2282
    Journal articles | 2011
    Arefian E; Kiani J; Soleimani M; Shariati SAM; Aghaee-Bakhtiari SH; Atashi A; Gheisari Y; Ahmadbeigi N; Banaei-Moghaddam AM; Naderi M; Namvarasl N; Good L; Faridani OR, 2011, 'Analysis of microRNA signatures using size-coded ligation-mediated PCR', Nucleic Acids Research, vol. 39, http://dx.doi.org/10.1093/nar/gkr214
    Journal articles | 2010
    Gastaldello S; Hildebrand S; Faridani O; Callegari S; Palmkvist M; Di Guglielmo C; Masucci MG, 2010, 'A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases', Nature Cell Biology, vol. 12, pp. 351 - 361, http://dx.doi.org/10.1038/ncb2035
    Journal articles | 2008
    Faridani OR; Mcinerney GM; Gradin K; Good L, 2008, 'Specific ligation to double-stranded RNA for analysis of cellular RNA::RNA interactions', Nucleic Acids Research, vol. 36, http://dx.doi.org/10.1093/nar/gkn445
    Journal articles | 2007
    Nikravesh A; Dryselius R; Faridani OR; Goh S; Sadeghizadeh M; Behmanesh M; Ganyu A; Klok EJ; Zain R; Good L, 2007, 'Antisense PNA accumulates in Escherichia coli and mediates a long post-antibiotic effect', Molecular Therapy, vol. 15, pp. 1537 - 1542, http://dx.doi.org/10.1038/sj.mt.6300209
    Journal articles | 2006
    Faridani OR; Nikravesh A; Pandey DP; Gerdes K; Good L, 2006, 'Competitive inhibition of natural antisense Sok-RNA interactions activates Hok-mediated cell killing in Escherichia coli', Nucleic Acids Research, vol. 34, pp. 5915 - 5922, http://dx.doi.org/10.1093/nar/gkl750
  • Conference Abstracts | 2020
    Zheleznyakova G; Piket E; Needhamsen M; Hagemann-Jensen M; Ekman D; Khademi M; Al Nimer F; Scicluna P; Faridani O; Olsson T; Piehl F; Jagodic M, 2020, 'Profiling of small non-coding rnas across cellular and biofluid compartments in patients with multiple sclerosis', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, ELECTR NETWORK, Vol. 26, pp. 183 - 184, presented at 8th Joint ACTRIMS-ECTRIMS Meeting (MSVirtual), ELECTR NETWORK, 11 September 2020 - 13 September 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000596547100364&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2019
    Hagemann-Jensen M; Ziegenhain C; Chen P; Ramsköld D; Hendriks G-J; Larsson AJM; Faridani O; Sandberg R, 2019, Single-cell RNA counting at allele- and isoform-resolution using Smart-seq3, http://dx.doi.org/10.1101/817924
    Conference Abstracts | 2019
    Zheleznyakova G; Piket E; Needhamsen M; Hagemann-Jensen M; Faridani O; Marabita F; Khademi M; Piehl F; Olsson T; Jagodic M, 2019, 'Genome-wide small-noncoding RNA analysis in patients with multiple sclerosis', in MULTIPLE SCLEROSIS JOURNAL, SAGE PUBLICATIONS LTD, Stockholm, SWEDEN, Vol. 25, pp. 726 - 726, presented at 35th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS) / 24th Annual Conference of Rehabilitation in MS, Stockholm, SWEDEN, 11 September 2019 - 13 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000485303103126&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints |
    Schnegg-Kaufmann A; Thoms JAI; Bhuyan GS; Hampton HR; Vaughan L; Rutherford K; Kakadia PM; Johansson EMV; Failes T; Arndt GM; Koval J; Lindeman R; Warburton P; Rodriguez-Meira A; Mead AJ; Unnikrishnan A; Bohlander SK; Papaemmanuil E; Faridani O; Jolly CJ; Zanini F; Pimanda JE, Single cell genotyping of matched bone marrow and peripheral blood cells in treatment naive and AZA-treated MDS and CMML, http://dx.doi.org/10.1101/2022.01.20.476890

I have received the 2019 Pathfinders Award for the work of developing a device that enriches CTCs from the blood of cancer patients. 

For more information please visit www.faridanilab.com.