Dr Paul   Ekert
Conjoint Associate Professor

Dr Paul Ekert

MB.BS, PhD, FRACP, FFS(Research)(RCPA)

medicine-health
Sch Women's&Children's Health

I am a clinician scientist, with 25 years experience as a consultant paediatrician and oncology research. I am appointed at the Children’s Cancer Institute, to lead the Translational Tumour Biology group, and cross-appointed at the Peter MacCallum Cancer Centre and Murdoch Children’s Research Institute (MCRI) to drive collaborative projects that link basic research with the discovery of novel therapeutic targets and genetic understanding of paediatric cancers.

In 2014 I was appointed as Group Leader of Cancer Research at The Murdoch Children’s Research Institute. I built a new molecular cancer research program linked to the clinical service, with 2 overarching aims. The first was to establish a research program of RNA sequencing of patient samples, focused primarily but not exclusively, on childhood Acute lymphoblastic Leukaemia.  I used RNA-sequencing as a tool to discover the driving genetic lesions, which were then modelled to explore their biology. The second aim was, as a lead investigator in the national and local initiatives in paediatric personalised medicine, to make these precision medicine trials available to the paediatric cancer population, and to expand our research portfolio to encompass cancer genomics in paediatric oncology.

In 2019 I took up a role as a Group Leader at the Children’s Cancer Institute (CCI), with cross-appointments at the Peter MacCallum Cancer and Murdoch Children’s Research Institute. I lead the Translational Tumour Biology group which explores the molecular biology and therapeutic targeting of genomic discoveries from the Zero Childhood Cancer patient cohort – the national child cancer personalized medicine program. This involves the development of models to investigate the functional molecular consequences of the genetic changes found in the patients, and to determine how they might best be therapeutically targeted.

Phone
02 9385197
Location
Children's Cancer Institute, Lowy Cancer Research Centre

Publications

  • Book Chapters | 2007
    Dr Paul Ekert
    Yu JY; Silke J; Ekert PG, 2007, 'Inhibitor of apoptosis proteins and caspases', in Apoptosis, Cell Signaling, and Human Diseases, pp. 313 - 334, http://dx.doi.org/10.1007/978-1-59745-199-4_15
  • Journal articles | 2021
    Dr Paul Ekert
    Nagabushan S; Lau LMS; Barahona P; Wong M; Sherstyuk A; Marshall GM; Tyrrell V; Wegner EA; Ekert PG; Cowley MJ; Mayoh C; Trahair TN; Crowe P; Anazodo A; Ziegler DS, 2021, 'Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor', NPJ PRECISION ONCOLOGY, vol. 5, http://dx.doi.org/10.1038/s41698-021-00145-8
    Journal articles | 2020
    Dr Paul Ekert
    Wong M; Mayoh C; Lau LMS; Khuong-Quang DA; Pinese M; Kumar A; Barahona P; Wilkie EE; Sullivan P; Bowen-James R; Syed M; Martincorena I; Abascal F; Sherstyuk A; Bolanos NA; Baber J; Priestley P; Dolman MEM; Fleuren EDG; Gauthier ME; Mould EVA; Gayevskiy V; Gifford AJ; Grebert-Wade D; Strong PA; Manouvrier E; Warby M; Thomas DM; Kirk J; Tucker K; O’Brien T; Alvaro F; McCowage GB; Dalla-Pozza L; Gottardo NG; Tapp H; Wood P; Khaw SL; Hansford JR; Moore AS; Norris MD; Trahair TN; Lock RB; Tyrrell V; Haber M; Marshall GM; Ziegler DS; Ekert PG; Cowley MJ, 2020, 'Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer', Nature Medicine, vol. 26, pp. 1742 - 1753, http://dx.doi.org/10.1038/s41591-020-1072-4
    Journal articles | 2020
    Dr Paul Ekert
    Brown LM; Lonsdale A; Zhu A; Davidson NM; Schmidt B; Hawkins A; Wallach E; Martin M; Mechinaud FM; Khaw SL; Bartolo RC; Ludlow LEA; Challis J; Brooks I; Petrovic V; Venn NC; Sutton R; Majewski IJ; Oshlack A; Ekert PG, 2020, 'The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia', Blood Advances, vol. 4, pp. 930 - 942, http://dx.doi.org/10.1182/bloodadvances.2019001008
    Journal articles | 2020
    Dr Paul Ekert
    Chen CCL; Deshmukh S; Jessa S; Hadjadj D; Lisi V; Andrade AF; Faury D; Jawhar W; Dali R; Suzuki H; Pathania M; A D; Dubois F; Woodward E; Hébert S; Coutelier M; Karamchandani J; Albrecht S; Brandner S; De Jay N; Gayden T; Bajic A; Harutyunyan AS; Marchione DM; Mikael LG; Juretic N; Zeinieh M; Russo C; Maestro N; Bassenden AV; Hauser P; Virga J; Bognar L; Klekner A; Zapotocky M; Vicha A; Krskova L; Vanova K; Zamecnik J; Sumerauer D; Ekert PG; Ziegler DS; Ellezam B; Filbin MG; Blanchette M; Hansford JR; Khuong-Quang DA; Berghuis AM; Weil AG; Garcia BA; Garzia L; Mack SC; Beroukhim R; Ligon KL; Taylor MD; Bandopadhayay P; Kramm C; Pfister SM; Korshunov A; Sturm D; Jones DTW; Salomoni P; Kleinman CL; Jabado N, 2020, 'Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis', Cell, vol. 183, pp. 1617 - 1633.e22, http://dx.doi.org/10.1016/j.cell.2020.11.012
    Journal articles | 2020
    Dr Paul Ekert
    Whitehouse JP; Howlett M; Hii H; Mayoh C; Wong M; Barahona P; Ajuyah P; White CL; Buntine MK; Dyke JM; Lee S; Valvi S; Stanley J; Andradas C; Carline B; Kuchibhotla M; Ekert PG; Cowley MJ; Gottardo NG; Endersby R, 2020, 'A novel orthotopic patient-derived xenograft model of radiation-induced glioma following medulloblastoma', Cancers, vol. 12, pp. 1 - 24, http://dx.doi.org/10.3390/cancers12102937
    Journal articles | 2020
    Dr Paul Ekert
    Khuong-Quang DA; Brown LM; Wong M; Mayoh C; Sexton-Oates A; Kumar A; Pinese M; Nagabushan S; Lau L; Ludlow LE; Gifford AJ; Rodriguez M; Desai J; Fox SB; Haber M; Ziegler DS; Hansford JR; Marshall GM; Cowley MJ; Ekert PG, 2020, 'Recurrent SPECC1L–NTRK fusions in pediatric sarcoma and brain tumors', Cold Spring Harbor Molecular Case Studies, vol. 6, http://dx.doi.org/10.1101/MCS.A005710
    Journal articles | 2020
    Dr Paul Ekert
    Cmero M; Schmidt B; Majewski I; Ekert P; Oshlack A; Davidson N, 2020, 'MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data', , http://dx.doi.org/10.1101/2020.06.03.131532
    Journal articles | 2020
    Dr Paul Ekert
    Terry RL; Meyran D; Ziegler DS; Haber M; Ekert PG; Trapani JA; Neeson PJ, 2020, 'Immune profiling of pediatric solid tumors', Journal of Clinical Investigation, vol. 130, pp. 3391 - 3402, http://dx.doi.org/10.1172/JCI137181
    Journal articles | 2020
    Dr Paul Ekert
    Moujalled DM; Hanna DT; Hediyeh-Zadeh S; Pomilio G; Brown L; Litalien V; Bartolo R; Fleming S; Chanrion M; Banquet S; Maragno AL; Kraus-Berthier L; Schoumacher M; Mullighan CG; Georgiou A; White CA; Lessene G; Huang DCS; Roberts AW; Geneste O; Rasmussen L; Davis MJ; Ekert PG; Wei A; Ng AP; Khaw SL, 2020, 'Cotargeting BCL-2 and MCL-1 in high-risk B-ALL', Blood Advances, vol. 4, pp. 2762 - 2767, http://dx.doi.org/10.1182/bloodadvances.2019001416
    Journal articles | 2020
    Dr Paul Ekert
    Ekert P, 2020, 'Signalling in high-risk paediatric cancers – Genomic insights driving therapeutic possibilities', Pathology, vol. 52, pp. S31 - S31, http://dx.doi.org/10.1016/j.pathol.2020.01.128
    Journal articles | 2020
    Dr Paul Ekert
    Smith KM; O Haire S; Khuong-Quang DA; Markman B; Gan HK; Ekert PG; O'Byrne KJ; Millward M; Solomon BJ; Tran B; Scott CL; Kee D; McArthur GA; Fellowes A; Weerasuriya R; Lynch E; Martyn M; Gaff C; Fox SB; Desai J, 2020, 'Evaluating barriers to uptake of comprehensive genomic profiling (CGP) in advanced cancer patients (pts).', Journal of Clinical Oncology, vol. 38, pp. 2033 - 2033, http://dx.doi.org/10.1200/jco.2020.38.15_suppl.2033
    Journal articles | 2020
    Dr Paul Ekert
    Kosasih HJ; Davidson NM; Bjelosevic S; Morrish E; Brennan MS; Oshlack A; Johnstone RW; Brumatti G; Khaw SL; Ekert PG, 2020, 'MLL-TFE3: A novel and aggressive KMT2A fusion identified in infant leukemia', Blood Advances, vol. 4, pp. 4918 - 4923, http://dx.doi.org/10.1182/BLOODADVANCES.2020002708
    Journal articles | 2020
    Dr Paul Ekert
    Fareh M; Zhao W; Hu W; Casan JML; Kumar A; Symons J; Voskoboinik I; Ekert P; Rudraraju R; Lewin S; Trapani J, 2020, 'Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance', , http://dx.doi.org/10.1101/2020.11.18.389312
    Journal articles | 2019
    Dr Paul Ekert
    Gayden T; Sepulveda FE; Khuong-Quang DA; Pratt J; Valera ET; Garrigue A; Kelso S; Sicheri F; Mikael LG; Hamel N; Bajic A; Dali R; Deshmukh S; Dervovic D; Schramek D; Guerin F; Taipale M; Nikbakht H; Majewski J; Moshous D; Charlebois J; Abish S; Bole-Feysot C; Nitschke P; Bader-Meunier B; Mitchell D; Thieblemont C; Battistella M; Gravel S; Nguyen VH; Conyers R; Diana JS; McCormack C; Prince HM; Besnard M; Blanche S; Ekert PG; Fraitag S; Foulkes WD; Fischer A; Neven B; Michonneau D; de Saint Basile G; Jabado N, 2019, 'Erratum to: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome (Nature Genetics, (2018), 50, 12, (1650-1657), 10.1038/s41588-018-0251-4)', Nature Genetics, vol. 51, pp. 196, http://dx.doi.org/10.1038/s41588-018-0304-8
    Journal articles | 2019
    Dr Paul Ekert
    Brown LM; Bartolo RC; Davidson NM; Schmidt B; Brooks I; Challis J; Petrovic V; Khuong-Quang DA; Mechinaud F; Khaw SL; Majewski IJ; Oshlack A; Ekert PG, 2019, 'Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia', Pediatric Blood and Cancer, vol. 66, http://dx.doi.org/10.1002/pbc.27897
    Journal articles | 2019
    Dr Paul Ekert
    Meyer C; Lopes BA; Caye-Eude A; Cavé H; Arfeuille C; Cuccuini W; Sutton R; Venn NC; Oh SH; Tsaur G; Escherich G; Feuchtinger T; Kosasih HJ; Khaw SL; Ekert PG; Pombo-de-Oliveira MS; Bidet A; Djahanschiri B; Ebersberger I; Zaliova M; Zuna J; Zermanova Z; Juvonen V; Grümayer RP; Fazio G; Cazzaniga G; Larghero P; Emerenciano M; Marschalek R, 2019, 'Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL–USP2 fusions', Leukemia, vol. 33, pp. 2306 - 2340, http://dx.doi.org/10.1038/s41375-019-0451-7
    Journal articles | 2019
    Dr Paul Ekert
    Moujalled D; Hanna D; Pomillio G; Litalien V; Fleming S; Chanrion M; Maragno A-L; Kraus-Berthier L; Khaw S; Lessene G; Huang D; Roberts A; Geneste O; Ekert P; Ng A; Wei A, 2019, 'IDENTIFICATION OF POTENT BH3-MIMETIC COMBINATIONS TARGETING PRO-SURVIVAL PATHWAYS IN HUMAN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIA', Experimental Hematology, vol. 76, pp. S79 - S80, http://dx.doi.org/10.1016/j.exphem.2019.06.411
    Journal articles | 2019
    Dr Paul Ekert
    Salmon J; Pomilio G; Moujalled D; Litalien V; MacRaild S; Teh C; Rijal S; Ivey A; T.C. T; Ekert P; Krous-Berthier L; Kloos I; Schoumacher M; Gray D; Wei A, 2019, 'ENHANCING EXPRESSION OF PRO-APOPTOTIC FACTORS THROUGH INHIBITION OF HDACS DRIVES P53-INDEPENDENT SYNERGY WITH VENETOCLAX FOR THE TREATMENT OF AML', Experimental Hematology, vol. 76, pp. S54 - S54, http://dx.doi.org/10.1016/j.exphem.2019.06.315
    Journal articles | 2018
    Dr Paul Ekert
    Ziegler DS; Wong M; Mayoh C; Kumar A; Tsoli M; Mould E; Tyrrell V; Khuong-Quang DA; Pinese M; Gayevskiy V; Cohn RJ; Lau LMS; Reynolds M; Cox MC; Gifford A; Rodriguez M; Cowley MJ; Ekert PG; Marshall GM; Haber M, 2018, 'Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma', British Journal of Cancer, vol. 119, pp. 693 - 696, http://dx.doi.org/10.1038/s41416-018-0251-2
    Journal articles | 2018
    Dr Paul Ekert
    Gayden T; Sepulveda FE; Khuong-Quang DA; Pratt J; Valera ET; Garrigue A; Kelso S; Sicheri F; Mikael LG; Hamel N; Bajic A; Dali R; Deshmukh S; Dervovic D; Schramek D; Guerin F; Taipale M; Nikbakht H; Majewski J; Moshous D; Charlebois J; Abish S; Bole-Feysot C; Nitschke P; Bader-Meunier B; Mitchell D; Thieblemont C; Battistella M; Gravel S; Nguyen VH; Conyers R; Diana JS; McCormack C; Prince HM; Besnard M; Blanche S; Ekert PG; Fraitag S; Foulkes WD; Fischer A; Neven B; Michonneau D; de Saint Basile G; Jabado N, 2018, 'Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome', Nature Genetics, vol. 50, pp. 1650 - 1657, http://dx.doi.org/10.1038/s41588-018-0251-4
    Journal articles | 2018
    Dr Paul Ekert
    Hassannia B; Wiernicki B; Ingold I; Qu F; Van Herck S; Tyurina YY; Bayir H; Abhari BA; Angeli JPF; Choi SM; Meul E; Heyninck K; Declerck K; Chirumamilla CS; Lahtela-Kakkonen M; Van Camp G; Krysko DV; Ekert PG; Fulda S; De Geest BG; Conrad M; Kagan VE; Berghe WV; Vandenabeele P; Berghe TV, 2018, 'Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma', Journal of Clinical Investigation, vol. 128, pp. 3341 - 3355, http://dx.doi.org/10.1172/JCI99032
    Journal articles | 2018
    Dr Paul Ekert
    Narayan N; Bracken CP; Ekert PG, 2018, 'MicroRNA-155 expression and function in AML: An evolving paradigm', Experimental Hematology, vol. 62, pp. 1 - 6, http://dx.doi.org/10.1016/j.exphem.2018.03.007
    Journal articles | 2018
    Dr Paul Ekert
    Teh TC; Nguyen NY; Moujalled DM; Segal D; Pomilio G; Rijal S; Jabbour A; Cummins K; Lackovic K; Blombery P; Thompson E; Ekert PG; Lessene G; Glaser SP; Huang DCS; Roberts AW; Guthridge MA; Wei AH, 2018, 'Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1', Leukemia, vol. 32, pp. 303 - 312, http://dx.doi.org/10.1038/leu.2017.243
    Journal articles | 2018
    Dr Paul Ekert
    Hercus TR; Kan WLT; Broughton SE; Tvorogov D; Ramshaw HS; Sandow JJ; Nero TL; Dhagat U; Thompson EJ; Tung Shing KSC; McKenzie DR; Wilson NJ; Owczarek CM; Vairo G; Nash AD; Tergaonkar V; Hughes T; Ekert PG; Samuel MS; Bonder CS; Grimbaldeston MA; Parker MW; Lopez AF, 2018, 'Role of the β common (βc) family of cytokines in health and disease', Cold Spring Harbor Perspectives in Biology, vol. 10, http://dx.doi.org/10.1101/cshperspect.a028514
    Journal articles | 2018
    Dr Paul Ekert
    Lee B; Tran B; Hsu AL; Taylor GR; Fox SB; Fellowes A; Marquis R; Mooi J; Desai J; Doig K; Ekert P; Gaff C; Herath D; Hamilton A; James P; Roberts A; Snyder R; Waring P; McArthur G, 2018, 'Exploring the feasibility and utility of exome-scale tumour sequencing in a clinical setting', Internal Medicine Journal, vol. 48, pp. 786 - 794, http://dx.doi.org/10.1111/imj.13806
    Journal articles | 2018
    Dr Paul Ekert
    Schmidt BM; Davidson NM; Hawkins ADK; Bartolo R; Majewski IJ; Ekert PG; Oshlack A, 2018, 'Clinker: visualizing fusion genes detected in RNA-seq data', GigaScience, vol. 7, http://dx.doi.org/10.1093/gigascience/giy079
    Journal articles | 2018
    Dr Paul Ekert
    Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin JX; Gayevskiy V; Kumar A; Kaplan W; Ekert PG; Saletta F; Franshaw L; Liu J; Gifford A; Weber MA; Rodriguez M; Cohn RJ; Arndt G; Tyrrell V; Haber M; Trahair T; Marshall GM; McDonald K; Cowley MJ; Ziegler DS, 2018, 'Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer', Cancer Biology and Therapy, vol. 19, pp. 1078 - 1087, http://dx.doi.org/10.1080/15384047.2018.1491498
    Journal articles | 2018
    Dr Paul Ekert
    Salmon J; Pomilio G; Moujalled D; MacRaild S; Teh C; Rijal S; Ivey A; Teh TC; Ekert P; Schoumacher M; Kraus-Berthier L; Kloos I; Gray D; Wei A, 2018, 'Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity In AML', Experimental Hematology, vol. 64, pp. S99 - S100, http://dx.doi.org/10.1016/j.exphem.2018.06.138
    Journal articles | 2017
    Dr Paul Ekert
    Narayan N; Morenos L; Phipson B; Willis SN; Brumatti G; Eggers S; Lalaoui N; Brown LM; Kosasih HJ; Bartolo RC; Zhou L; Catchpoole D; Saffery R; Oshlack A; Goodall GJ; Ekert PG, 2017, 'Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia', Leukemia, vol. 31, pp. 808 - 820, http://dx.doi.org/10.1038/leu.2016.279
    Journal articles | 2017
    Dr Paul Ekert
    Wittwer NL; Brumatti G; Marchant C; Sandow JJ; Pudney MK; Dottore M; D’Andrea RJ; Lopez AF; Ekert PG; Ramshaw HS, 2017, 'High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression', Blood Advances, vol. 1, pp. 1067 - 1079, http://dx.doi.org/10.1182/bloodadvances.2016002931
    Journal articles | 2017
    Dr Paul Ekert
    Brown LM; Hanna DT; Khaw SL; Ekert PG, 2017, 'Dysregulation of BCL-2 family proteins by leukemia fusion genes', Journal of Biological Chemistry, vol. 292, pp. 14325 - 14333, http://dx.doi.org/10.1074/jbc.R117.799056
    Journal articles | 2017
    Dr Paul Ekert
    Conyers R; Costello B; La Gerche A; Tripaydonis A; Burns C; Ludlow L; Lange P; Ekert P; Mechinaud F; Cheung M; Martin M; Elliot D, 2017, 'Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?', Internal Medicine Journal, vol. 47, pp. 1166 - 1172, http://dx.doi.org/10.1111/imj.13481
    Journal articles | 2017
    Dr Paul Ekert
    Sandow JJ; Infusini G; Holik AZ; Brumatti G; Averink TV; Ekert PG; Webb AI, 2017, 'Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death', Proteomics - Clinical Applications, vol. 11, http://dx.doi.org/10.1002/prca.201700013
    Journal articles | 2017
    Dr Paul Ekert
    Craig LA; Ekert PG; Conyers R; Elliott DA, 2017, 'Genetic determinants of anthracycline cardiotoxicity – ready for the clinic?', British Journal of Clinical Pharmacology, vol. 83, pp. 1141 - 1142, http://dx.doi.org/10.1111/bcp.13195
    Journal articles | 2017
    Dr Paul Ekert
    Fischer K; Masouras D; Daunt C; Dias S; Ekert P; Strasser A; Vaux D; Jabbour A, 2017, 'Cytokine signalling in haematopoietic cells', Experimental Hematology, vol. 53, pp. S107 - S107, http://dx.doi.org/10.1016/j.exphem.2017.06.262
    Journal articles | 2017
    Dr Paul Ekert
    Ekert PG; Jabbour AM; Manoharan A, 2017, 'Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma (vol 108, pg 1461, 2006)', BLOOD, vol. 130, pp. 1684 - 1684, http://dx.doi.org/10.1182/blood-2017-08-802397
    Journal articles | 2017
    Dr Paul Ekert
    Brumatti G; Ma C; Lalaoui N; Nguyen N-Y; Navarro M; Tanzer MC; Richmond J; Ghisi M; Salmon JM; Silke N; Pomilio G; Glaser SP; de Valle E; Gugasyan R; Gurthridge MA; Condon SM; Johnstone RW; Lock R; Salvesen G; Wei A; Vaux DL; Ekert PG; Silke J, 2017, 'The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia (vol 8, 339ra69, 2016)', SCIENCE TRANSLATIONAL MEDICINE, vol. 9, http://dx.doi.org/10.1126/scitranslmed.aan8181
    Journal articles | 2017
    Dr Paul Ekert
    Schmidt B; Davidson N; Hawkins ADK; Bartolo R; Majewski I; Ekert P; Oshlack A, 2017, 'Clinker: visualising fusion genes detected in RNA-seq data', , http://dx.doi.org/10.1101/218586
    Journal articles | 2016
    Dr Paul Ekert
    Brumatti G; Ma C; Lalaoui N; Nguyen NY; Navarro M; Tanzer MC; Richmond J; Ghisi M; Salmon JM; Silke N; Pomilio G; Glaser SP; De Valle E; Gugasyan R; Gurthridge MA; Condon SM; Johnstone RW; Lock R; Salvesen G; Wei A; Vaux DL; Ekert PG; Silke J, 2016, 'The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia', Science Translational Medicine, vol. 8, http://dx.doi.org/10.1126/scitranslmed.aad3099
    Journal articles | 2016
    Dr Paul Ekert
    Stark Z; Tan TY; Chong B; Brett GR; Yap P; Walsh M; Yeung A; Peters H; Mordaunt D; Cowie S; Amor DJ; Savarirayan R; McGillivray G; Downie L; Ekert PG; Theda C; James PA; Yaplito-Lee J; Ryan MM; Leventer RJ; Creed E; Macciocca I; Bell KM; Oshlack A; Sadedin S; Georgeson P; Anderson C; Thorne N; Gaff C; White SM, 2016, 'A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders', Genetics in Medicine, vol. 18, pp. 1090 - 1096, http://dx.doi.org/10.1038/gim.2016.1
    Journal articles | 2016
    Dr Paul Ekert
    Lalaoui N; Johnstone R; Ekert PG, 2016, 'Autophagy and AML - Food for thought', Cell Death and Differentiation, vol. 23, pp. 5 - 6, http://dx.doi.org/10.1038/cdd.2015.136
    Journal articles | 2016
    Dr Paul Ekert
    Goodall KJ; Finch-Edmondson ML; Van Vuuren J; Yeoh GC; Gentle IE; Vince JE; Ekert PG; Vaux DL; Callus BA, 2016, 'Cycloheximide can induce bax/bak dependent myeloid cell death independently of multiple BH3-only proteins', PLoS ONE, vol. 11, http://dx.doi.org/10.1371/journal.pone.0164003
    Journal articles | 2016
    Dr Paul Ekert
    Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Correction: Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (Cancer Cell (2016) 30(3) (499–500) (S1535610816000350) (10.1016/j.ccell.2016.01.006))', Cancer Cell, vol. 30, pp. 499 - 500, http://dx.doi.org/10.1016/j.ccell.2016.08.009
    Journal articles | 2016
    Dr Paul Ekert
    Lalaoui N; Hänggi K; Brumatti G; Chau D; Nguyen NYN; Vasilikos L; Spilgies LM; Heckmann DA; Ma C; Ghisi M; Salmon JM; Matthews GM; de Valle E; Moujalled DM; Menon MB; Spall SK; Glaser SP; Richmond J; Lock RB; Condon SM; Gugasyan R; Gaestel M; Guthridge M; Johnstone RW; Munoz L; Wei A; Ekert PG; Vaux DL; Wong WWL; Silke J, 2016, 'Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics', Cancer Cell, vol. 29, pp. 145 - 158, http://dx.doi.org/10.1016/j.ccell.2016.01.006
    Journal articles | 2016
    Dr Paul Ekert
    Perini G; Milazzo G; Narayan N; Ekert PG, 2016, 'Letting the breaks off MYCN', Cell Death and Differentiation, vol. 23, pp. 1904 - 1905, http://dx.doi.org/10.1038/cdd.2016.112
    Journal articles | 2015
    Dr Paul Ekert
    Lalaoui N; Lindqvist LM; Sandow JJ; Ekert PG, 2015, 'The molecular relationships between apoptosis, autophagy and necroptosis', Seminars in Cell and Developmental Biology, vol. 39, pp. 63 - 69, http://dx.doi.org/10.1016/j.semcdb.2015.02.003
    Journal articles | 2014
    Dr Paul Ekert
    Rickard JA; O'Donnell JA; Evans JM; Lalaoui N; Poh AR; Rogers T; Vince JE; Lawlor KE; Ninnis RL; Anderton H; Hall C; Spall SK; Phesse TJ; Abud HE; Cengia LH; Corbin J; Mifsud S; Di Rago L; Metcalf D; Ernst M; Dewson G; Roberts AW; Alexander WS; Murphy JM; Ekert PG; Masters SL; Vaux DL; Croker BA; Gerlic M; Silke J, 2014, 'RIPK1 regulates RIPK3-MLKL-driven systemic inflammation and emergency hematopoiesis', Cell, vol. 157, pp. 1175 - 1188, http://dx.doi.org/10.1016/j.cell.2014.04.019
    Journal articles | 2014
    Dr Paul Ekert
    Sadras T; Perugini M; Kok CH; Iarossi DG; Heatley SL; Brumatti G; Samuel MS; To LB; Lewis ID; Lopez AF; Ekert PG; Ramshaw HS; D'Andrea RJ, 2014, 'Interleukin-3-mediated regulation of β-catenin in myeloid transformation and acute myeloid leukemia', Journal of Leukocyte Biology, vol. 96, pp. 83 - 91, http://dx.doi.org/10.1189/jlb.2AB1013-559R
    Journal articles | 2014
    Dr Paul Ekert
    Gangoda L; Doerflinger M; Srivastava R; Narayan N; Edgington LE; Orian J; Hawkins C; O'Reilly LA; Gu H; Bogyo M; Ekert P; Strasser A; Puthalakath H, 2014, 'Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice', Cell Death and Differentiation, vol. 21, pp. 1815 - 1824, http://dx.doi.org/10.1038/cdd.2014.98
    Journal articles | 2014
    Dr Paul Ekert
    Sandow JJ; Dorstyn L; O'Reilly LA; Tailler M; Kumar S; Strasser A; Ekert PG, 2014, 'ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis', Cell Death and Differentiation, vol. 21, pp. 475 - 480, http://dx.doi.org/10.1038/cdd.2013.168
    Journal articles | 2013
    Dr Paul Ekert
    Green BD; Jabbour AM; Sandow JJ; Riffkin CD; Masouras D; Daunt CP; Salmanidis M; Brumatti G; Hemmings BA; Guthridge MA; Pearson RB; Ekert PG, 2013, 'Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations', Cell Death and Differentiation, vol. 20, pp. 1341 - 1349, http://dx.doi.org/10.1038/cdd.2013.63
    Journal articles | 2013
    Dr Paul Ekert
    Salmanidis M; Brumatti G; Narayan N; Green BD; Van Den Bergen JA; Sandow JJ; Bert AG; Silke N; Sladic R; Puthalakath H; Rohrbeck L; Okamoto T; Bouillet P; Herold MJ; Goodall GJ; Jabbour AM; Ekert PG, 2013, 'Hoxb8 regulates expression of microRNAs to control cell death and differentiation', Cell Death and Differentiation, vol. 20, pp. 1370 - 1380, http://dx.doi.org/10.1038/cdd.2013.92
    Journal articles | 2013
    Dr Paul Ekert
    Thomas D; Powell JA; Green BD; Barry EF; Ma Y; Woodcock J; Fitter S; Zannettino ACW; Pitson SM; Hughes TP; Lopez AF; Shepherd PR; Wei AH; Ekert PG; Guthridge MA, 2013, 'Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival', PLoS Biology, vol. 11, http://dx.doi.org/10.1371/journal.pbio.1001515
    Journal articles | 2013
    Dr Paul Ekert
    Rahimi A; Lee YY; Abdella H; Doerflinger M; Gangoda L; Srivastava R; Xiao K; Ekert PG; Puthalakath H, 2013, 'Role of p53 in cAMP/PKA pathway mediated apoptosis', Apoptosis, vol. 18, pp. 1492 - 1499, http://dx.doi.org/10.1007/s10495-013-0895-6
    Journal articles | 2013
    Dr Paul Ekert
    Brumatti G; Salmanidis M; Kok CH; Bilardi RA; Sandow JJ; Silke N; Mason K; Visser J; Jabbour AM; Glaser SP; Okamoto T; Bouillet P; D'Andrea RJ; Ekert PG, 2013, 'HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia', Oncotarget, vol. 4, pp. 1933 - 1947, http://dx.doi.org/10.18632/oncotarget.1306
    Journal articles | 2013
    Dr Paul Ekert
    Hercus TR; Dhagat U; Kan WLT; Broughton SE; Nero TL; Perugini M; Sandow JJ; D'Andrea RJ; Ekert PG; Hughes T; Parker MW; Lopez AF, 2013, 'Signalling by the βc family of cytokines', Cytokine and Growth Factor Reviews, vol. 24, pp. 189 - 201, http://dx.doi.org/10.1016/j.cytogfr.2013.03.002
    Journal articles | 2013
    Dr Paul Ekert
    Gurzeler U; Rabachini T; Dahinden CA; Salmanidis M; Brumatti G; Ekert PG; Echeverry N; Bachmann D; Simon HU; Kaufmann T, 2013, 'In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8', Allergy: European Journal of Allergy and Clinical Immunology, vol. 68, pp. 604 - 613, http://dx.doi.org/10.1111/all.12140
    Journal articles | 2013
    Dr Paul Ekert
    Wensveen FM; Geest CR; Libregts SFWM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2013, 'BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis', Apoptosis, vol. 18, pp. 1306 - 1318, http://dx.doi.org/10.1007/s10495-013-0890-y
    Journal articles | 2013
    Dr Paul Ekert
    Wong NC; Ng J; Hall NE; Lunke S; Salmanidis M; Brumatti G; Ekert PG; Craig JM; Saffery R, 2013, 'Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA', Genomics, vol. 102, pp. 38 - 46, http://dx.doi.org/10.1016/j.ygeno.2013.04.014
    Journal articles | 2013
    Dr Paul Ekert
    Bandopadhayay P; Jabbour AM; Riffkin C; Salmanidis M; Gordon L; Popovski D; Rigby L; Ashley DM; Watkins DN; Thomas DM; Algar E; Ekert PG, 2013, 'The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts', BMC Cancer, vol. 13, http://dx.doi.org/10.1186/1471-2407-13-585
    Journal articles | 2013
    Dr Paul Ekert
    Lock RB, 2013, 'Targeting acute myeloid leukemia by dual inhibition of P13K signalling and Cdk9-mediated Mcl-1 transcription', Blood, vol. 122, pp. 738 - 748, http://dx.doi.org/10.1182/blood-2012-08-447441
    Journal articles | 2013
    Dr Paul Ekert
    Brumatti G; Ekert PG, 2013, 'Seeking a MCL-1 inhibitor', Cell Death and Differentiation, vol. 20, pp. 1440 - 1441, http://dx.doi.org/10.1038/cdd.2013.114
    Journal articles | 2012
    Dr Paul Ekert
    Hercus TR; Broughton SE; Ekert PG; Ramshaw HS; Perugini M; Grimbaldeston M; Woodcock JM; Thomas D; Pitson S; Hughes T; D'Andrea RJ; Parker MW; Lopez AF, 2012, 'The GM-CSF receptor family: Mechanism of activation and implications for disease', Growth Factors, vol. 30, pp. 63 - 75, http://dx.doi.org/10.3109/08977194.2011.649919
    Journal articles | 2012
    Dr Paul Ekert
    Jabbour AM; Gordon L; Daunt CP; Green BD; Kok CH; D'Andrea R; Ekert PG, 2012, 'p53-dependent transcriptional responses to interleukin-3 signaling', PLoS ONE, vol. 7, http://dx.doi.org/10.1371/journal.pone.0031428
    Journal articles | 2012
    Dr Paul Ekert
    Sandow JJ; Jabbour AM; Condina MR; Daunt CP; Stomski FC; Green BD; Riffkin CD; Hoffmann P; Guthridge MA; Silke J; Lopez AF; Ekert PG, 2012, 'Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death', Cell Death and Differentiation, vol. 19, pp. 633 - 641, http://dx.doi.org/10.1038/cdd.2011.131
    Journal articles | 2011
    Dr Paul Ekert
    Hahn CN; Chong CE; Carmichael CL; Wilkins EJ; Brautigan PJ; Li XC; Babic M; Lin M; Carmagnac A; Lee YK; Kok CH; Gagliardi L; Friend KL; Ekert PG; Butcher CM; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS; Scott HS, 2011, 'Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia', Nature Genetics, vol. 43, pp. 1012 - 1019, http://dx.doi.org/10.1038/ng.913
    Journal articles | 2011
    Dr Paul Ekert
    Ekert PG; Jabbour AM, 2011, 'Critical Evaluation of Antiepileptic Drugs in Epileptic Pregnant Women - Hungarian Experiences', The Open Cell Signaling Journal, vol. 3, pp. 20 - 26, http://dx.doi.org/10.2174/1876390101103010020
    Journal articles | 2010
    Dr Paul Ekert
    Oberle C; Huai J; Reinheckel T; Tacke M; Rassner M; Ekert PG; Buellesbach J; Borner C, 2010, 'Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes', Cell Death and Differentiation, vol. 17, pp. 1167 - 1178, http://dx.doi.org/10.1038/cdd.2009.214
    Journal articles | 2010
    Dr Paul Ekert
    Jabbour AM; Daunt CP; Green BD; Vogel S; Gordon L; Lee RS; Silke N; Pearson RB; Vandenberg CJ; Kelly PN; Nutt SL; Strasser A; Borner C; Ekert PG, 2010, 'Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation', Blood, vol. 115, pp. 344 - 352, http://dx.doi.org/10.1182/blood-2009-07-230730
    Journal articles | 2010
    Dr Paul Ekert
    Brumatti G; Salmanidis M; Ekert PG, 2010, 'Crossing paths: Interactions between the cell death machinery and growth factor survival signals', Cellular and Molecular Life Sciences, vol. 67, pp. 1619 - 1630, http://dx.doi.org/10.1007/s00018-010-0288-8
    Journal articles | 2010
    Dr Paul Ekert
    Lopez AF; Hercus TR; Ekert P; Littler DR; Guthridge M; Thomas D; Ramshaw HS; Stomski F; Perugini M; D'Andrea R; Grimbaldeston M; Parker MW, 2010, 'Molecular basis of cytokine receptor activation', IUBMB Life, vol. 62, pp. 509 - 518, http://dx.doi.org/10.1002/iub.350
    Journal articles | 2010
    Dr Paul Ekert
    Geest CR; Wensveen FM; Libregts SFWM; de Bruin AM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2010, 'Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis', Blood, vol. 116, pp. 4235 - 4235, http://dx.doi.org/10.1182/blood.v116.21.4235.4235
    Journal articles | 2010
    Dr Paul Ekert
    Scott HS; Hahn CN; Carmichael CL; Wilkins EJ; Chong C-E; Brautigan PJ; Li X-C; Stankovic M; Lin M; Carmagnac A; Butcher CM; Friend KL; Ekert PG; Kok CH; Brown AL; Lewis ID; To LB; Timms AE; Storek J; Moore S; Altree M; Escher R; Bardy PG; Suthers GK; D'Andrea RJ; Horwitz MS, 2010, 'GATA2 is a New Predisposition Gene for Familial Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)', Blood, vol. 116, http://dx.doi.org/10.1182/blood.v116.21.lba-3.lba-3
    Journal articles | 2010
    Dr Paul Ekert
    Kok CH; Brown AL; Ekert PG; D'Andrea RJ, 2010, 'Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML', Leukemia, vol. 24, pp. 1239 - 1243, http://dx.doi.org/10.1038/leu.2010.85
    Journal articles | 2009
    Dr Paul Ekert
    Hercus TR; Thomas D; Guthridge MA; Ekert PG; King-Scott J; Parker MW; Lopez AF, 2009, 'The granulocyte-macrophage colony-stimulating factor receptor: Linking its structure to cell signaling and its role in disease', Blood, vol. 114, pp. 1289 - 1298, http://dx.doi.org/10.1182/blood-2008-12-164004
    Journal articles | 2009
    Dr Paul Ekert
    Algar EM; Muscat A; Dagar V; Rickert C; Chow CW; Biegel JA; Ekert PG; Saffery R; Craig J; Johnstone RW; Ashley DM, 2009, 'Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors', PLoS ONE, vol. 4, http://dx.doi.org/10.1371/journal.pone.0004482
    Journal articles | 2009
    Dr Paul Ekert
    Jabbour AM; Heraud JE; Daunt CP; Kaufmann T; Sandow J; O'Reilly LA; Callus BA; Lopez A; Strasser A; Vaux DL; Ekert PG, 2009, 'Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim', Cell Death and Differentiation, vol. 16, pp. 555 - 563, http://dx.doi.org/10.1038/cdd.2008.179
    Journal articles | 2008
    Dr Paul Ekert
    Salmanidis M; Brumatti G; Jabbour AM; Green BD; Silke J; Bouillet P; Ekert PG, 2008, 'Regulated Hox Gene Expression Reveals a Novel Role for Hox Genes in Myeloid Cell Proliferation and Survival', Blood, vol. 112, pp. 5323 - 5323, http://dx.doi.org/10.1182/blood.v112.11.5323.5323
    Journal articles | 2008
    Dr Paul Ekert
    Callus BA; Moujallad DM; Silke J; Gerl R; Jabbour AM; Ekert PG; Vaux DL, 2008, 'Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins', JOURNAL OF MOLECULAR BIOLOGY, vol. 384, pp. 313 - 323, http://dx.doi.org/10.1016/j.jmb.2008.09.041
    Journal articles | 2008
    Dr Paul Ekert
    Callus BA; Ekert PG; Heraud JE; Jabbour AM; Kotevski A; Vince JE; Silke J; Vaux DL, 2008, 'Cytoplasmic p53 is not required for PUMA-induced apoptosis [1]', Cell Death and Differentiation, vol. 15, pp. 213 - 215, http://dx.doi.org/10.1038/sj.cdd.4402245
    Journal articles | 2007
    Dr Paul Ekert
    Mason KD; Carpinelli MR; Fletcher JI; Collinge JE; Hilton AA; Ellis S; Kelly PN; Ekert PG; Metcalf D; Roberts AW; Huang DCS; Kile BT, 2007, 'Programmed Anuclear Cell Death Delimits Platelet Life Span', Cell, vol. 128, pp. 1173 - 1186, http://dx.doi.org/10.1016/j.cell.2007.01.037
    Journal articles | 2007
    Dr Paul Ekert
    Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Strasser A, 2007, 'The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest', Cell, vol. 129, pp. 423 - 433, http://dx.doi.org/10.1016/j.cell.2007.03.017
    Journal articles | 2007
    Dr Paul Ekert
    Verhagen AM; Kratina TK; Hawkins CJ; Silke J; Ekert PG; Vaux DL, 2007, 'Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs', Cell Death and Differentiation, vol. 14, pp. 348 - 357, http://dx.doi.org/10.1038/sj.cdd.4402001
    Journal articles | 2007
    Dr Paul Ekert
    Kaufmann T; Tai L; Ekert PG; Huang DCS; Norris F; Lindemann RK; Johnstone RW; Dixit VM; Arnoult D; Strasser A, 2007, 'Response: Does Bid Play a Role in the DNA Damage Response?', Cell, vol. 130, pp. 10 - 11, http://dx.doi.org/10.1016/j.cell.2007.06.037
    Journal articles | 2006
    Dr Paul Ekert
    Ekert PG; Jabbour AM; Manoharan A; Heraud JE; Yu J; Pakusch M; Michalak EM; Kelly PN; Callus B; Kiefer T; Verhagen A; Silke J; Strasser A; Borner C; Vaux DL, 2006, 'Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma', Blood, vol. 108, pp. 1461 - 1468, http://dx.doi.org/10.1182/blood-2006-03-014209
    Journal articles | 2006
    Dr Paul Ekert
    Pardo J; Urban C; Galvez EM; Ekert PG; Müller U; Kwon-Chung J; Lobigs M; Müllbacher A; Wallich R; Borner C; Simon MM, 2006, 'The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice', Journal of Cell Biology, vol. 174, pp. 509 - 519, http://dx.doi.org/10.1083/jcb.200604044
    Journal articles | 2006
    Dr Paul Ekert
    Jabbour AM; Puryer MA; Yu JY; Lithgow T; Riffkin CD; Ashley DM; Vaux DL; Ekert PG; Hawkins CJ, 2006, 'Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1', Journal of Cell Science, vol. 119, pp. 2572 - 2582, http://dx.doi.org/10.1242/jcs.02985
    Journal articles | 2006
    Dr Paul Ekert
    Tan TY; Jameson JL; Campbell PE; Ekert PG; Zacharin M; Savarirayan R, 2006, 'Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review', American Journal of Medical Genetics, Part A, vol. 140, pp. 1778 - 1784, http://dx.doi.org/10.1002/ajmg.a.31365
    Journal articles | 2005
    Dr Paul Ekert
    Ho PK; Jabbour AM; Ekert PG; Hawkins CJ, 2005, 'Caspase-2 is resistant to inhibition by inhibitor of apoptosis proteins (IAPs) and can activate caspase-7', FEBS Journal, vol. 272, pp. 1401 - 1414, http://dx.doi.org/10.1111/j.1742-4658.2005.04573.x
    Journal articles | 2005
    Dr Paul Ekert
    Valianpour F; Mitsakos V; Schlemmer D; Towbin JA; Taylor JM; Ekert PG; Thorburn DR; Munnich A; Wanders RJA; Barth PG; Vaz FM, 2005, 'Monolysocardiolipins accumulate in Barth syndrome but do not lead to enhanced apoptosis', Journal of Lipid Research, vol. 46, pp. 1182 - 1195, http://dx.doi.org/10.1194/jlr.M500056-JLR200
    Journal articles | 2005
    Dr Paul Ekert
    Silke J; Kratina T; Chu D; Ekert PG; Day CL; Pakusch M; Huang DCS; Vaux DL, 2005, 'Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance', Proceedings of the National Academy of Sciences of the United States of America, vol. 102, pp. 16182 - 16187, http://dx.doi.org/10.1073/pnas.0502828102
    Journal articles | 2005
    Dr Paul Ekert
    Ekert PG; Vaux DL, 2005, 'The mitochondrial death squad: Hardened killers or innocent bystanders?', Current Opinion in Cell Biology, vol. 17, pp. 626 - 630, http://dx.doi.org/10.1016/j.ceb.2005.09.001
    Journal articles | 2005
    Dr Paul Ekert
    Filan PM; Mills JF; Clarnette TD; Ekert H; Ekert P, 2005, 'Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: A potential role for recombinant factor VIIa', Journal of Pediatrics, vol. 147, pp. 857 - 859, http://dx.doi.org/10.1016/j.jpeds.2005.07.034
    Journal articles | 2005
    Dr Paul Ekert
    Filan PM; Woodward M; Ekert PG, 2005, 'Images in paediatrics: Stuck long line syndrome', Archives of Disease in Childhood, vol. 90, pp. 558, http://dx.doi.org/10.1136/adc.2004.069559
    Journal articles | 2004
    Dr Paul Ekert
    Marsden VS; Ekert PG; Van Delft M; Vaux DL; Adams JM; Strasser A, 2004, 'Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9', Journal of Cell Biology, vol. 165, pp. 775 - 780, http://dx.doi.org/10.1083/jcb.200312030
    Journal articles | 2004
    Dr Paul Ekert
    Knight MJ; Riffkin CD; Ekert PG; Ashley DM; Hawkins CJ, 2004, 'Caspase-8 Levels Affect Necessity for Mitochondrial Amplification in Death Ligand-Induced Glioma Cell Apoptosis', Molecular Carcinogenesis, vol. 39, pp. 173 - 182, http://dx.doi.org/10.1002/mc.20011
    Journal articles | 2004
    Dr Paul Ekert
    Silke J; Kratina T; Ekert PG; Pakusch M; Vaux DL, 2004, 'Unlike Diablo/smac, Grim Promotes Global Ubiquitination and Specific Degradation of X Chromosome-linked Inhibitor of Apoptosis (XIAP) and Neither Cause Apoptosis', Journal of Biological Chemistry, vol. 279, pp. 4313 - 4321, http://dx.doi.org/10.1074/jbc.M305661200
    Journal articles | 2004
    Dr Paul Ekert
    Ekert PG; Read SH; Silke J; Marsden VS; Kaufmann H; Hawkins CJ; Gerl R; Kumar S; Vaux DL, 2004, 'Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die', Journal of Cell Biology, vol. 165, pp. 835 - 842, http://dx.doi.org/10.1083/jcb.200312031
    Journal articles | 2004
    Dr Paul Ekert
    Jabbour AM; Ho PK; Puryer MA; Ashley DM; Ekert PG; Hawkins CJ, 2004, 'The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast', Cell Death and Differentiation, vol. 11, pp. 1309 - 1316, http://dx.doi.org/10.1038/sj.cdd.4401501
    Journal articles | 2003
    Dr Paul Ekert
    Hennel SJ; Ekert PG; Volpe JJ; Inder TE, 2003, 'Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti', Pediatric Neurology, vol. 29, pp. 148 - 150, http://dx.doi.org/10.1016/S0887-8994(03)00150-4
    Journal articles | 2002
    Dr Paul Ekert
    Jabbour AM; Ekert PG; Coulson EJ; Knight MJ; Ashley DM; Hawkins CJ, 2002, 'The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects againts apoptosis', Cell Death and Differentiation, vol. 9, pp. 1311 - 1320, http://dx.doi.org/10.1038/sj.cdd.4401135
    Journal articles | 2002
    Dr Paul Ekert
    Marsden VS; O’Connor L; O’Reilly LA; Silke J; Metcalf D; Ekert PG; Huang DCS; Cecconi F; Kuida K; Tomaselli KJ; Roy S; Nicholson DW; Vaux DL; Bouillet P; Adams JM; Strasser A, 2002, 'Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome', Nature, vol. 419, pp. 634 - 637, http://dx.doi.org/10.1038/nature01101
    Journal articles | 2002
    Dr Paul Ekert
    Silke J; Hawkins CJ; Ekert PG; Chew J; Day CL; Pakusch M; Verhagen AM; Vaux DL, 2002, 'The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3- and caspase 9-interacting sites', Journal of Cell Biology, vol. 157, pp. 115 - 124, http://dx.doi.org/10.1083/jcb.200108085
    Journal articles | 2002
    Dr Paul Ekert
    Verhagen AM; Silke J; Ekert PG; Pakusch M; Kaufmann H; Connolly LM; Day CL; Tikoo A; Burke R; Wrobel C; Moritz RL; Simpson RJ; Vaux DL, 2002, 'HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins', Journal of Biological Chemistry, vol. 277, pp. 445 - 454, http://dx.doi.org/10.1074/jbc.M109891200
    Journal articles | 2002
    Dr Paul Ekert
    Read SH; Baliga BC; Ekert PG; Vaux DL; Kumar S, 2002, 'A novel Apaf-1-independent putative caspase-2 activation complex', Journal of Cell Biology, vol. 159, pp. 739 - 745, http://dx.doi.org/10.1083/jcb.200209004
    Journal articles | 2002
    Dr Paul Ekert
    O’Reilly LA; Ekert P; Harvey N; Marsden V; Cullen L; Vaux DL; Hacker G; Magnusson C; Pakusch M; Cecconi F; Kuida K; Strasser A; Huang DCS; Kumar S, 2002, 'Caspase-2 is not required for thymocyte or neuronal apoptosis even though cleavage of caspase-2 is dependent on both Apaf-1 and caspase-9', Cell Death and Differentiation, vol. 9, pp. 832 - 841, http://dx.doi.org/10.1038/sj.cdd.4401033
    Journal articles | 2001
    Dr Paul Ekert
    Hawkins CJ; Silke J; Verhagen AM; Foster R; Ekert PG; Ashley DM, 2001, 'Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism', Apoptosis, vol. 6, pp. 331 - 338, http://dx.doi.org/10.1023/A:1011329917895
    Journal articles | 2001
    Dr Paul Ekert
    Ekert PG; Silke J; Hawkins CJ; Verhagen AM; Vaux DL, 2001, 'DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9', Journal of Cell Biology, vol. 153, pp. 483 - 490, http://dx.doi.org/10.1083/jcb.152.3.483
    Journal articles | 2001
    Dr Paul Ekert
    Silke J; Ekert PG; Day CL; Hawkins CJ; Baca M; Chew J; Pakusch M; Verhagen AM; Vaux DL, 2001, 'Direct inhibition of caspase 3 is dispensable for the anti-apoptotic activity of XIAP', EMBO Journal, vol. 20, pp. 3114 - 3123, http://dx.doi.org/10.1093/emboj/20.12.3114
    Journal articles | 2001
    Dr Paul Ekert
    Mills JF; Dargaville PA; Coleman LT; Rosenfeld JV; Ekert PG, 2001, 'Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging', Journal of Pediatrics, vol. 138, pp. 105 - 108, http://dx.doi.org/10.1067/mpd.2001.109195
    Journal articles | 2001
    Dr Paul Ekert
    Ekert PG; Silke J, 2001, 'Till death do us part', Cell Death and Differentiation, vol. 8, pp. 662 - 664, http://dx.doi.org/10.1038/sj.cdd.4400895
    Journal articles | 2000
    Dr Paul Ekert
    Verhagen AM; Ekert PG; Pakusch M; Silke J; Connolly LM; Reid GE; Moritz RL; Simpson RJ; Vaux DL, 2000, 'Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins', Cell, vol. 102, pp. 43 - 53, http://dx.doi.org/10.1016/S0092-8674(00)00009-X
    Journal articles | 2000
    Dr Paul Ekert
    Silke J; Verhagen AM; Ekert PG; Vaux DL, 2000, 'Sequence as well as functional similarity for DIABLO/Smac and Grim, Reaper and Hid? [3]', Cell Death and Differentiation, vol. 7, pp. 1275, http://dx.doi.org/10.1038/sj.cdd.4400790
    Journal articles | 1999
    Dr Paul Ekert
    Ekert PG; Silke J; Vaux DL, 1999, 'Caspase inhibitors', Cell Death and Differentiation, vol. 6, pp. 1081 - 1086, http://dx.doi.org/10.1038/sj.cdd.4400594
    Journal articles | 1999
    Dr Paul Ekert
    Ekert PG; Silke J; Vaux DL, 1999, 'Inhibition of apoptosis and clonogenic survival of cells expressing crmA variants: Optimal caspase substrates are not necessarily optimal inhibitors', EMBO Journal, vol. 18, pp. 330 - 338, http://dx.doi.org/10.1093/emboj/18.2.330
    Journal articles | 1999
    Dr Paul Ekert
    Soilu-Hänninen M; Ekert P; Bucci T; Syroid D; Bartlett PF; Kilpatrick TJ, 1999, 'Nerve growth factor signaling through p75 induces apoptosis in Schwann cells via a Bcl-2-independent pathway', Journal of Neuroscience, vol. 19, pp. 4828 - 4838, http://dx.doi.org/10.1523/jneurosci.19-12-04828.1999
    Journal articles | 1999
    Dr Paul Ekert
    Ekert PA; Bucher DJ, 1999, 'Winter Use of Large-leafed Privet Ligustrum lucidum (Family: Oleaceae) by Birds in Suburban Lismore, New South Wales', Proceedings of the Linnean Society of New South Wales, vol. 1999, pp. 29 - 38
    Journal articles | 1998
    Dr Paul Ekert
    Ekert P; Perlman M; Steinlin M; Hao Y, 1998, 'Predicting the Outcome of Postasphyxial Hypoxic-Ischemic Encephalopathy Within 4 Hours of Birth', Obstetrical & Gynecological Survey, vol. 53, pp. 409 - 410, http://dx.doi.org/10.1097/00006254-199807000-00011
    Journal articles | 1998
    Dr Paul Ekert
    Ekert PG; Huang D; Vaux DL, 1998, 'Cloning and testing new genes to block specific caspase family members.† 998', Pediatric Research, vol. 43, pp. 172 - 172, http://dx.doi.org/10.1203/00006450-199804001-01019
    Journal articles | 1998
    Dr Paul Ekert
    Raju NV; Ekert P; Kumar A; Perlman M, 1998, 'Base Deficit (BD) in Babies with Post-asphyxial Hypoxic Ischemic Encephalopathy (PA-HIE) and relationship to Outcome 1107', Pediatric Research, vol. 43, pp. 190 - 190, http://dx.doi.org/10.1203/00006450-199804001-01128
    Journal articles | 1998
    Dr Paul Ekert
    Ekert P; Mougenot JF; De Lagausie P; Gerardin M; Le Bourgeois M; Munck A; Aigrain Y; Navarro J, 1998, 'Intussusception and appendiceal mucocele in a child with cystic fibrosis', Archives de Pediatrie, vol. 5, pp. 400 - 403, http://dx.doi.org/10.1016/S0929-693X(98)80027-4
    Journal articles | 1998
    Dr Paul Ekert
    Hawkins CJ; Ekert PG; Uren AG; Holmgreen SP; Vaux DL, 1998, 'Anti-apoptotic potential of insect cellular and viral IAPs in mammalian cells', Cell Death and Differentiation, vol. 5, pp. 569 - 576, http://dx.doi.org/10.1038/sj.cdd.4400389
    Journal articles | 1997
    Dr Paul Ekert
    Ekert PG; Keenan NK; Whyte HE; Boulton J; Taylor MJ, 1997, 'Visual evoked potentials for prediction of neurodevelopmental outcome in preterm infants', Neonatology, vol. 71, pp. 148 - 155, http://dx.doi.org/10.1159/000244410
    Journal articles | 1997
    Dr Paul Ekert
    Ekert PG; Vaux DL, 1997, 'Apoptosis and the immune system', British Medical Bulletin, vol. 53, pp. 591 - 603, http://dx.doi.org/10.1093/oxfordjournals.bmb.a011632
    Journal articles | 1997
    Dr Paul Ekert
    Ekert P; MacLusky N; Luo XP; Lehotay DC; Smith B; Post M; Tanswell AK, 1997, 'Dexamethasone prevents apoptosis in a neonatal rat model of hypoxic-ischemic encephalopathy (HIE) by a reactive oxygen species-independent mechanism', Brain Research, vol. 747, pp. 9 - 17, http://dx.doi.org/10.1016/S0006-8993(96)01201-2
    Journal articles | 1997
    Dr Paul Ekert
    Vaux DL; Hawkins CJ; Uren AG; Ekert PG, 1997, 'Motor neurone disease and the life of motor neurones', MEDICAL JOURNAL OF AUSTRALIA, vol. 166, pp. 109 - 109, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1997WE11200025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1997
    Dr Paul Ekert
    Ekert PG; Taylor MJ; Keenan NK; Boulton JE; Whyte HE, 1997, 'Early Somatosensory Evoked Potentials in Preterm Infants: Their Prognostic Utility', Neonatology, vol. 71, pp. 83 - 91, http://dx.doi.org/10.1159/000244401
    Journal articles | 1997
    Dr Paul Ekert
    Ekert P; Perlman M; Steinlin M; Hao Y, 1997, 'Predicting the outcome of postasphyxial hypoxic-ischemic encephalopathy within 4 hours of birth', Journal of Pediatrics, vol. 131, pp. 613 - 617, http://dx.doi.org/10.1016/S0022-3476(97)70072-6
    Journal articles | 1997
    Dr Paul Ekert
    Barnett CP; Perlman M; Ekert PG, 1997, 'Clinicopathological correlations in postasphyxial organ damage: A donor organ perspective', Pediatrics, vol. 99, pp. 797 - 799, http://dx.doi.org/10.1542/peds.99.6.797
    Journal articles | 1997
    Dr Paul Ekert
    Ekert PG; Vaux DL, 1997, 'Apoptosis, haemopoiesis and leukaemogenesis', Bailliere's Clinical Haematology, vol. 10, pp. 561 - 576, http://dx.doi.org/10.1016/S0950-3536(97)80026-1
    Journal articles | 1996
    Dr Paul Ekert
    Ekert PG; MacLusky N; Becker L; Post M; Tanswell AK, 1996, 'DEXAMETHASONE NEUROPROTECTION IS ASSOCIATED WITH PRESERVED EXPRESSION OF BCL-2 AND SUPPRESSION OF GLIAL FIBRILLARY ACID PROTEIN (GFAP). ▴ 1226', Pediatric Research, vol. 39, pp. 207 - 207, http://dx.doi.org/10.1203/00006450-199604001-01248
    Journal articles | 1996
    Dr Paul Ekert
    Ekert PG; MacLusky N; Ping X; Lahotay D; Post M; Tanswell AK, 1996, 'DEXAMETHASONE PREVENTS APOPTOSIS IN A RAT MODEL OF NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY (HIE) BY A FREE RADICAL INDEPENDENT MECHANISM. ▴ 1227', Pediatric Research, vol. 39, pp. 207 - 207, http://dx.doi.org/10.1203/00006450-199604001-01249
    Journal articles | 1996
    Dr Paul Ekert
    Barnett CP; Ekert PG; Perlman M, 1996, 'SERUM TRANSAMINASE MEASUREMENTS IN POST-ASPHYXIAL (PA) HYPOXIC ISCHEMIC ENCEPHALOPATHY (HIE). 1743', Pediatric Research, vol. 39, pp. 293 - 293, http://dx.doi.org/10.1203/00006450-199604001-01767
    Journal articles | 1996
    Dr Paul Ekert
    Taylor MJ; Boor R; Ekert PG, 1996, 'Preterm maturation of the somatosensory evoked potential', Electroencephalography and Clinical Neurophysiology - Evoked Potentials, vol. 100, pp. 448 - 452, http://dx.doi.org/10.1016/0168-5597(96)95218-1
    Journal articles | 1994
    Dr Paul Ekert
    Steinlin M; Ekert PG; Blaser S; Otsubo H; Taylor MJ; Whyte HE; Perlman M, 1994, 'Prediction of severe adverse outcome after moderate or severe birth asphyxia', Pediatric Neurology, vol. 11, pp. 81 - 81, http://dx.doi.org/10.1016/0887-8994(94)90146-5
    Journal articles | 1994
    Dr Paul Ekert
    Kalidasan V; Ekert P; Beasley SW, 1994, 'Associations of urachal abnormalities: Does patency of the urachus occur because of distal urinary tract obstruction?', Pediatric Surgery International, vol. 9, pp. 381 - 382, http://dx.doi.org/10.1007/BF01686007
    Journal articles | 1991
    Dr Paul Ekert
    Ekert P; Metreau JM; Zafrani ES; Fabre M; Buffet C; Etienne JP; Dhumeaux D, 1991, 'Hepatic cholesterol ester storage disease: Two new cases diagnosed in adults', Gastroenterologie Clinique et Biologique, vol. 15, pp. 441 - 444
    Journal articles | 1990
    Dr Paul Ekert
    Journal articles | 1989
    Dr Paul Ekert
    Dewan PA; Ekert P; Keogh EJ; Solomon JR, 1989, 'Epithelial bridging on burn patients following primary excision and grafting', Burns, vol. 15, pp. 129 - 131, http://dx.doi.org/10.1016/0305-4179(89)90145-9
    Journal articles | 1988
    Dr Paul Ekert
    EKERT P; TIBBALLS J; GORMAN D, 1988, 'Three patients with carbon monoxide poisoning treated with hyperbaric oxygen therapy', Journal of Paediatrics and Child Health, vol. 24, pp. 194 - 196, http://dx.doi.org/10.1111/j.1440-1754.1988.tb00324.x
  • Conference Abstracts | 2020
    Dr Paul Ekert
    Haber M; Cowley MJ; Ekert P; Lau L; Mould E; Gifford A; Lock RB; Marshall GM; Norris MD; O'Brien T; Dong AKQ; Thomas D; Trahair T; Tucker K; Ziegler DS; Tyrrell V, 2020, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer in Australia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 80, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020, http://dx.doi.org/10.1158/1538-7445.AM2020-SY09-02
    Conference Abstracts | 2020
    Dr Paul Ekert
    Barahona P; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Haber M; Lock RB; Marshall GM; Mayoh C; Mould E; Nagabushan S; Norris M; O’Brien T; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Ziegler DS; Tyrrell VJ; Ekert P; Cowley MJ; Lau L; Quang D-AK, 2020, 'Abstract A52: Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with high-risk cancer', in Poster Presentations - Proffered Abstracts, American Association for Cancer Research, presented at Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada, http://dx.doi.org/10.1158/1538-7445.pedca19-a52
    Conference Abstracts | 2020
    Dr Paul Ekert
    Dong-Anh K-Q; Nagabushan S; Manoharan N; Arndt G; Barahona P; Cowley MJ; Ekert PG; Failes T; Bolanos NF; Gauthier M; Gifford AJ; Haber M; Kumar A; Lock RB; Marshall GM; Mayoh C; Mould E; Norris MD; Gopalakrishnan A; Omer N; Trebilcock P; Trahair TN; Tsoli M; Tucker K; Wong M; Tyrrell V; Lau L; Ziegler DS, 2020, 'PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Vol. 22, pp. 302 - 302, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000606080100118&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2020
    Dr Paul Ekert
    Meyran D; Zhu J; Butler J; Macdonald S; Tantalo D; Thio N; Sek K; Ekert P; Kershaw M; Trapani J; Darcy P; Neeson P, 2020, 'EARLY-PHENOTYPE LEWIS Y CAR-T CELLS PERSIST BETTER IN VIVO AND INDUCE SOLID TUMOR REGRESSION IN COMBINATION WITH ANTI-PD1', in JOURNAL FOR IMMUNOTHERAPY OF CANCER, BMJ PUBLISHING GROUP, Vol. 8, pp. A76 - A78, http://dx.doi.org/10.1136/jitc-2020-SITC2020.0126
    Conference Papers | 2020
    Dr Paul Ekert
    Barahona P; Sherstyuk A; Cowley M; Ekert P; Kirk J; Khuong-Quang D-A; Kumar A; Lau L; Mayoh C; Marshall G; Moud E; O’Brien T; Pinese M; Thomas D; Tyrell V; Ziegler D; Haber M; Tucker K; Fuentes-Bolanos NA; Warby M, 2020, 'Abstract A03: Prevalence and spectrum of germline mutations in children with high-risk cancer', in Poster Presentations - Proffered Abstracts, American Association for Cancer Research, presented at Abstracts: AACR Special Conference on the Advances in Pediatric Cancer Research; September 17-20, 2019; Montreal, QC, Canada, http://dx.doi.org/10.1158/1538-7445.pedca19-a03
    Conference Abstracts | 2020
    Dr Paul Ekert
    Smith KM; Haire SO; Dong AK-Q; Markman B; Gan HK; Ekert PG; O'Byrne KJ; Millward M; Solomon BJ; Tran B; Scott CL; Kee D; McArthur GA; Fellowes A; Weerasuriya R; Lynch E; Martyn M; Gaff C; Fox SB; Desai J, 2020, 'Evaluating barriers to uptake of comprehensive genomic profiling (CGP) in advanced cancer patients (pts).', in JOURNAL OF CLINICAL ONCOLOGY, LIPPINCOTT WILLIAMS & WILKINS, ELECTR NETWORK, Vol. 38, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), ELECTR NETWORK, 29 May 2020 - 31 May 2020, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000560368301146&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Mould EV; Lau L; Arndt G; Barahona P; Cowley MJ; Ekert P; Failes T; Fletcher J; Gifford A; Grebert-Wade D; Haber M; Kamili A; Kumar A; Lock RB; Marshall GM; Mayoh C; Norris M; O'Brien T; Quang DAK; Strong P; Sherstyuk A; Trahair T; Tsoli M; Tucker K; Warby M; Wong M; Xie J; Ziegler DS; Tyrrell V, 2019, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Atlanta, GA, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Atlanta, GA, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.AM2019-3111
    Conference Abstracts | 2019
    Dr Paul Ekert
    Meyran D; Zhu J; Buttler J; Tantalo D; Neeson M; Ekert P; Kershaw M; Trapani J; Darcy P; Neeson P, 2019, 'DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER', in CYTOTHERAPY, ELSEVIER SCI LTD, Vol. 21, pp. E15 - E15, http://dx.doi.org/10.1016/j.jcyt.2019.04.050
    Conference Abstracts | 2019
    Dr Paul Ekert
    Haber M; Gamble L; Xiao L; Pandher R; Somers K; Murray J; Khan A; Yu D; Franshaw L; Burns MR; Tsoli M; Ehteda A; Cesare A; O'Connor A; Mussai F; de Santo C; Cheng P; Korotchkina L; Gurova K; Tyrrell V; Mould E; Lau L; Dong AKQ; Mayoh C; Arndt G; Barahona P; Failes T; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Gifford A; Grebert-Wade D; Kamili A; Kumar A; Nagabushan S; O'Brien T; Strong P; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Xie J; Evans K; Lock R; Chernova OB; Henderson M; Gudkov AV; Ekert P; Cowley MJ; Marshall GM; Ziegler DS; Norris MD, 2019, 'Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Montreal, CANADA, Vol. 80, pp. 23 - 24, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, Montreal, CANADA, 17 September 2019 - 20 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Tsoli M; Lau L; Barahona P; Mayoh C; Failes T; Wong M; Sherstyuk A; Gifford AJ; Kumar A; Mould E; Ung C; Tolhurst O; Gopalakrishnan A; Grebert-Wade D; Strong P; Trebilcock P; Lock R; Tyrrell V; Trahair T; Tucker K; Warby M; Arndt G; Norris M; Haber M; Marshall G; O’Brien T; Quang DAK; Cowley M; Ekert P; Ziegler DS, 2019, 'THER-23. RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRATED PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in Neuro-Oncology, Oxford University Press (OUP), Vol. 21, pp. ii118 - ii118, http://dx.doi.org/10.1093/neuonc/noz036.228
    Conference Abstracts | 2019
    Dr Paul Ekert
    Smith K; O'Haire S; Dong-Anh K-Q; Markman B; Gan H; Ekert PG; O'Byrne K; Milward M; Solomon B; Tran B; Scott C; McArthur G; Kee D; Fellowes A; Xu H; Martyn M; Lynch E; Lorgelly P; Gaff C; Fox S; Desai J, 2019, 'iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY, Vol. 15, pp. 184 - 185, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000493438400299&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Barahona P; Sherstyuk A; Cowley M; Ekert P; Kirk J; Dong-Anh K-Q; Kumar A; Lau L; Mayoh C; Marshall G; Moud E; O'Brien T; Pinese M; Thomas D; Tyrell V; Ziegler D; Haber M; Tucker K; Fuentes-Bolanos NA; Warby M, 2019, 'Prevalence and spectrum of germline mutations in children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Montreal, CANADA, Vol. 80, pp. 42 - 43, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, Montreal, CANADA, 17 September 2019 - 20 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400048&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Barahona P; Fletcher J; Fuentes-Bolanos N; Gauthier M-E; Haber M; Lock RB; Marshall GM; Mayoh C; Mould E; Nagabushan S; Norris M; O'Brien T; Sherstyuk A; Thomas D; Trahair T; Tucker K; Warby M; Wong M; Ziegler DS; Tyrrell VJ; Ekert P; Cowley MJ; Lau L; Quang D-AK, 2019, 'Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with highrisk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Montreal, CANADA, Vol. 80, pp. 70 - 71, presented at AACR Special Conference on the Advances in Pediatric Cancer Research, Montreal, CANADA, 17 September 2019 - 20 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000551367400096&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Fuentes-Bolanos N; Warby M; Barahona P; Sherstyuk A; Cowley M; Ekert P; Kirk J; Khuong-Quang DA; Amit K; Lau L; Mayoh C; Marshall G; Mould E; O'Brien TA; Pinese M; Thomas D; Tyrrell V; Ziegler D; Harber M; Tucker KM, 2019, 'Prevalence and Spectrum of Germline Mutations in Children with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 66, pp. S503 - S504, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488458005160&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Quang DAK; Lau L; Cowley MJ; Ekert PG; Gifford AJ; Haber M; Lock R; Marshall G; Mayoh C; Mould E; Norris M; O'Brien T; Trahair T; Tyrrell V; Ziegler DS, 2019, 'Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children and Adolescents with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 66, pp. S504 - S505, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488458005162&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Paul Ekert
    Tsoli M; Lau L; Barahona P; Mayoh C; Failes T; Wong M; Sherstyuk A; Gifford AJ; Kumar A; Mould E; Ung C; Tolhurst O; Gopalakrishnan A; Grebert-Wade D; Strong P; Trebilcock P; Lock R; Tyrrell V; Trahair T; Tucker K; Warby M; Arndt G; Norris M; Haber M; Marshall G; O'Brien T; Dong AKQ; Cowley M; Ekert P; Ziegler DS, 2019, 'RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRA-TM PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, San Francisco, CA, Vol. 21, pp. 118 - 118, presented at 5th Biennial Conference of the Society-for-Neuro-Oncology on Pediatric Neuro-Oncology Basic and Translational Research, San Francisco, CA, 03 May 2019 - 04 May 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000473243700229&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Dr Paul Ekert
    Khuong-Quang D-A; Gayden T; Sepulveda F; Pratt J; Valera E; Garrigue A; Kelso S; Sicheri F; Mikael L; Hamel N; Bajic A; Dali R; Dervovic D; Schramek D; Guerin F; Taipale M; Nikbakht H; Majewski J; Moshous D; Charlebois J; Abish S; Bole-Feysot C; Nitschke P; Bader-Meunier B; Mitchell D; Thieblemont C; Battistella M; Gravel S; Van-Hung N; Conyers R; Diana J-S; McCormack C; Prince HM; Besnard M; Blanche S; Ekert PG; Fraitag S; Foulkes WD; Fischer A; Neven B; Michonneau D; de Saint Basile G; Jabado N, 2018, 'Germline TIM-3 Mutations Characterize Sub-Cutaneous Panniculitis T-Cell Lymphomas with Hemophagocytic Lymphohistiocytic Syndrome', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-120297
    Conference Papers | 2018
    Dr Paul Ekert
    Salmon JM; Pomilio G; Moujalled DM; Macraild S; Teh CE; Riajl S; Ivey A; Teh T-C; Ekert PG; Kraus-Berthier L; Kloos I; Schoumacher M; Gray D; Wei AH, 2018, 'Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117403
    Conference Abstracts | 2018
    Dr Paul Ekert
    Tsoli M; Wadham C; Pinese M; Failes T; Joshi S; Mould E; Yin J; Gayevski V; Kumar A; Kaplan W; Ekert P; Franshaw L; Gifford A; Weber M; Rodriguez M; Mayoh C; Cohn R; Arndt G; Lock R; Tyrrell V; Norris M; Haber M; Lau L; Dong AKQ; Wong M; Trahair T; Marshall GM; Cowley MJ; Ziegler DS, 2018, 'Integrated genomics: drug screening and personalized xenograft development approach to identify precision treatments for aggressive pediatric brain tumors', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Chicago, IL, Vol. 78, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-137
    Conference Abstracts | 2018
    Dr Paul Ekert
    Mould E; Lau L; Arndt G; Barahona P; Cowley M; Ekert P; Failes T; Fletcher J; Gifford A; Haber M; Kamili A; Kumar A; Lock R; Marshall G; Mayoh C; Mead S; Norris M; O'Brien T; Pinese M; Dong AKQ; Trahair T; Tsoli M; Tucker K; Warby M; Wong M; Xie J; Ziegler D; Tyrrell V, 2018, 'Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, Chicago, IL, Vol. 78, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), Chicago, IL, 14 April 2018 - 18 April 2018, http://dx.doi.org/10.1158/1538-7445.AM2018-LB-138
    Conference Abstracts | 2018
    Dr Paul Ekert
    Tyrrell V; Lau L; Arndt G; Barahona P; Cowley M; Ekert P; Failes T; Fletcher J; Gifford A; Haber M; Kamili A; Kumar A; Lock R; Marshall G; Mayoh C; Mead S; Mould E; O'Brien T; Pinese M; Khuong-Quang DA; Thomas D; Trahair T; Tsoli M; Tucker K; Wharby M; Wong M; Xie J; Ziegler D, 2018, 'Zero childhood cancer – Accelerating translation of experimental oncology: Better matching drug to target', in Pathology, Elsevier BV, Vol. 50, pp. S31 - S31, http://dx.doi.org/10.1016/j.pathol.2017.12.072
    Conference Abstracts | 2018
    Dr Paul Ekert
    Ziegler D; Tsoli M; Tyrell V; Cohn R; Lau L; Cox M; Cowley M; Ekert P; Marshall G; Haber M, 2018, 'EAPH-09. POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA', in Neuro-Oncology, Oxford University Press (OUP), Vol. 20, pp. i67 - i67, http://dx.doi.org/10.1093/neuonc/noy059.178
    Conference Papers | 2018
    Dr Paul Ekert
    Brown LM; Huckstep H; Sandow J; Bartolo RC; Davidson N; Schmidt B; Bjelosevic S; Johnstone RW; Oshlack A; Davis M; Ekert PG, 2018, 'Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-117844
    Conference Papers | 2018
    Dr Paul Ekert
    Moujalled DM; Hanna DT; Pomilio G; Litalien V; Fleming S; Chanrion M; Maragno A-L; Kraus-Berthier L; Khaw SL; Lessene G; Huang D; Roberts AW; Geneste O; Ekert PG; Ng AP; Wei AH, 2018, 'Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, presented at 60th Annual Meeting of the American-Society-of-Hematology (ASH), San Diego, CA, 01 December 2018 - 04 December 2018, http://dx.doi.org/10.1182/blood-2018-99-114051
    Conference Abstracts | 2018
    Dr Paul Ekert
    Ziegler D; Tsoli M; Tyre V; Cohn R; Lau L; Cox M; Cowley M; Ekert P; Marshall G; Haber M, 2018, 'POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA', in NEURO-ONCOLOGY, OXFORD UNIV PRESS INC, Denver, CO, Vol. 20, pp. 67 - 67, presented at 18th International Symposium on Pediatric Neuro-Oncology (ISPNO), Denver, CO, 30 June 2018 - 03 July 2018, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000438339000180&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2018
    Dr Paul Ekert
    Ekert P; Wong M; Mould E; Gifford A; Norris M; Warby M; Trahair T; Tucker K; Ziegler D; Marshall G; O'Brien T; Haber M; Vanessa T; Cowley M, 2018, 'Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children with High-Risk Cancer', in PEDIATRIC BLOOD & CANCER, WILEY, Vol. 65, pp. S643 - S644, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000445195005221&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2017
    Dr Paul Ekert
    Lau L; Byrne J; Ekert PG; Failes T; Fellowes A; Fletcher J; Gifford A; Haber M; Kumar A; Lock R; Marshall G; McCowage GB; Mould E; Norris M; Trahair T; Tsoli M; Tyrrell V; Wadham C; Xie J; Ziegler DS, 2017, 'Pilot study of a comprehensive precision medicine platform for children with high-risk cancer.', in JOURNAL OF CLINICAL ONCOLOGY, AMER SOC CLINICAL ONCOLOGY, Chicago, IL, Vol. 35, presented at Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO), Chicago, IL, 02 June 2017 - 06 June 2017, http://dx.doi.org/10.1200/JCO.2017.35.15_suppl.10539
    Conference Papers | 2017
    Dr Paul Ekert
    Narayan N; Morenos L; Yuen HLA; Chen M; Fornerod M; Zwaan CM; Grigoriadis G; Ekert PG, 2017, 'Microrna-211-a Novel Oncogene in Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, Atlanta, GA, presented at 59th Annual Meeting of the American-Society-of-Hematology (ASH), Atlanta, GA, 09 December 2017 - 12 December 2017, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000432419406140&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Dr Paul Ekert
    Narayan N; Morenos L; Phipson B; Brumatti G; Eggers S; Saffery R; Willis S; Oshlack A; Goodall GJ; Ekert PG, 2016, 'The Dose-Dependent Effects of Microrna-155 in Acute Myeloid Leukemia', in BLOOD, AMER SOC HEMATOLOGY, San Diego, CA, presented at 58th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH), San Diego, CA, 03 December 2016 - 06 December 2016, http://dx.doi.org/10.1182/blood.V128.22.2841.2841
    Conference Papers | 2015
    Dr Paul Ekert
    Silke J; Ma C; Brumatti G; Lalaoui N; Ekert PG, 2015, 'The Role of Receptor Interacting Protein Kinase in Myelopoiesis in Health and Disease', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, presented at 57th Annual Meeting of the American-Society-of-Hematology, Orlando, FL, 05 December 2015 - 08 December 2015, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000368019000031&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2015
    Dr Paul Ekert
    Lee B; Hsu AL; Taylor GR; Fox S; Fellowes A; Mooi J; Desai J; Doig K; Ekert P; Gaff C; Gunawardana D; Hamilton A; James P; Roberts A; Snyder R; Waring P; McArthur G; Tran B, 2015, 'EXPLORING THE FEASIBILITY AND UTILITY OF EXOME-SCALE SEQUENCING OF TUMOURS IN A CLINICAL SETTING', in Asia-Pacific Journal of Clinical Oncology, WILEY-BLACKWELL, pp. 69 - 69, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000364320800023&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2014
    Dr Paul Ekert
    Lee BM; Mooi J; Fox S; Taylor GR; Fellowes A; Hsu AL; Desai J; Ekert P; Gaff C; Gunawardana D; Hamilton A; James P; Snyder R; Waring P; McArthur G; Ben T, 2014, 'INTEGRATION OF SCIENTISTS AND CLINICAL EXPERTS IN AUSTRALIA'S FIRST MOLECULAR TUMOUR BOARD FROM THE VICTORIAN COMPREHENSIVE CANCER CENTRE (VCCC)', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 180 - 180, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000345350900315&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Dr Paul Ekert
    Christie N; Ekert P; Lopez A; Ramshaw H, 2013, 'TOWARDS AN UNDERSTANDING OF THE BIOLOGICAL SIGNIFICANCE OF INCREASED IL-3R alpha EXPRESSION IN ACUTE MYELOID LEUKAEMIA STEM CELLS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vienna, AUSTRIA, pp. S48 - S48, presented at 42nd Annual Scientific Meeting of the International-Society-for-Experimental-Hematology-and-Stem-Cells (ISEH), Vienna, AUSTRIA, 22 August 2013 - 25 August 2013, http://dx.doi.org/10.1016/j.exphem.2013.05.190
    Conference Papers | 2013
    Dr Paul Ekert
    Thomas D; Powell JA; Parker MW; Ekert PG; Lock RB; Huang DC; Nilsson SK; Recher C; Wei AH; Guthridge MA, 2013, 'The selective targeting of cell survival pathways in leukemia', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, http://dx.doi.org/10.1158/1538-7445.FBCR13-A19
    Conference Papers | 2013
    Dr Paul Ekert
    Bandopadhayay P; Jabbour A; Riffkin C; Salmanidis M; Gordon L; Popovski D; Rigby L; Ashley D; Watkins D; Watkins D; Thomas D; Algar E; Ekert P, 2013, 'THE ONCOGENIC PROPERTIES OF THE EWS/WT1 FUSION PROTEIN OF DESMOPLASTIC SMALL ROUND CELL TUMOUR', in PEDIATRIC BLOOD & CANCER, WILEY-BLACKWELL, pp. 8 - 8, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000324735500026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Dr Paul Ekert
    Bandopadhayay P; Titgemeyer C; Siswara P; Dagar V; Barton R; Downie P; MeChinaud F; Ekert P; Algar E, 2011, 'THE INCIDENCE AND OUTCOME OF SOMATIC WT1 MUTATIONS IN CHILDREN WITH ACUTE MYELOID LEUKAEMIA', in PEDIATRIC BLOOD & CANCER, WILEY PERIODICALS, INC, pp. 773 - 773, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000295239600266&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2011
    Dr Paul Ekert
    Sadras T; Perugini M; Ramshaw HS; Salerno DG; Kok CH; Lewis ID; Lopez AF; Ekert PG; D'Andrea RJ, 2011, 'IL-3 REGULATES B-CATENIN IN MYELOID CELLS AND ENFORCED EXPRESSION OF B-CATENIN REDUCES THE DEPENDENCY ON IL-3 FOR SURVIVAL', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, pp. S81 - S81, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000293801700135&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Paul Ekert
    Thomas D; Powell JA; Barry EF; Woodcock J; Ekert PG; Green BD; Lee EM; Lock RB; Nilsson SK; Haylock DN; Lopez AF; Guthridge MA, 2010, 'THE PROTEIN KINASE ACTIVITY OF PHOSPHOINOSITIDE 3-KINASE ALPHA PROMOTES AUTONOMOUS CELL SURVIVAL IN AML STEM/PROGENITOR CELLS', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S87 - S87, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900175&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Paul Ekert
    Geest CR; Wensveen FM; Libregts SFWM; de Bruin AM; Derks IAM; Ekert PG; Labi V; Villunger A; Nolte MA; Eldering E, 2010, 'Role for BH3-Only Protein NOXA In Growth-Factor Deprivation and Early Erythropoiesis', in BLOOD, AMER SOC HEMATOLOGY, Orlando, FL, pp. 1720 - 1720, presented at 52nd Annual Meeting of the American-Society-of-Hematology (ASH), Orlando, FL, 04 December 2010 - 07 December 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000289662204654&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Paul Ekert
    Sadras T; Perugini M; Ramshaw HS; Salerno DG; Lewis ID; Lopez AF; Ekert PG; D'Andrea RJ, 2010, 'IL-3 MEDIATED ACTIVATION OF beta-CATENIN IN ACUTE MYELOID LEUKEMIA', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S59 - S59, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900120&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Paul Ekert
    Brumatti G; Salmanidis M; Silke N; van den Bergen J; Jabbour A; Bouillet P; Ekert P, 2010, 'A NOVEL ROLE FOR HOXA9 IN MYELOID CELLS. REGULATION OF BCL-2 FAMILY MEMBERS, CELL DEATH AND DIFFERENTIATION', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S63 - S63, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900128&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2010
    Dr Paul Ekert
    Powell JA; Thomas D; Barry EF; Kok CH; Ma LY; To LB; Brown A; Lewis ID; Goodall GJ; Speed TP; Woodcock J; Osato M; Ekert PG; Haylock DN; Nilsson SK; D'Andrea RJ; Lopez AF; Guthridge MA, 2010, 'TARGETING CELL SURVIVAL PATHWAYS IN ACUTE MYELOID LEUKEMIA', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Melbourne, AUSTRALIA, pp. S60 - S60, presented at 39th Annual Scientific Meeting of the ISEH - Society-for-Hematology-and-Stem-Cells, Melbourne, AUSTRALIA, 15 September 2010 - 18 September 2010, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000281168900122&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2008
    Dr Paul Ekert
    Ashley D; Muscat A; Dagar V; Rickert CH; Chow CW; Biegel JA; Ekert P; Saffery R; Craig J; Johnstone R; Algar E, 2008, 'Insights into the epigenetics of atypical teratoid rhabdoid tumors: The potential for treatment with histone deacetylase inhibitors', in NEURO-ONCOLOGY, DUKE UNIV PRESS, Chicago, IL, pp. 372 - 372, presented at 13th International Symposium on Pediatric Neuro-Oncology, Chicago, IL, 29 June 2008 - 02 July 2008, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000256974900025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2004
    Dr Paul Ekert
    Ashley DM; Riffkin CD; Ekert PG; Knight MJ; Hawkins CJ, 2004, 'Caspase-8 levels determine signalling pathways used in death ligand-induced glioma cell apoptosis', in NEURO-ONCOLOGY, DUKE UNIV PRESS, Boston, MA, pp. 402 - 402, presented at 11th International Symposium on Pediatric Neuro-Oncology, Boston, MA, 13 June 2004 - 16 June 2004, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000224332400324&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Dr Paul Ekert
    Ekert PG; Read S; Hawkins CJ; Marsden V; Silke J; Kumar S; Vaux DL, 2003, 'Caspase-9 can be activated in the absence of APAF-1 and bcl-2 provides clonal protection from growth-factor withdrawal induced apoptosis independent of APAF1 and Caspase-9', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, SEATTLE, WASHINGTON, pp. 276A - 276A, presented at Annual Meeting of the Pediatric-Academic-Society, SEATTLE, WASHINGTON, 03 May 2003 - 06 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000181897901574&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Dr Paul Ekert
    Ekert PG; Read S; Silke J; Marsden VS; Kaufmann H; Hawkins CJ; Gerl R; Kumar S; Vaux DL, 2003, 'Apaf-1, Caspase-2 and Caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, SEATTLE, WA, pp. 295A - 295A, presented at Annual Meeting of the Pediatric-Academic-Societies, SEATTLE, WA, 03 May 2003 - 06 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000220591101728&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2003
    Dr Paul Ekert
    Ekert PG; Jabbour A; Yu J; Puyer MA; Ho PK; Hawkins CJ, 2003, 'Modelling apoptosis pathways in yeast', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, SEATTLE, WA, pp. 300A - 300A, presented at Annual Meeting of the Pediatric-Academic-Societies, SEATTLE, WA, 03 May 2003 - 06 May 2003, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000220591101756&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2000
    Dr Paul Ekert
    Ekert PG; Silke J; Vaux DL, 2000, 'MIHA/XIAP blocks apoptosis induced by an auto-activating caspase 3 and UV irradiation and can bind to endogenous, activated caspase 3', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, pp. 68A - 68A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086155300397&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2000
    Dr Paul Ekert
    Mills JF; Dargaville PA; Coleman LT; Rosenfeld JV; Ekert PG, 2000, 'Magnetic resonance imaging is the investigation of choice in neonatal upper cervical spinal cord injury', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, pp. 417A - 417A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000086155302466&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1999
    Dr Paul Ekert
    Ekert PG; Silke J; Vaux DL, 1999, 'Genes inhibiting caspases rescue neuronal cells from apoptosis and allow functional survival of cells exposed to a death stimulus', in PEDIATRIC RESEARCH, INT PEDIATRIC RESEARCH FOUNDATION, INC, pp. 195A - 195A, http://dx.doi.org/10.1203/00006450-199904020-01161
    Conference Papers | 1996
    Dr Paul Ekert
    Ekert PG; MacLusky N; Becker L; Post M; Tanswell AK, 1996, 'Dexamethasone neuroprotection is associated with preserved expression of bcl-2 and suppression of glial fibrillary acid protein (GFAP).', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. 1226 - 1226, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UD23801226&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1996
    Dr Paul Ekert
    Ekert PG; MacLusky N; Ping X; Lahotav D; Post M; Tanswell AK, 1996, 'Dexamethasone prevents apoptosis in a rat model of neonatal hypoxic-ischemic encephalopathy (HIE) by a free radical independent mechanism.', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. 1227 - 1227, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UD23801227&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1996
    Dr Paul Ekert
    Barnett CP; Ekert PG; Perlman M, 1996, 'Serum transaminase measurements in post-asphyxial (PA) hypoxic ischemic encephalopathy (HIE).', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. 1743 - 1743, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1996UD23801743&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1995
    Dr Paul Ekert
    EKERT PG; STEINLIH M; WHYTE HE; PERIMAN M, 1995, 'PREDICTING OUTCOME OF SEVERE PERINATAL ASPHYXIA IN TERM INFANTS IN THE 1ST 12 HOURS OF LIFE', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. A254 - A254, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QP08201511&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1995
    Dr Paul Ekert
    STEINLIN M; EKERT PG; WHYTE HE; TAYLOR MJ; BLASER S; PERIMAN M, 1995, 'PREDICTION OF OUTCOME OF SEVERE PERINATAL ASPHYXIA IN TERM INFANTS SURVIVING THE 1ST 24 HOURS', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. A386 - A386, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1995QP08202298&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1994
    Dr Paul Ekert
    EKERT PG; TAYLOR MJ; WHYTE HE, 1994, 'VISUAL-EVOKED POTENTIALS (VEPS) FOR PREDICTION OF NEURODEVELOPMENTAL OUTCOME IN PRETERM INFANTS', in PEDIATRIC RESEARCH, WILLIAMS & WILKINS, pp. A268 - A268, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1994NG77901590&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 1992
    Dr Paul Ekert
    PELLETIER S; LANDI B; PIETTE JC; EKERT P; COUTELLIER A; DESMOULINS C; FADLALLAH JP; HERSON S; VALLA D, 1992, 'THE ANTIPHOSPHOLIPID SYNDROME (APS) AS THE 2ND CAUSE OF NONMALIGNANT BUDD-CHIARI SYNDROME (BCS)', in ARTHRITIS AND RHEUMATISM, LIPPINCOTT-RAVEN PUBL, pp. S238 - S238, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1992JR15801205&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

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