Dr Rajesh Kuppusamy

Dr Rajesh Kuppusamy

Visiting Fellow

 

Medicine & Health
School of Optometry and Vision Science

I am a dynamic and innovative researcher, currently pursuing the development of new antibiotics, antivirals, and disinfectants to tackle community and hospital-acquired infections. 

Throughout my vast experience in industry and academia, I have developed many novel compounds used to treat important human diseases such as cancer, cardiovascular disease, and bacterial infections. I am passionate about med chem research projects, training new researchers, and translating research into new products, and want to contribute my research for the benefit of working organisations and society.  

  • Journal articles | 2024
    Abdullah Aziz M; Kuppusamy R; Mazumder K; Hui A; Maulvi F; Stapleton F; Willcox M, 2024, 'Absorption and attachment of atropine to etafilcon A contact lenses', Contact Lens and Anterior Eye, http://dx.doi.org/10.1016/j.clae.2024.102246
    Journal articles | 2024
    Bahatheg G; Kuppusamy R; Yasir M; Bridge S; Mishra SK; Cranfield CG; StC. Black D; Willcox M; Kumar N, 2024, 'Dimeric peptoids as antibacterial agents', Bioorganic Chemistry, 147, http://dx.doi.org/10.1016/j.bioorg.2024.107334
    Journal articles | 2024
    Enninful GN; Kuppusamy R; Tiburu EK; Kumar N; Willcox MDP, 2024, 'Non-canonical amino acid bioincorporation into antimicrobial peptides and its challenges', Journal of Peptide Science, 30, http://dx.doi.org/10.1002/psc.3560
    Journal articles | 2024
    Hong Z; Yu TT; Yasir M; Sara M; Black DSC; Willcox MDP; Kuppusamy R; Kumar N, 2024, 'Daidzein-Based Amphiphilic Small Molecular Antimicrobial Peptidomimetics as Novel Antimicrobial Agents with Anti-Biofilm Activity', ChemistrySelect, 9, http://dx.doi.org/10.1002/slct.202400502
    Journal articles | 2024
    Maulvi FA; Desai DT; Kalaiselvan P; Dumpati S; Kuppusamy R; Masoudi S; Shah DO; Willcox MDP, 2024, 'Lipid-based eye drop formulations for the management of evaporative dry eyes', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102154
    Journal articles | 2024
    Sara M; Yasir M; Kalaiselvan P; Hui A; Kuppusamy R; Kumar N; Chakraborty S; Yu TT; Wong EHH; Molchanova N; Jenssen H; Lin JS; Barron AE; Willcox M, 2024, 'The activity of antimicrobial peptoids against multidrug-resistant ocular pathogens', Contact Lens and Anterior Eye, 47, http://dx.doi.org/10.1016/j.clae.2024.102124
    Journal articles | 2023
    Browne K; Kuppusamy R; Walsh WR; Black DSC; Willcox MDP; Kumar N; Chen R, 2023, 'Antimicrobial Peptidomimetics Prevent the Development of Resistance against Gentamicin and Ciprofloxacin in Staphylococcus and Pseudomonas Bacteria', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms241914966
    Journal articles | 2023
    Kuppusamy R; Browne K; Suresh D; Do Rosario RM; Chakraborty S; Yang S; Willcox M; Black D; Chen R; Kumar N, 2023, 'Transition Towards Antibiotic Hybrid Vehicles: The Next Generation Antibacterials', Current Medicinal Chemistry, 30, pp. 104 - 125, http://dx.doi.org/10.2174/0929867329666220613105424
    Journal articles | 2023
    Kuppusamy R; Yasir M; Yu TT; Voli F; Vittorio O; Miller MJ; Lewis P; Black DSC; Willcox M; Kumar N, 2023, 'Tuning the Anthranilamide Peptidomimetic Design to Selectively Target Planktonic Bacteria and Biofilm', Antibiotics, 12, pp. 585, http://dx.doi.org/10.3390/antibiotics12030585
    Journal articles | 2023
    Sabir S; Das T; Kuppusamy R; Yu TT; Willcox MD; Black DSC; Kumar N, 2023, 'Novel quinazolinone disulfide analogues as pqs quorum sensing inhibitors against Pseudomonas aeruginosa', Bioorganic Chemistry, 130, pp. 106226, http://dx.doi.org/10.1016/j.bioorg.2022.106226
    Journal articles | 2023
    Urmi UL; Attard S; Vijay AK; Willcox MDP; Kumar N; Islam S; Kuppusamy R, 2023, 'Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus', Antibiotics, 12, pp. 1436, http://dx.doi.org/10.3390/antibiotics12091436
    Journal articles | 2023
    Urmi UL; Vijay AK; Kuppusamy R; Islam S; Willcox MDP, 2023, 'A review of the antiviral activity of cationic antimicrobial peptides', Peptides, 166, http://dx.doi.org/10.1016/j.peptides.2023.171024
    Journal articles | 2023
    Urmi UL; Willcox MDP; Islam S; Kuppusamy R; Vijay AK, 2023, 'Ocular signs and symptoms of monkeypox virus infection, and possible role of the eye in transmission of the virus', Contact Lens and Anterior Eye, 46, pp. 101808, http://dx.doi.org/10.1016/j.clae.2022.101808
    Journal articles | 2023
    Willcox MDP; Bahatheg G; Carnt N; Kalaiselvan P; Kumar N; Kuppusamy R; Rayamajhee B; Sara M; Stapleton F; Vijay AK; Yasir M; Yu TT, 2023, 'Biofilms and contact lenses: problems and solutions', Microbiology Australia, 44, pp. 96 - 99, http://dx.doi.org/10.1071/MA23027
    Journal articles | 2022
    Aldilla VR; Chen R; Kuppusamy R; Chakraborty S; Willcox MDP; Black DSC; Thordarson P; Martin AD; Kumar N, 2022, 'Hydrogels with intrinsic antibacterial activity prepared from naphthyl anthranilamide (NaA) capped peptide mimics', Scientific Reports, 12, http://dx.doi.org/10.1038/s41598-022-26426-1
    Journal articles | 2022
    Bahatheg G; Kuppusamy R; Yasir M; Black DSC; Willcox M; Kumar N, 2022, 'Short Tryptamine-Based Peptoids as Potential Therapeutics for Microbial Keratitis: Structure-Function Correlation Studies', Antibiotics, 11, pp. 1074, http://dx.doi.org/10.3390/antibiotics11081074
    Journal articles | 2022
    Browne K; Kuppusamy R; Chen R; Willcox MDP; Walsh WR; Black DS; Kumar N, 2022, 'Bioinspired Polydopamine Coatings Facilitate Attachment of Antimicrobial Peptidomimetics with Broad-Spectrum Antibacterial Activity', International Journal of Molecular Sciences, 23, pp. 2952, http://dx.doi.org/10.3390/ijms23062952
    Journal articles | 2022
    Kalaiselvan P; Kuppusamy R; Kumar N; Willcox M, 2022, 'Antimicrobial activity of RK-7 peptide mimic against Staphylococcus aureus in solution and when immobilised onto contact lenses', Contact Lens and Anterior Eye, 45, pp. 101607 - 101607, http://dx.doi.org/10.1016/j.clae.2022.101607
    Journal articles | 2022
    Kalaiselvan P; Yasir M; Kuppusamy R; Willcox M; Vijay AK, 2022, 'Ability of Essential Oil Vapours to Reduce Numbers of Culturable Aerosolised Coronavirus, Bacteria and Fungi', Antibiotics, 11, pp. 393, http://dx.doi.org/10.3390/antibiotics11030393
    Journal articles | 2022
    Peguda HK; Carnt NA; Gu Z; Kumar N; Willcox MDP; Kuppusamy R, 2022, 'The Anti-Amoebic Activity of a Peptidomimetic against Acanthamoeba castellanii', Microorganisms, 10, pp. 2377, http://dx.doi.org/10.3390/microorganisms10122377
    Journal articles | 2022
    Wu J; Yu TT; Kuppusamy R; Hassan MM; Alghalayini A; Cranfield CG; Willcox MDP; Black DS; Kumar N, 2022, 'Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents', International Journal of Molecular Sciences, 23, pp. 4623, http://dx.doi.org/10.3390/ijms23094623
    Journal articles | 2021
    Chakraborty S; Kuppusamy R; Roohani I; Walsh WR; Willcox MDP; Kumar N; Chen R, 2021, 'Antibacterial peptidomimetic and characterization of its efficacy as an antibacterial and biocompatible coating for bioceramic-based bone substitutes', Materials Advances, 2, pp. 6369 - 6379, http://dx.doi.org/10.1039/d1ma00648g
    Journal articles | 2021
    Sabir S; Yu TT; Kuppusamy R; Almohaywi B; Iskander G; Das T; Willcox MDP; Black DS; Kumar N, 2021, 'Novel seleno-and thio-urea-containing dihydropyrrol-2-one analogues as antibacterial agents', Antibiotics, 10, pp. 321, http://dx.doi.org/10.3390/antibiotics10030321
    Journal articles | 2021
    Tummanapalli SS; Kuppusamy R; Yeo JH; Kumar N; New EJ; Willcox MDP, 2021, 'The role of nitric oxide in ocular surface physiology and pathophysiology', Ocular Surface, 21, pp. 37 - 51, http://dx.doi.org/10.1016/j.jtos.2021.04.007
    Journal articles | 2021
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Sara M; Ho J; Willcox MDP; Black DS; Kumar N, 2021, 'Polyphenylglyoxamide‐based amphiphilic small molecular peptidomimetics as antibacterial agents with anti‐biofilm activity', International Journal of Molecular Sciences, 22, pp. 7344, http://dx.doi.org/10.3390/ijms22147344
    Journal articles | 2020
    Yasir M; Dutta D; Hossain KR; Chen R; Ho KKK; Kuppusamy R; Clarke RJ; Kumar N; Willcox MDP, 2020, 'Mechanism of Action of Surface Immobilized Antimicrobial Peptides Against Pseudomonas aeruginosa', Frontiers in Microbiology, 10, pp. 3053, http://dx.doi.org/10.3389/fmicb.2019.03053
    Journal articles | 2020
    Yu TT; Bhadbhade M; Kuppusamy R; Black DSC; Kumar N, 2020, 'A facile synthesis of meta- and para-terphenylglyoxamide-based peptidomimetics', Tetrahedron Letters, 61, http://dx.doi.org/10.1016/j.tetlet.2020.152560
    Journal articles | 2020
    Yu TT; Kuppusamy R; Yasir M; Hassan MM; Alghalayini A; Gadde S; Deplazes E; Cranfield C; Willcox MDP; Black DS; Kumar N, 2020, 'Design, synthesis and biological evaluation of biphenylglyoxamide-based small molecular antimicrobial peptide mimics as antibacterial agents', International Journal of Molecular Sciences, 21, pp. 1 - 38, http://dx.doi.org/10.3390/ijms21186789
    Journal articles | 2019
    Kuppusamy R; Willcox M; Black DSC; Kumar N, 2019, 'Short cationic peptidomimetic antimicrobials', Antibiotics, 8, pp. 44, http://dx.doi.org/10.3390/antibiotics8020044
    Journal articles | 2018
    Kuppusamy R; Yasir M; Berry T; Cranfield CG; Nizalapur S; Yee E; Kimyon O; Taunk A; Ho KKK; Cornell B; Manefield M; Willcox M; Black DSC; Kumar N, 2018, 'Design and synthesis of short amphiphilic cationic peptidomimetics based on biphenyl backbone as antibacterial agents', European Journal of Medicinal Chemistry, 143, pp. 1702 - 1722, http://dx.doi.org/10.1016/j.ejmech.2017.10.066
    Journal articles | 2018
    Kuppusamy R; Yasir M; Yee E; Willcox M; Black DSC; Kumar N, 2018, 'Guanidine functionalized anthranilamides as effective antibacterials with biofilm disruption activity', Organic and Biomolecular Chemistry, 16, pp. 5871 - 5888, http://dx.doi.org/10.1039/c8ob01699b
    Journal articles | 2016
    Chittimalla SK; Koodalingam M; Bandi C; Putturu S; Kuppusamy R, 2016, 'Expedient Baylis-Hillman reaction protocol to functionalize cyclohexa-2,4-dienones', RSC Advances, 6, pp. 1460 - 1465, http://dx.doi.org/10.1039/c5ra21842j
    Journal articles | 2015
    Chittimalla SK; Kuppusamy R; Akavaram N, 2015, 'Palladium-catalyzed regioselective synthesis of oxygenated biphenyls', Synlett, 26, http://dx.doi.org/10.1055/s-0034-1379987
    Journal articles | 2015
    Chittimalla SK; Laxmi S; Ming Liing AC; Kai Jun JL; Kuppusamy R; Putturu S; Bandi C, 2015, 'An approach towards expanding the scope of masked o-benzoquinone dimers to generate diverse compound libraries', RSC Advances, 5, pp. 29391 - 29396, http://dx.doi.org/10.1039/c5ra03627e
    Journal articles | 2015
    Devasthale P; Wang W; Mignone J; Renduchintala K; Radhakrishnan S; Dhanapal J; Selvaraj J; Kuppusamy R; Pelleymounter MA; Longhi D; Huang N; Flynn N; Azzara AV; Rohrbach K; Devenny J; Rooney S; Thomas M; Glick S; Godonis H; Harvey S; Cullen MJ; Zhang H; Caporuscio C; Stetsko P; Grubb M; Huang C; Zhang L; Freeden C; Murphy BJ; Robl JA; Washburn WN, 2015, 'Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4412 - 4418, http://dx.doi.org/10.1016/j.bmcl.2015.09.018
    Journal articles | 2014
    Chittimalla SK; Bandi C; Putturu S; Kuppusamy R; Boellaard KC; Tan DCA; Lum DMJ, 2014, 'Access to 3-arylindoles through a tandem one-pot protocol involving dearomatization, a regioselective michael addition reaction, and rearomatization', European Journal of Organic Chemistry, 2014, pp. 2565 - 2575, http://dx.doi.org/10.1002/ejoc.201400079
    Journal articles | 2014
    Chittimalla SK; Kuppusamy R; Bandi C, 2014, 'A detour route for meta functionalization of phenols', Synlett, 25, pp. 1991 - 1996, http://dx.doi.org/10.1055/s-0034-1378395
    Journal articles | 2013
    Chittimalla SK; Kuppusamy R; Thiyagarajan K; Bandi C, 2013, 'Reaction of nitrile oxides with masked o-benzoquinones; Synthesis of highly functionalized isoxazolines', European Journal of Organic Chemistry, pp. 2715 - 2723, http://dx.doi.org/10.1002/ejoc.201201670
    Journal articles | 2012
    Chittimalla SK; Kuppusamy R; Chakrabarti A, 2012, '[3+2] Cycloaddition of masked o-benzoquinones with azomethine ylides', Synlett, 23, pp. 1901 - 1906, http://dx.doi.org/10.1055/s-0031-129043
  • Preprints | 2023
    Urmi UL; Attard S; Vijay AK; Willcox M; Kumar N; Islam S; Kuppusamy R, 2023, Antiviral Activity of Anthranilamide Peptidomimetics against Herpes Simplex Virus 1 and a Coronavirus, , http://dx.doi.org/10.20944/preprints202308.2017.v1
    Conference Papers | 2022
    Peguda HK; Kuppusamy R; Kumar N; Willcox MDP, 2022, 'Anti-amoebic activity of RK-7 peptide mimic against Acanthamoeba spp trophozoites', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000844437003302&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2022
    Sara M; Alex H; Chen R; Kumar N; Rajesh K; Kumar Mishara SK; Barron A; Yasir MUHAMMAD; Willcox M; Yasir M, 2022, 'Antimicrobial activity of peptoids against clinical pathogens.', in Antimicrobial activity of peptoids against clinical pathogens., USA, presented at peptoidsummit2022, USA, 11 August 2022 - 12 August 2022
    Patents | 2021
    Kumar N; Willcox M; Nizalapur S; Black D; Yu TT; Kuppusamy R, 2021, Antimicrobial compounds, Patent No. United States 2021 pat no. 10988444
    Conference Abstracts | 2021
    Sara M; Kuppusamy R; Afzal M; Khan M; Yasir M; Kalaiselvan P; Hui A; Kumar N; Willcox M, 2021, 'Synergistic activity of a peptide mimic with quinolones and cephalosporins against Staphylococcus aureus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vol. 62, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000690760500400&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2013
    Wang W; Devasthale P; Longhi D; Azzara A; Devenny J; Cullen MJ; Zhang M; Caporuscio C; Zhang L; Huang C; Rampulla R; Mathur A; Shi H; Sun L; Levesque P; Apedo A; Moore D; Hicks M; Krishna K; Radhakrishnan S; Kuppusamy R; Selvaraj J; Dhanapal J; Washburn W; Robl J; Murphy B, 2013, 'Discovery of pyrazolopyrrolidinone-derived melanin concentrating hormone receptor-1 antagonists as anti-obesity agents', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, IN, Indianapolis, presented at 246th National Meeting of the American-Chemical-Society (ACS), IN, Indianapolis, 08 September 2013 - 12 September 2013, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000329618405018&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1

  • Development of aerosolised disinfectant

  •   BridgeTech REDI Fellowship through MTP connects ($10000)
  • Academic Research Excellence Research Award by the School of Optometry and Vision Science UNSW

My research focuses on

  • Design and Synthesis of new antimicrobial peptides and peptidomimetics to kill many different types of microbes including bacteria, fungi, and viruses. 
  • Isolation of Bacteriophages.
  • Working on understanding the mode of action of antibacterial compounds.
  • Working on the self-assembly properties of developed peptidomimetic compounds for drug-delivery applications.

 

My Research Supervision

Co-supervisor for Ph.D. students on various projects such as the development of antibacterials, antivirals, drug delivery, surface coating of antibacterials, and engineering peptides

  • Ghayah Bahatheg 
  • Mst Umme Laila Urmi 
  • Md Abdullah Aziz
  • George Enninful
  • Samuel Attard
  • Manjulatha Sara

 

My Teaching