Associate Professor Robert Nordon
Associate Professor

Associate Professor Robert Nordon

MB BS BMedSci PhD

Engineering
Grad Sch: Biomedical Eng

I am an Associate Professor in the Graduate School of Biomedical Engineering. I work closely with industry in the fields of advanced manufacturing and medical technologies. Since 2016 I have been awarded over $5M in research grant funding in the fields of point-of-care diagnostics, cell and gene therapy manufacture and stem cell science.

 

 

Phone
+61 2 9385 0559
Location
Samuels Building UNSW Sydney NSW 2052 Australia
  • Book Chapters | 2017
    Ko KH; Nordon R; O Brien TA; Symonds G; Dolnikov A, 2017, 'Ex vivo expansion of hematopoietic stem cells to improve engraftment in stem cell transplantation', in Methods in Molecular Biology, pp. 301 - 311, http://dx.doi.org/10.1007/978-1-4939-6603-5_19
  • Journal articles | 2022
    Tang TCY; Xu N; Nordon R; Haber M; Micklethwaite K; Dolnikov A, 2022, 'Donor T cells for CAR T cell therapy', Biomarker Research, vol. 10, http://dx.doi.org/10.1186/s40364-022-00359-3
    Journal articles | 2021
    Inglis DW; Nordon RE; Beech JP; Rosengarten G, 2021, 'Microfluidic obstacle arrays induce large reversible shape change in red blood cells', Micromachines, vol. 12, http://dx.doi.org/10.3390/mi12070783
    Journal articles | 2020
    Cornwell JA; Li J; Mahadevan S; Draper JS; Joun GL; Zoellner H; Asli NS; Harvey RP; Nordon RE, 2020, 'TrackPad: Software for semi-automated single-cell tracking and lineage annotation', SoftwareX, vol. 11, http://dx.doi.org/10.1016/j.softx.2020.100440
    Journal articles | 2020
    Du EY; Ziaee F; Wang L; Nordon RE; Thordarson P, 2020, 'The correlations between structure, rheology, and cell growth in peptide-based multicomponent hydrogels', Polymer Journal, vol. 52, pp. 947 - 957, http://dx.doi.org/10.1038/s41428-020-0351-8
    Journal articles | 2020
    Wojciechowski JP; Martin AD; Du EY; Garvey CJ; Nordon RE; Thordarson P, 2020, 'Non-reversible heat-induced gelation of a biocompatible Fmoc-hexapeptide in water', Nanoscale, vol. 12, pp. 8262 - 8267, http://dx.doi.org/10.1039/d0nr00289e
    Journal articles | 2019
    Farbehi N; Patrick R; Dorison A; Xaymardan M; Janbandhu V; Wystub-Lis K; Ho JWK; Nordon RE; Harvey RP, 2019, 'Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury', eLife, vol. 8, http://dx.doi.org/10.7554/eLife.43882
    Journal articles | 2019
    Shen S; Ferrell K; Chaudhry K; Vu A; Nordon R; O'Brien T, 2019, 'MODULATION OF ANTI-TUMOUR ACTIVITY OF EX VIVO EXPANDED NK AND GD2CAR-NK CELLS AGAINST NEUROBLASTOMA', CYTOTHERAPY, vol. 21, pp. S20 - S20, http://dx.doi.org/10.1016/j.jcyt.2019.03.317
    Journal articles | 2018
    Cornwell JA; Nordon RE; Harvey RP, 2018, 'Analysis of cardiac stem cell self-renewal dynamics in serum-free medium by single cell lineage tracking', Stem Cell Research, vol. 28, pp. 115 - 124, http://dx.doi.org/10.1016/j.scr.2018.02.004
    Journal articles | 2017
    Rad ZF; Nordon RE; Anthony CJ; Bilston L; Prewett PD; Arns JY; Arns CH; Zhang L; Davies GJ, 2017, 'High-fidelity replication of thermoplastic microneedles with open microfluidic channels', Microsystems and Nanoengineering, vol. 3, http://dx.doi.org/10.1038/micronano.2017.34
    Journal articles | 2016
    Hassanzadeh-Barforoushi A; Shemesh J; Farbehi N; Asadnia M; Yeoh GH; Harvey RP; Nordon RE; Warkiani ME, 2016, 'A rapid co-culture stamping device for studying intercellular communication', Scientific Reports, vol. 6, http://dx.doi.org/10.1038/srep35618
    Journal articles | 2016
    Weiss DJ; Rasko JEJ; Cuende N; Ruiz MA; Ho HN; Nordon R; Wilton S; Dominici M; Srivastava A, 2016, 'Part 2: Making the "unproven" "proven"', Cytotherapy, vol. 18, pp. 120 - 123, http://dx.doi.org/10.1016/j.jcyt.2015.11.005
    Journal articles | 2015
    Christo SN; Diener KR; Nordon RE; Brown MP; Griesser HJ; Vasilev K; Christo FC; Hayball JD, 2015, 'Scrutinizing calcium flux oscillations in T lymphocytes to deduce the strength of stimulus', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep07760
    Journal articles | 2015
    Dominici M; Nichols K; Srivastava A; Weiss DJ; Eldridge P; Cuende N; Deans RJ; Rasko JEJ; Levine AD; Turner L; Griffin DL; O'Donnell L; Forte M; Mason C; Wagena E; Janssen W; Nordon R; Wall D; Ho HN; Ruiz MA; Wilton S; Horwitz EM; Gunter KC, 2015, 'Positioning a Scientific Community on Unproven Cellular Therapies: The 2015 International Society for Cellular Therapy Perspective', Cytotherapy, vol. 17, pp. 1663 - 1666, http://dx.doi.org/10.1016/j.jcyt.2015.10.007
    Journal articles | 2015
    Hallett RM; Huang C; Motazedian A; Der Mauer SA; Pond GR; Hassell JA; Nordon RE; Draper JS, 2015, 'Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy', Oncotarget, vol. 6, pp. 7040 - 7052, http://dx.doi.org/10.18632/oncotarget.3140
    Journal articles | 2013
    Cornwell J; Zhang H; Lim T; Resurreccion R; Port T; Rosengarten G; Nordon R; chen H, 2013, 'Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale', Lab on a chip : miniaturisation for chemistry, biology and bioengineering, vol. 13, pp. 2999 - 3007, http://dx.doi.org/10.1039/c3lc50123j
    Journal articles | 2011
    Irhimeh MR; Fitton JH; Ko KH; Lowenthal RM; Nordon RE, 2011, 'Formation of an adherent hematopoietic expansion culture using fucoidan', Annals of Hematology, vol. 90, pp. 1005 - 1015, http://dx.doi.org/10.1007/s00277-011-1185-4
    Journal articles | 2011
    Ko K; Holmes TA; Palladinetti P; Song E; Nordon RE; O Brien T; Dolnikov A, 2011, 'GSK-3β Inhibition Promotes Engraftment of Ex Vivo-Expanded Hematopoietic Stem Cells and Modulates Gene Expression', Stem Cells, vol. 29, pp. 108 - 118, http://dx.doi.org/10.1002/stem.551
    Journal articles | 2011
    Nordon RE; Ko K; Odell RA; Schroeder T, 2011, 'Multi-type branching models to describe cell differentiation programs', Journal of Theoretical Biology, vol. 277, pp. 7 - 18, http://dx.doi.org/10.1016/j.jtbi.2011.02.006
    Journal articles | 2008
    Godara P; McFarland CD; Nordon RE, 2008, 'Design of bioreactors for mesenchymal stem cell tissue engineering', Journal of Chemical Technology and Biotechnology, vol. 83, pp. 408 - 420, http://dx.doi.org/10.1002/jctb.1918
    Journal articles | 2008
    Nordon RE; Craig SJ; Foong F, 2008, 'Molecular engineering of the cellulosome complex for affinity and bioenergy applications', Biotechnology Letters, vol. 31, pp. 465 - 476, http://dx.doi.org/10.1007/s10529-008-9899-7
    Journal articles | 2007
    Ko K; Odell RA; Nordon RE, 2007, 'Analysis of cell differentiation by division tracking cytometry', CYTOMETRY PART A, vol. 71A, pp. 773 - 782, http://dx.doi.org/10.1002/cyto.a.20437
    Journal articles | 2006
    Craig SJ; Foong F; Nordon RE, 2006, 'Engineered proteins containing the cohesin and dockerin domains from Clostridium thermocellum provides a reversible, high affinity interaction for biotechnology applications', Journal of Biotechnology, vol. 121, pp. 165 - 173, http://dx.doi.org/10.1016/j.jbiotec.2005.07.005
  • Conference Abstracts | 2019
    Li J; Bruveris F; Ed S; Elefanty A; Lao O; Ng E; Nordon R; Ralph P, 2019, 'THE ROLE OF SHEAR STRESS IN THE GENERATION OF DEFINITIVE HAEMATOPOIETIC LINEAGES AND ARTERIAL VASCULATURE FROM HUMAN PLURIPOTENT STEM CELLS AT THE SINGLE-CELL LEVEL', in EXPERIMENTAL HEMATOLOGY, ELSEVIER SCIENCE INC, Vol. 76, pp. S73 - S74, http://dx.doi.org/10.1016/j.exphem.2019.06.390

Scaling microfluidics for cell manufacture. Australian Research Council Linkage Grant LP160100570 (2016-2019)

Manufacturing 3D microstructures for the medical device industry. Australian Research Council Linkage Grant LP160100573 (2016-2019)

Development of electrophoretic cell sorters. Australian Research Council Linkage Grant LP190100029 (2020-2023)

CRC-P "Making cell and gene therapy affordable with a microbioreactor" UNSW, Genesys, CSL (2021-2023)

1. Developing single use-disposables for plant scale production of cells for clinical therapies

The biopharmaceutical sector has relied  on large-volume, batch-fed, stainless-steel fermentation reactors to manufacture biologics at great scale where one batch run equals thousands of products. However, a rapidly evolving biopharmaceutical industry now requires cost-effective technologies to manufacture multiple diverse biologics. This problem is particularly acute for manufacture of personalised cell and gene therapy products where one batch run equals one product. Our research focuses on developing microfluidic devices for cell manufacture, and fabricating these devices as single-use disposables for plant scale production.

2. Modelling human heart and blood development from pluripotent stem cells on a microfluidic chip

We have used lab-on-chip to mimic foetal circulation and to model human blood formation from cells that line blood vessels. We are currently studying the influence of pulsatile fluid shears stress on generation of blood stem cells. We are also investigating the use of hydrogels to pattern embyonic development of the cardiovascular system.

3. Single cell analysis by live cell imaging and RNA seq
We develop software and microfluidic tools for single cell analysis including software to automate cell tracking and to analysis cell fate using single cell RNA seq.

My Research Supervision

Farzaneh Ziaee

Eric Du