Dr Robert Weatheritt
Conjoint Associate Professor

Dr Robert Weatheritt

PhD

Medicine & Health
School of Clinical Medicine

Associate Professor Robert Weatheritt is an ARC Future Fellow, an EMBL Australia Group Leader at BABS in UNSW Sydney and a Lab Head at the Garvan Institute. Dr. Weatheritt received his PhD from EMBL Heidelberg and then proceeded to undertaken a Postdoctoral fellow at the University of Cambridge and the University of Toronto. Dr. Weatheritt opened his lab in 2018 focusing on combining data data approaches with CRISPR screening approaches and transcriptomics to understand the role of RNA in driving cellular phenotypes. Dr. Weatheritt has published over 40 peer-reviewed articles in high-impact journals including multiple papers in Nature, Cell and Science. 

Location
School of Biotechnology and Biomolecular Sciences
  • Journal articles | 2022
    Barutcu AR; Wu M; Braunschweig U; Dyakov BJA; Luo Z; Turner KM; Durbic T; Lin ZY; Weatheritt RJ; Maass PG; Gingras AC; Blencowe BJ, 2022, 'Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns', Molecular Cell, vol. 82, pp. 1035 - 1052.e9, http://dx.doi.org/10.1016/j.molcel.2021.12.010
    Journal articles | 2022
    Bournazos AM; Riley LG; Bommireddipalli S; Ades L; Akesson LS; Al-Shinnag M; Alexander SI; Archibald AD; Balasubramaniam S; Berman Y; Beshay V; Boggs K; Bojadzieva J; Brown NJ; Bryen SJ; Buckley MF; Chong B; Davis MR; Dawes R; Delatycki M; Donaldson L; Downie L; Edwards C; Edwards M; Engel A; Ewans LJ; Faiz F; Fennell A; Field M; Freckmann ML; Gallacher L; Gear R; Goel H; Goh S; Goodwin L; Hanna B; Harraway J; Higgins M; Ho G; Hopper BK; Horton AE; Hunter MF; Huq AJ; Josephi-Taylor S; Joshi H; Kirk E; Krzesinski E; Kumar KR; Lemckert F; Leventer RJ; Lindsey-Temple SE; Lunke S; Ma A; Macaskill S; Mallawaarachchi A; Marty M; Marum JE; McCarthy HJ; Menezes MP; McLean A; Milnes D; Mohammad S; Mowat D; Niaz A; Palmer EE; Patel C; Patel SG; Phelan D; Pinner JR; Rajagopalan S; Regan M; Rodgers J; Rodrigues M; Roxburgh RH; Sachdev R; Roscioli T; Samarasekera R; Sandaradura SA; Savva E; Schindler T; Shah M; Sinnerbrink IB; Smith JM; Smith RJ; Springer A; Stark Z; Strom SP; Sue CM; Tan K; Tan TY; Tantsis E; Tchan MC; Thompson BA; Trainer AH; van Spaendonck-Zwarts K; Walsh R; Warwick L; White S; White SM; Williams MG, 2022, 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, vol. 24, pp. 130 - 145, http://dx.doi.org/10.1016/j.gim.2021.09.001
    Journal articles | 2022
    Wang J; Weatheritt R; Voineagu I, 2022, 'ALUminating The Mechanisms Underlying Primate Cortex Evolution', Biological Psychiatry, http://dx.doi.org/10.1016/j.biopsych.2022.04.021
    Journal articles | 2021
    Ha KCH; Sterne-Weiler T; Morris Q; Weatheritt RJ; Blencowe BJ, 2021, 'Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity', Nature Communications, vol. 12, pp. 335, http://dx.doi.org/10.1038/s41467-020-20483-8
    Journal articles | 2021
    Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 2021, 'Evolutionary dynamics of circular rnas in primates', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.69148
    Journal articles | 2020
    Farini D; Cesari E; Weatheritt RJ; La Sala G; Naro C; Pagliarini V; Bonvissuto D; Medici V; Guerra M; Di Pietro C; Rizzo FR; Musella A; Carola V; Centonze D; Blencowe BJ; Marazziti D; Sette C, 2020, 'A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum', Cell Reports, vol. 31, http://dx.doi.org/10.1016/j.celrep.2020.107703
    Journal articles | 2020
    Gonatopoulos-Pournatzis T; Niibori R; Salter EW; Weatheritt RJ; Tsang B; Farhangmehr S; Liang X; Braunschweig U; Roth J; Zhang S; Henderson T; Sharma E; Quesnel-Vallières M; Permanyer J; Maier S; Georgiou J; Irimia M; Sonenberg N; Forman-Kay JD; Gingras AC; Collingridge GL; Woodin MA; Cordes SP; Blencowe BJ, 2020, 'Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions', Molecular Cell, vol. 77, pp. 1176 - 1192.e16, http://dx.doi.org/10.1016/j.molcel.2020.01.006
    Journal articles | 2020
    Luck K; Kim DK; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Coté AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin SF; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; De Rouck S; Duran-Frigola M; Ennajdaoui H; Goebels F; Goehring L; Gopal A; Haddad G; Hatchi E; Helmy M; Jacob Y; Kassa Y; Landini S; Li R; van Lieshout N; MacWilliams A; Markey D; Paulson JN; Rangarajan S; Rasla J; Rayhan A; Rolland T; San-Miguel A; Shen Y; Sheykhkarimli D; Sheynkman GM; Simonovsky E; Taşan M; Tejeda A; Tropepe V; Twizere JC; Wang Y; Weatheritt RJ; Weile J; Xia Y; Yang X; Yeger-Lotem E; Zhong Q; Aloy P; Bader GD; De Las Rivas J; Gaudet S; Hao T; Rak J; Tavernier J; Hill DE; Vidal M; Roth FP; Calderwood MA, 2020, 'A reference map of the human binary protein interactome', Nature, vol. 580, pp. 402 - 408, http://dx.doi.org/10.1038/s41586-020-2188-x
    Journal articles | 2020
    Rodrigues DC; Mufteev M; Weatheritt RJ; Djuric U; Ha KCH; Ross PJ; Wei W; Piekna A; Sartori MA; Byres L; Mok RSF; Zaslavsky K; Pasceri P; Diamandis P; Morris Q; Blencowe BJ; Ellis J, 2020, 'Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome', Cell Reports, vol. 30, pp. 4179 - 4196.e11, http://dx.doi.org/10.1016/j.celrep.2020.02.107
    Journal articles | 2019
    Avgan N; Wang JI; Fernandez-Chamorro J; Weatheritt RJ, 2019, 'Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control', Breast Cancer Research, vol. 21, pp. 141, http://dx.doi.org/10.1186/s13059-019-1757-5
    Journal articles | 2019
    Quesnel-Vallières M; Weatheritt RJ; Cordes SP; Blencowe BJ, 2019, 'Autism spectrum disorder: insights into convergent mechanisms from transcriptomics', Nature Reviews Genetics, vol. 20, pp. 51 - 63, http://dx.doi.org/10.1038/s41576-018-0066-2
    Journal articles | 2018
    Sterne-Weiler T; Weatheritt RJ; Best AJ; Ha KCH; Blencowe BJ, 2018, 'Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop', Molecular Cell, vol. 72, pp. 187 - 200.e6, http://dx.doi.org/10.1016/j.molcel.2018.08.018
    Journal articles | 2017
    Gueroussov S; Weatheritt RJ; O'Hanlon D; Lin ZY; Narula A; Gingras AC; Blencowe BJ, 2017, 'Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing', Cell, vol. 170, pp. 324 - 339.e23, http://dx.doi.org/10.1016/j.cell.2017.06.037
    Journal articles | 2017
    Han H; Braunschweig U; Gonatopoulos-Pournatzis T; Weatheritt RJ; Hirsch CL; Ha KCH; Radovani E; Nabeel-Shah S; Sterne-Weiler T; Wang J; O'Hanlon D; Pan Q; Ray D; Zheng H; Vizeacoumar F; Datti A; Magomedova L; Cummins CL; Hughes TR; Greenblatt JF; Wrana JL; Moffat J; Blencowe BJ, 2017, 'Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors', Molecular Cell, vol. 65, pp. 539 - 553.e7, http://dx.doi.org/10.1016/j.molcel.2017.01.011
    Journal articles | 2017
    Sterne-Weiler T; Weatheritt R; Best A; Ha K; Blencowe B, 2017, 'Whippet: an efficient method for the detection and quantification of alternative splicing reveals extensive transcriptomic complexity', , http://dx.doi.org/10.1101/158519
    Journal articles | 2016
    Dominguez D; Tsai YH; Weatheritt R; Wang Y; Blencowe BJ; Wang Z, 2016, 'An extensive program of periodic alternative splicing linked to cell cycle progression', eLife, vol. 5, http://dx.doi.org/10.7554/eLife.10288
    Journal articles | 2016
    Latysheva NS; Oates ME; Maddox L; Flock T; Gough J; Buljan M; Weatheritt RJ; Babu MM, 2016, 'Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer', Molecular Cell, vol. 63, pp. 579 - 592, http://dx.doi.org/10.1016/j.molcel.2016.07.008
    Journal articles | 2016
    Weatheritt RJ; Sterne-Weiler T; Blencowe BJ, 2016, 'The ribosome-engaged landscape of alternative splicing', Nature Structural and Molecular Biology, vol. 23, pp. 1117 - 1123, http://dx.doi.org/10.1038/nsmb.3317
    Journal articles | 2015
    Latysheva NS; Flock T; Weatheritt RJ; Chavali S; Babu MM, 2015, 'How do disordered regions achieve comparable functions to structured domains?', Protein Science, vol. 24, pp. 909 - 922, http://dx.doi.org/10.1002/pro.2674
    Journal articles | 2014
    Davey NE; Van Roey K; Weatheritt RJ; Toedt G; Uyar B; Altenberg B; Budd A; Diella F; Dinkel H; Gibson TJ, 2014, 'Erratum: Attributes of short linear motifs (Molecular BioSystems (2012) 8 (268-281) DOI: 10.1039/C1MB05231D)', Molecular BioSystems, vol. 10, pp. 2481, http://dx.doi.org/10.1039/C4MB90028F
    Journal articles | 2014
    Dinkel H; Van Roey K; Michael S; Davey NE; Weatheritt RJ; Born D; Speck T; Krüger D; Grebnev G; Kubań M; Strumillo M; Uyar B; Budd A; Altenberg B; Seiler M; Chemes LB; Glavina J; Sánchez IE; Diella F; Gibson TJ, 2014, 'The eukaryotic linear motif resource ELM: 10 years and counting', Nucleic Acids Research, vol. 42, http://dx.doi.org/10.1093/nar/gkt1047
    Journal articles | 2014
    Flock T; Weatheritt RJ; Latysheva NS; Babu MM, 2014, 'Controlling entropy to tune the functions of intrinsically disordered regions', Current Opinion in Structural Biology, vol. 26, pp. 62 - 72, http://dx.doi.org/10.1016/j.sbi.2014.05.007
    Journal articles | 2014
    Irimia M; Weatheritt RJ; Ellis JD; Parikshak NN; Gonatopoulos-Pournatzis T; Babor M; Quesnel-Vallières M; Tapial J; Raj B; O'Hanlon D; Barrios-Rodiles M; Sternberg MJE; Cordes SP; Roth FP; Wrana JL; Geschwind DH; Blencowe BJ, 2014, 'A highly conserved program of neuronal microexons is misregulated in autistic brains', Cell, vol. 159, pp. 1511 - 1523, http://dx.doi.org/10.1016/j.cell.2014.11.035
    Journal articles | 2014
    Uyar B; Weatheritt RJ; Dinkel H; Davey NE; Gibson TJ, 2014, 'Proteome-wide analysis of human disease mutations in short linear motifs: Neglected players in cancer?', Molecular BioSystems, vol. 10, pp. 2626 - 2642, http://dx.doi.org/10.1039/c4mb00290c
    Journal articles | 2014
    Van Der Lee R; Buljan M; Lang B; Weatheritt RJ; Daughdrill GW; Dunker AK; Fuxreiter M; Gough J; Gsponer J; Jones DT; Kim PM; Kriwacki RW; Oldfield CJ; Pappu RV; Tompa P; Uversky VN; Wright PE; Babu MM, 2014, 'Classification of intrinsically disordered regions and proteins', Chemical Reviews, vol. 114, pp. 6589 - 6631, http://dx.doi.org/10.1021/cr400525m
    Journal articles | 2014
    Van Roey K; Uyar B; Weatheritt RJ; Dinkel H; Seiler M; Budd A; Gibson TJ; Davey NE, 2014, 'Short linear motifs: Ubiquitous and functionally diverse protein interaction modules directing cell regulation', Chemical Reviews, vol. 114, pp. 6733 - 6778, http://dx.doi.org/10.1021/cr400585q
    Journal articles | 2014
    Weatheritt RJ; Gibson TJ; Babu MM, 2014, 'Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems', Nature Structural and Molecular Biology, vol. 21, pp. 833 - 839, http://dx.doi.org/10.1038/nsmb.2876
    Journal articles | 2013
    Reyes A; Anders S; Weatheritt RJ; Gibson TJ; Steinmetz LM; Huber W, 2013, 'Drift and conservation of differential exon usage across tissues in primate species', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, pp. 15377 - 15382, http://dx.doi.org/10.1073/pnas.1307202110
    Journal articles | 2013
    Van Roey K; Dinkel H; Weatheritt RJ; Gibson TJ; Davey NE, 2013, 'The switches.ELM resource: A compendium of conditional regulatory interaction interfaces', Science Signaling, vol. 6, http://dx.doi.org/10.1126/scisignal.2003345
    Journal articles | 2013
    Weatheritt RJ; Babu MM, 2013, 'The hidden codes that shape protein evolution', Science, vol. 342, pp. 1325 - 1326, http://dx.doi.org/10.1126/science.1248425
    Journal articles | 2012
    Davey NE; Van Roey K; Weatheritt RJ; Toedt G; Uyar B; Altenberg B; Budd A; Diella F; Dinkel H; Gibson TJ, 2012, 'Attributes of short linear motifs', Molecular BioSystems, vol. 8, pp. 268 - 281, http://dx.doi.org/10.1039/c1mb05231d
    Journal articles | 2012
    Dinkel H; Michael S; Weatheritt RJ; Davey NE; Van Roey K; Altenberg B; Toedt G; Uyar B; Seiler M; Budd A; Jödicke L; Dammert MA; Schroeter C; Hammer M; Schmidt T; Jehl P; McGuigan C; Dymecka M; Chica C; Luck K; Via A; Chatr-Aryamontri A; Haslam N; Grebnev G; Edwards RJ; Steinmetz MO; Meiselbach H; Diella F; Gibson TJ, 2012, 'ELM - The database of eukaryotic linear motifs', Nucleic Acids Research, vol. 40, http://dx.doi.org/10.1093/nar/gkr1064
    Journal articles | 2012
    Weatheritt RJ; Davey NE; Gibson TJ, 2012, 'Linear motifs confer functional diversity onto splice variants', Nucleic Acids Research, vol. 40, pp. 7123 - 7131, http://dx.doi.org/10.1093/nar/gks442
    Journal articles | 2012
    Weatheritt RJ; Gibson TJ, 2012, 'Linear motifs: Lost in (pre)translation', Trends in Biochemical Sciences, vol. 37, pp. 333 - 341, http://dx.doi.org/10.1016/j.tibs.2012.05.001
    Journal articles | 2012
    Weatheritt RJ; Jehl P; Dinkel H; Gibson TJ, 2012, 'iELM-a web server to explore short linear motif-mediated interactions', Nucleic Acids Research, vol. 40, http://dx.doi.org/10.1093/nar/gks444
    Journal articles | 2012
    Weatheritt RJ; Luck K; Petsalaki E; Davey NE; Gibson TJ, 2012, 'The identification of short linear motif-mediated interfaces within the human interactome', Bioinformatics, vol. 28, pp. 976 - 982, http://dx.doi.org/10.1093/bioinformatics/bts072
    Journal articles | 2009
    Gould CM; Diella F; Via A; Puntervoll P; Gemünd C; Chabanis-Davidson S; Michael S; Sayadi A; Bryne JC; Chica C; Seiler M; Davey NE; Haslam N; Weatheritt RJ; Budd A; Hughes T; Paś J; Rychlewski L; Travé G; Aasland R; Helmer-Citterich M; Linding R; Gibson TJ, 2009, 'ELM: The status of the 2010 eukaryotic linear motif resource', Nucleic Acids Research, vol. 38, http://dx.doi.org/10.1093/nar/gkp1016
    Journal articles | 2009
    Krumbholz K; Nobis EA; Weatheritt RJ; Fink GR, 2009, 'Executive control of spatial attention shifts in the auditory compared to the visual modality', Human Brain Mapping, vol. 30, pp. 1457 - 1469, http://dx.doi.org/10.1002/hbm.20615
    Journal articles | 2009
    Yanashima R; Kitagawa N; Matsubara Y; Weatheritt R; Oka K; Kikuchi S; Tomita M; Ishizaki S, 2009, 'Network features and pathway analyses of a signal transduction cascade', Frontiers in Neuroinformatics, vol. 3, http://dx.doi.org/10.3389/neuro.11.013.2009
    Journal articles | 2009
    Yanashima R; Kitagawa N; Matsubara Y; Weatheritt R; Oka K; Kikuchi S; Tomita M; Ishizaki S, 2009, '[Not Available].', Front Neuroinform, vol. 3, pp. 13, http://dx.doi.org/10.3389/neuro.11/013.2009
    Journal articles |
    Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 'Evolutionary dynamics of circular RNAs in primates', , http://dx.doi.org/10.1101/2021.05.01.442284
  • Datasets | 2017
    Babu MM; Weatheritt R, 2017, Faculty Opinions recommendation of Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters., http://dx.doi.org/10.3410/f.726377327.793527925
    Datasets | 2013
    Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of A pH-regulated quality control cycle for surveillance of secretory protein assembly., http://dx.doi.org/10.3410/f.718011800.793484658
    Datasets | 2013
    Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of MBNL proteins repress ES-cell-specific alternative splicing and reprogramming., http://dx.doi.org/10.3410/f.718018320.793480969
    Datasets | 2013
    Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins., http://dx.doi.org/10.3410/f.717959010.793480968
    Preprints |
    Luck K; Kim D-K; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Cote AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin S-F; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; De Rouck S; Duran-Frigola M; Ennajdaoui H; Goebels F; Goehring L; Gopal A; Haddad G; Hatchi E; Helmy M; Jacob Y; Kassa Y; Landini S; Li R; van Lieshout N; MacWilliams A; Markey D; Paulson JN; Rangarajan S; Rasla J; Rayhan A; Rolland T; San-Miguel A; Shen Y; Sheykhkarimli D; Sheynkman GM; Simonovsky E; Taşan M; Tejeda A; Twizere J-C; Wang Y; Weatheritt RJ; Weile J; Xia Y; Yang X; Yeger-Lotem E; Zhong Q; Aloy P; Bader GD; De Las Rivas J; Gaudet S; Hao T; Rak J; Tavernier J; Tropepe V; Hill DE; Vidal M; Roth FP; Calderwood MA, A reference map of the human protein interactome, http://dx.doi.org/10.1101/605451
    Preprints |
    Rodrigues DC; Mufteev M; Weatheritt RJ; Djuric U; Ha KCH; Ross PJ; Zaslavsky K; Mok RSF; Wei W; Piekna A; Byres L; Pasceri P; Diamandis P; Morris Q; Blencowe BJ; Ellis J, Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome, http://dx.doi.org/10.2139/ssrn.3364378
    Preprints |
    Skvortsova K; Bertrand S; Voronov D; Duckett PE; Ross SE; Magri MS; Maeso I; Weatheritt RJ; Gomez-Skarmeta JL; Arnone MI; Escriva H; Bogdanovic O, Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins, http://dx.doi.org/10.1101/2021.11.07.467601

  • NSW Health RNA Future Leaders Program (2022-2025)
    • Title: Developing in vivo CRISPR RNA engineering to prevent disease
  • Australian Research Council Future Fellowship (2022-2026)
    • Title: Dissecting cell cycle regulation using programmable gene editing technology
  • NSW Cancer Council Grant (2021-2024)
    • Title: What makes triple-negative breast cancer tumours more likely to spread beyond the breast? 
  • NSW Cancer Institute Fellowship (2021-2024)
    • P-bodies: a novel mechanism driving triple negative breast cancer?
  • ARC Discovery Project Grant (2020-2023) with Irinia Voineagu (UNSW Sydney)
    • Title: Investigating the biogenesis and function of circular RNAs in the brain

Alternative splicing, Intrinsically disordered regions, Post-transcriptional regulation, Neuroscience, Autism-spectrum disorder, RNA, Proteomics, Structural Bioinformatics, RNA-Seq