Dr Shweta   Gautam
Conjoint Associate Lecturer

Dr Shweta Gautam

PhD in Biochemistry and Molecular Genetics

M.Sc. in Biotechnology

 

Medicine & Health
SWS Clinical School

I am a molecular biologist with a PhD in Biochemistry and Molecular Genetics from The University of New South Wales (Sydney). I hold a master's degree in Biotechnology and bachelor's degree in Chemistry from India.   

Currently, I work as a Postdoc with the Gastrointestinal Viral Oncology Group, School of South West Clinical School, Ingham Institute, Liverpool. The group investigates the association of human papillomavirus and related biomarkers in oesophageal adenocarcinoma. I am especially interested in studying the signatures within the human papillomavirus associated and viral negative oesophageal adenocarcinoma using  mutiomics approach.   

My PhD work investigated the sequence preference of anti-cancer drug bleomycin and gamma radiation on telomeric rich plasmid DNA sequences. Briefly, bleomycin is an anti-tumour agent that is clinically used to treat several types of cancers. Bleomycin cleaves DNA at specific DNA sequences and genome-wide DNA sequencing specificity data indicated that the sequence 5'-RTGT*AY (where T* is the site of bleomycin cleavage, R is G/A and Y is T/C) is preferentially cleaved by bleomycin in human cells. By systematic variation of single nucleotides in the 5'-RTGT*AY sequence, this study was able to investigate the effect of nucleotide changes on bleomycin cleavage efficiency. I also examined the DNA sequence specificity of gamma radiation- induced DNA damage in purified DNA sequences. Furthermore, a comparison between the radiation-induced damage plasmid DNA and genome-wide human DNA data was studied.

I have over five years of postgraduate research experience from the Post Graduate Institute of Medical Education and Research (PGIMER), India. I reviewed the role of Isoniazid (an anti-tuberculosis drug) on Potts’ spine patients while working in the Department of Nuclear Medicine. I also worked in the Department of Histopathology and evaluated the mRNA expression levels in medulloblastoma and primitive neuroectodermal tumours. 

 

Phone
+61-2-8738 9193

Publications

  • Journal articles | 2020
    Dr Shweta Gautam
    Rajendra S; Pavey D; McKay O; Merrett N; Gautam SD, 2020, 'Human papillomavirus infection in esophageal squamous cell carcinoma and esophageal adenocarcinoma: a concise review', Annals of the New York Academy of Sciences, vol. 1482, pp. 36 - 48, http://dx.doi.org/10.1111/nyas.14509
    Journal articles | 2020
    Dr Shweta Gautam
    Murray V; Hardie ME; Gautam SD, 2020, 'Comparison of different methods to determine the DNA sequence preference of ionising radiation-induced DNA damage', Genes, vol. 11, http://dx.doi.org/10.3390/genes11010008
    Journal articles | 2020
    Dr Shweta Gautam
    Rajendra S; Sharma P; Gautam SD; Saxena M; Kapur A; Sharma P; Merrett N; Yang T; Santos LD; Pavey D; Sharaiha O; McKay O; Dixson H; Xuan W, 2020, 'Association of Biomarkers for Human Papillomavirus with Survival among Adults with Barrett High-grade Dysplasia and Esophageal Adenocarcinoma', JAMA Network Open, vol. 3, pp. e1921189, http://dx.doi.org/10.1001/jamanetworkopen.2019.21189
    Journal articles | 2020
    Dr Shweta Gautam
    Sharma P; Gautam SD; Rajendra S, 2020, 'Importance of investigating high-risk human papillomavirus in lymph node metastasis of esophageal adenocarcinoma', World Journal of Gastroenterology, vol. 26, pp. 2729 - 2739, http://dx.doi.org/10.3748/WJG.V26.I21.2729
    Journal articles | 2019
    Dr Shweta Gautam
    Hardie ME; Gautam SD; Murray V, 2019, 'The genome-wide sequence preference of ionising radiation-induced cleavage in human DNA', Molecular Biology Reports, vol. 46, pp. 3731 - 3745, http://dx.doi.org/10.1007/s11033-019-04815-6
    Journal articles | 2018
    Dr Shweta Gautam
    Gautam SD; Hardie ME; Murray V, 2018, 'The Sequence Preference of Gamma-Radiation-Induced Damage in End-Labeled DNA after Heat Treatment', Radiation Research, vol. 189, pp. 238 - 250, http://dx.doi.org/10.1667/RR14886.1
    Journal articles | 2017
    Dr Shweta Gautam
    Gautam SD; Chen JK; Murray V, 2017, 'The DNA sequence specificity of bleomycin cleavage in a systematically altered DNA sequence', Journal of Biological Inorganic Chemistry, vol. 22, pp. 881 - 892, http://dx.doi.org/10.1007/s00775-017-1466-z

Awards

Australian Postgraduate Award (2013-2017)

Grants

Narellan Rotary Men's Health Award-2020

Media