Dr Siiri   Iismaa
Conjoint Senior Lecturer

Dr Siiri Iismaa

Qualifications:

BSc (Hons I) University Medal, Australian National University 

PhD in Molecular Biology and Genetics, Australian National University

Postdoctoral Fellow at UC Irvine, CA, USA

Senior Postdoctoral Fellow, Heart Research Institute, Sydney

Senior Scientist, Victor Chang CardiacResearch Institute and Conjoint Senior Lecturer, UNSW

medicine-health
St Vincent's Clinical School

Dr Iismaa is an internationally respected and highly regarded scientist at the Victor Chang Cardiac Research Institute.  Her research interest is in cardiovascular diseases, which are the leading cause of premature death and disability in our society, and the nation’s most costly diseases.

Phone
+61 419 330 117
Location
Molecular Cardiology and Biophysics Division Victor Chang Cardiac Research Institute Level 5, 405 Liverpool St, Darlinghurst, NSW, 2010

Publications

  • Book Chapters | 2016
    Dr Siiri Iismaa
    Iismaa SE, 2016, 'Insights into transglutaminase 2 function gained from genetically modified animal models', in Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery, Springer, pp. 83 - 115, http://dx.doi.org/10.1007/978-4-431-55825-5_4
    Book Chapters | 2002
    Dr Siiri Iismaa
    Nanda N; Iismaa SE, 2002, 'Transglutaminases', in John Wiley & Sons Inc. (ed.), Wiley Encyclopedia of Molecular Medicine, Volumes 1-5, edn. Original, John Wiley & Sons, pp. 3222 - 3224
    Book Chapters | 1995
    Dr Siiri Iismaa
    Graham RM; Riek RP; Iismaa S; Chen S, 1995, 'Adrenergic and dopamine receptors', in Molecular Nephrology, edn. Original, Marcel Dekker, New York, pp. 143 - 155
  • Journal articles | 2021
    Dr Siiri Iismaa
    Guo Y; Yu ZY; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, 2021, 'The ca2+-activated cation channel trpm4 is a positive regulator of pressure overload-induced cardiac hypertrophy', eLife, vol. 10, http://dx.doi.org/10.7554/eLife.66582
    Journal articles | 2021
    Dr Siiri Iismaa
    Griffin KJ; Simpson KR; Beckers CML; Newell LM; Cheah LT; Yuldasheva NY; Iismaa S; Jackson CL; Scott JDA; Pease RJ, 2021, 'Transglutaminase 2 moderates the expansion of mouse abdominal aortic aneurysms', JVS: Vascular Science, vol. 2, pp. 95 - 109, http://dx.doi.org/10.1016/j.jvssci.2021.04.002
    Journal articles | 2021
    Dr Siiri Iismaa
    Iismaa SE; Hesselson S; McGrath-Cadell L; Muller DW; Fatkin D; Giannoulatou E; Kovacic J; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women', Heart Lung and Circulation, vol. 30, pp. 27 - 35, http://dx.doi.org/10.1016/j.hlc.2020.05.110
    Journal articles | 2021
    Dr Siiri Iismaa
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Vatner S; Feneley M; Graham RM, 2021, 'Adaptation to exercise-induced stress is not dependent on cardiomyocyte α1A-adrenergic receptors', Journal of Molecular and Cellular Cardiology, vol. 155, pp. 78 - 87, http://dx.doi.org/10.1016/j.yjmcc.2021.02.010
    Journal articles | 2021
    Dr Siiri Iismaa
    McGrath-Cadell L; Iismaa SE; Hesselson S; Muller DW; Fatkin D; Giannoulatou E; Kovacic JC; Graham RM, 2021, 'Recent Updates on Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia', International Journal of Integrative Cardiology, vol. 3, http://dx.doi.org/10.47275/2690-862x-121
    Journal articles | 2020
    Dr Siiri Iismaa
    Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, 2020, 'DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling', Scientific Reports, vol. 10, pp. 21918, http://dx.doi.org/10.1038/s41598-020-78825-x
    Journal articles | 2020
    Dr Siiri Iismaa
    Suzuki AS; Yagi R; Kimura MY; Iwamura C; Shinoda K; Onodera A; Hirahara K; Tumes DJ; Koyama-Nasu R; Iismaa SE; Graham RM; Motohashi S; Nakayama T, 2020, 'Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation', Frontiers in Immunology, vol. 11, http://dx.doi.org/10.3389/fimmu.2020.01536
    Journal articles | 2020
    Dr Siiri Iismaa
    Carss KJ; Baranowska AA; Armisen J; Webb TR; Hamby SE; Premawardhana D; Al-Hussaini A; Wood A; Wang Q; Deevi SVV; Vitsios D; Lewis SH; Kotecha D; Bouatia-Naji N; Hesselson S; Iismaa SE; Tarr I; McGrath-Cadell L; Muller DW; Dunwoodie SL; Fatkin D; Graham RM; Giannoulatou E; Samani NJ; Petrovski S; Haefliger C; Adlam D, 2020, 'Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation from Genome Sequencing', Circulation: Genomic and Precision Medicine, pp. 630 - 639, http://dx.doi.org/10.1161/CIRCGEN.120.003030
    Journal articles | 2020
    Dr Siiri Iismaa
    Zhang J; Grosso Jasutkar H; Yan R; Woo JM; Lee KW; Im JY; Junn E; Iismaa SE; Mouradian MM, 2020, 'Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice', Neuroscience, vol. 441, pp. 58 - 64, http://dx.doi.org/10.1016/j.neuroscience.2020.05.047
    Journal articles | 2020
    Dr Siiri Iismaa
    Griffin KJ; Newell LM; Simpson KR; Beckers CML; Drinkhill MJ; Standeven KF; Cheah LT; Iismaa SE; Grant PJ; Jackson CL; Pease RJ, 2020, 'Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency', Atherosclerosis, vol. 294, pp. 1 - 9, http://dx.doi.org/10.1016/j.atherosclerosis.2019.12.013
    Journal articles | 2020
    Dr Siiri Iismaa
    Nicks AM; Kesteven SH; Li M; Wu J; Chan AY; Naqvi N; Husain A; Feneley MP; Smith NJ; Iismaa SE; Graham RM, 2020, 'Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes', Scientific Reports, vol. 10, pp. 15318, http://dx.doi.org/10.1038/s41598-020-72273-3
    Journal articles | 2019
    Dr Siiri Iismaa
    Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Motreff P; Belle L; Dupouy P; Barnay P; Meneveau N; Gilard M; Rioufol G; Range G; Brunel P; Delarche N; Filippi E; Le Bivic L; Harbaoui B; Benamer H; Cayla G; Varenne O; Manzo-Silberman SP; Silvain J; Spaulding C; Caussin C; Gerbaud E; Valy Y; Koning R; Lhermusier T; Champin S; Salengro E; Fluttaz A; Zabalawi A; Cottin Y; Teiger E; Saint-Etienne C; Ducrocq G; Marliere S; Boiffard E; Aubry P; Georges JL; Bresson D; De Poli F; Karrillon G; Roule V; Bali L; Valla M; Gerbay A; Houpe D; Dubreuil O; Monnier A; Mayaud N; Manchuelle A; Commeau P; Bedossa M; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, vol. 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085
    Journal articles | 2019
    Dr Siiri Iismaa
    McGrath-Cadell L; Hesselson S; Iismaa S; Mishra K; Wong C; Fatkin D; Dunwoodie S; Harvey R; Holloway C; Muller D; Giannoulatou E; Graham R, 2019, 'Familial Clustering of Spontaneous Coronary Artery Dissection', Heart, Lung and Circulation, vol. 28, pp. S330 - S330, http://dx.doi.org/10.1016/j.hlc.2019.06.454
    Journal articles | 2019
    Dr Siiri Iismaa
    McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'P5540Familial clustering of spontaneous coronary artery dissection', European Heart Journal, vol. 40, http://dx.doi.org/10.1093/eurheartj/ehz746.0486
    Journal articles | 2019
    Dr Siiri Iismaa
    Lorand L; Iismaa SE, 2019, 'Transglutaminase diseases: From biochemistry to the bedside', FASEB Journal, vol. 33, pp. 3 - 12, http://dx.doi.org/10.1096/fj.201801544R
    Journal articles | 2019
    Dr Siiri Iismaa
    Mishra K; Junday K; Wong CMY; Chan AY; Hesselson S; Muller DW; Iismaa SE; Mehta A; Graham RM, 2019, 'Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection', Stem Cell Research, vol. 41, pp. 101584 - 101584, http://dx.doi.org/10.1016/j.scr.2019.101584
    Journal articles | 2019
    Dr Siiri Iismaa
    Poole LG; Pant A; Baker KS; Kopec AK; Cline-Fedewa HM; Iismaa SE; Flick MJ; Luyendyk JP, 2019, 'Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase', Journal of Thrombosis and Haemostasis, vol. 17, pp. 113 - 125, http://dx.doi.org/10.1111/jth.14330
    Journal articles | 2019
    Dr Siiri Iismaa
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', Circulation Research, vol. 125, http://dx.doi.org/10.1161/res.125.suppl_1.579
    Journal articles | 2019
    Dr Siiri Iismaa
    Lorand L; Iismaa SE, 2019, 'Correction to: Transglutaminase diseases: from biochemistry to the bedside (The FASEB Journal, (2019), 33, 1, (3-12), 10.1096/fj.201801544R)', FASEB Journal, vol. 33, pp. 4653, http://dx.doi.org/10.1096/fj.201801544RERR
    Journal articles | 2018
    Dr Siiri Iismaa
    Mižíková I; Pfeffer T; Nardiello C; Surate Solaligue DE; Steenbock H; Tatsukawa H; Silva DM; Vadász I; Herold S; Pease RJ; Iismaa SE; Hitomi K; Seeger W; Brinckmann J; Morty RE, 2018, 'Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia', FEBS Journal, vol. 285, pp. 3056 - 3076, http://dx.doi.org/10.1111/febs.14596
    Journal articles | 2018
    Dr Siiri Iismaa
    Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, vol. 8, http://dx.doi.org/10.1038/s41598-018-24525-6
    Journal articles | 2018
    Dr Siiri Iismaa
    Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', npj Regenerative Medicine, vol. 3, http://dx.doi.org/10.1038/s41536-018-0044-5
    Journal articles | 2018
    Dr Siiri Iismaa
    Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, vol. 9, http://dx.doi.org/10.1186/s13293-018-0173-y
    Journal articles | 2016
    Dr Siiri Iismaa
    Iismaa SE, 2016, 'The prostate-specific protein, transglutaminase 4 (TG4), is an autoantigen associated with male subfertility', Annals of Translational Medicine, vol. 4, http://dx.doi.org/10.21037/atm.2016.10.02
    Journal articles | 2015
    Dr Siiri Iismaa
    Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, vol. 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069
    Journal articles | 2015
    Dr Siiri Iismaa
    Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, vol. 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038
    Journal articles | 2014
    Dr Siiri Iismaa
    Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, vol. 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001
    Journal articles | 2014
    Dr Siiri Iismaa
    Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, vol. 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035
    Journal articles | 2014
    Dr Siiri Iismaa
    Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, vol. 9, http://dx.doi.org/10.1371/journal.pone.0099024
    Journal articles | 2013
    Dr Siiri Iismaa
    Tong L; Png E; AiHua H; Yong SS; Yeo HL; Riau A; Mendoz E; Charausia SS; Lim CT; Yiu TW; Iismaa SE, 2013, 'Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion', Biochimica et Biophysica ACTA - Molecular Cell Research, vol. 1833, pp. 1304 - 1315, http://dx.doi.org/10.1016/j.bbamcr.2013.02.030
    Journal articles | 2013
    Dr Siiri Iismaa
    Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, vol. 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346
    Journal articles | 2013
    Dr Siiri Iismaa
    Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, vol. 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143
    Journal articles | 2012
    Dr Siiri Iismaa
    Liu T, 2012, 'Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase', European Journal of Cancer, vol. 48, pp. 3278 - 3287, http://dx.doi.org/10.1016/j.ejca.2012.02.067
    Journal articles | 2012
    Dr Siiri Iismaa
    Basso M; Berlin J; Xia L; Sleiman SF; Ko B; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Iismaa SE; Willis D; Cho S; Ratan R, 2012, 'Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation', Journal of Neuroscience, vol. 32, pp. 6561 - 6569, http://dx.doi.org/10.1523/JNEUROSCI.3353-11.2012
    Journal articles | 2012
    Dr Siiri Iismaa
    Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, vol. 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011
    Journal articles | 2012
    Dr Siiri Iismaa
    Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, vol. 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96
    Journal articles | 2012
    Dr Siiri Iismaa
    Iismaa SE; Basso M; Berlin J; Xia L; Sleiman SF; Kuo T; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Willis D; Cho S, 2012, 'Transglutaminase 2 Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation', Journal of Neuroscience, vol. 32, pp. 11157 - 11157, http://dx.doi.org/10.1523/JNEUROSCI.2552-12.2012
    Journal articles | 2011
    Dr Siiri Iismaa
    Fatkin D; Mohl M; Iismaa SE; Xiao XH; Friedrich O; Wagner ; Nikolova-Krstevski ; Wu J; Yu ZY; Feneley MP; Allen ; Graham RM, 2011, 'Regulation of murine cardiac contractility by activation of alpha(1A)-adrenergic receptor-operated Ca(2+) entry', Cardiovascular Research, vol. 91, pp. 310 - 319, http://dx.doi.org/10.1093/cvr/cvr081
    Journal articles | 2011
    Dr Siiri Iismaa
    Olsen K; Iismaa SE; Sapinoro R; Kottman RM; Kulkarni AA; Johnson G, 2011, 'Transglutaminase 2 and its role in pulmonary fibrosis', American Journal of Respiratory and Critical Care Medicine, vol. 184, pp. 699 - 707, http://dx.doi.org/10.1164/rccm.201101-0013OC
    Journal articles | 2011
    Dr Siiri Iismaa
    Wouters MA; Iismaa S; Fan SW; Haworth NL; Haworth , 2011, 'Thiol-based redox signalling: Rust never sleeps', International Journal of Biochemistry and Cell Biology, vol. 43, pp. 1079 - 1085, http://dx.doi.org/10.1016/j.biocel.2011.04.002
    Journal articles | 2010
    Dr Siiri Iismaa
    McConoughey S; Basso SJ; Nietsetskaya Z; Sleiman SF; Smirnova T; Langley B; Mahishi L; Cooper AJ; Antonyak MA; Cerione RA; Li B; Starkov A; Chaturvedi R; Beale M; Coppola G; Geschwind D; Ryu H; Li XR; Iismaa SE; Pallos J; Pasternack R; Hils M; Fan J; Raymond LA; Marsh JL; Thompson LM; Ratan R, 2010, 'Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease', EMBO Journal, vol. 2, pp. 349 - 370, http://dx.doi.org/10.1002/emmm.201000084
    Journal articles | 2010
    Dr Siiri Iismaa
    Liu T, 2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, vol. 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041
    Journal articles | 2010
    Dr Siiri Iismaa
    Mohl M; Xiao X-H; Prosser H; Iismaa S; Feneley M; Graham R, 2010, 'Involvement of a Novel a1A-Adrenergic Receptor-Coupled Signaling Pathway in Cardiac Contractility', FASEB JOURNAL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506325&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Dr Siiri Iismaa
    Zhao X; Vatner DE; Park M; Yan L; IIsmaa S; Graham R; Vatner SF, 2010, 'Transgenic Rats with Cardiac Overexpression of alpha1A Adrenergic Receptors are protected from Myocardial Ischemia by a Nitric Oxide Mechanism', FASEB JOURNAL, vol. 24, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675500791&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Dr Siiri Iismaa
    Tatsukawa H; Fukaya Y; Frampton G; Martinez-Fuentes A; Suzuki K; Kuo T; Nagatsuma K; Shimokado K; Okuno M; Wu J; Iismaa SE; Matsuura T; Tsukamoto H; Zern M; Graham RM; Kojima S, 2009, 'Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1', Gastroenterology, vol. 136, pp. 1783 - 1795, http://dx.doi.org/10.1053/j.gastro.2009.01.007
    Journal articles | 2009
    Dr Siiri Iismaa
    Iismaa SE; Mearns BM; Lorand L; Graham RM, 2009, 'Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders', Physiological Reviews, vol. 89, pp. 991 - 1023, http://dx.doi.org/10.1152/physrev.00044.2008
    Journal articles | 2006
    Dr Siiri Iismaa
    Begg G; Carrington L; Stokes P; Matthews JM; Wouters MA; Husain A; Lorand L; Iismaa SE; Graham RM, 2006, 'Mechanism of allosteric regulation of transglutaminase 2 by GTP', Proceedings of the National Academy of Sciences of the United States of America, vol. 103, pp. 19683 - 19688, http://dx.doi.org/10.1073/pnas.0609283103
    Journal articles | 2006
    Dr Siiri Iismaa
    Begg GE; Holman SR; Stokes PH; Matthews JM; Graham RM; Iismaa SE, 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200
    Journal articles | 2006
    Dr Siiri Iismaa
    Begg G; Holman S; Stokes P; Matthews J; Graham RM; Iismaa SE; Holman , 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', The Journal of Biological Chemistry, vol. 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200
    Journal articles | 2006
    Dr Siiri Iismaa
    Iismaa S; Begg G; Graham RM, 2006, 'Cross-linking transglutaminases with G protein-coupled receptor signaling.', Science S Stke, vol. 353, pp. pe34, http://dx.doi.org/10.1126/stke.3532006pe34
    Journal articles | 2005
    Dr Siiri Iismaa
    Krasnikov B; Kim SY; McConoughey S; Ryu H; Xu H; Stavrovskaya I; Iismaa S; Mearns BM; Ratan R; Blass J; Gibson G; Cooper A, 2005, 'Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria', Biochemistry, vol. 44, pp. 7830 - 7843, http://dx.doi.org/10.1021/bi0500877
    Journal articles | 2005
    Dr Siiri Iismaa
    Begg G; Iismaa S; Carrington L; Holman S; Graham RM; Holman , 2005, 'Allosteric inactivation of transglutaminase 2 by GTP involves stabilisation of a conformational substate and formation of a critical Cys/Tyr H-bond', Biophysical Journal, vol. 88, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226378500064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Dr Siiri Iismaa
    Begg G; Iismaa SE; Carrington L; Holman S; Husain A; Graham RM; Holman , 2005, 'Allosteric regulation of the transamidase activity of transglutaminase 2 by guanine nucleotide', FEBS Journal, vol. 272, pp. 408 - 408, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000234826102212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Dr Siiri Iismaa
    Krasnikov B; Ratan R; Gibson G; Iismaa SE; Cooper A, 2005, 'Transglutaminase activity in non-synaptosomal mouse brain and liver mitochondria', Journal of Neurochemistry, vol. 94, pp. 41 - 41, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000230317200115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2003
    Dr Siiri Iismaa
    Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, vol. 22, pp. 12636 - 12641, http://dx.doi.org/10.1073/pnas.1635052100
    Journal articles | 2003
    Dr Siiri Iismaa
    Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, vol. 92, pp. 1059 - 1061, http://dx.doi.org/10.1161/01.RES.0000075792.92001.D4
    Journal articles | 2002
    Dr Siiri Iismaa
    Iismaa SE, 2002, 'Structure and function of tissue transglutaminase.', Minerva Biotecnologica, vol. 14, pp. 113 - 119
    Journal articles | 2002
    Dr Siiri Iismaa
    Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, vol. 99, pp. 2738 - 2742, http://dx.doi.org/10.1073/pnas.052715799
    Journal articles | 2002
    Dr Siiri Iismaa
    Mearns BM; Nanda N; Michalicek J; Iismaa SE; Graham RM, 2002, 'Impaired wound healing and altered fibroblast cytoskeletal dynamics in Gh knockout mice.', Minerva Biotecnologica, vol. 14, pp. 218
    Journal articles | 2001
    Dr Siiri Iismaa
    Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, vol. 276, pp. 20673 - 20678, http://dx.doi.org/10.1074/jbc.M010846200
    Journal articles | 2001
    Dr Siiri Iismaa
    Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678
    Journal articles | 2000
    Dr Siiri Iismaa
    Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, vol. 275, pp. 18259 - 18265, http://dx.doi.org/10.1074/jbc.M000583200
    Journal articles | 1999
    Dr Siiri Iismaa
    Harrison C; Raftery MJ; Walsh J; Alewood P; Iismaa S; Thliveris S; Geczy C, 1999, 'Oxidation regulates the inflammatory properties of the murine S100 protein S100A8', The Journal of Biological Chemistry, vol. 274, pp. 8561 - 8569, http://dx.doi.org/10.1074/jbc.274.13.8561
    Journal articles | 1999
    Dr Siiri Iismaa
    Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, vol. 366, pp. 151 - 156, http://dx.doi.org/10.1006/abbi.1999.1189
    Journal articles | 1997
    Dr Siiri Iismaa
    Yen T; Harrison C; Devery JM; Leong S; Iismaa S; Yoshimura T; Geczy C, 1997, 'Induction of the S100 chemotactic protein CP10, in murine microvascular endothelial cells by proinflammatory stimuli', Blood, vol. 90, pp. 4812 - 4821
    Journal articles | 1997
    Dr Siiri Iismaa
    Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, vol. 36, pp. 11655 - 11664, http://dx.doi.org/10.1021/bi970545e
    Journal articles | 1997
    Dr Siiri Iismaa
    Yen T; Harrison CA; Devery JM; Leong S; Iismaa SE; Yoshimura T; Geczy CL, 1997, 'Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli', Blood, vol. 90, pp. 4812 - 4821, http://dx.doi.org/10.1182/blood.v90.12.4812
    Journal articles | 1996
    Dr Siiri Iismaa
    Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, vol. 271, pp. 32385 - 32391, https://www.ncbi.nlm.nih.gov/pubmed/8943303
    Journal articles | 1996
    Dr Siiri Iismaa
    Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, vol. 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385
    Journal articles | 1994
    Dr Siiri Iismaa
    Vázquez A; Shen B; Negaard K; Iismaa S; Burgess B, 1994, 'Overexpression of ferredoxin I in azotobacter vinelandii', Protein Expression and Purification, vol. 5, pp. 96 - 102, http://dx.doi.org/10.1006/prep.1994.1014
    Journal articles | 1994
    Dr Siiri Iismaa
    Iismaa SE; hu S; Kocher M; Lackmann M; Harrison CA; Thliveris S; Geczy CL, 1994, 'Recombinant and Cellular Expression of the Murine Chemotactic Protein, CP-10', DNA and Cell Biology, vol. 13, pp. 183 - 192, http://dx.doi.org/10.1089/dna.1994.13.183
    Journal articles | 1993
    Dr Siiri Iismaa
    Lackmann M; Rajasekariah P; Iismaa SE; Jones G; Cornish CJ; Hu S; Simpson RJ; Moritz RL; Geczy CL, 1993, 'Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10', Journal of Immunology, vol. 150, pp. 2981 - 2991
    Journal articles | 1993
    Dr Siiri Iismaa
    Le O; Shen B; Iismaa SE; Burgess BK, 1993, 'Azotobacter vinelandii mutS: Nucleotide sequence and mutant analysis', Journal of Bacteriology, vol. 175, pp. 7707 - 7710, http://dx.doi.org/10.1128/jb.175.23.7707-7710.1993
    Journal articles | 1993
    Dr Siiri Iismaa
    HU SP; IISMAA S; HUME D; GECZY C, 1993, 'EFFECT OF CSF-1, LPS, INF-GAMMA ON CP-10 EXPRESSION IN BONE-MARROW DERIVED-MACROPHAGES', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 50 - 50, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500099&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1993
    Dr Siiri Iismaa
    IISMAA SE; HU SP; KOCHER M; GECZY CL, 1993, 'CELLULAR EXPRESSION OF CP-10 IN MURINE MYELOID CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 49 - 49, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1991
    Dr Siiri Iismaa
    Soman J; Iismaa S; Stout CD, 1991, 'Crystallographic analysis of two site-directed mutants of azotobacter vinelandii ferredoxin', Journal of Biological Chemistry, vol. 266, pp. 21558 - 21562
    Journal articles | 1991
    Dr Siiri Iismaa
    Iismaa SE; Vazquez AE; Jensen GM; Stephens PJ; Butt JN; Armstrong FA; Burgess BK, 1991, 'Site-directed mutagenesis of azotobacter vinelandii ferredoxin I. Changes in [4Fe-4S] cluster reduction potential and reactivity', Journal of Biological Chemistry, vol. 266, pp. 21563 - 21571
    Journal articles | 1989
    Dr Siiri Iismaa
    Martin AE; Burgess BK; Iismaa SE; Smartt CT; Jacobson MR; Dean DR, 1989, 'Construction and characterization of an Azotobacter vinelandii strain with mutations in the genes encoding flavodoxin and ferredoxin I', Journal of Bacteriology, vol. 171, pp. 3162 - 3167, http://dx.doi.org/10.1128/jb.171.6.3162-3167.1989
    Journal articles | 1989
    Dr Siiri Iismaa
    Iismaa SE; Ealing PM; Scott KF; Watson JM, 1989, 'Molecular linkage of the nifl fix and nod gene regions in Rhixobium leguminosarum biovear trifolii', Molecular Microbiology, vol. 3, pp. 1753 - 1764, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00161.x
    Journal articles | 1989
    Dr Siiri Iismaa
    Iismaa SE; Watson JM, 1989, 'The nifA gene product from Rhizobium leguminosarum biovar trifolii lacks the N‐terminal domain found in other NifA proteins', Molecular Microbiology, vol. 3, pp. 943 - 955, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00244.x
    Journal articles | 1989
    Dr Siiri Iismaa
    Burgess B; Martin A; Iismaa S; Stout C; Cash V; Dean D; Jensen G; Stephens P, 1989, 'Site directed mutagenesis of Azotobacter vinelandii ferredoxin I: [FeS] cluster driven protein rearrangement', Journal of Inorganic Biochemistry, vol. 36, pp. 229 - 229, http://dx.doi.org/10.1016/0162-0134(89)84244-8
    Journal articles | 1987
    Dr Siiri Iismaa
    Iismaa SE; Watson JM, 1987, 'A gene upstream of the rhizobium trifolii nifa gene encodes a ferredoxin-like protein', Nucleic Acids Research, vol. 15, pp. 3180, http://dx.doi.org/10.1093/nar/15.7.3180
  • Conference Abstracts | 2019
    Dr Siiri Iismaa
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, Boston, MA, Vol. 125, presented at 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions - Integrative Approaches to Complex Cardiovascular Diseases, Boston, MA, 29 July 2019 - 01 August 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000511467800348&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    Dr Siiri Iismaa
    McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'Familial clustering of spontaneous coronary artery dissection', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Paris, FRANCE, Vol. 40, pp. 3414 - 3414, presented at Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, Paris, FRANCE, 31 August 2019 - 04 September 2019, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000507313003083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Dr Siiri Iismaa
    Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2014
    Dr Siiri Iismaa
    Nicks AM; Li M; Wu J; Kesteven SH; Fenely MP; Smith NJ; Iismaa SE; Graham RM, 2014, 'A SURGICAL MODEL OF HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY IN MICE BY SUPRARENAL AORTIC CONSTRICTION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, Adelaide, AUSTRALIA, Vol. 65, pp. E39 - E39, presented at 36th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), Adelaide, AUSTRALIA, 26 November 2014 - 28 November 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352490400055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Dr Siiri Iismaa
    Yu Z; Lismaa S; Tan JC; Marcininec T; McMahon AC; Sharp D; Kesteven SH; Xiao X; Reichelt M; Wang ZM; Williamson DJ; Graham RM; Fenely M, 2007, 'Cardiac restricted alpha 1A-Adrenergic receptor overexpression in the adult rodent heart induces a hypersensitive contractile response to adrenergic stimulation with reduced baseline contractility but no hypertrophy', in Circulation, Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 195 - 195, presented at 80th Annual Scientific Session of the American-Heart-Association, Orlando, Florida, USA, 04 November 2007 - 07 November 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250394300864&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

Awards

1980-1983 Tertiary Education Scholarship  

1984-1988 Commonwealth Postgraduate Scholarship 

1988-1990 US Biotechnology Training Program Award

1991-1994 NHMRC Postdoctoral Award 

1999 VCCRI Award for Research Excellence 

2000 VCCRI Award for Research Excellence 

2013 St Vincent’s Campus Symposium Award for Research Excellence

2015 Japan Society for the Promotion of Science (JSPS) Fellowship

Grants

Media