Dr Siiri Iismaa

Dr Siiri Iismaa

Conjoint Senior Lecturer

Qualifications:

BSc (Hons I) University Medal, Australian National University 

PhD in Molecular Biology and Genetics, Australian National University

Postdoctoral Fellow at UC Irvine, CA, USA

Senior Postdoctoral Fellow, Heart Research Institute, Sydney

Senior Scientist, Victor Chang CardiacResearch Institute and Conjoint Senior Lecturer, UNSW

Medicine & Health
School of Clinical Medicine

I am an internationally respected and highly regarded scientist at the Victor Chang Cardiac Research Institute with research interests in cardiovascular diseases, which are the leading cause of premature death and disability in our society, and the nation’s most costly diseases.

Phone
+61 419 330 117
Location
Molecular Cardiology and Biophysics Division Victor Chang Cardiac Research Institute Level 5, 405 Liverpool St, Darlinghurst, NSW, 2010
  • Book Chapters | 2016
    Iismaa SE, 2016, 'Insights into transglutaminase 2 function gained from genetically modified animal models', in Transglutaminases: Multiple Functional Modifiers and Targets for New Drug Discovery, Springer, pp. 83 - 115, http://dx.doi.org/10.1007/978-4-431-55825-5_4
    Book Chapters | 2002
    Nanda N; Iismaa SE, 2002, 'Transglutaminases', in John Wiley & Sons Inc. (ed.), Wiley Encyclopedia of Molecular Medicine, Volumes 1-5, edn. Original, John Wiley & Sons, pp. 3222 - 3224
    Book Chapters | 1995
    Graham RM; Riek RP; Iismaa S; Chen S, 1995, 'Adrenergic and dopamine receptors', in Molecular Nephrology, edn. Original, Marcel Dekker, New York, pp. 143 - 155
  • Journal articles | 2024
    McGrath-Cadell L; Hesselson S; Thompson JL; Iismaa SE; Tarr I; Muller DWM; Kovacic JC; Graham RM; Giannoulatou E, 2024, 'COL3A1 Variants in Spontaneous Coronary Artery Dissection', JACC: Advances, 3, http://dx.doi.org/10.1016/j.jacadv.2024.100986
    Journal articles | 2024
    Murphy BM; Le Grande MR; Rogerson MC; Hesselson S; Iismaa SE; Graham RM; Jackson AC, 2024, 'Prevalence and correlates of anxiety and depressive symptoms after Spontaneous Coronary Artery Dissection (SCAD): a cross-sectional study.', Eur J Cardiovasc Nurs, http://dx.doi.org/10.1093/eurjcn/zvae071
    Journal articles | 2024
    Tarr I; Hesselson S; Troup M; Young P; Thompson JL; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Muller DWM; Iismaa SE; Kovacic JC; Graham RM; Giannoulatou E, 2024, 'Polygenic Risk in Families with Spontaneous Coronary Artery Dissection', JAMA Cardiology, 9, pp. 254 - 261, http://dx.doi.org/10.1001/jamacardio.2023.5194
    Journal articles | 2024
    Weddell J; Rogerson M; Gallagher R; Hesselson S; Iismaa S; Graham R; Jackson A; Redfern J; Buckley T; Murphy B, 2024, 'Cognitive and Physical Fatigue: The Experience and Consequences of ‘Brain Fog’ after Spontaneous Coronary Artery Dissection (SCAD): A Qualitative Study', Heart, Lung and Circulation, 33, pp. S321 - S321, http://dx.doi.org/10.1016/j.hlc.2024.06.426
    Journal articles | 2024
    Weddell J; Rogerson MC; Gallagher R; Hesselson S; Iismaa SE; Graham RM; Jackson AC; Redfern J; Buckley T; Murphy BM, 2024, 'Cognitive and physical fatigue: the experience and consequences of 'brain fog' after Spontaneous Coronary Artery Dissection (SCAD), a qualitative study.', Eur J Cardiovasc Nurs, http://dx.doi.org/10.1093/eurjcn/zvae097
    Journal articles | 2023
    Adlam D; Berrandou TE; Georges A; Nelson CP; Giannoulatou E; Henry J; Ma L; Blencowe M; Turley TN; Yang ML; Chopade S; Finan C; Braund PS; Sadeg-Sayoud I; Iismaa SE; Kosel ML; Zhou X; Hamby SE; Cheng J; Liu L; Tarr I; Muller DWM; d’Escamard V; King A; Brunham LR; Baranowska-Clarke AA; Debette S; Amouyel P; Olin JW; Patil S; Hesselson SE; Junday K; Kanoni S; Aragam KG; Butterworth AS; Bakker MK; Ruigrok YM; Tweet MS; Gulati R; Combaret N; Kadian-Dodov D; Kalman JM; Fatkin D; Hingorani AD; Saw J; Webb TR; Hayes SN; Yang X; Ganesh SK; Olson TM; Kovacic JC; Graham RM; Samani NJ; Bouatia-Naji N, 2023, 'Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation', Nature Genetics, 55, pp. 964 - 972, http://dx.doi.org/10.1038/s41588-023-01410-1
    Journal articles | 2023
    Bax M; Junday K; Iismaa SE; Kaidonis X; Muller D; Hesselson S; Graham RM, 2023, 'Generation of induced pluripotent stem cell lines from a sister pair who suffered post-partum or recurrent Spontaneous Coronary Artery Dissections', Stem Cell Research, 73, http://dx.doi.org/10.1016/j.scr.2023.103238
    Journal articles | 2023
    Bax M; Junday K; Tarr I; Hesselson S; McGrath-Cadell L; Iismaa S; Giannoulatou E; Graham R, 2023, 'Proteomic Analysis Reveals TGFB Pathway Perturbation in Spontaneous Coronary Artery Dissection (SCAD) Patient iPSC Derived Endothelial Cells', Heart, Lung and Circulation, 32, pp. S416 - S416, http://dx.doi.org/10.1016/j.hlc.2023.06.585
    Journal articles | 2023
    McGrath-Cadell L; Hesselson S; Thompson J; Iismaa S; Tarr I I; Muller D; Kovacic J; Graham R; Giannoulatou E, 2023, 'COL3A1 Mutations in Spontaneous Coronary Artery Dissection', Heart, Lung and Circulation, 32, pp. S126 - S126, http://dx.doi.org/10.1016/j.hlc.2023.06.757
    Journal articles | 2023
    Murphy BM; Rogerson MC; Hesselson S; Iismaa SE; Hoover V; Le Grande M; Graham RM; Jackson AC, 2023, 'Prevalence of Anxiety, Depression, and Distress in SCAD and Non-SCAD AMI Patients: A Comparative Study', Journal of Cardiopulmonary Rehabilitation and Prevention, 43, pp. 338 - 345, http://dx.doi.org/10.1097/HCR.0000000000000782
    Journal articles | 2023
    Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, 2023, 'Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction', Scientific Reports, 13, http://dx.doi.org/10.1038/s41598-023-41894-9
    Journal articles | 2023
    Yiu TW; Holman SR; Kaidonis X; Graham RM; Iismaa SE, 2023, 'Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner', International Journal of Molecular Sciences, 24, http://dx.doi.org/10.3390/ijms241411475
    Journal articles | 2022
    Bax M; Junday K; Iismaa S; Hesselson S; Tarr I; McGrath-Cadell L; Dunwoodie S; Giannoulatou E; Graham R, 2022, 'Induced Pluripotent Stem Cell-Derived Models of Spontaneous Coronary Artery Dissection', Heart, Lung and Circulation, 31, pp. S87 - S87, http://dx.doi.org/10.1016/j.hlc.2022.06.097
    Journal articles | 2022
    Bax M; Romanov V; Junday K; Giannoulatou E; Martinac B; Kovacic JC; Liu R; Iismaa SE; Graham RM, 2022, 'Arterial dissections: Common features and new perspectives', Frontiers in Cardiovascular Medicine, 9, http://dx.doi.org/10.3389/fcvm.2022.1055862
    Journal articles | 2022
    Murphy BM; Rogerson MC; Hesselson S; Iismaa SE; Graham RM; Jackson AC, 2022, 'Psychosocial impacts of spontaneous coronary artery dissection: A qualitative study', PLoS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0273978
    Journal articles | 2022
    Nicks AM; Holman SR; Chan AY; Tsang M; Young PE; Humphreys DT; Naqvi N; Husain A; Li M; Smith NJ; Iismaa SE; Graham RM, 2022, 'Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts', Journal of Molecular and Cellular Cardiology, 170, pp. 47 - 59, http://dx.doi.org/10.1016/j.yjmcc.2022.05.012
    Journal articles | 2022
    Tarr I; Hesselson S; Iismaa SE; Rath E; Monger S; Troup M; Mishra K; Wong CMY; Hsu PC; Junday K; Humphreys DT; Adlam D; Webb TR; Baranowska-Clarke AA; Hamby SE; Carss KJ; Samani NJ; Bax M; McGrath-Cadell L; Kovacic JC; Dunwoodie SL; Fatkin D; Muller DWM; Graham RM; Giannoulatou E, 2022, 'Exploring the Genetic Architecture of Spontaneous Coronary Artery Dissection Using Whole-Genome Sequencing', Circulation: Genomic and Precision Medicine, 15, pp. 267 - 277, http://dx.doi.org/10.1161/CIRCGEN.121.003527
    Journal articles | 2022
    Wu J; Nicks AM; Skowno JJ; Feneley MP; Graham RM; Iismaa SE, 2022, 'Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery', Journal of Visualized Experiments, http://dx.doi.org/10.3791/64004-v
    Journal articles | 2022
    Wu J; Nicks AM; Skowno JJ; Feneley MP; Graham RM; Iismaa SE, 2022, 'Anesthesia and Intubation of Preadolescent Mouse Pups for Cardiothoracic Surgery', Journal of Visualized Experiments, 2022, http://dx.doi.org/10.3791/64004
    Journal articles | 2022
    Yu ZY; Gong H; Kesteven S; Guo Y; Wu J; Li JV; Cheng D; Zhou Z; Iismaa SE; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 is the cardiac mechanosensor that initiates the cardiomyocyte hypertrophic response to pressure overload in adult mice', Nature Cardiovascular Research, 1, pp. 577 - 591, http://dx.doi.org/10.1038/s44161-022-00082-0
    Journal articles | 2022
    2022, 'Abstract 12681: GWAS Meta-Analysis in SCAD, a Women Predominant Ischemic Heart Disease, Reveals Common Variants and Genes Related to Artery Integrity and Tissue-Mediated Coagulation', Circulation, 146, pp. a12681 - a12681, http://dx.doi.org/10.1161/circ.146.suppl_1.12681
    Journal articles | 2021
    Bax M; Junday K; Hesselson S; Iismaa S; Tarr I; McGrath-Cadell L; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham R, 2021, 'Modelling Spontaneous Coronary Artery Dissection With iPSC-Derived Vascular Cells', Heart, Lung and Circulation, 30, pp. S131 - S131, http://dx.doi.org/10.1016/j.hlc.2021.06.089
    Journal articles | 2021
    Griffin KJ; Simpson KR; Beckers CML; Newell LM; Cheah LT; Yuldasheva NY; Iismaa S; Jackson CL; Scott JDA; Pease RJ, 2021, 'Transglutaminase 2 moderates the expansion of mouse abdominal aortic aneurysms', JVS-Vascular Science, 2, pp. 95 - 109, http://dx.doi.org/10.1016/j.jvssci.2021.04.002
    Journal articles | 2021
    Guo Y; Yu ZY; Wu J; Gong H; Kesteven S; Iismaa SE; Chan AY; Holman S; Pinto S; Pironet A; Cox CD; Graham RM; Vennekens R; Feneley MP; Martinac B, 2021, 'The ca2+-activated cation channel trpm4 is a positive regulator of pressure overload-induced cardiac hypertrophy', eLife, 10, http://dx.doi.org/10.7554/eLife.66582
    Journal articles | 2021
    Iismaa SE; Hesselson S; McGrath-Cadell L; Muller DW; Fatkin D; Giannoulatou E; Kovacic J; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia: Vasculopathies With a Predilection for Women', Heart Lung and Circulation, 30, pp. 27 - 35, http://dx.doi.org/10.1016/j.hlc.2020.05.110
    Journal articles | 2021
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Vatner S; Feneley M; Graham RM, 2021, 'Adaptation to exercise-induced stress is not dependent on cardiomyocyte α1A-adrenergic receptors', Journal of Molecular and Cellular Cardiology, 155, pp. 78 - 87, http://dx.doi.org/10.1016/j.yjmcc.2021.02.010
    Journal articles | 2021
    McGrath-Cadell L; Hesselson S; Tarr I; Iismaa S; Bax M; Junday K; Dunwoodie S; Fatkin D; Kovacic J; Muller D; Giannoulatou E; Graham B, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a Family History of Aortic Artery Dissection—A Case Series', Heart, Lung and Circulation, 30, pp. S252 - S252, http://dx.doi.org/10.1016/j.hlc.2021.06.350
    Journal articles | 2021
    McGrath-Cadell L; Hesselson S; Tarr I; Iismaa SE; Bax M; Junday K; Dunwoodie SE; Fatkin D; Kovacic J; Muller DWM; Giannoulatou E; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a family history of aortic artery dissection, a case series', European Heart Journal, 42, http://dx.doi.org/10.1093/eurheartj/ehab724.2787
    Journal articles | 2021
    McGrath-Cadell L; Iismaa SE; Hesselson S; Muller DW; Fatkin D; Giannoulatou E; Kovacic JC; Graham RM, 2021, 'Recent Updates on Spontaneous Coronary Artery Dissection and Fibromuscular Dysplasia', International Journal of Integrative Cardiology, 3, http://dx.doi.org/10.47275/2690-862x-121
    Journal articles | 2021
    Naqvi N; Iismaa SE; Graham RM; Husain A, 2021, 'Mechanism-Based Cardiac Regeneration Strategies in Mammals', Frontiers in Cell and Developmental Biology, 9, http://dx.doi.org/10.3389/fcell.2021.747842
    Journal articles | 2021
    Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'Abstract 11948: A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', Circulation, 144, http://dx.doi.org/10.1161/circ.144.suppl_1.11948
    Journal articles | 2021
    2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', Circulation, 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949
    Journal articles | 2020
    Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, 2020, 'DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling', Scientific Reports, 10, pp. 21918, http://dx.doi.org/10.1038/s41598-020-78825-x
    Journal articles | 2020
    Carss KJ; Baranowska AA; Armisen J; Webb TR; Hamby SE; Premawardhana D; Al-Hussaini A; Wood A; Wang Q; Deevi SVV; Vitsios D; Lewis SH; Kotecha D; Bouatia-Naji N; Hesselson S; Iismaa SE; Tarr I; McGrath-Cadell L; Muller DW; Dunwoodie SL; Fatkin D; Graham RM; Giannoulatou E; Samani NJ; Petrovski S; Haefliger C; Adlam D, 2020, 'Spontaneous Coronary Artery Dissection: Insights on Rare Genetic Variation From Genome Sequencing', Circulation: Genomic and Precision Medicine, 13, pp. E003030, http://dx.doi.org/10.1161/CIRCGEN.120.003030
    Journal articles | 2020
    Griffin KJ; Newell LM; Simpson KR; Beckers CML; Drinkhill MJ; Standeven KF; Cheah LT; Iismaa SE; Grant PJ; Jackson CL; Pease RJ, 2020, 'Transglutaminase 2 limits the extravasation and the resultant myocardial fibrosis associated with factor XIII-A deficiency', Atherosclerosis, 294, pp. 1 - 9, http://dx.doi.org/10.1016/j.atherosclerosis.2019.12.013
    Journal articles | 2020
    Nicks AM; Kesteven SH; Li M; Wu J; Chan AY; Naqvi N; Husain A; Feneley MP; Smith NJ; Iismaa SE; Graham RM, 2020, 'Pressure overload by suprarenal aortic constriction in mice leads to left ventricular hypertrophy without c-Kit expression in cardiomyocytes', Scientific Reports, 10, http://dx.doi.org/10.1038/s41598-020-72273-3
    Journal articles | 2020
    Suzuki AS; Yagi R; Kimura MY; Iwamura C; Shinoda K; Onodera A; Hirahara K; Tumes DJ; Koyama-Nasu R; Iismaa SE; Graham RM; Motohashi S; Nakayama T, 2020, 'Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation', Frontiers in Immunology, 11, http://dx.doi.org/10.3389/fimmu.2020.01536
    Journal articles | 2020
    Zhang J; Grosso Jasutkar H; Yan R; Woo JM; Lee KW; Im JY; Junn E; Iismaa SE; Mouradian MM, 2020, 'Transglutaminase 2 Depletion Attenuates α-Synuclein Mediated Toxicity in Mice', Neuroscience, 441, pp. 58 - 64, http://dx.doi.org/10.1016/j.neuroscience.2020.05.047
    Journal articles | 2019
    Adlam D; Olson TM; Combaret N; Kovacic JC; Iismaa SE; Al-Hussaini A; O'Byrne MM; Bouajila S; Georges A; Mishra K; Braund PS; d'Escamard V; Huang S; Margaritis M; Nelson CP; de Andrade M; Kadian-Dodov D; Welch CA; Mazurkiewicz S; Jeunemaitre X; Motreff P; Belle L; Dupouy P; Barnay P; Meneveau N; Gilard M; Rioufol G; Range G; Brunel P; Delarche N; Filippi E; Le Bivic L; Harbaoui B; Benamer H; Cayla G; Varenne O; Manzo-Silberman SP; Silvain J; Spaulding C; Caussin C; Gerbaud E; Valy Y; Koning R; Lhermusier T; Champin S; Salengro E; Fluttaz A; Zabalawi A; Cottin Y; Teiger E; Saint-Etienne C; Ducrocq G; Marliere S; Boiffard E; Aubry P; Georges JL; Bresson D; De Poli F; Karrillon G; Roule V; Bali L; Valla M; Gerbay A; Houpe D; Dubreuil O; Monnier A; Mayaud N; Manchuelle A; Commeau P; Bedossa M; Wong CMY; Giannoulatou E; Sweeting M; Muller D; Wood A; McGrath-Cadell L; Fatkin D; Dunwoodie SL; Harvey R; Holloway C; Empana JP; Jouven X; Nikpay M; Goel A; Won HH; Hall LM; Willenborg C; Kanoni S; Saleheen D; Kyriakou T; Hopewell JC; Webb TR; Zeng L; Dehghan A; Alver M; Armasu SM; Auro K; Bjonnes A; Chasman DI; Chen S, 2019, 'Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection', Journal of the American College of Cardiology, 73, pp. 58 - 66, http://dx.doi.org/10.1016/j.jacc.2018.09.085
    Journal articles | 2019
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Abstract 579: Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', Circulation Research, 125, http://dx.doi.org/10.1161/res.125.suppl_1.579
    Journal articles | 2019
    Lorand L; Iismaa SE, 2019, 'Correction to: Transglutaminase diseases: from biochemistry to the bedside (The FASEB Journal, (2019), 33, 1, (3-12), 10.1096/fj.201801544R)', FASEB Journal, 33, pp. 4653, http://dx.doi.org/10.1096/fj.201801544RERR
    Journal articles | 2019
    Lorand L; Iismaa SE, 2019, 'Transglutaminase diseases: From biochemistry to the bedside', FASEB Journal, 33, pp. 3 - 12, http://dx.doi.org/10.1096/fj.201801544R
    Journal articles | 2019
    McGrath-Cadell L; Hesselson S; Iismaa S; Mishra K; Wong C; Fatkin D; Dunwoodie S; Harvey R; Holloway C; Muller D; Giannoulatou E; Graham R, 2019, 'Familial Clustering of Spontaneous Coronary Artery Dissection', Heart, Lung and Circulation, 28, pp. S330 - S330, http://dx.doi.org/10.1016/j.hlc.2019.06.454
    Journal articles | 2019
    McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'P5540Familial clustering of spontaneous coronary artery dissection', European Heart Journal, 40, http://dx.doi.org/10.1093/eurheartj/ehz746.0486
    Journal articles | 2019
    Mishra K; Junday K; Wong CMY; Chan AY; Hesselson S; Muller DW; Iismaa SE; Mehta A; Graham RM, 2019, 'Generation of VCCRIi001-A, a human induced pluripotent stem cell line, from a patient with spontaneous coronary artery dissection', Stem Cell Research, 41, http://dx.doi.org/10.1016/j.scr.2019.101584
    Journal articles | 2019
    Poole LG; Pant A; Baker KS; Kopec AK; Cline-Fedewa HM; Iismaa SE; Flick MJ; Luyendyk JP, 2019, 'Chronic liver injury drives non-traditional intrahepatic fibrin(ogen) crosslinking via tissue transglutaminase', Journal of Thrombosis and Haemostasis, 17, pp. 113 - 125, http://dx.doi.org/10.1111/jth.14330
    Journal articles | 2018
    Coleman JLJ; Mouat MA; Wu J; Jancovski N; Bassi JK; Chan AY; Humphreys DT; Mrad N; Yu ZY; Ngo T; Iismaa S; Dos Remedios CG; Feneley MP; Allen AM; Graham RM; Smith NJ, 2018, 'Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control', Biology of Sex Differences, 9, pp. 14, http://dx.doi.org/10.1186/s13293-018-0173-y
    Journal articles | 2018
    Iismaa SE; Kaidonis X; Nicks AM; Bogush N; Kikuchi K; Naqvi N; Harvey RP; Husain A; Graham RM, 2018, 'Comparative regenerative mechanisms across different mammalian tissues', npj Regenerative Medicine, 3, pp. 6, http://dx.doi.org/10.1038/s41536-018-0044-5
    Journal articles | 2018
    Iismaa SE; Li M; Kesteven S; Wu J; Chan AY; Holman SR; Calvert JW; Haq AU; Nicks AM; Naqvi N; Husain A; Feneley MP; Graham RM, 2018, 'Cardiac hypertrophy limits infarct expansion after myocardial infarction in mice', Scientific Reports, 8, pp. 6114, http://dx.doi.org/10.1038/s41598-018-24525-6
    Journal articles | 2018
    Mižíková I; Pfeffer T; Nardiello C; Surate Solaligue DE; Steenbock H; Tatsukawa H; Silva DM; Vadász I; Herold S; Pease RJ; Iismaa SE; Hitomi K; Seeger W; Brinckmann J; Morty RE, 2018, 'Targeting transglutaminase 2 partially restores extracellular matrix structure but not alveolar architecture in experimental bronchopulmonary dysplasia', FEBS Journal, 285, pp. 3056 - 3076, http://dx.doi.org/10.1111/febs.14596
    Journal articles | 2016
    Iismaa SE, 2016, 'The prostate-specific protein, transglutaminase 4 (TG4), is an autoantigen associated with male subfertility', Annals of Translational Medicine, 4, http://dx.doi.org/10.21037/atm.2016.10.02
    Journal articles | 2015
    Cannon L; Yu ZY; Marciniec T; Waardenberg AJ; Iismaa SE; Nikolova-Krstevski V; Neist E; Ohanian M; Qiu MR; Rainer S; Harvey RP; Feneley MP; Graham RM; Fatkin D, 2015, 'Irreversible triggers for hypertrophic cardiomyopathy are established in the early postnatal period', Journal of the American College of Cardiology, 65, pp. 560 - 569, http://dx.doi.org/10.1016/j.jacc.2014.10.069
    Journal articles | 2015
    Naqvi N; Singh R; Iismaa SE; Li M; Calvert JW; Martin DIK; Harvey RP; Graham RM; Husain A, 2015, 'Cardiomyocytes Replicate and their Numbers Increase in Young Hearts', Cell, 163, pp. 783 - 784, http://dx.doi.org/10.1016/j.cell.2015.10.038
    Journal articles | 2014
    Li M; Iismaa SE; Naqvi N; Nicks A; Husain A; Graham RM, 2014, 'Thyroid hormone action in postnatal heart development', Stem Cell Research, 13, pp. 582 - 591, http://dx.doi.org/10.1016/j.scr.2014.07.001
    Journal articles | 2014
    Naqvi N; Li M; Calvert JW; Tejada T; Lambert JP; Wu J; Kesteven SH; Holman SR; Matsuda T; Lovelock JD; Howard WW; Iismaa SE; Chan AY; Crawford BH; Wagner MB; Martin DIK; Lefer DJ; Graham RM; Husain A, 2014, 'A proliferative burst during preadolescence establishes the final cardiomyocyte number', Cell, 157, pp. 795 - 807, http://dx.doi.org/10.1016/j.cell.2014.03.035
    Journal articles | 2014
    Yu ZY; Tan JC; McMahon AC; Iismaa SE; Xiao H; Kesteven SH; Reichelt ME; Mohl MC; Smith NJ; Fatkin D; Allen D; Head SI; Graham RM; Feneley MP, 2014, 'RhoA/ROCK signaling and pleiotropic α1A-adrenergic receptor regulation of cardiac contractility', PLoS ONE, 9, pp. e99024, http://dx.doi.org/10.1371/journal.pone.0099024
    Journal articles | 2013
    Lismaa SE; Aplin M; Holman S; Yiu T; Jackson K; Burchfield JG; Mitchell CJ; O'Reilly L; Davenport A; Cantley J; Schmitz-Peiffer C; Biden TJ; Cooney GJ; Graham RM, 2013, 'Glucose Homeostasis in Mice Is Transglutaminase 2 Independent', PLoS One, 8, pp. Article numbere63346, http://dx.doi.org/10.1371/journal.pone.0063346
    Journal articles | 2013
    Tong L; Png E; AiHua H; Yong SS; Yeo HL; Riau A; Mendoz E; Charausia SS; Lim CT; Yiu TW; Iismaa SE, 2013, 'Molecular mechanism of transglutaminase-2 in corneal epithelial migration and adhesion', Biochimica et Biophysica ACTA - Molecular Cell Research, 1833, pp. 1304 - 1315, http://dx.doi.org/10.1016/j.bbamcr.2013.02.030
    Journal articles | 2013
    Yu Z; Tan J; McMahon A; Iismaa S; Xiao X; Kesteven S; Reichelt M; Mohl M; Dai Y; Sketchley A; Yang L; Gong H; Fatkin D; Allen D; Head S; Graham R; Feneley M, 2013, 'Studies of a Mouse Model of Cardiac α1A-Adrenergic Receptor Overexpression Provide Evidence For a Critical Role of RhoA/ROCK Signalling in Cardiac Contractility', Heart, Lung and Circulation, 22, pp. S59 - S59, http://dx.doi.org/10.1016/j.hlc.2013.05.143
    Journal articles | 2012
    Basso M; Berlin J; Xia L; Sleiman SF; Ko B; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Iismaa SE; Willis D; Cho S; Ratan R, 2012, 'Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation', Journal of Neuroscience, 32, pp. 6561 - 6569, http://dx.doi.org/10.1523/JNEUROSCI.3353-11.2012
    Journal articles | 2012
    Iismaa SE; Aplin M; Yiu T-W; Wu J; Du X-J; Graham RM, 2012, '877 TransglutaminAse 2 is cardioprotective following MyoCardal INFARCTION, but plays no role in cardiac hyPERtrophy', Journal of Hypertension, 30, pp. e256 - e256, http://dx.doi.org/10.1097/01.hjh.0000420443.49005.96
    Journal articles | 2012
    Iismaa SE; Basso M; Berlin J; Xia L; Sleiman SF; Kuo T; Haskew-Layton R; Kim E; Antonyak MA; Cerione RA; Willis D; Cho S, 2012, 'Transglutaminase 2 Inhibition Protects against Oxidative Stress-Induced Neuronal Death Downstream of Pathological ERK Activation', Journal of Neuroscience, 32, pp. 11157 - 11157, http://dx.doi.org/10.1523/JNEUROSCI.2552-12.2012
    Journal articles | 2012
    Liu T; Marshall G; Iismaa S; Liu P; Xu N, 2012, 'Enhancing the anticancer effect of the histone deacetylase inhibitor by activating transglutaminase', European Journal of Cancer, 48, pp. 3278 - 3287, http://dx.doi.org/10.1016/j.ejca.2012.02.067
    Journal articles | 2012
    Zhao X; Park J; Ho D; Gao S; Yan L; Ge H; Iismaa S; Lin L; Tian B; Vatner DE; Graham RM; Vatner SF, 2012, 'Cardiomyocyte overexpression of the á 1A-adrenergic receptor in the rat phenocopies second but not first window preconditioning', American Journal of Physiology - Heart and Circulatory Physiology, 302, pp. H1614 - H1624, http://dx.doi.org/10.1152/ajpheart.01072.2011
    Journal articles | 2011
    Fatkin D; Mohl M; Iismaa SE; Xiao XH; Friedrich O; Wagner ; Nikolova-Krstevski ; Wu J; Yu ZY; Feneley MP; Allen ; Graham RM, 2011, 'Regulation of murine cardiac contractility by activation of alpha(1A)-adrenergic receptor-operated Ca(2+) entry', Cardiovascular Research, 91, pp. 310 - 319
    Journal articles | 2011
    Olsen K; Iismaa SE; Sapinoro R; Kottman RM; Kulkarni AA; Johnson G, 2011, 'Transglutaminase 2 and its role in pulmonary fibrosis', American Journal of Respiratory and Critical Care Medicine, 184, pp. 699 - 707
    Journal articles | 2011
    Wouters MA; Iismaa S; Fan SW; Haworth NL; Haworth , 2011, 'Thiol-based redox signalling: Rust never sleeps', International Journal of Biochemistry and Cell Biology, 43, pp. 1079 - 1085, http://dx.doi.org/10.1016/j.biocel.2011.04.002
    Journal articles | 2010
    Liu T, 2010, 'Opposing Effects of Two Tissue Transglutaminase Protein Isoforms in Neuroblastoma Cell Differentiation', The Journal of Biological Chemistry, 285, pp. 3561 - 3567, http://dx.doi.org/10.1074/jbc.M109.053041
    Journal articles | 2010
    McConoughey S; Basso SJ; Nietsetskaya Z; Sleiman SF; Smirnova T; Langley B; Mahishi L; Cooper AJ; Antonyak MA; Cerione RA; Li B; Starkov A; Chaturvedi R; Beale M; Coppola G; Geschwind D; Ryu H; Li XR; Iismaa SE; Pallos J; Pasternack R; Hils M; Fan J; Raymond LA; Marsh JL; Thompson LM; Ratan R, 2010, 'Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease', EMBO Journal, 2, pp. 349 - 370
    Journal articles | 2010
    Mohl M; Xiao X-H; Prosser H; Iismaa S; Feneley M; Graham R, 2010, 'Involvement of a Novel a1A-Adrenergic Receptor-Coupled Signaling Pathway in Cardiac Contractility', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675506325&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2010
    Zhao X; Vatner DE; Park M; Yan L; IIsmaa S; Graham R; Vatner SF, 2010, 'Transgenic Rats with Cardiac Overexpression of alpha1A Adrenergic Receptors are protected from Myocardial Ischemia by a Nitric Oxide Mechanism', FASEB JOURNAL, 24, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000208675500791&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 2009
    Iismaa SE; Mearns BM; Lorand L; Graham RM, 2009, 'Transglutaminases and disease: Lessons from genetically engineered mouse models and inherited disorders', Physiological Reviews, 89, pp. 991 - 1023
    Journal articles | 2009
    Tatsukawa H; Fukaya Y; Frampton G; Martinez-Fuentes A; Suzuki K; Kuo T; Nagatsuma K; Shimokado K; Okuno M; Wu J; Iismaa SE; Matsuura T; Tsukamoto H; Zern M; Graham RM; Kojima S, 2009, 'Role of Transglutaminase 2 in Liver Injury via Cross-linking and Silencing of Transcription Factor Sp1', Gastroenterology, 136, pp. 1783 - 1795, http://dx.doi.org/10.1053/j.gastro.2009.01.007
    Journal articles | 2006
    Begg G; Carrington L; Stokes P; Matthews JM; Wouters MA; Husain A; Lorand L; Iismaa SE; Graham RM, 2006, 'Mechanism of allosteric regulation of transglutaminase 2 by GTP', Proceedings of the National Academy of Sciences of the United States of America, 103, pp. 19683 - 19688, http://dx.doi.org/10.1073/pnas.0609283103
    Journal articles | 2006
    Begg G; Holman S; Stokes P; Matthews J; Graham RM; Iismaa SE; Holman , 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', The Journal of Biological Chemistry, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200
    Journal articles | 2006
    Begg GE; Holman SR; Stokes PH; Matthews JM; Graham RM; Iismaa SE, 2006, 'Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity', JOURNAL OF BIOLOGICAL CHEMISTRY, 281, pp. 12603 - 12609, http://dx.doi.org/10.1074/jbc.M600146200
    Journal articles | 2006
    Iismaa S; Begg G; Graham RM, 2006, 'Cross-linking transglutaminases with G protein-coupled receptor signaling.', Science S Stke, 353, pp. pe34, http://dx.doi.org/10.1126/stke.3532006pe34
    Journal articles | 2005
    Begg G; Iismaa S; Carrington L; Holman S; Graham RM; Holman , 2005, 'Allosteric inactivation of transglutaminase 2 by GTP involves stabilisation of a conformational substate and formation of a critical Cys/Tyr H-bond', Biophysical Journal, 88, pp. 15A - 15A, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000226378500064&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Begg G; Iismaa SE; Carrington L; Holman S; Husain A; Graham RM; Holman , 2005, 'Allosteric regulation of the transamidase activity of transglutaminase 2 by guanine nucleotide', FEBS Journal, 272, pp. 408 - 408, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000234826102212&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2005
    Krasnikov B; Kim SY; McConoughey S; Ryu H; Xu H; Stavrovskaya I; Iismaa S; Mearns BM; Ratan R; Blass J; Gibson G; Cooper A, 2005, 'Transglutaminase activity is present in highly purified nonsynaptosomal mouse brain and liver mitochondria', Biochemistry, 44, pp. 7830 - 7843
    Journal articles | 2005
    Krasnikov B; Ratan R; Gibson G; Iismaa SE; Cooper A, 2005, 'Transglutaminase activity in non-synaptosomal mouse brain and liver mitochondria', Journal of Neurochemistry, 94, pp. 41 - 41, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000230317200115&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a
    Journal articles | 2003
    Iismaa SE; Graham RM, 2003, 'Dissecting cardiac hypertrophy and signalling pathways: evidence for an interaction between multifunctional G proteins and prostanoids', Corc Res, 92, pp. 1059 - 1061, http://dx.doi.org/10.1161/01.RES.0000075792.92001.D4
    Journal articles | 2003
    Iismaa SE; Holman S; Wouters MA; Lorand L; Graham RM; Husain A; Holman , 2003, 'Evolutionary specialization of a tryptophan indole group for transition-state stabilization by eukaryotic transglutaminases', Proceedings of the National Academy of Sciences of the United States of America, 22, pp. 12636 - 12641, http://dx.doi.org/10.1073/pnas.1635052100
    Journal articles | 2002
    Iismaa SE, 2002, 'Structure and function of tissue transglutaminase.', Minerva Biotecnologica, 14, pp. 113 - 119
    Journal articles | 2002
    Mearns BM; Nanda N; Michalicek J; Iismaa SE; Graham RM, 2002, 'Impaired wound healing and altered fibroblast cytoskeletal dynamics in Gh knockout mice.', Minerva Biotecnologica, 14, pp. 218
    Journal articles | 2002
    Murthy SN; Iismaa SE; Begg G; Freymann DM; Graham RM; Lorand L, 2002, 'Conserved tryptophan in the core domain of transglutaminase is essential for catalytic activity.', Proceedings of the National Academy of Sciences of the United States of America, 99, pp. 2738 - 2742, http://dx.doi.org/10.1073/pnas.052715799
    Journal articles | 2001
    Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/Transglutaminase II', The Journal of Biological Chemistry, 276, pp. 20673 - 20678, http://dx.doi.org/10.1074/jbc.M010846200
    Journal articles | 2001
    Nanda N; Iismaa SE; Owens WA; Husain A; Mackay F; Graham RM, 2001, 'Targeted inactivation of Gh/tissue transglutaminase II', The Journal of Biological Chemistry, pp. 20673 - 20678
    Journal articles | 2000
    Iismaa S; Wu M; Nanda N; Church WB; Graham RM, 2000, 'GTP binding and signaling by Gh/transglutaminase II involves distinct residues in a unique GTP-binding pocket.', The Journal of Biological Chemistry, 275, pp. 18259 - 18265
    Journal articles | 1999
    Harrison C; Raftery MJ; Walsh J; Alewood P; Iismaa S; Thliveris S; Geczy C, 1999, 'Oxidation regulates the inflammatory properties of the murine S100 protein S100A8', The Journal of Biological Chemistry, 274, pp. 8561 - 8569, http://dx.doi.org/10.1074/jbc.274.13.8561
    Journal articles | 1999
    Nanda N; Iismaa SE; Copeland NG; Gilbert DM; Jenkins NA; Graham RM; Sutrave P, 1999, 'Organisation and chromosomal mapping of mouse Gh/tissue transglutaminase gene (Tgm2)', Archives of Biochemistry and Biophysics, 366, pp. 151 - 156, http://dx.doi.org/10.1006/abbi.1999.1189
    Journal articles | 1997
    Iismaa S; Chung L; Wu M; Teller DC; Yee VC; Graham RM, 1997, 'The core domain of the tissue transglutaminase, Gh, hydrolyzes GTP and ATP', Biochemistry, 36, pp. 11655 - 11664, http://dx.doi.org/10.1021/bi970545e
    Journal articles | 1997
    Yen T; Harrison C; Devery JM; Leong S; Iismaa S; Yoshimura T; Geczy C, 1997, 'Induction of the S100 chemotactic protein CP10, in murine microvascular endothelial cells by proinflammatory stimuli', Blood, 90, pp. 4812 - 4821
    Journal articles | 1997
    Yen T; Harrison CA; Devery JM; Leong S; Iismaa SE; Yoshimura T; Geczy CL, 1997, 'Induction of the S100 Chemotactic Protein, CP-10, in Murine Microvascular Endothelial Cells by Proinflammatory Stimuli', Blood, 90, pp. 4812 - 4821, http://dx.doi.org/10.1182/blood.v90.12.4812
    Journal articles | 1996
    Chen S; Lin F; Iismaa S; Lee KN; Birckbichler PJ; Graham RM, 1996, 'α1-adrenergic receptor signaling via G(h) is subtype specific and independent of its transglutaminase activity', Journal of Biological Chemistry, 271, pp. 32385 - 32391, http://dx.doi.org/10.1074/jbc.271.50.32385
    Journal articles | 1996
    Chen S; Lin F; Iismaa SE; Lee K; Birckbichler PJ; Graham RM, 1996, 'Alpha1-Adrenergic receptor signalling via Gh is subtype-specific and independent of its transglutaminase activity', The Journal of Biological Chemistry, 271, pp. 32385 - 32391
    Journal articles | 1994
    Iismaa SE; hu S; Kocher M; Lackmann M; Harrison CA; Thliveris S; Geczy CL, 1994, 'Recombinant and Cellular Expression of the Murine Chemotactic Protein, CP-10', DNA and Cell Biology, 13, pp. 183 - 192, http://dx.doi.org/10.1089/dna.1994.13.183
    Journal articles | 1994
    Vázquez A; Shen B; Negaard K; Iismaa S; Burgess B, 1994, 'Overexpression of ferredoxin I in azotobacter vinelandii', Protein Expression and Purification, 5, pp. 96 - 102, http://dx.doi.org/10.1006/prep.1994.1014
    Journal articles | 1993
    HU SP; IISMAA S; HUME D; GECZY C, 1993, 'EFFECT OF CSF-1, LPS, INF-GAMMA ON CP-10 EXPRESSION IN BONE-MARROW DERIVED-MACROPHAGES', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 50 - 50, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500099&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1993
    IISMAA SE; HU SP; KOCHER M; GECZY CL, 1993, 'CELLULAR EXPRESSION OF CP-10 IN MURINE MYELOID CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, pp. 49 - 49, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:A1993ME18500098&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Journal articles | 1993
    Lackmann M; Rajasekariah P; Iismaa SE; Jones G; Cornish CJ; Hu S; Simpson RJ; Moritz RL; Geczy CL, 1993, 'Identification of a chemotactic domain of the pro-inflammatory S100 protein CP-10', Journal of Immunology, 150, pp. 2981 - 2991
    Journal articles | 1993
    Le O; Shen B; Iismaa SE; Burgess BK, 1993, 'Azotobacter vinelandii mutS: Nucleotide sequence and mutant analysis', Journal of Bacteriology, 175, pp. 7707 - 7710, http://dx.doi.org/10.1128/jb.175.23.7707-7710.1993
    Journal articles | 1991
    Iismaa SE; Vazquez AE; Jensen GM; Stephens PJ; Butt JN; Armstrong FA; Burgess BK, 1991, 'Site-directed mutagenesis of azotobacter vinelandii ferredoxin I. Changes in [4Fe-4S] cluster reduction potential and reactivity', Journal of Biological Chemistry, 266, pp. 21563 - 21571
    Journal articles | 1991
    Soman J; Iismaa S; Stout CD, 1991, 'Crystallographic analysis of two site-directed mutants of azotobacter vinelandii ferredoxin', Journal of Biological Chemistry, 266, pp. 21558 - 21562
    Journal articles | 1989
    Burgess B; Martin A; Iismaa S; Stout C; Cash V; Dean D; Jensen G; Stephens P, 1989, 'Site directed mutagenesis of Azotobacter vinelandii ferredoxin I: [FeS] cluster driven protein rearrangement', Journal of Inorganic Biochemistry, 36, pp. 229 - 229, http://dx.doi.org/10.1016/0162-0134(89)84244-8
    Journal articles | 1989
    Iismaa SE; Ealing PM; Scott KF; Watson JM, 1989, 'Molecular linkage of the nifl fix and nod gene regions in Rhixobium leguminosarum biovear trifolii', Molecular Microbiology, 3, pp. 1753 - 1764, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00161.x
    Journal articles | 1989
    Iismaa SE; Watson JM, 1989, 'The nifA gene product from Rhizobium leguminosarum biovar trifolii lacks the N‐terminal domain found in other NifA proteins', Molecular Microbiology, 3, pp. 943 - 955, http://dx.doi.org/10.1111/j.1365-2958.1989.tb00244.x
    Journal articles | 1989
    Martin AE; Burgess BK; Iismaa SE; Smartt CT; Jacobson MR; Dean DR, 1989, 'Construction and characterization of an Azotobacter vinelandii strain with mutations in the genes encoding flavodoxin and ferredoxin I', Journal of Bacteriology, 171, pp. 3162 - 3167, http://dx.doi.org/10.1128/jb.171.6.3162-3167.1989
    Journal articles | 1987
    Iismaa SE; Watson JM, 1987, 'A gene upstream of the rhizobium trifolii nifa gene encodes a ferredoxin-like protein', Nucleic Acids Research, 15, pp. 3180, http://dx.doi.org/10.1093/nar/15.7.3180
  • Preprints | 2023
    Murtha LA; Hardy SA; Mabotuwana NS; Bigland MJ; Bailey T; Raguram K; Liu S; Ngo DT; Sverdlov AL; Tomin T; Birner-Gruenberger R; Hume RD; Iismaa SE; Humphreys DT; Patrick R; Chong JJH; Lee RJ; Harvey RP; Graham RM; Rainer PP; Boyle AJ, 2023, Fibulin-3 is necessary to prevent cardiac rupture following myocardial infarction, http://dx.doi.org/10.21203/rs.3.rs-3055737/v1
    Conference Abstracts | 2022
    Adiam D; Berrandou TE; Georges A; Nelson CP; Giannoulatou E; Ma L; Blencowe M; Turley T; Yang M-L; Iismaa S; Tarr I; Muller D; Hesselson S; Junday K; Fatkin D; Combaret N; Saw J; Webb T, 2022, 'GWAS Meta-Analysis in SCAD, a Women Predominant Ischemic Heart Disease, Reveals Common Variants and Genes Related to Artery Integrity and Tissue-Mediated Coagulation', in Circulation, Lippincott, Williams & Wilkins, IL, Chicago, Vol. 146, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, IL, Chicago, 05 November 2022 - 06 November 2022, https://www.ahajournals.org/doi/10.1161/circ.146.suppl_1.12681
    Preprints | 2022
    Adlam D; Berrandou T-E; Georges A; Nelson CP; Giannoulatou E; Henry J; Ma L; Blencowe M; Turley TN; Yang M-L; Braund PS; Sadeg-Sayoud I; Iismaa SE; Kosel ML; Zhou X; Hamby SE; Cheng J; Liu L; Tarr I; Muller DWM; d’Escamard V; King A; Brunham LR; Baranowska-Clarke AA; Debette S; Amouyel P; Olin JW; Patil S; Hesselson SE; Junday K; Kanoni S; Aragam K; Butterworth AS; Tweet MS; Gulati R; Combaret N; Kadian-Dodov D; Kalman J; Fatkin D; Saw J; Webb TR; Hayes SN; Yang X; Ganesh SK; Olson TM; Kovacic JC; Graham RM; Samani NJ; Bouatia-Naji N, 2022, Genome-wide association meta-analysis of spontaneous coronary artery dissection reveals common variants and genes related to artery integrity and tissue-mediated coagulation, http://dx.doi.org/10.1101/2022.07.05.22277238
    Conference Abstracts | 2022
    Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham RM; Cox CD; Feneley MP; Martinac B, 2022, 'Piezo1 and TRPM4 work in tandem to initiate cardiac hypertrophic signalling in response to pressure overload', in BIOPHYSICAL JOURNAL, CELL PRESS, Vol. 121, pp. 493A - 493A, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000759523003214&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2021
    McGrath-Cadell L; Hesselson S; Tarr I; Iismaa SE; Bax M; Junday K; Dunwoodie SE; Fatkin D; Kovacic J; Muller DWM; Giannoulatou E; Graham RM, 2021, 'Spontaneous Coronary Artery Dissection (SCAD) and a family history of aortic artery dissection, a case series', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, Vol. 42, pp. 2787 - 2787, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000720456903088&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2021
    Nicks A; Holman S; Chan A; Tsang M; Young P; Humphreys D; Naqvi N; Husain A; Li M; Smith N; Iismaa S; Graham R, 2021, Standardised method for cardiomyocyte isolation and purification from individual murine neonatal, infant, and adult hearts, http://dx.doi.org/10.1101/2021.09.30.462562
    Conference Papers | 2021
    Nicks AM; Holman SR; Chan AY; Pang C-HJ; Tsang M; Naqvi N; Husain A; Li M; Humphreys DT; Smith NJ; Iismaa SE; Graham RM, 2021, 'A Standardized Method to Isolate and Purify Cardiomyocytes from Individual Mouse Hearts Irrespective of Postnatal Age', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004371&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2021
    Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Abstract 11949: Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in Circulation, Vol. 144, pp. a11949 - a11949, http://dx.doi.org/10.1161/circ.144.suppl_1.11949
    Conference Papers | 2021
    Tarr I; Hesselson S; Iismaa S; Troup M; Young P; Mishra K; Wong C; Junday K; Humphreys D; Dunwoodie S; Fatkin D; Muller D; Graham RM; Giannoulatou E, 2021, 'Disease-Specific and Comorbidity-Related Polygenic Risk in Spontaneous Coronary Artery Dissection', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000752020004372&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints | 2021
    Wu J; Nicks AM; Skowno JJ; Feneley MP; Iismaa SE; Graham RM, 2021, Anesthesia and Intubation of 10-Day Old C57BL/6J Mouse Pups for Cardiothoracic Surgery, , http://dx.doi.org/10.21203/rs.3.rs-1144085/v1
    Preprints | 2021
    Yu Z-Y; Gong H; Kesteven S; Guo Y; Wu J; Li J; Iismaa S; Kaidonis X; Graham R; Cox C; Feneley M; Martinac B, 2021, Piezo1 is the cardiac mechanosensor that initiates the hypertrophic response to pressure overload, http://dx.doi.org/10.21203/rs.3.rs-895561/v1
    Preprints | 2020
    Bogush N; Tan L; Naib H; Faizullabhoy E; Calvert JW; Iismaa SE; Gupta A; Ramchandran R; Martin DIK; Graham RM; Husain A; Naqvi N, 2020, DUSP5 expression in left ventricular cardiomyocytes of young hearts regulates thyroid hormone (T3)-induced proliferative ERK1/2 signaling, http://dx.doi.org/10.21203/rs.3.rs-73803/v1
    Preprints | 2020
    Guo Y; Yu Z-Y; Wu J; Gong H; Kesteven S; Iismaa S; Chan A; Holman S; Pinto S; Pironet A; Cox C; Graham R; Vennekens R; Feneley M; Martinac B, 2020, The Ca2+-activated cation channel TRPM4 is a positive regulator of pressure overload-induced cardiac hypertrophy, http://dx.doi.org/10.1101/2020.12.21.423727
    Conference Abstracts | 2019
    Kaidonis X; Niu W; Chan AY; Kesteven S; Wu J; Iismaa SE; Feneley M; Graham RM, 2019, 'Involvement of the Alpha 1A-Adrenergic Receptor in the Cardiac Adaptation to Physiological Stress', in CIRCULATION RESEARCH, LIPPINCOTT WILLIAMS & WILKINS, MA, Boston, Vol. 125, presented at 14th Annual American-Heart-Association's Basic Cardiovascular Sciences (BCVS) Scientific Sessions - Integrative Approaches to Complex Cardiovascular Diseases, MA, Boston, 29 July 2019 - 01 August 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000511467800348&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2019
    McGrath-Cadell L; Hesselson S; Iismaa SE; Mishra K; Wong CMY; Fatkin D; Dunwoodie SL; Harvey R; Holloway CJ; Muller DWM; Giannoulatou E; Graham RM, 2019, 'Familial clustering of spontaneous coronary artery dissection', in EUROPEAN HEART JOURNAL, OXFORD UNIV PRESS, FRANCE, Paris, Vol. 40, pp. 3414 - 3414, presented at Congress of the European-Society-of-Cardiology (ESC) / World Congress of Cardiology, FRANCE, Paris, 31 August 2019 - 04 September 2019, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000507313003083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Nicks AM; Humphreys DT; Holman SR; Chan AY; Djordjevic D; Naqvi N; Husain A; Smith NJ; Ho JW; Iismaa SE; Graham RM, 2018, 'Transcription Factors Driving Postnatal Cardiomyocyte Maturation', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000528619405230&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2018
    Poole L; Pant A; Baker KS; Kopec AK; Cline-Fedewa HM; Iismaa SE; Flick MJ; Luyendyk JP, 2018, 'Thrombin-Mediated Fibrin Polymer Formation Does Not Exacerbate Experimental Hepatic Fibrosis', in HEPATOLOGY, WILEY, CA, San Francisco, pp. 121A - 121A, presented at Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases (AASLD) / Liver Meeting, CA, San Francisco, 09 November 2018 - 13 November 2018, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000446020500192&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2016
    Nicks AM; Holman SR; Chan A; Humphreys DT; Smith NJ; Ho JW; Naqvi N; Husain A; Graham RM; Iismaa SE, 2016, 'Distinct Transcriptomic Signatures Across Postnatal Cardiomyocyte Development', in CIRCULATION, LIPPINCOTT WILLIAMS & WILKINS, LA, New Orleans, presented at Scientific Sessions of the American-Heart-Association / Resuscitation Science Symposium, LA, New Orleans, 12 November 2016 - 16 November 2016, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000396816606015&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Abstracts | 2014
    Nicks AM; Li M; Wu J; Kesteven SH; Fenely MP; Smith NJ; Iismaa SE; Graham RM, 2014, 'A SURGICAL MODEL OF HYPERTENSION AND LEFT VENTRICULAR HYPERTROPHY IN MICE BY SUPRARENAL AORTIC CONSTRICTION', in HYPERTENSION, LIPPINCOTT WILLIAMS & WILKINS, AUSTRALIA, Adelaide, Vol. 65, pp. E39 - E39, presented at 36th Annual Scientific Meeting of the High-Blood-Pressure-Research-Council-of-Australia (HBPRCA), AUSTRALIA, Adelaide, 26 November 2014 - 28 November 2014, https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352490400055&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Conference Papers | 2007
    Yu Z; Lismaa S; Tan JC; Marcininec T; McMahon AC; Sharp D; Kesteven SH; Xiao X; Reichelt M; Wang ZM; Williamson DJ; Graham RM; Fenely M, 2007, 'Cardiac restricted alpha 1A-Adrenergic receptor overexpression in the adult rodent heart induces a hypersensitive contractile response to adrenergic stimulation with reduced baseline contractility but no hypertrophy', in Circulation, Lippincott Williams & Wilkins, Philadelphia, PA, USA, pp. 195 - 195, presented at 80th Annual Scientific Session of the American-Heart-Association, Orlando, Florida, USA, 04 November 2007 - 07 November 2007, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000250394300864&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a

1980-1983 Tertiary Education Scholarship  

1984-1988 Commonwealth Postgraduate Scholarship 

1988-1990 US Biotechnology Training Program Award

1991-1994 NHMRC Postdoctoral Award 

1999 VCCRI Award for Research Excellence 

2000 VCCRI Award for Research Excellence 

2013 St Vincent’s Campus Symposium Award for Research Excellence

2015 Japan Society for the Promotion of Science (JSPS) Fellowship

Key Research Areas:

  • Cardiac regeneration
  • Spontaneous Coronary Artery Dissection 

Research Overview:

1. Cardiac regeneration

As the body grows and matures, heart muscle cells lose their ability to divide. This limits the ability of the heart muscle to regenerate after a heart attack. We are determining the transcriptomic and epigenomic signatures that underpin postnatal CM development to identify the molecular roadblocks that prevent heart muscle repair. Insights into these processes should be directly applicable to the development of powerful new treatments for heart disease.

2. Spontaneous Coronary Artery Dissection 

Spontaneous coronary artery dissection (SCAD) is an epicardial coronary artery dissection (tear) unrelated to atherosclerosis or trauma. It presents predominantly (95%) in women who are not overweight, have few conventional cardiovascular risk factors and it is often associated with pregnancy, and physical or emotional stress. It is the cause of 2-4% of all cases presenting with acute coronary syndrome and accounts for up to 35% of cases of myocardial infarction in women aged <50 yr. The epidemiology, pathogenesis and optimal approaches to diagnosis and management are poorly understood. We are elucidating the genetics and biology of SCAD by 

  • whole genome sequencing (WGS) to identify variants associated with SCAD
  • phenotypic characterisation of human induced pluripotent stem cell (hiPSC-derived) cells from SCAD patients and controls