Dr Simon   Brayford
Conjoint Lecturer

Dr Simon Brayford

Medicine & Health
Sch Women's&Children's Health

Dr Simon Brayford is a researcher at the Children's Cancer Institute and UNSW Conjoint Lecturer. His research interests include cell-signalling, metastasis and understanding mechanisms contributing to chemotherapy resistance in tumours. The aim of this research is to develop novel, multi-targeted therapeutic strategies for a range of adult and childhood cancers.

Location
Level 1, Lowy Cancer Research Centre

Publications

  • Book Chapters | 2015
    Brayford S; Schevzov G; Vos J; Gunning P, 2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16
  • Journal articles | 2019
    Brayford S; Kenny FN; Hiratsuka T; Serna-Morales E; Yolland L; Luchici A; Stramer BM, 2019, 'Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations', Journal of Cell Science, vol. 132, http://dx.doi.org/10.1242/jcs.223974
    Journal articles | 2016
    Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028
    Journal articles | 2021
    Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2021, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, http://dx.doi.org/10.1038/s41563-021-01087-z
    Journal articles | 2021
    Law AL; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2021, 'Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration', Nature Communications, vol. 12, pp. 5687, http://dx.doi.org/10.1038/s41467-021-25916-6
    Book Chapters | 2015
    Brayford S; Schevzov G; Vos J; Gunning P, 2015, 'The role of the actin cytoskeleton in cancer and its potential use as a therapeutic target', in The Cytoskeleton in Health and Disease, pp. 373 - 391, http://dx.doi.org/10.1007/978-1-4939-2904-7_16
  • Conference Presentations | 2018
    Brayford S, 2018, 'EphB2 acts via ERK signalling to promote active cell repulsion and cell sorting', presented at The Dynamic Cell III, Manchester Conference Centre, Manchester, UK, 19 March 2018 - 21 March 2018, https://www.eventsforce.net/biochemsoc/frontend/reg/absViewDocumentFE.csp?popup=1&documentID=298&eventID=17
    Conference Presentations | 2014
    Brayford S; Schevzov G; Hardeman EC; Bear JE; Gunning PW, 2014, 'Tropomyosin 5a/b actin filaments collaborate with arp2/3 actin filaments to regulate cell motility.', Vol. 25, presented at ASCB/IFCB Meeting, Philadelphia, PA, 06 December 2014 - 10 December 2014, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000352094100083&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=891bb5ab6ba270e68a29b250adbe88d1
    Preprints |
    Brayford S; Serna-Morales E; Luchici A; Hiratsuka T; Stramer BM, EphB2 and ERK signaling are required for heterotypic contact inhibition of locomotion to drive cell sorting, http://dx.doi.org/10.1101/373696
    Preprints |
    Law A-L; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration, http://dx.doi.org/10.1101/2020.05.11.083030
    Journal articles | 2021
    Cagigas ML; Bryce NS; Ariotti N; Brayford S; Gunning PW; Hardeman EC, 2021, 'Correlative cryo-ET identifies actin/tropomyosin filaments that mediate cell–substrate adhesion in cancer cells and mechanosensitivity of cell proliferation', Nature Materials, http://dx.doi.org/10.1038/s41563-021-01087-z
    Journal articles | 2021
    Law AL; Jalal S; Pallett T; Mosis F; Guni A; Brayford S; Yolland L; Marcotti S; Levitt JA; Poland SP; Rowe-Sampson M; Jandke A; Köchl R; Pula G; Ameer-Beg SM; Stramer BM; Krause M, 2021, 'Nance-Horan Syndrome-like 1 protein negatively regulates Scar/WAVE-Arp2/3 activity and inhibits lamellipodia stability and cell migration', Nature Communications, vol. 12, pp. 5687, http://dx.doi.org/10.1038/s41467-021-25916-6
    Journal articles | 2019
    Brayford S; Kenny FN; Hiratsuka T; Serna-Morales E; Yolland L; Luchici A; Stramer BM, 2019, 'Heterotypic contact inhibition of locomotion can drive cell sorting between epithelial and mesenchymal cell populations', Journal of Cell Science, vol. 132, http://dx.doi.org/10.1242/jcs.223974
    Journal articles | 2016
    Brayford S; Bryce NS; Schevzov G; Haynes EM; Bear JE; Hardeman EC; Gunning PW, 2016, 'Tropomyosin promotes lamellipodial persistence by collaborating with Arp2/3 at the leading edge', Current Biology, vol. 26, pp. 1312 - 1318, http://dx.doi.org/10.1016/j.cub.2016.03.028

Awards

Grants

Media