Dr Sj   Shen
Postdoctoral Fellow

Dr Sj Shen

2019 - Doctor of Philosophy (Medicine). Monash University / Monash Medical Centre

2014 - Bachelor of Biomedical Sciences (Honours). Monash University / Immunology

Medicine & Health
St. George Clin Sch- Operating

Dr Sj Sijie Shen is a postdoctoral fellow in A/Prof Amany Zekry's group, based at Microbiome Research Centre, St George Clinical School, Kogarah NSW. His research investigates the intricate interactions between host immunity and gut microbiota, and how alterations in the gut contributes and modulates inflammation in the liver. By better understanding the mechanisms that underlie how this "gut-liver axis" impacts liver inflammation and disease, he hopes to find how modifying the gut microbiota can prevent or halt the progression of liver cancer.

Dr Shen is a researcher in respiratory and gastrointestinal tract diseases, with a major focus on the interaction between host immunity and microbiota. He has a special interest in the role that diet plays in immune responses and disease progression and modification. Prior to his current role, Dr Shen trained as a postdoctoral fellow at UTS / Centenary Institute investigating the importance of microbiota in respiratory diseases.

Dr Shen completed his PhD at Monash University (2019) examining the interplay between the gut microbiota and neutrophils in a mouse model of colitis. His research topic during his 3rd year research project and Honours (Monash University) was examining the role of dietary fibre and short-chain fatty acids in a mouse models of lung inflammation (allergic airways disease and aspergillosis) and oesophagitis.

Location
Microbiome Research Centre St George Hospital, Kogarah

Publications

  • Journal articles | 2021
    Dr Sj Shen
    Nucera F; Lo Bello F; Shen SS; Ruggeri P; Coppolino I; Di Stefano A; Stellato C; Casolaro V; Hansbro PM; Adcock IM; Caramori G, 2021, 'Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD', CURRENT MEDICINAL CHEMISTRY, vol. 28, pp. 2577 - 2653, http://dx.doi.org/10.2174/0929867327999200819145327
    Journal articles | 2020
    Dr Sj Shen
    Pinkerton JW; Kim RY; Koeninger L; Armbruster NS; Hansbro NG; Brown AC; Jayaraman R; Shen S; Malek N; Cooper MA; Nordkild P; Horvat JC; Jensen BAH; Wehkamp J; Hansbro PM, 2020, 'Human beta-defensin-2 suppresses key features of asthma in murine models of allergic airways disease', CLINICAL AND EXPERIMENTAL ALLERGY, vol. 51, pp. 120 - 131, http://dx.doi.org/10.1111/cea.13766
    Journal articles | 2020
    Dr Sj Shen
    Paudel KR; Dharwal V; Patel VK; Galvao I; Wadhwa R; Malyla V; Shen SS; Budden KF; Hansbro NG; Vaughan A; Yang IA; Kohonen-Corish MRJ; Bebawy M; Dua K; Hansbro PM, 2020, 'Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases', Frontiers in Medicine, vol. 7, pp. 554, http://dx.doi.org/10.3389/fmed.2020.00554
    Journal articles | 2020
    Dr Sj Shen
    Donovan C; Liu G; Shen S; Marshall JE; Kim RY; Alemao CA; Budden KF; Choi JP; Kohonen-Corish M; El-Omar EM; Yang IA; Hansbro PM, 2020, 'The role of the microbiome and the NLRP3 inflammasome in the gut and lung', Journal of Leukocyte Biology, vol. 108, pp. 925 - 935, http://dx.doi.org/10.1002/JLB.3MR0720-472RR
    Journal articles | 2020
    Dr Sj Shen
    Galvao I; Kim RY; Shen S; Budden KF; Vieira AT; Hansbro PM, 2020, 'Emerging therapeutic targets and preclinical models for severe asthma', EXPERT OPINION ON THERAPEUTIC TARGETS, vol. 24, pp. 845 - 857, http://dx.doi.org/10.1080/14728222.2020.1786535
    Journal articles | 2019
    Dr Sj Shen
    Wen SW; Shim R; Ho L; Wanrooy BJ; Srikhanta YN; Prame Kumar K; Nicholls AJ; Shen SJ; Sepehrizadeh T; de Veer M; Srikanth VK; Ma H; Phan TG; Lyras D; Wong CHY, 2019, 'Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke', Aging Cell, vol. 18, http://dx.doi.org/10.1111/acel.12980
    Journal articles | 2018
    Dr Sj Shen
    Shen S; Kumar KP; Stanley D; Moore RJ; Thi THV; Wen SW; Hickey MJ; Wong CHY, 2018, 'Invariant Natural Killer T Cells Shape the Gut Microbiota and Regulate Neutrophil Recruitment and Function During Intestinal Inflammation', FRONTIERS IN IMMUNOLOGY, vol. 9, http://dx.doi.org/10.3389/fimmu.2018.00999
    Journal articles | 2016
    Dr Sj Shen
    Shen S; Wong CH, 2016, 'Bugging inflammation: role of the gut microbiota', CLINICAL & TRANSLATIONAL IMMUNOLOGY, vol. 5, http://dx.doi.org/10.1038/cti.2016.12
    Journal articles | 2015
    Dr Sj Shen
    Thorburn AN; McKenzie CI; Shen S; Stanley D; Macia L; Mason LJ; Roberts LK; Wong CHY; Shim R; Robert R; Chevalier N; Tan JK; Marino E; Moore RJ; Wong L; McConville MJ; Tull DL; Wood LG; Murphy VE; Mattes J; Gibson PG; Mackay CR, 2015, 'Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites', NATURE COMMUNICATIONS, vol. 6, http://dx.doi.org/10.1038/ncomms8320

Awards

Grants

Media