Dr Steffen   Docken
Research Fellow

Dr Steffen Docken

PhD, MSc, MSc, BA

Medicine & Health
The Kirby Institute

I am a Postdoctoral Research Fellow in the Infection Analytics Program at the Kirby Institute, UNSW, and my research centres around increasing our understanding of the mechanisms underlying diseases. Currently, I primarily work on using mathematical modelling to further our understanding of the mechanisms involved in HIV's reactivation from treatment induced latency and study how variation in the viral replication cycle affects disease progression. I received his Ph.D. in applied mathematics from the University of California, Davis in 2018, where my dissertation research focused on studying the effects of anti-arrhythmic drugs on electrical signalling in the heart.

In my research, I frequently implement mathematical techniques from probability theory, dynamical systems theory, and singular perturbation analysis.

Publications

  • Journal articles | 2021
    Dr Steffen Docken
    Docken SS; Clancy CE; Lewis TJ, 2021, 'Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model', PLoS Computational Biology, vol. 17, pp. e1009145, http://dx.doi.org/10.1371/journal.pcbi.1009145
    Journal articles | 2021
    Dr Steffen Docken
    Eustaquio PC; Docken SS; Leyritana KT; Wulandari LPL, 2021, 'HIV care cascade among cisgender men who have sex with men in a key population-led community center in the Philippines', International Journal of STD and AIDS, vol. 32, pp. 718 - 728, http://dx.doi.org/10.1177/0956462420987435
    Journal articles | 2020
    Dr Steffen Docken
    Corder RM; de Lima ACP; Khoury DS; Docken SS; Davenport MP; Ferreira MU, 2020, 'Quantifying and preventing plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil', PLoS Neglected Tropical Diseases, vol. 14, pp. 1 - 16, http://dx.doi.org/10.1371/journal.pntd.0008526
    Journal articles | 2020
    Dr Steffen Docken
    DeMarino C; Cowen M; Pleet ML; Pinto DO; Khatkar P; Erickson J; Docken SS; Russell N; Reichmuth B; Phan T; Kuang Y; Anderson DM; Emelianenko M; Kashanchi F, 2020, 'Differences in Transcriptional Dynamics Between T-cells and Macrophages as Determined by a Three-State Mathematical Model', Scientific Reports, vol. 10, http://dx.doi.org/10.1038/s41598-020-59008-0
    Journal articles | 2019
    Dr Steffen Docken
    Ciocanel MV; Docken SS; Gasper RE; Dean C; Carlson BE; Olufsen MS, 2019, 'Cardiovascular regulation in response to multiple hemorrhages: analysis and parameter estimation', Biological Cybernetics, vol. 113, pp. 105 - 120, http://dx.doi.org/10.1007/s00422-018-0781-y
    Conference Abstracts | 2019
    Dr Steffen Docken
    Furutani K; Docken S; Vorobyov IV; Clancy CE; Lewis TJ; Sack JT, 2019, 'A Kinetic Mechanism Underlying hERG Facilitation by a Blocker', in Biophysical Journal, Elsevier BV, Vol. 116, pp. 245a - 245a, http://dx.doi.org/10.1016/j.bpj.2018.11.1343
    Conference Abstracts | 2018
    Dr Steffen Docken
    Docken SS; Lewis TJ; Clancy CE, 2018, 'Mechanisms Underlying Rate-Dependent Effects of State-Specific Binding of Sodium Channel Blockers in Cardiac Tissue: Insights from Idealized Models', in Biophysical Journal, Elsevier BV, Vol. 114, pp. 489a - 489a, http://dx.doi.org/10.1016/j.bpj.2017.11.2682
    Journal articles | 2016
    Dr Steffen Docken
    Yang PC; Boras BW; Jeng MT; Docken SS; Lewis TJ; McCulloch AD; Harvey RD; Clancy CE, 2016, 'A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation', PLoS Computational Biology, vol. 12, pp. e1005005, http://dx.doi.org/10.1371/journal.pcbi.1005005
    Conference Abstracts | 2016
    Dr Steffen Docken
    Yang P-C; Boras B; Jeng M-T; Docken S; Lewis T; McCulloch A; Harvey R; Clancy C, 2016, 'A Computational Investigation Predicts Mechanisms of Subcellular cAMP Compartmentation', in Biophysical Journal, Elsevier BV, Vol. 110, pp. 590a - 590a, http://dx.doi.org/10.1016/j.bpj.2015.11.3151
    Journal articles | 2015
    Dr Steffen Docken
    Walcott S; Docken S; Harris SP, 2015, 'Effects of cardiac myosin binding protein-C on actin motility are explained with a drag-activation-competition model', Biophysical Journal, vol. 108, pp. 10 - 13, http://dx.doi.org/10.1016/j.bpj.2014.11.1852
    Conference Abstracts | 2015
    Dr Steffen Docken
    Walcott S; Docken S; Harris SP, 2015, 'Effects of Cardiac Myosin Binding Protein-C on Actin Motility are Explained with a Drag-Activation-Competition Model', in Biophysical Journal, Elsevier BV, Vol. 108, pp. 339a - 339a, http://dx.doi.org/10.1016/j.bpj.2014.11.1849

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