Dr Tom Peat

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Dr Tom Peat received a BA in biophysics and biochemistry from the University of California at Berkeley, and obtained Masters and PhD degrees from Columbia University. Tom has been involved with early-stage biotech companies in the US and has founded two companies in Australia. He has contributed over 300 structures to the Protein Data Bank and has been actively involved in fragment screening and other tools for structure-based drug development. Two of the projects he has been involved with have progressed into phase 2 clinical trials for cancer treatments.

E-mail

t.peat@unsw.edu.au

Book Chapters | 2015

2015, 'Crystallization: Digging into the past to learn lessons for the future', in , pp. 141 - 159, http://dx.doi.org/10.1007/978-1-4939-2230-7_8

Book Chapters | 2012

Hill RJ; Graham LD; Turner KA; Howell L; Tohidi-Esfahani D; Fernley R; Grusovin J; Ren B; Pilling P; Lu L; Phan T; Lovrecz GO; Pollard M; Pawlak-Skrzecz A; Streltsov VA; Peat TS; Winkler DA; Lawrence MC, 2012, 'Chapter Four Structure and Function of Ecdysone Receptors—Interactions with Ecdysteroids and Synthetic Agonists', in Insect Growth Disruptors, Elsevier, pp. 299 - 351, http://dx.doi.org/10.1016/b978-0-12-391500-9.00004-8

Book Chapters | 2012

2012, 'Structure and Function of Ecdysone Receptors-Interactions with Ecdysteroids and Synthetic Agonists', in Advances in Insect Physiology, pp. 299 - 351, http://dx.doi.org/10.1016/B978-0-12-391500-9.00004-8
Journal articles | 2022

Satta A; Esquirol L; Ebert BE; Newman J; Peat TS; Plan M; Schenk G; Vickers CE, 2022, 'Molecular characterization of cyanobacterial short-chain prenyltransferases and discovery of a novel GGPP phosphatase', FEBS Journal, 289, pp. 6672 - 6693, http://dx.doi.org/10.1111/febs.16556

Journal articles | 2022

2022, 'Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed', Acta Crystallographica Section D: Structural Biology, 78, pp. 599 - 612, http://dx.doi.org/10.1107/S2059798322002625

Journal articles | 2021

2021, 'Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices', Nature Communications, 12, pp. 7137, http://dx.doi.org/10.1038/s41467-021-27184-w

Journal articles | 2021

2021, 'Privileged scaffolds in medicinal chemistry: Studies on pyrazolo[1,5-a]pyrimidines on sulfonamide containing Carbonic Anhydrase inhibitors', Bioorganic and Medicinal Chemistry Letters, 49, http://dx.doi.org/10.1016/j.bmcl.2021.128309

Journal articles | 2021

2021, 'Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins', Scientific Reports, 11, pp. 5247, http://dx.doi.org/10.1038/s41598-021-84551-9

Journal articles | 2021

2021, 'The glitazone class of drugs as carbonic anhydrase inhibitors—a spin-off discovery from fragment screening', Molecules, 26, http://dx.doi.org/10.3390/molecules26103010

Journal articles | 2020

2020, 'Azidothymidine "clicked" into 1,2,3-Triazoles: First Report on Carbonic Anhydrase-Telomerase Dual-Hybrid Inhibitors', Journal of Medicinal Chemistry, 63, pp. 7392 - 7409, http://dx.doi.org/10.1021/acs.jmedchem.0c00636

Journal articles | 2020

2020, 'Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application', Advances in Microbial Physiology, 76, pp. 129 - 186, http://dx.doi.org/10.1016/bs.ampbs.2020.01.004

Journal articles | 2020

2020, 'Crystal structures of human ENPP1 in apo and bound forms', Acta Crystallographica Section D: Structural Biology, 76, pp. 889 - 898, http://dx.doi.org/10.1107/S2059798320010505

Journal articles | 2020

2020, 'Discovery of Potent Dual-Tailed Benzenesulfonamide Inhibitors of Human Carbonic Anhydrases Implicated in Glaucoma and in Vivo Profiling of Their Intraocular Pressure-Lowering Action', Journal of Medicinal Chemistry, 63, pp. 3317 - 3326, http://dx.doi.org/10.1021/acs.jmedchem.9b02090

Journal articles | 2020

2020, 'HBO1 is required for the maintenance of leukaemia stem cells', Nature, 577, pp. 266 - 270, http://dx.doi.org/10.1038/s41586-019-1835-6

Journal articles | 2020

2020, 'The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein', Acta Crystallographica Section F: Structural Biology Communications, 76, pp. 583 - 589, http://dx.doi.org/10.1107/S2053230X20015216

Journal articles | 2020

2020, 'X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX', Bioorganic Chemistry, 97, http://dx.doi.org/10.1016/j.bioorg.2020.103669

Journal articles | 2019

2019, 'Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects', European Journal of Medicinal Chemistry, 177, pp. 188 - 197, http://dx.doi.org/10.1016/j.ejmech.2019.05.058

Journal articles | 2019

2019, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', Structural Dynamics, 6, pp. 064701, http://dx.doi.org/10.1063/1.5122849

Journal articles | 2019

2019, 'Structural Basis for the Allosteric Regulation of the SbtA Bicarbonate Transporter by the PII-like Protein, SbtB, from Cyanobium sp. PCC7001', Biochemistry, 58, pp. 5030 - 5039, http://dx.doi.org/10.1021/acs.biochem.9b00880

Journal articles | 2019

2019, 'Structures of the transcriptional regulator BgaR, a lactose sensor', Acta Crystallographica Section D: Structural Biology, 75, pp. 639 - 646, http://dx.doi.org/10.1107/S2059798319008131

Journal articles | 2019

2019, 'Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity', European Journal of Medicinal Chemistry, 181, pp. 111586, http://dx.doi.org/10.1016/j.ejmech.2019.111586

Journal articles | 2019

2019, 'The evolving story of AtzT, a periplasmic binding protein', Acta Crystallographica Section D: Structural Biology, 75, pp. 995 - 1002, http://dx.doi.org/10.1107/S2059798319013883

Journal articles | 2018

Baell JB; Leaver DJ; Hermans SJ; Kelly GL; Brennan MS; Downer NL; Nguyen N; Wichmann J; McRae HM; Yang Y; Cleary B; Lagiakos HR; Mieruszynski S; Pacini G; Vanyai HK; Bergamasco MI; May RE; Davey BK; Morgan KJ; Sealey AJ; Wang B; Zamudio N; Wilcox S; Garnham AL; Sheikh BN; Aubrey BJ; Doggett K; Chung MC; de Silva M; Bentley J; Pilling P; Hattarki M; Dolezal O; Dennis ML; Falk H; Ren B; Charman SA; White KL; Rautela J; Newbold A; Hawkins ED; Johnstone RW; Huntington ND; Peat TS; Heath JK; Strasser A; Parker MW; Smyth GK; Street IP; Monahan BJ; Voss AK; Thomas T, 2018, 'Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth', Nature, 560, pp. 253 - 257, http://dx.doi.org/10.1038/s41586-018-0387-5

Journal articles | 2018

2018, '8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase', Chemistry - A European Journal, 24, pp. 1922 - 1930, http://dx.doi.org/10.1002/chem.201704730

Journal articles | 2018

2018, 'A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. Strain ADP', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0206949

Journal articles | 2018

2018, 'An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme', Journal of Biological Chemistry, 293, pp. 7880 - 7891, http://dx.doi.org/10.1074/jbc.RA118.001996

Journal articles | 2018

2018, 'Cryo-EM structure of the active, G s -protein complexed, human CGRP receptor', Nature, 561, pp. 492 - 497, http://dx.doi.org/10.1038/s41586-018-0535-y

Journal articles | 2018

2018, 'Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology', ACS Medicinal Chemistry Letters, 9, pp. 462 - 467, http://dx.doi.org/10.1021/acsmedchemlett.8b00076

Journal articles | 2018

2018, 'Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects', European Journal of Medicinal Chemistry, 154, pp. 210 - 219, http://dx.doi.org/10.1016/j.ejmech.2018.05.026

Journal articles | 2018

2018, 'Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841', PLoS ONE, 13, http://dx.doi.org/10.1371/journal.pone.0192736

Journal articles | 2018

2018, 'Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus', Acta Crystallographica Section F: Structural Biology Communications, 74, pp. 39 - 45, http://dx.doi.org/10.1107/S2053230X17017708

Journal articles | 2018

2018, 'Synthesis, structure and bioactivity of primary sulfamate-containing natural products', Bioorganic and Medicinal Chemistry Letters, 28, pp. 3009 - 3013, http://dx.doi.org/10.1016/j.bmcl.2018.04.038

Journal articles | 2017

2017, 'Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 29 - 35, http://dx.doi.org/10.1107/S2053230X16019658

Journal articles | 2017

2017, 'Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors', ACS Medicinal Chemistry Letters, 8, pp. 963 - 968, http://dx.doi.org/10.1021/acsmedchemlett.7b00280

Journal articles | 2017

2017, 'High-resolution X-ray structures of two functionally distinct members of the cyclic amide hydrolase family of Toblerone fold enzymes', Applied and Environmental Microbiology, 83, http://dx.doi.org/10.1128/AEM.03365-16

Journal articles | 2017

2017, 'Identification of a New Zinc Binding Chemotype by Fragment Screening', Journal of Medicinal Chemistry, 60, pp. 7333 - 7349, http://dx.doi.org/10.1021/acs.jmedchem.7b00606

Journal articles | 2017

2017, 'Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis', Crystal Growth and Design, 17, pp. 5667 - 5674, http://dx.doi.org/10.1021/acs.cgd.7b00519

Journal articles | 2017

2017, 'Reverse engineering: Transaminase biocatalyst development using ancestral sequence reconstruction', Green Chemistry, 19, pp. 5375 - 5380, http://dx.doi.org/10.1039/c7gc02343j

Journal articles | 2017

2017, 'T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein', PLoS Pathogens, 13, pp. e1006469 - e1006469, http://dx.doi.org/10.1371/journal.ppat.1006469

Journal articles | 2017

2017, 'The nanoscience behind the art of: In-meso crystallization of membrane proteins', Nanoscale, 9, pp. 754 - 763, http://dx.doi.org/10.1039/c6nr07634c

Journal articles | 2017

2017, 'Understanding the control of grape berry ripening and developing opportunities for its manipulation', Acta Horticulturae, 1157, pp. 1 - 10, http://dx.doi.org/10.17660/ActaHortic.2017.1157.1

Journal articles | 2017

2017, 'X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC', Acta Crystallographica Section:F Structural Biology Communications, 73, pp. 24 - 28, http://dx.doi.org/10.1107/S2053230X16020008

Journal articles | 2016

Angeli A; Peat TS; Bartolucci G; Nocentini A; Supuran CT; Carta F, 2016, 'Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors', Organic and Biomolecular Chemistry, 14, pp. 11353 - 11356, http://dx.doi.org/10.1039/c6ob02299e

Journal articles | 2016

2016, 'A β-alanine catabolism pathway containing a highly promiscuous ω-transaminase in the 12-aminododecanate-degrading Pseudomonas sp. strain AAC', Applied and Environmental Microbiology, 82, pp. 3846 - 3856, http://dx.doi.org/10.1128/AEM.00665-16

Journal articles | 2016

2016, 'An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C', Journal of Medicinal Chemistry, 59, pp. 5462 - 5470, http://dx.doi.org/10.1021/acs.jmedchem.6b00443

Journal articles | 2016

2016, 'Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination', Journal of Medicinal Chemistry, 59, pp. 2192 - 2204, http://dx.doi.org/10.1021/acs.jmedchem.5b01940

Journal articles | 2016

2016, 'Some of the most interesting CASP11 targets through the eyes of their authors', Proteins: Structure, Function and Bioinformatics, 84, pp. 34 - 50, http://dx.doi.org/10.1002/prot.24942

Journal articles | 2016

2016, 'Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli', Journal of Medicinal Chemistry, 59, pp. 5248 - 5263, http://dx.doi.org/10.1021/acs.jmedchem.6b00002

Journal articles | 2016

2016, 'Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae', Scientific Reports, 6, pp. 35198, http://dx.doi.org/10.1038/srep35198

Journal articles | 2015

Tanpure RP; Ren B; Peat TS; Bornaghi LF; Vullo D; Supuran CT; Poulsen SA, 2015, 'Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site', Journal of Medicinal Chemistry, 58, pp. 1494 - 1501, http://dx.doi.org/10.1021/jm501798g

Journal articles | 2015

2015, 'Identification of a highly conserved allosteric binding site on Mnk1 and Mnk2 s', Molecular Pharmacology, 88, pp. 935 - 948, http://dx.doi.org/10.1124/mol.115.100131

Journal articles | 2015

2015, 'Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst', Nature Communications, 6, http://dx.doi.org/10.1038/ncomms10278

Journal articles | 2015

2015, 'Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 1505 - 1513, http://dx.doi.org/10.1107/S1399004715009219

Journal articles | 2015

2015, 'The structure of the hexameric atrazine chlorohydrolase AtzA', Acta Crystallographica Section D: Biological Crystallography, 71, pp. 710 - 720, http://dx.doi.org/10.1107/S1399004715000619

Journal articles | 2015

2015, 'Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain', Australian Journal of Chemistry, 68, pp. 1871 - 1879, http://dx.doi.org/10.1071/CH15587

Journal articles | 2015

2015, 'X-Ray structure and mutagenesis studies of the n-isopropylammelide isopropylaminohydrolase, AtzC', PLoS ONE, 10, pp. e0137700, http://dx.doi.org/10.1371/journal.pone.0137700

Journal articles | 2015

2015, 'X-Ray structure of the amidase domain of AtzF, the allophanate hydrolase from the cyanuric acid-mineralizing multienzyme complex', Applied and Environmental Microbiology, 81, pp. 470 - 480, http://dx.doi.org/10.1128/AEM.02783-14

Journal articles | 2014

2014, '300-fold increase in production of the Zn²⁺-dependent dechlorinase trzN in soluble form via apoenzyme stabilization', Applied and Environmental Microbiology, 80, pp. 4003 - 4011, http://dx.doi.org/10.1128/AEM.00916-14

Journal articles | 2014

2014, 'A drunken search in crystallization space', Acta Crystallographica Section F: Structural Biology Communications, 70, pp. 1303 - 1311, http://dx.doi.org/10.1107/S2053230X1401841X

Journal articles | 2014

2014, 'Crystallization and preliminary X-ray diffraction analysis of the amidase domain of allophanate hydrolase from Pseudomonas sp. strain ADP', Acta Crystallographica Section F:Structural Biology Communications, 70, pp. 310 - 315, http://dx.doi.org/10.1107/S2053230X13034705

Journal articles | 2014

2014, 'Cyclic secondary sulfonamides: Unusually good inhibitors of cancer-related carbonic anhydrase enzymes', Journal of Medicinal Chemistry, 57, pp. 3522 - 3531, http://dx.doi.org/10.1021/jm500255y

Journal articles | 2014

2014, 'Interrogating HIV integrase for compounds that bind - A SAMPL challenge', Journal of Computer-Aided Molecular Design, 28, pp. 347 - 362, http://dx.doi.org/10.1007/s10822-014-9721-7

Journal articles | 2014

2014, 'Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 565 - 571, http://dx.doi.org/10.1107/S1399004713031052

Journal articles | 2014

2014, 'Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from staphylococcus aureus', Journal of Medicinal Chemistry, 57, pp. 9612 - 9626, http://dx.doi.org/10.1021/jm501417f

Journal articles | 2014

2014, 'The structure of vanin 1: A key enzyme linking metabolic disease and inflammation', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 3320 - 3329, http://dx.doi.org/10.1107/S1399004714022767

Journal articles | 2014

2014, 'Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits', Acta Crystallographica Section D: Biological Crystallography, 70, pp. 1954 - 1964, http://dx.doi.org/10.1107/S1399004714009626

Journal articles | 2014

2014, 'What's in a name? Moving towards a limited vocabulary for macromolecular crystallisation', Australian Journal of Chemistry, 67, pp. 1813 - 1817, http://dx.doi.org/10.1071/CH14199

Journal articles | 2013

Zhang L; Holmes IP; HochgrÃ¤fe F; Walker SR; Ali NA; Humphrey ES; Wu J; De Silva M; Kersten WJ A; Connor T; Falk H; Allan L; Street IP; Bentley JD; Pilling PA; Monahan BJ; Peat TS; Daly RJ, 2013, 'Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling', Journal of Proteome Research, 12, pp. 3104 - 3116, http://dx.doi.org/10.1021/pr3008495

Journal articles | 2013

2013, 'Construction of the CSIRO fragment library', Australian Journal of Chemistry, 66, pp. 1473 - 1482, http://dx.doi.org/10.1071/CH13325

Journal articles | 2013

2013, 'Correction: Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design (PLoS ONE)', PLoS ONE, 8, http://dx.doi.org/10.1371/annotation/eb238f0f-7582-4318-af95-64ac98d3b0be

Journal articles | 2013

2013, 'Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 712 - 718, http://dx.doi.org/10.1107/S1744309113014152

Journal articles | 2013

2013, 'Cyanuric acid hydrolase: Evolutionary innovation by structural concatenation', Molecular Microbiology, 88, pp. 1149 - 1163, http://dx.doi.org/10.1111/mmi.12249

Journal articles | 2013

2013, 'Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0058298

Journal articles | 2013

2013, 'Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK', PLoS ONE, 8, http://dx.doi.org/10.1371/journal.pone.0059535

Journal articles | 2013

2013, 'Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 69, pp. 275 - 279, http://dx.doi.org/10.1107/S174430911300184X

Journal articles | 2013

2013, 'Fragment screening for the modelling community: SPR, ITC, and crystallography', Australian Journal of Chemistry, 66, pp. 1507 - 1517, http://dx.doi.org/10.1071/CH13302

Journal articles | 2013

2013, 'Fragment screening on Staphylococcus aureus HPPK - A folate pathway target', Australian Journal of Chemistry, 66, pp. 1537 - 1543, http://dx.doi.org/10.1071/CH13298

Journal articles | 2013

2013, 'Parallel screening of low molecular weight fragment libraries: Do differences in methodology affect hit identification?', Journal of Biomolecular Screening, 18, pp. 147 - 159, http://dx.doi.org/10.1177/1087057112465979

Journal articles | 2012

2012, 'Crystal structure of an indole-3-acetic acid amido synthetase from grapevine involved in auxin homeostasis', Plant Cell, 24, pp. 4525 - 4538, http://dx.doi.org/10.1105/tpc.112.102921

Journal articles | 2012

2012, 'On the need for an international effort to capture, share and use crystallization screening data', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 68, pp. 253 - 258, http://dx.doi.org/10.1107/S1744309112002618

Journal articles | 2012

2012, 'Small molecule inhibitors of the LEDGF site of human immunodeficiency virus integrase identified by fragment screening and structure based design', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0040147

Journal articles | 2012

2012, 'Structure of S. aureus HPPK and the discovery of a new substrate site inhibitor', PLoS ONE, 7, http://dx.doi.org/10.1371/journal.pone.0029444

Journal articles | 2012

2012, 'The DINGO dataset: A comprehensive set of data for the SAMPL challenge', Journal of Computer-Aided Molecular Design, 26, pp. 497 - 503, http://dx.doi.org/10.1007/s10822-011-9521-2

Journal articles | 2011

2011, 'A double-emulsion microfluidic platform for in vitro green fluorescent protein expression', Journal of Micromechanics and Microengineering, 21, http://dx.doi.org/10.1088/0960-1317/21/5/054032

Journal articles | 2011

2011, 'An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets', Journal of Biomolecular Screening, 16, pp. 1196 - 1205, http://dx.doi.org/10.1177/1087057111421631

Journal articles | 2011

2011, 'Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site', ChemBioChem, 12, pp. 2311 - 2315, http://dx.doi.org/10.1002/cbic.201100350

Journal articles | 2011

2011, 'Crystallization of an apo form of human arginase: Using all the tools in the toolbox simultaneously', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 67, pp. 90 - 93, http://dx.doi.org/10.1107/S1744309110046208

Journal articles | 2011

2011, 'Enzyme synthesis and activity assay in microfluidic droplets on a chip', Engineering in Life Sciences, 11, pp. 157 - 164, http://dx.doi.org/10.1002/elsc.201000043

Journal articles | 2011

2011, 'Evaluating protic ionic liquids as protein crystallization additives', Crystal Growth and Design, 11, pp. 1777 - 1785, http://dx.doi.org/10.1021/cg1017104

Journal articles | 2011

2011, 'Structural basis for a new mechanism of inhibition of HIV-1 integrase identified by fragment screening and structure-based design', Antiviral Chemistry and Chemotherapy, 21, pp. 155 - 168, http://dx.doi.org/10.3851/IMP1716

Journal articles | 2010

2010, 'A human monoclonal antibody against insulin-like growth factor-II blocks the growth of human hepatocellular carcinoma cell lines in vitro and in vivo', Molecular Cancer Therapeutics, 9, pp. 1809 - 1819, http://dx.doi.org/10.1158/1535-7163.MCT-09-1134

Journal articles | 2010

2010, 'A new crystal form of human vascular adhesion protein 1', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 1572 - 1578, http://dx.doi.org/10.1107/S1744309110041515

Journal articles | 2010

2010, 'Crystallization and preliminary X-ray analysis of 6 - Hydroxymethyl-7,8- dihydropterin pyrophosphokinase from Staphylococcus aureus', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 66, pp. 575 - 578, http://dx.doi.org/10.1107/S1744309110010857

Journal articles | 2010

2010, 'Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation', Molecular Microbiology, 78, pp. 561 - 575, http://dx.doi.org/10.1111/j.1365-2958.2010.07356.x

Journal articles | 2010

2010, 'Structural and functional basis of resistance to neuraminidase inhibitors of influenza B viruses', Journal of Medicinal Chemistry, 53, pp. 6421 - 6431, http://dx.doi.org/10.1021/jm100621s

Journal articles | 2010

2010, 'The C6 Web Tool: A resource for the rational selection of crystallization conditions', Crystal Growth and Design, 10, pp. 2785 - 2792, http://dx.doi.org/10.1021/cg1004209

Journal articles | 2009

2009, 'A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract', Lab on a Chip, 9, pp. 3391 - 3398, http://dx.doi.org/10.1039/b911581a

Journal articles | 2009

2009, 'Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 65, pp. 945 - 948, http://dx.doi.org/10.1107/S1744309109024932

Journal articles | 2009

2009, 'Practical aspects of the SAMPL challenge: Providing an extensive experimental data set for the modeling community', Journal of Biomolecular Screening, 14, pp. 1245 - 1250, http://dx.doi.org/10.1177/1087057109348220

Journal articles | 2008

2008, 'Phoenito experiments: Combining the strengths of commercial crystallization automation', Acta Crystallographica Section F: Structural Biology and Crystallization Communications, 64, pp. 991 - 996, http://dx.doi.org/10.1107/S1744309108029667

Journal articles | 2005

2005, 'Structural analysis of a set of proteins resulting from a bacterial genomics project', Proteins: Structure, Function and Genetics, 60, pp. 787 - 796, http://dx.doi.org/10.1002/prot.20541

Journal articles | 2005

2005, 'Tapping the Protein Data Bank for crystallization information', Acta Crystallographica Section D: Biological Crystallography, 61, pp. 1662 - 1669, http://dx.doi.org/10.1107/S0907444905033202

Journal articles | 2004

2004, 'Crystal Structure of YIGZ, a Conserved Hypothetical Protein from Escherichia coli K12 with a Novel Fold', Proteins: Structure, Function and Genetics, 55, pp. 775 - 777, http://dx.doi.org/10.1002/prot.20087

Journal articles | 2004

2004, 'The 1.59 Å Resolution Crystal Structure of TM0096, a Flavin Mononucleotide Binding Protein from Thermotoga maritima', Proteins: Structure, Function and Genetics, 55, pp. 772 - 774, http://dx.doi.org/10.1002/prot.20086

Journal articles | 2002

2002, 'From information management to protein annotation: Preparing protein structures for drug discovery', Acta Crystallographica Section D: Biological Crystallography, 58, pp. 1968 - 1970, http://dx.doi.org/10.1107/S0907444902016852

Journal articles | 2001

2001, 'A structural genomics approach to the study of quorum sensing: Crystal structures of three LuxS orthologs', Structure, 9, pp. 527 - 537, http://dx.doi.org/10.1016/S0969-2126(01)00613-X

Journal articles | 2001

2001, 'Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase', European Journal of Biochemistry, 268, pp. 5842 - 5850, http://dx.doi.org/10.1046/j.0014-2956.2001.02529.x

Journal articles | 2000

2000, 'Structural genomics in the post-genomics era: The shapes of things to come', Current Opinion in Drug Discovery and Development, 3, pp. 399 - 407

Journal articles | 1999

1999, 'Haloalkane dehalogenases: Structure of a Rhodococcus enzyme', Biochemistry, 38, pp. 16105 - 16114, http://dx.doi.org/10.1021/bi9913855

Journal articles | 1999

1999, 'Intermolecular cleavage by UmuD-like enzymes: Identification of residues required for cleavage and substrate specificity', Journal of Molecular Biology, 285, pp. 2199 - 2209, http://dx.doi.org/10.1006/jmbi.1998.2433

Journal articles | 1998

1998, 'A nondenaturing purification scheme for the DNA-binding domain of poly(ADP-ribose) polymerase, a structure-specific DNA-binding protein', Protein Expression and Purification, 14, pp. 79 - 86, http://dx.doi.org/10.1006/prep.1998.0919

Journal articles | 1998

1998, 'Class-directed structure determination: Foundation for a protein structure initiative', Protein Science, 7, pp. 1851 - 1856, http://dx.doi.org/10.1002/pro.5560070901

Journal articles | 1998

1998, 'Novel Escherichia coli umuD' mutants: Structure-function insights into SOS mutagenesis', Journal of Bacteriology, 180, pp. 4658 - 4666, http://dx.doi.org/10.1128/jb.180.17.4658-4666.1998

Journal articles | 1998

1998, 'Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 Å resolution', Structure, 6, pp. 1207 - 1214, http://dx.doi.org/10.1016/S0969-2126(98)00120-8

Journal articles | 1996

1996, 'Production and crystallization of a selenomethionyl variant of UmuD', an Escherichia coli SOS response protein', Proteins: Structure, Function and Genetics, 25, pp. 506 - 509, http://dx.doi.org/10.1002/(SICI)1097-0134(199608)25:4<506::AID-PROT10>3.3.CO;2-Z

Journal articles | 1996

1996, 'Structure of the UmuD′ protein and its regulation in response to DNA damage', Nature, 380, pp. 727 - 730, http://dx.doi.org/10.1038/380727a0

Journal articles | 1996

1996, 'The UmuD' protein filament and its potential role in damage induced mutagenesis', Structure, 4, pp. 1401 - 1412, http://dx.doi.org/10.1016/S0969-2126(96)00148-7

Journal articles | 1995

1995, 'Characterization of crystals of the thermostable DNA polymerase I from thermus aquaticus', Proteins: Structure, Function, and Bioinformatics, 23, pp. 111 - 114, http://dx.doi.org/10.1002/prot.340230112
Preprints | 2019

2019, Structural basis for the allosteric regulation of the SbtA bicarbonate transporter by the P_II-like protein, SbtB, fromCyanobiumsp. PCC7001, , http://dx.doi.org/10.1101/762807

Conference Papers | 2018

2018, 'Fragment screening for a protein-protein interaction inhibitor to WDR5', in ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES, INT UNION CRYSTALLOGRAPHY, pp. A139 - A139, http://dx.doi.org/10.1107/S0108767318098604

Conference Papers | 2013

2013, 'How to fabricate robust microfluidic systems for a dollar', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033508

Conference Papers | 2013

2013, 'Integrated microdroplet-based system for enzyme synthesis and sampling', in Proceedings of SPIE - The International Society for Optical Engineering, http://dx.doi.org/10.1117/12.2033569

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Dr Tom Peat