Dr Ying Zhu

Dr Ying Zhu

Adjunct Fellow Levels A-C
  • PhD, Chemistry, The University of New South Wales (UNSW), Australia (01/2015)
  • Bachelor’s degree, Materials Science and Engineering, Huazhong University of Science and Technology, China (06/2009)

 

Medicine & Health
School of Clinical Medicine

Dr Zhu is a Senior Lecturer from the School of Biomedical Engineering at UTS. She is also holding an adjunct position with the School of Clinical Medicine at UNSW Sydney. Dr Zhu completed her PhD in the area of optical biosensors with Professor Justin Gooding (Editor-in-Chief of ACS Sensor) from 2011 to 2015 in Australia’s top biosensor and biodevice group at UNSW. Dr Zhu’s subsequent postdoc work (2015-2017) in the Thayer School of Engineering at Dartmouth College (ranked 55th among American engineering schools) extended her expertise in biosensors to the field of translational cancer research. Dr Zhu was supported by Cancer Institute NSW Early Career Fellowship (2017-2020) to further establish her work in using nanoplasmonic biosensors for cancer diagnosis. She joined UTS in 2020 as a Lecturer and was promoted to Senior Lecturer in 2023. Dr Zhu was a recipient of DECRA 2024.

Phone
+61 2 9385 5804
  • Book Chapters | 2014
    Gooding JJ; Zhu Y, 2014, '5 Modifying porous silicon with self-assembled monolayers for biomedical applications', in Porous Silicon for Biomedical Applications, Elsevier, pp. 81 - 103, http://dx.doi.org/10.1533/9780857097156.1.81
    Book Chapters | 2014
    Gooding JJ; Zhu Y, 2014, 'Modifying porous silicon with self-assembled monolayers for biomedical applications', in Porous Silicon for Biomedical Applications, Elsevier Ltd., Cambridge, UK, pp. 81 - 103, http://dx.doi.org/10.1533/9780857097156.1.81
    Book Chapters | 2014
    Santos HA; Canham LT; Salonen J; Mäkilä E; Koshida N; Kolasinski KW; Gooding JJ; Zhu Y; De Stefano L; Rea I; Giardina P; Longobardi S; Torres-Costa V; Martín-Palma RJ; Srinivasan S; Leonard F; Kuncewicz TM; Godin B; Airaksinen AJ; Liu Q; Brown VL; He L; Massad-Ivanir N; Segal E; Weiss SM; Lehto V-P; Riikonen J; Prestidge CA; Barnes TJ; Fernandez-Moure JS; Evangelopoulos M; Scaria S; Martinez JO; Brown BS; Coronel AC; Chan P; Weiner B; Ferrari M; Tasciotti E; Park J-H; McInnes SJP; Voelcker NH; Coffer JL; Collart Dutilleul P-Y; Deville de Périère D; Cuisinier FJ; Cunin F; Gergely C, 2014, 'Contributor contact details', in Porous Silicon for Biomedical Applications, Elsevier, pp. xiii - xvi, http://dx.doi.org/10.1016/b978-0-85709-711-8.50023-4
  • Journal articles | 2023
    Zhand S; Zhu Y; Nazari H; Sadraeian M; Warkiani ME; Jin D, 2023, 'Correction to "Thiolate DNAzymes on Gold Nanoparticles for Isothermal Amplification and Detection of Mesothelioma-derived Exosomal PD-L1 mRNA".', Anal Chem, 95, pp. 12193, http://dx.doi.org/10.1021/acs.analchem.3c03312
    Journal articles | 2023
    Zhand S; Zhu Y; Nazari H; Sadraeian M; Warkiani ME; Jin D, 2023, 'Thiolate DNAzymes on Gold Nanoparticles for Isothermal Amplification and Detection of Mesothelioma-derived Exosomal PD-L1 mRNA', Analytical Chemistry, 95, pp. 3228 - 3237, http://dx.doi.org/10.1021/acs.analchem.2c04046
    Journal articles | 2022
    Huang G; Liu Y; Wang D; Zhu Y; Wen S; Ruan J; Jin D, 2022, 'Upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles', eLight, 2, http://dx.doi.org/10.1186/s43593-022-00031-1
    Journal articles | 2022
    Huang G; Zhu Y; Wen S; Mei H; Liu Y; Wang D; Maddahfar M; Su QP; Lin G; Chen Y; Jin D, 2022, 'Single Small Extracellular Vesicle (sEV) Quantification by Upconversion Nanoparticles', Nano Letters, http://dx.doi.org/10.1021/acs.nanolett.2c00724
    Journal articles | 2021
    Bai X; Ni J; Beretov J; Wasinger VC; Wang S; Zhu Y; Graham P; Li Y, 2021, 'Activation of the eIF2 alpha/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis', REDOX BIOLOGY, 43, http://dx.doi.org/10.1016/j.redox.2021.101993
    Journal articles | 2021
    Bai X; Ni J; Beretov J; Wasinger VC; Wang S; Zhu Y; Graham P; Li Y, 2021, 'Activation of the eIF2α/ATF4 axis drives triple-negative breast cancer radioresistance by promoting glutathione biosynthesis', Redox Biology, 43, http://dx.doi.org/10.1016/j.redox.2021.101993
    Journal articles | 2021
    Zhand S; Xiao K; Razavi Bazaz S; Zhu Y; Bordhan P; Jin D; Warkiani ME, 2021, 'Improving capture efficiency of human cancer cell derived exosomes with nanostructured metal organic framework functionalized beads', Applied Materials Today, 23, http://dx.doi.org/10.1016/j.apmt.2021.100994
    Journal articles | 2021
    Zhu Y; Reece PJ, 2021, 'Differential Interference Contrast-Based Interrogation of Plasmonic Gold Nanohole Arrays for Label-Free Imaging Sensing', ACS Applied Nano Materials, 4, pp. 10657 - 10664, http://dx.doi.org/10.1021/acsanm.1c02100
    Journal articles | 2020
    Huang G; Lin G; Zhu Y; Duan W; Jin D, 2020, 'Emerging technologies for profiling extracellular vesicle heterogeneity', Lab on a Chip, 20, pp. 2423 - 2437, http://dx.doi.org/10.1039/d0lc00431f
    Journal articles | 2020
    Pang B; Zhu Y; Ni J; Ruan J; Thompson J; Malouf D; Bucci J; Graham P; Li Y, 2020, 'Quality assessment and comparison of plasma-derived extracellular vesicles separated by three commercial kits for prostate cancer diagnosis', International Journal of Nanomedicine, 15, pp. 10241 - 10256, http://dx.doi.org/10.2147/IJN.S283106
    Journal articles | 2020
    Pang B; Zhu Y; Ni J; Thompson J; Malouf D; Bucci J; Graham P; Li Y, 2020, 'Extracellular vesicles: The next generation of biomarkers for liquid biopsy-based prostate cancer diagnosis', Theranostics, 10, pp. 2309 - 2326, http://dx.doi.org/10.7150/thno.39486
    Journal articles | 2020
    2020, 'Impact of metal crystallinity-related morphologies on the sensing performance of plasmonic nanohole arrays', , http://dx.doi.org/10.1039/d0nr00619j
    Journal articles | 2019
    Feng X; Bai X; Ni J; Wasinger VC; Beretov J; Zhu Y; Graham P; Li Y, 2019, 'CHTOP in chemoresistant epithelial ovarian cancer: A novel and potential therapeutic target', Frontiers in Oncology, 9, pp. 557, http://dx.doi.org/10.3389/fonc.2019.00557
    Journal articles | 2019
    2019, 'Liquid biopsy in ovarian cancer: Recent advances in circulating extracellular vesicle detection for early diagnosis and monitoring progression', , http://dx.doi.org/10.7150/thno.34692
    Journal articles | 2019
    2019, 'Micropatterning of porous silicon Bragg reflectors with poly(ethylene glycol) to fabricate cell microarrays: Towards single cell sensing', , http://dx.doi.org/10.1016/j.bios.2018.12.001
    Journal articles | 2017
    Chorsi HT; Zhu Y; Zhang JXJ, 2017, 'Patterned Plasmonic Surfaces - Theory, Fabrication, and Applications in Biosensing', Journal of Microelectromechanical Systems, 26, pp. 718 - 739, http://dx.doi.org/10.1109/JMEMS.2017.2699864
    Journal articles | 2016
    Yang Y; Ciampi S; Zhu Y; Gooding JJ, 2016, 'Light-Activated Electrochemistry for the Two-Dimensional Interrogation of Electroactive Regions on a Monolithic Surface with Dramatically Improved Spatial Resolution', Journal of Physical Chemistry C, 120, pp. 13032 - 13038, http://dx.doi.org/10.1021/acs.jpcc.6b02289
    Journal articles | 2016
    Zhu Y; Kekalo K; NDong C; Huang Y-Y; Shubitidze F; Griswold KE; Baker I; Zhang JXJ, 2016, 'Magnetic-Nanoparticle-Based Immunoassays-on-Chip: Materials Synthesis, Surface Functionalization, and Cancer Cell Screening', ADVANCED FUNCTIONAL MATERIALS, 26, pp. 3953 - 3972, http://dx.doi.org/10.1002/adfm.201504176
    Journal articles | 2015
    Choudhury MH; Ciampi S; Yang Y; Tavallaie R; Zhu Y; Zarei L; Gonçales VR; Gooding JJ; Goncales V, 2015, 'Connecting electrodes with light: One wire, many electrodes', Chemical Science, 6, pp. 6769 - 6776, http://dx.doi.org/10.1039/c5sc03011k
    Journal articles | 2014
    Soeriyadi AH; Zhu Y; Reece P; Gooding JJ, 2014, 'Modification of porous silicon rugate filters through thiol-yne photochemistry', AIP Conference Proceedings, 1586, pp. 35 - 38, http://dx.doi.org/10.1063/1.4866725
    Journal articles | 2014
    Zhu Y; Soeriyadi AH; Parker SG; Reece PJ; Gooding JJ, 2014, 'Chemical patterning on preformed porous silicon photonic crystals: Towards multiplex detection of protease activity at precise positions', Journal of Materials Chemistry B, 2, pp. 3582 - 3588, http://dx.doi.org/10.1039/c4tb00281d
    Journal articles | 2013
    Gupta B; Zhu Y; Guan B; Reece PJ; Gooding JJ, 2013, 'Functionalised porous silicon as a biosensor: Emphasis on monitoring cells in vivo and in vitro', Analyst, 138, pp. 3593 - 3615, http://dx.doi.org/10.1039/c3an00081h
    Journal articles | 2013
    Ngalim SH; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy.', Journal of visualized experiments : JoVE, http://dx.doi.org/10.3791/50310
    Journal articles | 2013
    Zhu Y; Gupta B; Guan B; Ciampi S; Reece PJ; Gooding JJ, 2013, 'Photolithographic strategy for patterning preformed, chemically modified, porous silicon photonic crystal using click chemistry', ACS Applied Materials and Interfaces, 5, pp. 6514 - 6521, http://dx.doi.org/10.1021/am4006012
    Journal articles | 2012
    Ciampi S; Guan B; Darwish N; Zhu Y; Reece PJ; Gooding JJ, 2012, 'A Multimodal Optical and Electrochemical Device for Monitoring Surface Reactions: Redox Active Surfaces in Porous Silicon Rugate Filters', Physical Chemistry Chemical Physics, 14, pp. 16433 - 16439, http://dx.doi.org/10.1039/c2cp43461j
    Journal articles | 2011
    Zhang Y; He J; Zhu Y; Chen H; Ma H, 2011, 'Directly observed Au-S bond breakage due to swelling of the anchored polyelectrolyte', Chemical Communications, 47, pp. 1190 - 1192, http://dx.doi.org/10.1039/c0cc04291a
    Journal articles | 2011
    Zhu Y; Lv B; Zhang P; Ma H, 2011, 'Swelling induced Au-S bond breakage is determined by the molecular composition of surface tethered copolymers - Carboxylated poly(OEGMA-r-HEMA)', Chemical Communications, 47, pp. 9855 - 9857, http://dx.doi.org/10.1039/c1cc13106k
    Journal articles | 2010
    Zhu Y; Yang D; Ma H, 2010, 'One-step fabrication of porous polymeric microcage via electrified jetting', Nanoscale, 2, pp. 910 - 912, http://dx.doi.org/10.1039/c0nr00081g
    Journal articles | 2009
    Yang D; Liu X; Jin Y; Zhu Y; Zeng D; Jiang X; Ma H, 2009, 'Electrospinning of poly(dimethylsiloxane)/poly(methyl methacrylate) nanofibrous membrane: Fabrication and application in protein microarrays', Biomacromolecules, 10, pp. 3335 - 3340, http://dx.doi.org/10.1021/bm900955p
  • Conference Abstracts | 2019
    Bai X; Feng X; Ni J; Beretov J; Deng J; Zhu Y; Graham P; Li Y, 2019, 'CHTOP is a novel therapeutic target for chemoresistant epithelial ovarian cancer therapy', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, GA, Atlanta, Vol. 79, presented at Annual Meeting of the American-Association-for-Cancer-Research (AACR), GA, Atlanta, 29 March 2019 - 03 April 2019, http://dx.doi.org/10.1158/1538-7445.SABCS18-4754
    Preprints | 2017
    Chorsi HT; Zhu Y; Zhang JXJ, 2017, Decorative Plasmonic Surfaces, , http://dx.doi.org/10.48550/arxiv.1705.00573

Dr Zhu has secured $1.35m external funds. She was the lead CI in 90% of them ($1.2m). Below is the detailed list:

  • Ying Zhu, Optical Metasurface for Single Small Extracellular Vesicle Analysis, DECRA 2024, A$450,000, 2023
  • Ying Zhu, Phoebe Phillips, Nham Tran, George Sharbeen, A blood test for early detection of pancreatic cancer by single extracellular vesicle analysis, Pankind Innovation Grants, A$99,697, 2022
  • Ying Zhu, Yong Li, Phoebe Phillips, Peter J. Reece, Multiparameter analysis of exosomes for non-invasive early detection of pancreatic cancer using a point-of-care nanoplasmonic sensor, Pankind Innovation Grants, A$96,033, 2020
  • Yong Li, Ying Zhu, Peter J. Reece, Chee Khoon Lee, Raymond Wong, Combining nanoplasmonic profiling with machine learning for non-invasive early detection of ovarian cancer using plasma exosomes, Ovarian Cancer Research Foundation, A$134,026, 2020 (external)
  • Ying Zhu, Rapid isolation and analysis of circulating exosomes using label-free nanoplasmonic sensors for non-invasive breast cancer diagnostics, Cancer Institute NSW Early Career Fellowship, A$572,268, 2017-2020 (external)

  • Young Investigator Award, 2018, Lion Club of Kogarah Inc.
  • 1st Price, Basic Science, Medical Research Symposium 2018, St George & Sutherland Hospital
  • Rising Star Award, 2018, Australian Association of Chinese Biomedical Scientists
  • Cancer Institute NSW Early Career Fellowship, 2017-2020
  • Chinese Government Award for Outstanding Students Abroad, 2014
  • UNSW Tuition Fee Scholarship, 2011-2014

Dr Zhu is the group leader of the Laboratory of In-Vitro NanoDiagnostics. She is rapidly gaining international recognition as an emerging leader in her field, recognised by her publications in prestigious journals. Out of her 29 publications, 81.8% are in the top 10% of journals and 91% are in the Q1 journals. Ying’s works have received 843 citations with an H-index of 17, including a 1% highly cited paper in Clinical Medicine. Ying has secured $1.89m research funds. She was the lead CI in 90% of her external funds, including two prestigious fellowships: DECRA and Cancer Institute NSW Early Career Fellowship. Dr Zhu’s current research focuses on advancing diagnostic technologies by translating frontier nanoscale tools. She works in a multidisciplinary field across chemistry, physics, materials, nanotechnology and biomedicine. She has been dedicated to translational biomedical research via the development of new analytical technologies using a multi-disciplinary, highly collaborative, “bench-to-bedside” approach.