We are proud to announce that WWSW lab has become the first green-certified lab in Sydney and the second lab in Australia. A special thanks and congratulations to Nancy Martin La Rotta whose efforts made this achievement possible.
Congratulations to Chanchanok Chaichim and Lital Livni who submitted their PhD theses in 2021.
Congratulations to the neuroscience honors students who graduated from the TNF in 2020:
If you are interested in studying with us, please find your favorite team or project and contact them directly.
Chamini J Perera, Samuel S Duffy, Justin G Lees, Cristina F Kim, Barbara Cameron, Vasso Apostolopoulos and Gila Moalem-Taylor “Active immunization with myelin-derived altered peptide ligand reduces mechanical pain hypersensitivity following peripheral nerve injury”Journal of Neuroinflammation doi: 10.1186/s12974-015-0253-4.
This is Chamini’s first publication from her PhD studies with Neuropathic pain research group.
The study was the first to identify the effects of active immunisation with myelin derived altered peptide ligand (APL) on neuropathic pain following peripheral nerve injury. We found that immune deviation by active immunisation with a non-encephalitogenic myelin-derived APL mediates an analgesic effect in neuropathic animals. Although the underlying mechanisms remain unknown, our results suggest that modulating neuroinflammation by decreased infiltration of T cells and macrophages, upregulation of anti-inflammatory macrophages in the injured nerve, and upregulation of splenic regulatory T cells are all possible explanations. These findings suggest the potential application of immunisation with myelin-derived APL for the treatment of peripheral neuropathic pain.