PSC-derived Organoids

Cerebral organoids are 3D brain-like structures derived from pluripotent stem cells, replicating key features of the developing human brain. We generate these organoids using established protocols (Lancaster et al. 2013). Alternative protocols are available upon request.

Branching lung organoids are 3D models derived from stem cells that replicate lung development and function, ideal for studying lung diseases and infections. We generate these organoids in-house using a robust, reproducible kit from STEMCell Technologies.

Assembloids are advanced 3D models combining multiple organoids or cell types to study complex interactions. Cerebral, immune, and vascular assembloids are valuable for investigating brain-immune system interactions, tumour vascularisation, disease mechanisms, and therapeutic responses.

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GIT-related Organoids: Gastrointestinal tract (GIT) organoids are 3D models derived from stem cells, replicating the structure and function of tissues like the stomach, intestines, and colon. These organoids are valuable for studying digestion, disease mechanisms, and drug testing.

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Respiratory organoids are 3D structures derived from stem cells that replicate the complexity of the respiratory system, including airways and alveolar regions. These models are used to study lung development, respiratory diseases, and host-pathogen interactions.

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Vascular organoids are complex 3D structures developed from stem cells that closely mimic the architecture and function of human blood vessels. These models are invaluable for studying vascular development, angiogenesis, the mechanisms underlying vascular diseases and exploring regenerative therapies.

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