The PrEPARE Project is investigating the attitudes of gay and bisexual men to new HIV prevention technologies, particularly pre-exposure prophylaxis (PrEP) and treatment as prevention. The first phase of the project, conducted in 2011 and 2012, involved an online survey of over 1500 men and qualitative interviews with a subset of those men. This phase identified that a relatively small proportion of gay and bisexual men were very interested in using PrEP and that willingness to use PrEP was concentrated among men who appeared to be most at risk of HIV. We also compared the attitudes of HIV-positive and HIV-negative men towards PrEP and treatment as prevention, revealing scepticism about treatment as prevention in both groups of men. Follow-up online surveys were conducted in 2013, 2015, 2017 and 2019, showing more positive attitudes to treatment as prevention, greater interest in and support for PrEP, and the rapid uptake of PrEP by HIV-negative men, particularly between 2015 and 2019.