Understanding how we can use different materials to optimise and transform medical technologies. We work across areas from dental materials, mechanics of biological tissues to manufactured impacts.
We have extensive research expertise in additive manufacturing of metallic materials for orthopaedic and dental implants (e.g., via laser powder bed fusion). While additive manufacturing enables the production of patient specific and customizable implants, it also imbues unique microstructures and properties that must be well understood prior to clinical implementation. Additionally, we are investigating the shape memory behaviour of metals and polymers produced by various additive manufacturing routes.
Our researchers are working to develop novel and improved dental restorative materials by better understanding the relationships between their material structure and their mechanical and biological performance in the oral environment.
The human body is a complex biomechanical system comprised of many multi-functional load bearing tissues such as bone, teeth, skin, etc. Our research focuses on understanding the response of these tissues to mechanical forces and biological stimuli, with the long-term goal of guiding improved clinical outcomes in orthopaedics, dentistry, dermatologic surgery, etc.
We also seek to understand the mechanical behaviour of biological tissues from the natural world to enhance our understanding of how nature has optimised materials design and to provide inspiration for synthetic biomaterials development.
The significance of using laser-irradiated gold nanoparticles (GNP) embedded in biological tissues arises from their unique strong optical resonance absorption. This occurs in the so-called therapeutic window at wavelengths between 0.6 μm to 1.4 μm which results in a controllable, rapid temperature increase. This can be a powerful tool for the localised hyperthermia in the vicinity of targeted diseased cells and lead to destroying cancer cells or bacteria. Targeted heat generation can be also achieved using magnetic nanoparticles activated by alternating magnetic field.
We develop advanced nanomaterials with an optimum enhancement of absorption or scattering of light which can be used for both hyperthermia and imaging/diagnostics of diseases. A three-dimensional computational modelling is aimed to predict nanoparticles aggregates under the influence of different stimuli such as pH or magnetic field.
In magnetic field experiments we will impose alternating magnetic field and study the effects of alternating and rotating magnetic fields on the aggregation and disaggregation of nanoparticles and resulting heat generation. <./p>
Examples of the projects: