From cells to tissue: modelling the electrophysiology of the human heart

Abstract: 

This talk gives an overview on the use of non-local or fractional models for modelling the electrophysiology of the heart when taking into account the heterogeneous nature of cardiac tissue. Space fractional partial differential equations will be introduced along with some new computational and modelling approaches. We will then show how model parameters can be extracted from a variety of sources including a heart in a dish, ECGs and Diffusion Tensor Magnetic Resonance Images and using clinical data we will attempt to construct spatial biomarkers for understanding hypertrophic cardiomyopathy via the disarray of the cardiac fibres.

This is joint work with Dr Alfonso Bueno-Orovio, Professor Blanca Rodriguez, Dr David Kay and Professor Vicente Grau (Oxford)